{"id":"https://openalex.org/W4402964530","doi":"https://doi.org/10.14719/pst.3224","title":"A molecular docking insight: Phyllanthus niruri L. constituents targeting MMP-9 for angiogenesis inhibition and IL-1beta for antiinflammatory action in endometriosis therapy","display_name":"A molecular docking insight: Phyllanthus niruri L. constituents targeting MMP-9 for angiogenesis inhibition and IL-1beta for antiinflammatory action in endometriosis therapy","publication_year":2024,"publication_date":"2024-09-30","ids":{"openalex":"https://openalex.org/W4402964530","doi":"https://doi.org/10.14719/pst.3224"},"language":"en","primary_location":{"id":"doi:10.14719/pst.3224","doi":"https://doi.org/10.14719/pst.3224","is_oa":true,"landing_page_url":"https://doi.org/10.14719/pst.3224","pdf_url":"https://www.horizonepublishing.com/index.php/PST/article/download/3224/3911","source":{"id":"https://openalex.org/S4210213485","display_name":"Plant Science Today","issn_l":"2348-1900","issn":["2348-1900"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Science Today","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4402964530"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.horizonepublishing.com/index.php/PST/article/download/3224/3911","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057652509","display_name":"Eka Tri Wulandari","orcid":"https://orcid.org/0000-0002-4434-5188","observed_orcids":["https://orcid.org/0000-0002-4434-5188"]},"institutions":[{"id":"https://openalex.org/I119896790","display_name":"Sebelas Maret University","ror":"https://ror.org/021hq5q33","country_code":"ID","type":"education","lineage":["https://openalex.org/I119896790"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Eka Tri Wulandari","raw_affiliation_strings":["Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta 57126, Indonesia"],"raw_orcid":"https://orcid.org/0000-0003-4015-9449","affiliations":[{"raw_affiliation_string":"Doctoral Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta 57126, Indonesia","institution_ids":["https://openalex.org/I119896790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071038003","display_name":"Soetrisno Soetrisno","orcid":"https://orcid.org/0000-0003-0404-3676","observed_orcids":["https://orcid.org/0000-0003-0404-3676"]},"institutions":[{"id":"https://openalex.org/I119896790","display_name":"Sebelas Maret University","ror":"https://ror.org/021hq5q33","country_code":"ID","type":"education","lineage":["https://openalex.org/I119896790"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Soetrisno","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret\u2014USM Hospital, Surakarta 57126, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sebelas Maret\u2014USM Hospital, Surakarta 57126, Indonesia","institution_ids":["https://openalex.org/I119896790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042059527","display_name":"Bambang Purwanto","orcid":"https://orcid.org/0000-0002-5494-4571","observed_orcids":["https://orcid.org/0000-0002-5494-4571"]},"institutions":[{"id":"https://openalex.org/I119896790","display_name":"Sebelas Maret University","ror":"https://ror.org/021hq5q33","country_code":"ID","type":"education","lineage":["https://openalex.org/I119896790"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Bambang Purwanto","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret\u2014USM Hospital, Surakarta 57126, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-5494-4571","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret\u2014USM Hospital, Surakarta 57126, Indonesia","institution_ids":["https://openalex.org/I119896790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060229448","display_name":"Reviono Reviono","orcid":"https://orcid.org/0000-0001-5606-7587","observed_orcids":["https://orcid.org/0000-0001-5606-7587"]},"institutions":[{"id":"https://openalex.org/I119896790","display_name":"Sebelas Maret University","ror":"https://ror.org/021hq5q33","country_code":"ID","type":"education","lineage":["https://openalex.org/I119896790"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Reviono","raw_affiliation_strings":["Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sebelas Maret\u2014USM Hospital, Surakarta 57126, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sebelas Maret\u2014USM Hospital, Surakarta 57126, Indonesia","institution_ids":["https://openalex.org/I119896790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014561465","display_name":"Yogi Ertanto","orcid":"https://orcid.org/0000-0001-6739-9608","observed_orcids":["https://orcid.org/0000-0001-6739-9608"]},"institutions":[{"id":"https://openalex.org/I4210112051","display_name":"Indonesia Defense University","ror":"https://ror.org/02v4mmk55","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210112051"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yogi Ertanto","raw_affiliation_strings":["Faculty of Military Pharmacy, Universitas Pertahanan Republik Indonesia, Bogor 16810, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-6739-9608","affiliations":[{"raw_affiliation_string":"Faculty of Military Pharmacy, Universitas Pertahanan Republik Indonesia, Bogor 16810, Indonesia","institution_ids":["https://openalex.org/I4210112051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016376542","display_name":"Joko Sunowo","orcid":"https://orcid.org/0000-0001-5799-0912","observed_orcids":["https://orcid.org/0000-0001-5799-0912"]},"institutions":[{"id":"https://openalex.org/I4210086930","display_name":"Universitas Malahayati","ror":"https://ror.org/00567j574","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210086930"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Joko Sunowo","raw_affiliation_strings":["Department of Pharmacy Study Program, Faculty of Health Sciences, Malahayati University, Lampung 35152, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-5799-0912","affiliations":[{"raw_affiliation_string":"Department of Pharmacy Study Program, Faculty of Health Sciences, Malahayati University, Lampung 35152, Indonesia","institution_ids":["https://openalex.org/I4210086930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1327,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34689255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.5435000061988831,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.32280001044273376,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.04960000142455101,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phyllanthus-niruri","display_name":"Phyllanthus niruri","score":0.9800000190734863},{"id":"https://openalex.org/keywords/endometriosis","display_name":"endometriosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9079999923706055},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9449999928474426},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/kaempferol","display_name":"kaempferol","score":0.9940000176429749},{"id":"https://openalex.org/keywords/galangin","display_name":"galangin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/herbacetin","display_name":"herbacetin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8109999895095825},{"id":"https://openalex.org/keywords/mmp-9-inhibitors","display_name":"MMP-9 inhibitors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/il-1beta-inhibitors","display_name":"IL-1\u03b2 inhibitors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cytotoxicity-prediction","display_name":"cytotoxicity prediction","score":0.6010000109672546},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C2776718122","wikidata":"https://www.wikidata.org/wiki/Q310927","display_name":"Phyllanthus","level":2,"score":0.8790899515151978},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6693751811981201},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.6172913908958435},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6006457209587097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5574427843093872},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5068753361701965},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4395100474357605},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22881430387496948},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.22198796272277832}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.14719/pst.3224","doi":"https://doi.org/10.14719/pst.3224","is_oa":true,"landing_page_url":"https://doi.org/10.14719/pst.3224","pdf_url":"https://www.horizonepublishing.com/index.php/PST/article/download/3224/3911","source":{"id":"https://openalex.org/S4210213485","display_name":"Plant Science Today","issn_l":"2348-1900","issn":["2348-1900"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Science Today","raw_type":"journal-article"},{"id":"pmh:oai:ojs.horizonepublishing.com:article/3224","doi":null,"is_oa":true,"landing_page_url":"http://horizonepublishing.com/journals/index.php/PST/article/view/3224","pdf_url":null,"source":{"id":"https://openalex.org/S4210213485","display_name":"Plant Science Today","issn_l":"2348-1900","issn":["2348-1900"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"10.14719/pst.2024.11.4","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.14719/pst.3224","doi":"https://doi.org/10.14719/pst.3224","is_oa":true,"landing_page_url":"https://doi.org/10.14719/pst.3224","pdf_url":"https://www.horizonepublishing.com/index.php/PST/article/download/3224/3911","source":{"id":"https://openalex.org/S4210213485","display_name":"Plant Science Today","issn_l":"2348-1900","issn":["2348-1900"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Science Today","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324621","display_name":"Universitas Sebelas Maret","ror":"https://ror.org/021hq5q33"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402964530.pdf","grobid_xml":"https://content.openalex.org/works/W4402964530.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2615428957","https://openalex.org/W2788721046","https://openalex.org/W2810983458","https://openalex.org/W2893133903","https://openalex.org/W2971693998","https://openalex.org/W3014772889","https://openalex.org/W3037361388","https://openalex.org/W4320169783","https://openalex.org/W4321458257","https://openalex.org/W4389524958","https://openalex.org/W4390228251","https://openalex.org/W4391260949","https://openalex.org/W4391375908","https://openalex.org/W4392881914"],"related_works":["https://openalex.org/W3208937902","https://openalex.org/W4378843867","https://openalex.org/W4402451808","https://openalex.org/W4206280009","https://openalex.org/W4403820824","https://openalex.org/W7160269586","https://openalex.org/W4310168478","https://openalex.org/W2905520267","https://openalex.org/W4411310730","https://openalex.org/W4416138442"],"abstract_inverted_index":{"Endometriosis,":[0],"characterized":[1],"by":[2],"inflammatory":[3,32],"lesions":[4],"resembling":[5],"endometrium":[6],"outside":[7],"the":[8,44,54,187],"uterine":[9],"cavity,":[10],"induces":[11],"chronic":[12],"inflammation,":[13],"anatomical":[14],"changes":[15],"and":[16,34,46,63,80,91,97,103,107,129,148,176,207],"persistent":[17],"pain.":[18],"The":[19,83],"expression":[20,115,155],"of":[21,48,56,86,127,162,190],"Interleukin":[22],"1beta":[23],"(IL-1beta)":[24],"is":[25,41],"significantly":[26],"associated":[27],"with":[28,131],"endometriosis,":[29,194],"contributing":[30],"to":[31,138],"process":[33],"fertility":[35],"issues.":[36],"Matrix":[37],"metalloproteinase":[38],"9":[39],"(MMP-9)":[40],"crucial":[42],"in":[43,60,135,200],"adhesion":[45],"angiogenesis":[47],"endometrial":[49],"tissue.":[50],"This":[51],"study":[52],"investigates":[53],"potential":[55,151,171,178,189],"Phyllanthus":[57],"niruri":[58,111,192],"L.":[59],"inhibiting":[61],"MMP-9":[62,90,114,174],"IL-1beta":[64,92],"through":[65],"molecular":[66],"docking":[67,70,167],"analysis.":[68],"Molecular":[69,166],"was":[71],"performed":[72],"using":[73,101],"Discovery":[74],"Studio":[75],"Visualizer,":[76],"Open":[77],"Babel,":[78],"PyRx":[79],"AutoDock":[81],"Vina.":[82],"inhibitory":[84,116],"activities":[85],"bioactive":[87],"compounds":[88],"on":[89],"were":[93,99],"predicted.":[94],"Biological":[95,140],"activity":[96,141],"cytotoxicity":[98,161],"assessed":[100],"PASS":[102],"CLC-Pred":[104,157],"respectively.":[105],"Kaempferol":[106],"quercetin":[108,128],"from":[109],"P.":[110,191],"exhibited":[112],"significant":[113],"activity.":[117],"Search":[118],"Tool":[119],"for":[120,193,197],"Interacting":[121],"Chemicals":[122],"(STITCH)":[123],"analysis":[124,142,158],"revealed":[125],"interactions":[126],"galangin":[130,149],"specific":[132],"proteins":[133],"involved":[134],"pathways":[136],"related":[137],"endometriosis.":[139],"indicated":[143],"that":[144],"quercetin,":[145],"kaempferol,":[146],"herbacetin":[147],"show":[150],"as":[152,172,179],"MMP":[153],"-9":[154],"inhibitors.":[156],"suggested":[159],"high":[160],"kaempferol":[163],"against":[164],"glioma.":[165],"results":[168],"showed":[169],"quercetin's":[170],"an":[173,180],"inhibitor":[175],"galangin's":[177],"IL-1":[181],"beta":[182],"inhibitor.":[183],"These":[184],"findings":[185],"support":[186],"therapeutic":[188],"providing":[195],"insights":[196],"further":[198],"research":[199],"developing":[201],"innovative":[202],"therapies":[203],"targeting":[204],"endometriosis-related":[205],"inflammation":[206],"angiogenesis.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-09-30T00:00:00"}
