{"id":"https://openalex.org/W4403043810","doi":"https://doi.org/10.1158/1078-0432.27142531","title":"Figure 1 from Elacestrant in ER+, HER2\u2212 Metastatic Breast Cancer with ESR1-Mutated Tumors: Subgroup Analyses from the Phase III EMERALD Trial by Prior Duration of Endocrine Therapy plus CDK4/6 Inhibitor and in Clinical Subgroups","display_name":"Figure 1 from Elacestrant in ER+, HER2\u2212 Metastatic Breast Cancer with ESR1-Mutated Tumors: Subgroup Analyses from the Phase III EMERALD Trial by Prior Duration of Endocrine Therapy plus CDK4/6 Inhibitor and in Clinical Subgroups","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403043810","doi":"https://doi.org/10.1158/1078-0432.27142531"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.27142531","doi":"https://doi.org/10.1158/1078-0432.27142531","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.27142531","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.27142531","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034972183","display_name":"Aditya Bardia","orcid":"https://orcid.org/0000-0003-4885-1157","observed_orcids":["https://orcid.org/0000-0003-4885-1157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aditya Bardia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4885-1157","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051629490","display_name":"Javier Cort\u00e9s","orcid":"https://orcid.org/0000-0001-7623-1583","observed_orcids":["https://orcid.org/0000-0001-7623-1583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Javier Cort\u00e9s","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7623-1583","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005286764","display_name":"Fran\u00e7ois\u2010Cl\u00e9ment Bidard","orcid":"https://orcid.org/0000-0001-5932-8949","observed_orcids":["https://orcid.org/0000-0001-5932-8949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois-Cl\u00e9ment Bidard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5932-8949","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007579054","display_name":"Patrick Neven","orcid":"https://orcid.org/0000-0002-1434-9460","observed_orcids":["https://orcid.org/0000-0002-1434-9460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Neven","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1434-9460","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029469753","display_name":"Jos\u00e9 \u00c1. Garc\u00eda-S\u00e1enz","orcid":"https://orcid.org/0000-0001-6880-0301","observed_orcids":["https://orcid.org/0000-0001-6880-0301"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Garcia-S\u00e1enz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6880-0301","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108994707","display_name":"Phillipe Aftimos","orcid":"https://orcid.org/0000-0001-9946-4726","observed_orcids":["https://orcid.org/0000-0001-9946-4726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillipe Aftimos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9946-4726","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071432873","display_name":"Joyce O\u2019Shaughnessy","orcid":"https://orcid.org/0000-0002-2955-5523","observed_orcids":["https://orcid.org/0000-0002-2955-5523","https://orcid.org/0000-0001-6764-2807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce O\u2019Shaughnessy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2955-5523","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032612608","display_name":"Janice M. Lu","orcid":"https://orcid.org/0009-0006-8926-6367","observed_orcids":["https://orcid.org/0009-0006-8926-6367"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janice Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-8926-6367","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046584965","display_name":"Giulia Tonini","orcid":"https://orcid.org/0009-0004-4835-4059","observed_orcids":["https://orcid.org/0009-0004-4835-4059"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giulia Tonini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-4835-4059","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044631743","display_name":"Simona Scartoni","orcid":"https://orcid.org/0009-0005-3306-4689","observed_orcids":["https://orcid.org/0009-0005-3306-4689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Scartoni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-3306-4689","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101861644","display_name":"Alessandro Paoli","orcid":"https://orcid.org/0000-0002-1128-6839","observed_orcids":["https://orcid.org/0000-0002-1128-6839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandro Paoli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1128-6839","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085370027","display_name":"Monica Binaschi","orcid":"https://orcid.org/0000-0002-3155-3164","observed_orcids":["https://orcid.org/0000-0002-3155-3164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Binaschi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3155-3164","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113412902","display_name":"Tomer Wasserman","orcid":"https://orcid.org/0009-0007-2468-8371","observed_orcids":["https://orcid.org/0009-0007-2468-8371"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomer Wasserman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2468-8371","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5047918797","display_name":"Virginia Kaklamani","orcid":"https://orcid.org/0000-0002-3313-8458","observed_orcids":["https://orcid.org/0000-0002-3313-8458"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virginia Kaklamani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3313-8458","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elacestrant","display_name":"elacestrant","score":0.9980000257492065},{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.8410000205039978},{"id":"https://openalex.org/keywords/er-positive-her2-negative-breast-cancer","display_name":"ER-positive HER2-negative breast cancer","score":0.7620000243186951},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endocrine-therapy-duration","display_name":"endocrine therapy duration","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9850000143051147},{"id":"https://openalex.org/keywords/emerald-trial","display_name":"EMERALD trial","score":0.8650000095367432},{"id":"https://openalex.org/keywords/subgroup-analysis","display_name":"subgroup analysis","score":0.8930000066757202}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3959794342517853},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33460238575935364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23133549094200134}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.27142531","doi":"https://doi.org/10.1158/1078-0432.27142531","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.27142531","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.27142531","doi":"https://doi.org/10.1158/1078-0432.27142531","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.27142531","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403043584","https://openalex.org/W4403043220","https://openalex.org/W4403043845","https://openalex.org/W4403043250","https://openalex.org/W4401204768","https://openalex.org/W4403043269","https://openalex.org/W4396591679","https://openalex.org/W4322772316","https://openalex.org/W4379284538","https://openalex.org/W4403044111"],"abstract_inverted_index":{"PFS":[0,16],"in":[1,9,17,27],"patients":[2,18],"who":[3],"received":[4],"prior":[5,23],"ET+CDK4/6i":[6,24],"\u226512":[7,25],"months":[8,26],"the":[10,28],"metastatic":[11,29],"setting.":[12],"Kaplan\u2013Meier":[13],"estimates":[14],"of":[15],"with":[19],"ESR1-mutated":[20],"tumors":[21],"and":[22],"setting":[30],"(n":[31],"=":[32],"159).":[33]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-10-02T00:00:00"}