{"id":"https://openalex.org/W4403003272","doi":"https://doi.org/10.1186/s43088-024-00556-z","title":"Synergistic strategies for cancer treatment: leveraging natural products, drug repurposing and molecular targets for integrated therapy","display_name":"Synergistic strategies for cancer treatment: leveraging natural products, drug repurposing and molecular targets for integrated therapy","publication_year":2024,"publication_date":"2024-09-30","ids":{"openalex":"https://openalex.org/W4403003272","doi":"https://doi.org/10.1186/s43088-024-00556-z"},"language":"en","primary_location":{"id":"doi:10.1186/s43088-024-00556-z","doi":"https://doi.org/10.1186/s43088-024-00556-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43088-024-00556-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43088-024-00556-z.pdf","source":{"id":"https://openalex.org/S2764610058","display_name":"Beni-Suef University Journal of Basic and Applied Sciences","issn_l":"2314-8535","issn":["2314-8535","2314-8543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://link.springer.com/content/pdf/10.1186/s43088-024-00556-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087683431","display_name":"M. Indira","orcid":"https://orcid.org/0000-0002-7141-6682","observed_orcids":["https://orcid.org/0000-0002-7141-6682"]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Indira Mikkili","raw_affiliation_strings":["Department of Biotechnology, Vignan\u2019s Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, 522213, India"],"raw_orcid":"https://orcid.org/0000-0002-7141-6682","affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Vignan\u2019s Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, 522213, India","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080927670","display_name":"Jagadish Kumar Suluvoy","orcid":"https://orcid.org/0000-0002-4071-2235","observed_orcids":["https://orcid.org/0000-0002-4071-2235"]},"institutions":[{"id":"https://openalex.org/I149313025","display_name":"Vignan's Foundation for Science, Technology & Research","ror":"https://ror.org/03bzf1g85","country_code":"IN","type":"education","lineage":["https://openalex.org/I149313025"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jagadish Kumar Suluvoy","raw_affiliation_strings":["Department of Biotechnology, Vignan\u2019s Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, 522213, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Vignan\u2019s Foundation for Science Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, 522213, India","institution_ids":["https://openalex.org/I149313025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017288747","display_name":"Jesse Joel Thathapudi","orcid":"https://orcid.org/0000-0003-2055-947X","observed_orcids":["https://orcid.org/0000-0003-2055-947X"]},"institutions":[{"id":"https://openalex.org/I119668213","display_name":"Karunya University","ror":"https://ror.org/03k23nv15","country_code":"IN","type":"education","lineage":["https://openalex.org/I119668213"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jesse Joel Thathapudi","raw_affiliation_strings":["Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, 641114, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu, 641114, India","institution_ids":["https://openalex.org/I119668213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108642781","display_name":"Krupanidhi Srirama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krupanidhi Srirama","raw_affiliation_strings":["Srimaharshi Research Institute of Vedic Technology, Guntur, 522006, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Srimaharshi Research Institute of Vedic Technology, Guntur, 522006, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087683431"],"corresponding_institution_ids":["https://openalex.org/I149313025"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":2.008,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.86143775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.05169999971985817,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.03620000183582306,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.8510000109672546},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9589999914169312},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.8270000219345093},{"id":"https://openalex.org/keywords/molecular-targets","display_name":"molecular targets","score":0.7419999837875366},{"id":"https://openalex.org/keywords/inflammation-in-cancer","display_name":"inflammation in cancer","score":0.7799999713897705},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.7720000147819519},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9679999947547913},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.8799999952316284},{"id":"https://openalex.org/keywords/epicatechin","display_name":"epicatechin","score":0.890999972820282},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.7005499601364136},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.6894193887710571},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.6693916320800781},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5662178993225098},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.5381539463996887},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4671482443809509},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35149431228637695},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32988929748535156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3289288580417633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14480674266815186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07885372638702393},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1186/s43088-024-00556-z","doi":"https://doi.org/10.1186/s43088-024-00556-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43088-024-00556-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43088-024-00556-z.pdf","source":{"id":"https://openalex.org/S2764610058","display_name":"Beni-Suef University Journal of Basic and Applied Sciences","issn_l":"2314-8535","issn":["2314-8535","2314-8543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:dcbb0955cebc4bbd9fa849c3f5e78bc6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dcbb0955cebc4bbd9fa849c3f5e78bc6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences, Vol 13, Iss 1, Pp 1-17 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43088-024-00556-z","doi":"https://doi.org/10.1186/s43088-024-00556-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43088-024-00556-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43088-024-00556-z.pdf","source":{"id":"https://openalex.org/S2764610058","display_name":"Beni-Suef University Journal of Basic and Applied Sciences","issn_l":"2314-8535","issn":["2314-8535","2314-8543"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Beni-Suef University Journal of Basic and Applied Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403003272.pdf","grobid_xml":"https://content.openalex.org/works/W4403003272.grobid-xml"},"referenced_works_count":141,"referenced_works":["https://openalex.org/W1481453425","https://openalex.org/W1950362769","https://openalex.org/W2015584686","https://openalex.org/W2023695511","https://openalex.org/W2189686546","https://openalex.org/W2190337443","https://openalex.org/W2229080685","https://openalex.org/W2231754559","https://openalex.org/W2280075563","https://openalex.org/W2291906260","https://openalex.org/W2315745196","https://openalex.org/W2337558949","https://openalex.org/W2346809494","https://openalex.org/W2502470328","https://openalex.org/W2529393993","https://openalex.org/W2540001873","https://openalex.org/W2552444886","https://openalex.org/W2556736570","https://openalex.org/W2566077590","https://openalex.org/W2567423087","https://openalex.org/W2588035357","https://openalex.org/W2588162473","https://openalex.org/W2604979870","https://openalex.org/W2611157898","https://openalex.org/W2613437998","https://openalex.org/W2615356320","https://openalex.org/W2735527928","https://openalex.org/W2737455129","https://openalex.org/W2745566224","https://openalex.org/W2755759724","https://openalex.org/W2759519500","https://openalex.org/W2759896015","https://openalex.org/W2767481881","https://openalex.org/W2767943714","https://openalex.org/W2770849724","https://openalex.org/W2771136768","https://openalex.org/W2771472591","https://openalex.org/W2772371813","https://openalex.org/W2776639172","https://openalex.org/W2781676449","https://openalex.org/W2791115421","https://openalex.org/W2797393628","https://openalex.org/W2803627340","https://openalex.org/W2883041905","https://openalex.org/W2884005373","https://openalex.org/W2886036357","https://openalex.org/W2888404374","https://openalex.org/W2888459204","https://openalex.org/W2896002881","https://openalex.org/W2900222387","https://openalex.org/W2902564651","https://openalex.org/W2910792891","https://openalex.org/W2916045508","https://openalex.org/W2924457271","https://openalex.org/W2937333740","https://openalex.org/W2940168990","https://openalex.org/W2944651326","https://openalex.org/W2946704044","https://openalex.org/W2949049625","https://openalex.org/W2952998155","https://openalex.org/W2954128860","https://openalex.org/W2957897619","https://openalex.org/W2959497269","https://openalex.org/W2966443920","https://openalex.org/W2978605903","https://openalex.org/W2980136515","https://openalex.org/W2990155150","https://openalex.org/W2991641780","https://openalex.org/W2992420623","https://openalex.org/W2997649643","https://openalex.org/W2999529909","https://openalex.org/W3003540629","https://openalex.org/W3003697872","https://openalex.org/W3007929693","https://openalex.org/W3011225606","https://openalex.org/W3011644616","https://openalex.org/W3016796267","https://openalex.org/W3017767374","https://openalex.org/W3036531306","https://openalex.org/W3036918539","https://openalex.org/W3039977092","https://openalex.org/W3040617046","https://openalex.org/W3044296243","https://openalex.org/W3047464973","https://openalex.org/W3080312648","https://openalex.org/W3084214017","https://openalex.org/W3086670596","https://openalex.org/W3087617819","https://openalex.org/W3087671942","https://openalex.org/W3096770695","https://openalex.org/W3096961211","https://openalex.org/W3103277063","https://openalex.org/W3109549597","https://openalex.org/W3110515178","https://openalex.org/W3117486003","https://openalex.org/W3118981383","https://openalex.org/W3119952098","https://openalex.org/W3137159898","https://openalex.org/W3139571508","https://openalex.org/W3148994527","https://openalex.org/W3157638995","https://openalex.org/W3167831104","https://openalex.org/W3180375767","https://openalex.org/W3180882235","https://openalex.org/W3184960677","https://openalex.org/W3186665037","https://openalex.org/W3187643350","https://openalex.org/W3194242714","https://openalex.org/W3196956620","https://openalex.org/W3197720409","https://openalex.org/W3199189658","https://openalex.org/W3205482305","https://openalex.org/W3216057564","https://openalex.org/W4205715478","https://openalex.org/W4206379535","https://openalex.org/W4213371154","https://openalex.org/W4220885170","https://openalex.org/W4221040717","https://openalex.org/W4221052906","https://openalex.org/W4224062070","https://openalex.org/W4293065473","https://openalex.org/W4293217939","https://openalex.org/W4297023662","https://openalex.org/W4306677945","https://openalex.org/W4308000873","https://openalex.org/W4312138835","https://openalex.org/W4313259898","https://openalex.org/W4316664297","https://openalex.org/W4317932949","https://openalex.org/W4319297976","https://openalex.org/W4321372972","https://openalex.org/W4367838943","https://openalex.org/W4378349368","https://openalex.org/W4382051786","https://openalex.org/W4386744151","https://openalex.org/W4387432337","https://openalex.org/W4389143138","https://openalex.org/W4390614740","https://openalex.org/W4390984807","https://openalex.org/W4391994727","https://openalex.org/W4392354717"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W2998072103"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Uncontrolled":[2],"cell":[3],"proliferation":[4],"is":[5,95,135],"a":[6,22,42],"major":[7],"cause":[8],"of":[9,54,125,132,154,161,170,223,257],"cancer":[10,100,262],"development":[11,120],"and":[12,19,44,50,71,88,122,157,163,194,205,215,221,238,255],"progression.":[13],"Inflammation":[14,49],"along":[15,166],"with":[16,167],"inflammatory":[17],"mediators":[18],"cells":[20],"play":[21],"significant":[23],"role":[24],"in":[25,29,31,64,261],"cancer.":[26,51,174],"Cancer":[27],"ranks":[28],"second":[30],"mortality":[32],"rates,":[33],"following":[34],"cardiac":[35],"diseases.":[36],"Phytochemicals":[37],"from":[38],"medicinal":[39],"plants":[40],"offer":[41],"natural":[43,78,190,230],"effective":[45,216],"approach":[46,211],"for":[47,140,172,181,235,242],"treating":[48,173],"Main":[52],"body":[53],"the":[55,123,151,158,253],"abstract":[56,265],"Animal":[57],"studies":[58],"provide":[59],"evidence":[60],"that":[61,202],"phytochemicals":[62,162],"present":[63],"food":[65],"acts":[66],"as":[67,112],"antioxidants,":[68],"anti-aging":[69],"molecules,":[70],"health":[72],"promoters,":[73],"thereby":[74],"extending":[75],"lifespan.":[76],"These":[77],"compounds":[79],"include":[80],"quercetin,":[81],"epicatechin,":[82],"resveratrol,":[83],"curcumin,":[84],"kaempferol,":[85],"vitamin":[86],"C":[87],"carotenoids.":[89],"However,":[90],"clinical":[91,127,178,246],"data":[92,180],"on":[93,185],"humans":[94],"still":[96],"awaited.":[97],"Conventional":[98],"allopathic":[99],"therapies":[101,201],"often":[102],"have":[103],"severe":[104],"side":[105,152],"effects.":[106,208],"Recently,":[107],"drug":[108,133,192],"repurposing":[109,134,193,233],"has":[110],"emerged":[111],"an":[113],"alternative":[114],"strategy":[115],"offering":[116],"lower":[117],"costs,":[118],"shorter":[119],"times":[121],"advantage":[124],"existing":[126,236],"data.":[128],"The":[129,147],"primary":[130],"goal":[131],"to":[136,251],"discover":[137],"new":[138],"uses":[139],"approved":[141],"or":[142],"experimental":[143],"drugs.":[144],"Short":[145],"conclusion":[146],"current":[148],"review":[149],"elucidates":[150],"effects":[153,160],"synthetic":[155],"drugs":[156,165],"beneficial":[159],"non-oncological":[164],"their":[168],"mechanisms":[169],"action":[171],"Additionally,":[175,245],"it":[176],"highlights":[177],"trial":[179],"various":[182],"cancers":[183],"focusing":[184],"molecular":[186,195,240],"targets.":[187],"By":[188],"integrating":[189],"products,":[191],"targets,":[196],"we":[197],"can":[198],"develop":[199],"multifaceted":[200],"maximize":[203],"efficacy":[204,254],"minimize":[206],"adverse":[207],"This":[209],"integrated":[210],"promises":[212],"more":[213],"personalized":[214],"treatments,":[217],"improving":[218],"patient":[219],"outcomes":[220],"quality":[222],"life.":[224],"Future":[225],"research":[226],"should":[227,248],"identifying":[228],"novel":[229],"compounds,":[231],"explore":[232],"opportunities":[234],"drugs,":[237],"elucidate":[239],"targets":[241],"precise":[243],"therapy.":[244],"trials":[247],"be":[249],"conducted":[250],"validate":[252],"safety":[256],"these":[258],"combined":[259],"strategies":[260],"patients.":[263],"Graphical":[264]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}