{"id":"https://openalex.org/W4403041998","doi":"https://doi.org/10.3390/nu16193333","title":"Effect of Personalized Prebiotic and Probiotic Supplements on the Symptoms of Irritable Bowel Syndrome: An Open-Label, Single-Arm, Multicenter Clinical Trial","display_name":"Effect of Personalized Prebiotic and Probiotic Supplements on the Symptoms of Irritable Bowel Syndrome: An Open-Label, Single-Arm, Multicenter Clinical Trial","publication_year":2024,"publication_date":"2024-10-01","ids":{"openalex":"https://openalex.org/W4403041998","doi":"https://doi.org/10.3390/nu16193333","pmid":"https://pubmed.ncbi.nlm.nih.gov/39408300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11478705"},"language":"en","primary_location":{"id":"doi:10.3390/nu16193333","doi":"https://doi.org/10.3390/nu16193333","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu16193333","pdf_url":"https://www.mdpi.com/2072-6643/16/19/3333/pdf?version=1727918906","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6643/16/19/3333/pdf?version=1727918906","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022860706","display_name":"Nozomi Matsuura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802592688","display_name":"Kirin (Japan)","ror":"https://ror.org/0586k5242","country_code":"JP","type":"company","lineage":["https://openalex.org/I2802592688"]},{"id":"https://openalex.org/I4405272671","display_name":"Kirin Holdings Company, Limited (Japan)","ror":"https://ror.org/04h6fcw63","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nozomi Matsuura","raw_affiliation_strings":["Institute of Health Science, Health Science Business Division, Kirin Holdings Company, Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health Science, Health Science Business Division, Kirin Holdings Company, Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I2802592688","https://openalex.org/I4405272671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037272480","display_name":"Masaya Kanayama","orcid":"https://orcid.org/0009-0006-6288-4691","observed_orcids":["https://orcid.org/0009-0006-6288-4691"]},"institutions":[{"id":"https://openalex.org/I2802592688","display_name":"Kirin (Japan)","ror":"https://ror.org/0586k5242","country_code":"JP","type":"company","lineage":["https://openalex.org/I2802592688"]},{"id":"https://openalex.org/I4405272671","display_name":"Kirin Holdings Company, Limited (Japan)","ror":"https://ror.org/04h6fcw63","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272671"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaya Kanayama","raw_affiliation_strings":["Institute of Health Science, Health Science Business Division, Kirin Holdings Company, Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health Science, Health Science Business Division, Kirin Holdings Company, Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I2802592688","https://openalex.org/I4405272671"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuta Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802592688","display_name":"Kirin (Japan)","ror":"https://ror.org/0586k5242","country_code":"JP","type":"company","lineage":["https://openalex.org/I2802592688"]},{"id":"https://openalex.org/I4405272671","display_name":"Kirin Holdings Company, Limited (Japan)","ror":"https://ror.org/04h6fcw63","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405272671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuta Watanabe","raw_affiliation_strings":["Institute of Health Science, Health Science Business Division, Kirin Holdings Company, Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Health Science, Health Science Business Division, Kirin Holdings Company, Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I2802592688","https://openalex.org/I4405272671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109453176","display_name":"Hirokazu Yamada","orcid":"https://orcid.org/0009-0009-2162-9346","observed_orcids":["https://orcid.org/0009-0009-2162-9346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hirokazu Yamada","raw_affiliation_strings":["EviPRO Co., Ltd., Chiyoda, Tokyo 101-0032, Japan","Soiken Inc., Chiyoda, Tokyo 101-0052, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EviPRO Co., Ltd., Chiyoda, Tokyo 101-0032, Japan","institution_ids":[]},{"raw_affiliation_string":"Soiken Inc., Chiyoda, Tokyo 101-0052, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102827779","display_name":"Loukia Lili","orcid":"https://orcid.org/0000-0002-0285-2712","observed_orcids":["https://orcid.org/0000-0002-0285-2712"]},"institutions":[{"id":"https://openalex.org/I4405266904","display_name":"Thorne HealthTech, Inc. (United States)","ror":"https://ror.org/00a0rwr60","country_code":"US","type":"company","lineage":["https://openalex.org/I4405266904"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loukia Lili","raw_affiliation_strings":["Thorne HealthTech, Inc., New York, NY 10019, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thorne HealthTech, Inc., New York, NY 10019, USA","institution_ids":["https://openalex.org/I4405266904"]}]},{"author_position":"last","author":{"id":null,"display_name":"Akira Torii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Torii","raw_affiliation_strings":["Torii Medical Clinic, Setagaya, Tokyo 157-0066, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Torii Medical Clinic, Setagaya, Tokyo 157-0066, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037272480"],"corresponding_institution_ids":["https://openalex.org/I2802592688","https://openalex.org/I4405272671"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3296},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3296},"fwci":4.8719,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.95555651,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"19","first_page":"3333","last_page":"3333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ibs-subtypes","display_name":"IBS subtypes","score":0.6690000295639038},{"id":"https://openalex.org/keywords/diarrhea-predominant-irritable-bowel-syndrome","display_name":"diarrhea-predominant irritable bowel syndrome","score":0.800000011920929},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-constipation","display_name":"irritable bowel syndrome with constipation","score":1.0},{"id":"https://openalex.org/keywords/ibs-m","display_name":"IBS-M","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ibs-symptom-severity","display_name":"IBS symptom severity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/symptom-improvement","display_name":"symptom improvement","score":0.49799999594688416},{"id":"https://openalex.org/keywords/dietary-supplements","display_name":"dietary supplements","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8933702707290649},{"id":"https://openalex.org/C2775980262","wikidata":"https://www.wikidata.org/wiki/Q218870","display_name":"Prebiotic","level":2,"score":0.8508530855178833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8452577590942383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7612992525100708},{"id":"https://openalex.org/C2781112942","wikidata":"https://www.wikidata.org/wiki/Q178436","display_name":"Constipation","level":2,"score":0.7226661443710327},{"id":"https://openalex.org/C2780255968","wikidata":"https://www.wikidata.org/wiki/Q1816730","display_name":"Probiotic","level":3,"score":0.7090439200401306},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.664408266544342},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6616441011428833},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5017445087432861},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4807293713092804},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4670960307121277},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4357629418373108},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4103664755821228},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.1127936840057373},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08935821056365967},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056692","descriptor_name":"Prebiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/nu16193333","doi":"https://doi.org/10.3390/nu16193333","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu16193333","pdf_url":"https://www.mdpi.com/2072-6643/16/19/3333/pdf?version=1727918906","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11478705","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11478705","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11478705/pdf/nutrients-16-03333.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Text"},{"id":"pmid:39408300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39408300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/nu16193333","doi":"https://doi.org/10.3390/nu16193333","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu16193333","pdf_url":"https://www.mdpi.com/2072-6643/16/19/3333/pdf?version=1727918906","source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F3246099000","display_name":"Kirin Holdings Company","ror":"https://ror.org/04h6fcw63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403041998.pdf","grobid_xml":"https://content.openalex.org/works/W4403041998.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1965487992","https://openalex.org/W1988999476","https://openalex.org/W2005633616","https://openalex.org/W2010971619","https://openalex.org/W2019423204","https://openalex.org/W2026964505","https://openalex.org/W2031153328","https://openalex.org/W2052159025","https://openalex.org/W2053593613","https://openalex.org/W2065163505","https://openalex.org/W2080104941","https://openalex.org/W2083278327","https://openalex.org/W2103441770","https://openalex.org/W2106829739","https://openalex.org/W2118992568","https://openalex.org/W2146589073","https://openalex.org/W2147884617","https://openalex.org/W2294867081","https://openalex.org/W2504563199","https://openalex.org/W2530691947","https://openalex.org/W2558837609","https://openalex.org/W2560913755","https://openalex.org/W2657252452","https://openalex.org/W2807175397","https://openalex.org/W2810071907","https://openalex.org/W2932529928","https://openalex.org/W2934588014","https://openalex.org/W2950964375","https://openalex.org/W2951836243","https://openalex.org/W2990905783","https://openalex.org/W2996060321","https://openalex.org/W3023294057","https://openalex.org/W3039696217","https://openalex.org/W3093405588","https://openalex.org/W3116213524","https://openalex.org/W3135453701","https://openalex.org/W3136479525","https://openalex.org/W3160476175","https://openalex.org/W3201234280","https://openalex.org/W3211779138","https://openalex.org/W4211073917","https://openalex.org/W4237858437","https://openalex.org/W4283034610","https://openalex.org/W4283753674","https://openalex.org/W4284879977","https://openalex.org/W4294549693","https://openalex.org/W4306403802","https://openalex.org/W4312094208","https://openalex.org/W4313251789","https://openalex.org/W4361295785","https://openalex.org/W4361300667","https://openalex.org/W4362638032","https://openalex.org/W4385480033","https://openalex.org/W4386962563","https://openalex.org/W4391358887","https://openalex.org/W4400241283"],"related_works":["https://openalex.org/W4387157761","https://openalex.org/W2972055286","https://openalex.org/W3109123831","https://openalex.org/W3211292548","https://openalex.org/W6927047288","https://openalex.org/W3105693930","https://openalex.org/W2001298761","https://openalex.org/W4318043413","https://openalex.org/W7131883935","https://openalex.org/W2510462781"],"abstract_inverted_index":{"Background/Objectives:":[0],"Prebiotics":[1],"and":[2,40,47,61,78,88,145,191,200,215],"probiotics":[3],"have":[4],"been":[5],"reported":[6],"to":[7,33,84,111,196],"improve":[8],"symptoms":[9],"of":[10,18,29,37,207],"irritable":[11],"bowel":[12],"syndrome":[13],"(IBS).":[14],"Nevertheless,":[15],"the":[16,24,35,85,102,105,184,205],"effects":[17,36],"prebiotics/probiotics":[19],"can":[20],"vary":[21],"depending":[22],"on":[23,44],"IBS":[25,48,56,59,63,86,201,208],"subtypes.":[26],"The":[27,91,98],"purpose":[28],"this":[30,170],"study":[31],"was":[32,101],"investigate":[34],"personalized":[38,189],"prebiotic":[39,77,190],"probiotic":[41,79,192],"supplements":[42,80,94,193],"based":[43],"intestinal":[45,89,198],"microbiota":[46,199],"subtypes":[49,87],"in":[50,104,120,133,157,211],"patients.":[51],"Methods:":[52],"Patients":[53],"with":[54,135,159,183,213],"diarrhea-type":[55],"(IBS-D),":[57],"constipation-type":[58],"(IBS-C),":[60],"mixed-type":[62],"(IBS-M)":[64],"were":[65,81,176],"enrolled":[66],"(n":[67],"=":[68,74,143,153,167],"40":[69],"per":[70],"group;":[71],"total:":[72],"n":[73],"120).":[75],"Personalized":[76],"determined":[82],"according":[83,195],"microbiota.":[90],"patients":[92,122,134,212],"received":[93],"for":[95],"4":[96],"weeks.":[97],"primary":[99],"outcome":[100],"change":[103],"IBS-severity":[106,115],"scoring":[107,116],"system":[108,117],"from":[109],"baseline":[110],"week":[112],"4.":[113],"Results:The":[114],"significantly":[118],"decreased":[119],"all":[121],"(\u221238.0":[123],"[95%":[124,138,148,162],"confidence":[125],"interval":[126],"(CI):":[127],"\u221253.6,":[128],"\u221222.4];":[129],"p":[130,142,152,166],"<":[131],"0.001),":[132],"IBS-D":[136],"(\u221244.5":[137],"CI:":[139,149,163],"\u221270.6,":[140],"\u221218.5];":[141],"0.004)":[144],"IBS-C":[146,214],"(\u221251.2":[147],"\u221279.4,":[150],"\u221222.9];":[151],"0.002),":[154],"but":[155],"not":[156],"those":[158],"IBS-M":[160],"(\u221220.0":[161],"\u221248.0,":[164],"8.1];":[165],"0.47).":[168],"In":[169,187],"study,":[171],"no":[172],"serious":[173],"adverse":[174],"events":[175],"observed":[177],"that":[178],"had":[179],"a":[180],"causal":[181],"relationship":[182],"intervention.":[185],"Conclusions:":[186],"conclusion,":[188],"selected":[194],"individual":[197],"subtype":[202],"may":[203],"alleviate":[204],"severity":[206],"symptoms,":[209],"particularly":[210],"IBS-D.":[216]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2024-10-02T00:00:00"}