{"id":"https://openalex.org/W4403000930","doi":"https://doi.org/10.1016/j.lungcan.2024.107963","title":"MTAP as an emerging biomarker in thoracic malignancies","display_name":"MTAP as an emerging biomarker in thoracic malignancies","publication_year":2024,"publication_date":"2024-09-30","ids":{"openalex":"https://openalex.org/W4403000930","doi":"https://doi.org/10.1016/j.lungcan.2024.107963","pmid":"https://pubmed.ncbi.nlm.nih.gov/39357262"},"language":"en","primary_location":{"id":"doi:10.1016/j.lungcan.2024.107963","doi":"https://doi.org/10.1016/j.lungcan.2024.107963","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2024.107963","pdf_url":"https://www.lungcancerjournal.info/article/S0169-5002(24)00497-5/pdf","source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.lungcancerjournal.info/article/S0169-5002(24)00497-5/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055213408","display_name":"Magdalena M. Brune","orcid":"https://orcid.org/0000-0002-9236-1377","observed_orcids":["https://orcid.org/0000-0002-9236-1377"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Magdalena M. Brune","raw_affiliation_strings":["Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-9236-1377","affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011344718","display_name":"Spasenija Savic Prince","orcid":"https://orcid.org/0000-0002-4065-5111","observed_orcids":["https://orcid.org/0000-0002-4065-5111"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Spasenija Savic Prince","raw_affiliation_strings":["Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038850576","display_name":"Tatjana Vlajnic","orcid":"https://orcid.org/0000-0002-1067-6771","observed_orcids":["https://orcid.org/0000-0002-1067-6771"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tatjana Vlajnic","raw_affiliation_strings":["Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005702328","display_name":"Obinna Chijioke","orcid":"https://orcid.org/0000-0003-4247-5947","observed_orcids":["https://orcid.org/0000-0003-4247-5947"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Obinna Chijioke","raw_affiliation_strings":["Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4247-5947","affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030853080","display_name":"Luca Roma","orcid":"https://orcid.org/0000-0003-4632-5372","observed_orcids":["https://orcid.org/0000-0003-4632-5372"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luca Roma","raw_affiliation_strings":["Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4632-5372","affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020553707","display_name":"David K\u00f6nig","orcid":"https://orcid.org/0000-0003-3559-6855","observed_orcids":["https://orcid.org/0000-0003-3559-6855"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David K\u00f6nig","raw_affiliation_strings":["Division of Medical Oncology, University Hospital Basel, Basel, Petersgraben 4, CH-4031 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3559-6855","affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, University Hospital Basel, Basel, Petersgraben 4, CH-4031 Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000570624","display_name":"Lukas Bubendorf","orcid":"https://orcid.org/0000-0001-5970-1803","observed_orcids":["https://orcid.org/0000-0001-5970-1803"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Lukas Bubendorf","raw_affiliation_strings":["Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland. Electronic address: lukas.bubendorf@usb.ch"],"raw_orcid":"https://orcid.org/0000-0001-5970-1803","affiliations":[{"raw_affiliation_string":"Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Sch\u00f6nbeinstrasse 40, CH-4031 Basel, Switzerland. Electronic address: lukas.bubendorf@usb.ch","institution_ids":["https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000570624"],"corresponding_institution_ids":["https://openalex.org/I2802542264"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":{"value":3230,"currency":"USD","value_usd":3230},"fwci":2.5717,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92092778,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"197","issue":null,"first_page":"107963","last_page":"107963"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5346999764442444,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtap-deficiency","display_name":"MTAP deficiency","score":0.8659999966621399},{"id":"https://openalex.org/keywords/9p21-loss","display_name":"9p21 loss","score":0.8889999985694885},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/pleural-mesothelioma","display_name":"pleural mesothelioma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7850000262260437},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-response","display_name":"immune checkpoint inhibitor response","score":0.7020000219345093},{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.847000002861023},{"id":"https://openalex.org/keywords/methylthioadenosine","display_name":"methylthioadenosine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.9940000176429749},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.984000027179718},{"id":"https://openalex.org/keywords/thoracic-tumors","display_name":"thoracic tumors","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.923092246055603},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6813734769821167},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.409803569316864},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.37018293142318726},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3575896620750427},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011683","descriptor_name":"Purine-Nucleoside Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lungcan.2024.107963","doi":"https://doi.org/10.1016/j.lungcan.2024.107963","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2024.107963","pdf_url":"https://www.lungcancerjournal.info/article/S0169-5002(24)00497-5/pdf","source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},{"id":"pmid:39357262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39357262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung cancer (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.lungcan.2024.107963","doi":"https://doi.org/10.1016/j.lungcan.2024.107963","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.lungcan.2024.107963","pdf_url":"https://www.lungcancerjournal.info/article/S0169-5002(24)00497-5/pdf","source":{"id":"https://openalex.org/S100767427","display_name":"Lung Cancer","issn_l":"0169-5002","issn":["0169-5002","1872-8332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6996552923","display_name":"Tissue-equivalents of lymphoid clonal haematopoiesis of indeterminate potential (L-CHIP): A potential precursor lesion of lymphoma","funder_award_id":"217648","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4403000930.pdf","grobid_xml":"https://content.openalex.org/works/W4403000930.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1509654956","https://openalex.org/W1596893076","https://openalex.org/W1814719322","https://openalex.org/W1943334024","https://openalex.org/W1964252968","https://openalex.org/W1967792461","https://openalex.org/W1967901647","https://openalex.org/W1979312829","https://openalex.org/W1986161382","https://openalex.org/W2003653590","https://openalex.org/W2031049709","https://openalex.org/W2031734862","https://openalex.org/W2043712928","https://openalex.org/W2070454905","https://openalex.org/W2073826304","https://openalex.org/W2089032784","https://openalex.org/W2094274553","https://openalex.org/W2096259125","https://openalex.org/W2106825335","https://openalex.org/W2125173333","https://openalex.org/W2153056550","https://openalex.org/W2155717535","https://openalex.org/W2257573908","https://openalex.org/W2287840388","https://openalex.org/W2321587450","https://openalex.org/W2328623642","https://openalex.org/W2468937921","https://openalex.org/W2527905628","https://openalex.org/W2587048937","https://openalex.org/W2736517046","https://openalex.org/W2796107408","https://openalex.org/W2796582438","https://openalex.org/W2805761735","https://openalex.org/W2886498337","https://openalex.org/W2887772874","https://openalex.org/W2889646458","https://openalex.org/W2892640821","https://openalex.org/W2911511335","https://openalex.org/W2952513725","https://openalex.org/W2975871857","https://openalex.org/W2989944812","https://openalex.org/W3001535056","https://openalex.org/W3044762253","https://openalex.org/W3095426280","https://openalex.org/W3110002524","https://openalex.org/W3116530739","https://openalex.org/W3118711697","https://openalex.org/W3120155456","https://openalex.org/W3120617198","https://openalex.org/W3124625890","https://openalex.org/W3152660991","https://openalex.org/W3198723801","https://openalex.org/W3200575659","https://openalex.org/W3200875713","https://openalex.org/W3202358592","https://openalex.org/W3210069284","https://openalex.org/W4200442476","https://openalex.org/W4206010328","https://openalex.org/W4223653113","https://openalex.org/W4224264543","https://openalex.org/W4283278266","https://openalex.org/W4283323046","https://openalex.org/W4283453295","https://openalex.org/W4283716902","https://openalex.org/W4283817812","https://openalex.org/W4293765212","https://openalex.org/W4297575310","https://openalex.org/W4299806079","https://openalex.org/W4320507349","https://openalex.org/W4323664333","https://openalex.org/W4323928748","https://openalex.org/W4324365148","https://openalex.org/W4376275201","https://openalex.org/W4378471674","https://openalex.org/W4385650986","https://openalex.org/W4386857186","https://openalex.org/W4387131673","https://openalex.org/W4387618152","https://openalex.org/W4388132293","https://openalex.org/W4389244877","https://openalex.org/W4389391413","https://openalex.org/W4390607606","https://openalex.org/W4391745477","https://openalex.org/W4394684357","https://openalex.org/W4394875919","https://openalex.org/W4394936205","https://openalex.org/W4395702529","https://openalex.org/W6635785074","https://openalex.org/W6640521702","https://openalex.org/W6651518017","https://openalex.org/W6668600665","https://openalex.org/W6678585998","https://openalex.org/W6851145067","https://openalex.org/W6865853598"],"related_works":["https://openalex.org/W7079548958","https://openalex.org/W7220410036","https://openalex.org/W4283453295","https://openalex.org/W4413452052","https://openalex.org/W3170326834","https://openalex.org/W4409691338","https://openalex.org/W7137806361","https://openalex.org/W4405134521","https://openalex.org/W2031049709","https://openalex.org/W7133496134"],"abstract_inverted_index":{"S-methyl-5'-thioadenosine":[0],"phosphorylase":[1],"(MTAP)":[2],"deficiency":[3,161],"is":[4,19,44,109,245],"an":[5,56,89,111,164],"emerging":[6,112],"biomarker":[7,114,154],"in":[8,21,46,63,105,115,119,214,222,265],"non-small":[9],"cell":[10],"lung":[11],"cancer":[12,123],"(NSCLC)":[13],"and":[14,93,121,146,242,268,276],"beyond.":[15],"The":[16],"MTAP":[17,80,99,126,148,160,188,235,264],"gene":[18],"located":[20],"the":[22,30,47,68,72,132,143,168,195,232,257,261],"chromosomal":[23],"region":[24],"9p21.3,":[25],"which":[26,101],"shows":[27],"one":[28],"of":[29,42,49,74,79,107,142,167,198,234,263],"most":[31],"common":[32],"homozygous":[33],"deletions":[34],"across":[35],"all":[36],"human":[37],"cancers":[38],"(9p21":[39],"loss).":[40],"Loss":[41],"9p21":[43,75],"found":[45],"majority":[48],"pleural":[50],"mesotheliomas,":[51],"where":[52],"it":[53,201],"serves":[54,150],"as":[55,88,151,228],"established":[57],"diagnostic":[58,95,238],"marker.":[59,97],"Until":[60],"recently,":[61],"fluorescence":[62],"situ":[64],"hybridization":[65],"(FISH)":[66],"was":[67],"gold":[69],"standard":[70],"for":[71,155,205,240],"detection":[73],"losses,":[76],"but":[77],"loss":[78,127,149],"expression":[81],"by":[82,179],"immunohistochemistry":[83],"(IHC)":[84],"gains":[85],"increasing":[86],"importance":[87],"easy":[90],"to":[91,129,134,163,175,247],"apply":[92],"cost-effective":[94],"surrogate":[96],"Besides,":[98],"loss,":[100],"has":[102],"been":[103],"reported":[104],"13%":[106],"NSCLC,":[108],"becoming":[110],"predictive":[113,153,230],"two":[116],"different":[117,270],"scenarios":[118],"NSCLC":[120,241],"other":[122,243],"types:":[124],"1)":[125],"seems":[128],"negatively":[130],"predict":[131],"response":[133],"immune":[135],"checkpoint":[136],"inhibitor":[137],"(ICI)":[138],"treatment":[139,158],"via":[140],"silencing":[141],"tumor":[144,190],"microenvironment,":[145],"2)":[147],"a":[152,202,229],"novel":[156],"targeted":[157],"strategies.":[159],"leads":[162],"impaired":[165],"function":[166,197],"protein":[169],"arginine":[170],"methyltransferase":[171],"5":[172],"(PRMT5)":[173],"due":[174],"its":[176,226],"partial":[177],"inhibition":[178],"MTAP's":[180],"accumulating":[181],"substrate":[182],"methylthioadenosine":[183],"(MTA).":[184],"This":[185],"process":[186],"leaves":[187],"deficient":[189],"cells":[191],"heavily":[192],"dependent":[193],"on":[194,260],"remaining":[196],"PRMT5,":[199],"making":[200],"perfect":[203],"target":[204],"synthetic":[206],"lethality.":[207],"Indeed,":[208],"MTA-cooperative":[209],"PRMT5-inhibitors":[210],"are":[211],"now":[212],"tested":[213],"several":[215],"clinical":[216],"trials":[217],"with":[218],"promising":[219],"early":[220],"results":[221],"solid":[223],"malignancies.":[224],"With":[225],"emergence":[227],"biomarker,":[231],"implementation":[233],"IHC":[236],"into":[237],"routine":[239],"tumors":[244,267],"likely":[246],"take":[248],"place":[249],"soon.":[250],"In":[251],"this":[252],"review":[253],"article,":[254],"we":[255],"summarize":[256],"current":[258],"literature":[259],"role":[262],"thoracic":[266],"evaluate":[269],"testing":[271],"methods,":[272],"including":[273],"IHC,":[274],"FISH":[275],"next":[277],"generation":[278],"sequencing.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-10-01T00:00:00"}
