{"id":"https://openalex.org/W4402923488","doi":"https://doi.org/10.3390/bioengineering11100972","title":"Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets","display_name":"Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets","publication_year":2024,"publication_date":"2024-09-27","ids":{"openalex":"https://openalex.org/W4402923488","doi":"https://doi.org/10.3390/bioengineering11100972","pmid":"https://pubmed.ncbi.nlm.nih.gov/39451348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11505586"},"language":"en","primary_location":{"id":"doi:10.3390/bioengineering11100972","doi":"https://doi.org/10.3390/bioengineering11100972","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering11100972","pdf_url":"https://www.mdpi.com/2306-5354/11/10/972/pdf?version=1727428728","source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2306-5354/11/10/972/pdf?version=1727428728","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055002672","display_name":"Jacob Jahn","orcid":"https://orcid.org/0000-0003-0745-7049","observed_orcids":["https://orcid.org/0000-0003-0745-7049"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Jahn","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":"https://orcid.org/0000-0003-0745-7049","affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093049920","display_name":"Quinn T. Ehlen","orcid":"https://orcid.org/0000-0001-9410-8124","observed_orcids":["https://orcid.org/0000-0001-9410-8124"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Quinn T. Ehlen","raw_affiliation_strings":["University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041863942","display_name":"Lee D. Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Kaplan","raw_affiliation_strings":["Department of Orthopedics, University of Miami, Miami, FL 33136, USA","UHealth Sports Medicine Institute, University of Miami, Miami, FL 33136, USA","University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"UHealth Sports Medicine Institute, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]},{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040279086","display_name":"Thomas Michael Best","orcid":"https://orcid.org/0000-0003-2836-161X","observed_orcids":["https://orcid.org/0000-0003-2836-161X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Best","raw_affiliation_strings":["Department of Orthopedics, University of Miami, Miami, FL 33136, USA","UHealth Sports Medicine Institute, University of Miami, Miami, FL 33136, USA","University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":"https://orcid.org/0000-0003-2836-161X","affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"UHealth Sports Medicine Institute, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]},{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077425238","display_name":"Zhipeng Meng","orcid":"https://orcid.org/0000-0003-4756-6303","observed_orcids":["https://orcid.org/0000-0003-4756-6303"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhipeng Meng","raw_affiliation_strings":["Department of Molecular and Cellular Pharmacology, Miller School of Medicine, Miami, FL 33136, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","University of Miami Miller School of Medicine, Miami, FL 33136, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Pharmacology, Miller School of Medicine, Miami, FL 33136, USA","institution_ids":[]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026453606","display_name":"Chun-Yuh Charles Huang","orcid":"https://orcid.org/0000-0002-8848-258X","observed_orcids":["https://orcid.org/0000-0002-8848-258X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]},{"id":"https://openalex.org/I4210157065","display_name":"Sylvester Comprehensive Cancer Center","ror":"https://ror.org/0552r4b12","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chun-Yuh Huang","raw_affiliation_strings":["Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, USA","Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","UHealth Sports Medicine Institute, University of Miami, Miami, FL 33136, USA"],"raw_orcid":"https://orcid.org/0000-0002-8848-258X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210157065"]},{"raw_affiliation_string":"UHealth Sports Medicine Institute, University of Miami, Miami, FL 33136, USA","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026453606"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935","https://openalex.org/I4210157065"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":0.1587,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.16912851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"11","issue":"10","first_page":"972","last_page":"972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.22470000386238098,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":1.0},{"id":"https://openalex.org/keywords/chondrocyte-homeostasis","display_name":"chondrocyte homeostasis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/proinflammatory-signaling","display_name":"pro-inflammatory signaling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.9188028573989868},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.628637433052063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5992330312728882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5526870489120483},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.5410069823265076},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5267108082771301},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4303339123725891},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4102891683578491},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26817166805267334},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.239031583070755},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.16262924671173096},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1533782184123993}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/bioengineering11100972","doi":"https://doi.org/10.3390/bioengineering11100972","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering11100972","pdf_url":"https://www.mdpi.com/2306-5354/11/10/972/pdf?version=1727428728","source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11505586","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11505586","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11505586/pdf/bioengineering-11-00972.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering (Basel)","raw_type":"Text"},{"id":"pmid:39451348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39451348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:90c3b19f95bc4edeaca9e6a39284f0d4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/90c3b19f95bc4edeaca9e6a39284f0d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering, Vol 11, Iss 10, p 972 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/bioengineering11100972","doi":"https://doi.org/10.3390/bioengineering11100972","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering11100972","pdf_url":"https://www.mdpi.com/2306-5354/11/10/972/pdf?version=1727428728","source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000915041","display_name":"Roles of mechanotransduction in organ regeneration and fibrosis","funder_award_id":"R35GM142504","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402923488.pdf","grobid_xml":"https://content.openalex.org/works/W4402923488.grobid-xml"},"referenced_works_count":139,"referenced_works":["https://openalex.org/W1491831470","https://openalex.org/W1551310212","https://openalex.org/W1839227508","https://openalex.org/W1975348834","https://openalex.org/W1984830754","https://openalex.org/W1985090780","https://openalex.org/W1995160678","https://openalex.org/W1999661963","https://openalex.org/W2001682695","https://openalex.org/W2002176520","https://openalex.org/W2010240830","https://openalex.org/W2010356581","https://openalex.org/W2013868307","https://openalex.org/W2016145855","https://openalex.org/W2019335338","https://openalex.org/W2020511240","https://openalex.org/W2022731821","https://openalex.org/W2028149799","https://openalex.org/W2031354391","https://openalex.org/W2044188743","https://openalex.org/W2044474278","https://openalex.org/W2049798407","https://openalex.org/W2060070915","https://openalex.org/W2061697928","https://openalex.org/W2071359561","https://openalex.org/W2082289799","https://openalex.org/W2083096715","https://openalex.org/W2084435232","https://openalex.org/W2097444304","https://openalex.org/W2101471525","https://openalex.org/W2114128492","https://openalex.org/W2119974097","https://openalex.org/W2125212340","https://openalex.org/W2128431867","https://openalex.org/W2129989339","https://openalex.org/W2134949545","https://openalex.org/W2134956953","https://openalex.org/W2146548807","https://openalex.org/W2148056172","https://openalex.org/W2156718395","https://openalex.org/W2159568138","https://openalex.org/W2159601540","https://openalex.org/W2164340373","https://openalex.org/W2166023631","https://openalex.org/W2168636113","https://openalex.org/W2171501785","https://openalex.org/W2204551059","https://openalex.org/W2410413380","https://openalex.org/W2422665013","https://openalex.org/W2528271696","https://openalex.org/W2529188573","https://openalex.org/W2560057190","https://openalex.org/W2570624998","https://openalex.org/W2581704163","https://openalex.org/W2592090300","https://openalex.org/W2724499431","https://openalex.org/W2732361353","https://openalex.org/W2741224413","https://openalex.org/W2751617223","https://openalex.org/W2755666968","https://openalex.org/W2769632036","https://openalex.org/W2786676368","https://openalex.org/W2790381776","https://openalex.org/W2793436565","https://openalex.org/W2793677924","https://openalex.org/W2820932019","https://openalex.org/W2884590209","https://openalex.org/W2886070416","https://openalex.org/W2886442927","https://openalex.org/W2890313526","https://openalex.org/W2898585678","https://openalex.org/W2903169176","https://openalex.org/W2905097208","https://openalex.org/W2919989386","https://openalex.org/W2921000340","https://openalex.org/W2936365255","https://openalex.org/W2949233066","https://openalex.org/W2966798736","https://openalex.org/W2993692320","https://openalex.org/W2998531235","https://openalex.org/W3003757839","https://openalex.org/W3011875247","https://openalex.org/W3035734167","https://openalex.org/W3039149575","https://openalex.org/W3045145592","https://openalex.org/W3047064327","https://openalex.org/W3089690220","https://openalex.org/W3091826861","https://openalex.org/W3098597306","https://openalex.org/W3110061620","https://openalex.org/W3115872251","https://openalex.org/W3125190770","https://openalex.org/W3149424833","https://openalex.org/W3159933130","https://openalex.org/W3162932895","https://openalex.org/W3165286686","https://openalex.org/W3173326119","https://openalex.org/W3210425098","https://openalex.org/W4200317486","https://openalex.org/W4200324094","https://openalex.org/W4205198867","https://openalex.org/W4206918928","https://openalex.org/W4210944770","https://openalex.org/W4212856044","https://openalex.org/W4220749791","https://openalex.org/W4225373568","https://openalex.org/W4303699554","https://openalex.org/W4304806793","https://openalex.org/W4306362030","https://openalex.org/W4308770456","https://openalex.org/W4309172128","https://openalex.org/W4309245960","https://openalex.org/W4311158234","https://openalex.org/W4316371662","https://openalex.org/W4320341097","https://openalex.org/W4321275886","https://openalex.org/W4376115623","https://openalex.org/W4378573796","https://openalex.org/W4378767751","https://openalex.org/W4380265011","https://openalex.org/W4380680490","https://openalex.org/W4380684416","https://openalex.org/W4382981961","https://openalex.org/W4385798749","https://openalex.org/W4386042200","https://openalex.org/W4386373535","https://openalex.org/W4387521845","https://openalex.org/W4390502078","https://openalex.org/W4390745819","https://openalex.org/W4391175163","https://openalex.org/W4391933516","https://openalex.org/W4392193829","https://openalex.org/W4392515858","https://openalex.org/W4393900059","https://openalex.org/W4394958877","https://openalex.org/W4396857761","https://openalex.org/W4396914671","https://openalex.org/W4398773700","https://openalex.org/W4399049734"],"related_works":["https://openalex.org/W4392515858","https://openalex.org/W7220594267","https://openalex.org/W7160537152","https://openalex.org/W2919989386","https://openalex.org/W7008557895","https://openalex.org/W3115872251","https://openalex.org/W4392812918","https://openalex.org/W2570624998","https://openalex.org/W4398773700","https://openalex.org/W7094373094"],"abstract_inverted_index":{"In":[0],"this":[1,155,180,189,203,212],"review,":[2],"we":[3,205],"explore":[4],"the":[5,19,22,47,53,60,74,78,105,118,128,134,138,158,161,164,220],"intricate":[6],"relationship":[7,165],"between":[8,130,166],"glucose":[9,114,131,167,200],"metabolism":[10,30,132,168],"and":[11,59,85,101,133,144,151,169,171,195,199],"mechanotransduction":[12,70,96,170,198],"pathways,":[13],"with":[14],"a":[15,32,123,173],"specific":[16,181],"focus":[17],"on":[18,163],"role":[20,89],"of":[21,49,55,62,107,125,140,160,175,183,223],"Hippo":[23,75,119,135],"signaling":[24,57,146],"pathway":[25,76,120,136],"in":[26,35,46,90,113],"chondrocyte":[27,38,92,149],"pathophysiology.":[28],"Glucose":[29],"is":[31],"vital":[33],"element":[34],"maintaining":[36,91],"proper":[37],"function,":[39],"but":[40],"it":[41],"has":[42],"also":[43],"been":[44],"implicated":[45],"pathogenesis":[48],"osteoarthritis":[50],"(OA)":[51],"via":[52,122],"induction":[54],"pro-inflammatory":[56],"pathways":[58,71,97],"establishment":[61],"an":[63,87],"intracellular":[64],"environment":[65],"conducive":[66],"to":[67,80,82,104,147,179,207,214],"OA.":[68,108,224],"Alternatively,":[69],"such":[72],"as":[73],"possess":[77],"capacity":[79],"respond":[81],"mechanical":[83,145],"stimuli":[84],"have":[86],"integral":[88],"homeostasis.":[93],"However,":[94],"these":[95],"can":[98],"be":[99],"dysregulated":[100],"potentially":[102],"contribute":[103],"progression":[106],"We":[109],"discussed":[110],"how":[111],"alterations":[112],"levels":[115],"may":[116,191],"modulate":[117],"components":[121],"variety":[124],"mechanisms.":[126],"Characterizing":[127],"interaction":[129],"highlights":[137],"necessity":[139],"balancing":[141],"both":[142],"metabolic":[143],"maintain":[148],"health":[150],"optimal":[152],"functionality.":[153],"Furthermore,":[154],"review":[156,204],"demonstrates":[157],"scarcity":[159],"literature":[162],"provides":[172],"summary":[174],"current":[176],"research":[177,187,210],"dedicated":[178],"area":[182],"study.":[184],"Ultimately,":[185],"increased":[186],"into":[188,211],"topic":[190,213],"elucidate":[192],"novel":[193],"mechanisms":[194],"relationships":[196],"integrating":[197],"metabolism.":[201],"Through":[202],"hope":[206],"inspire":[208],"future":[209],"develop":[215],"innovative":[216],"treatments":[217],"for":[218],"addressing":[219],"clinical":[221],"challenges":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2024-09-28T00:00:00"}