{"id":"https://openalex.org/W4402919331","doi":"https://doi.org/10.3390/medicina60101592","title":"When to Intervene in Acute Necrotizing Pancreatitis: A Narrative Review of the Optimal Timing for Intervention Strategies","display_name":"When to Intervene in Acute Necrotizing Pancreatitis: A Narrative Review of the Optimal Timing for Intervention Strategies","publication_year":2024,"publication_date":"2024-09-27","ids":{"openalex":"https://openalex.org/W4402919331","doi":"https://doi.org/10.3390/medicina60101592","pmid":"https://pubmed.ncbi.nlm.nih.gov/39459378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11509130"},"language":"en","primary_location":{"id":"doi:10.3390/medicina60101592","doi":"https://doi.org/10.3390/medicina60101592","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina60101592","pdf_url":"https://www.mdpi.com/1648-9144/60/10/1592/pdf?version=1727591219","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1648-9144/60/10/1592/pdf?version=1727591219","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037804854","display_name":"Daniel Paramythiotis","orcid":"https://orcid.org/0000-0001-9787-7391","observed_orcids":["https://orcid.org/0000-0001-9787-7391"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Daniel Paramythiotis","raw_affiliation_strings":["First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0001-9787-7391","affiliations":[{"raw_affiliation_string":"First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012739379","display_name":"Eleni Karlafti","orcid":"https://orcid.org/0000-0001-7094-0338","observed_orcids":["https://orcid.org/0000-0001-7094-0338"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Eleni Karlafti","raw_affiliation_strings":["Emergency Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","First Propaedeutic Department of Internal Medicine, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0001-7094-0338","affiliations":[{"raw_affiliation_string":"Emergency Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]},{"raw_affiliation_string":"First Propaedeutic Department of Internal Medicine, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084016998","display_name":"Dimitrios Tsavdaris","orcid":"https://orcid.org/0000-0001-6403-999X","observed_orcids":["https://orcid.org/0000-0001-6403-999X"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dimitrios Tsavdaris","raw_affiliation_strings":["First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0001-6403-999X","affiliations":[{"raw_affiliation_string":"First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068402584","display_name":"Alexandros E. Giakoustidis","orcid":"https://orcid.org/0000-0002-3786-4609","observed_orcids":["https://orcid.org/0000-0002-3786-4609","https://orcid.org/0000-0002-3184-8616"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I4210104108","display_name":"Papageorgiou General Hospital","ror":"https://ror.org/01663qy58","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210104108"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Alexandros Giakoustidis","raw_affiliation_strings":["First Surgery Department, University General Hospital of Thessaloniki Papageorgiou, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-3786-4609","affiliations":[{"raw_affiliation_string":"First Surgery Department, University General Hospital of Thessaloniki Papageorgiou, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I4210104108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060204733","display_name":"Stavros Panidis","orcid":"https://orcid.org/0000-0001-7354-5456","observed_orcids":["https://orcid.org/0000-0001-7354-5456"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Stavros Panidis","raw_affiliation_strings":["First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058704330","display_name":"Aris Ioannidis","orcid":"https://orcid.org/0000-0003-3865-6358","observed_orcids":["https://orcid.org/0000-0003-3865-6358"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Aristeidis Ioannidis","raw_affiliation_strings":["First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0003-3865-6358","affiliations":[{"raw_affiliation_string":"First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045612893","display_name":"Panos K. Prassopoulos","orcid":"https://orcid.org/0000-0003-0720-7760","observed_orcids":["https://orcid.org/0000-0003-0720-7760"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panos Prassopoulos","raw_affiliation_strings":["Department of Radiology, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089575046","display_name":"Antonios Michalopoulos","orcid":"https://orcid.org/0000-0003-1918-9619","observed_orcids":["https://orcid.org/0000-0003-1918-9619"]},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Antonios Michalopoulos","raw_affiliation_strings":["First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Propaedeutic Surgery Department, University General Hospital of Thessaloniki AHEPA, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012739379"],"corresponding_institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2046},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2046},"fwci":1.3252,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.78157662,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"60","issue":"10","first_page":"1592","last_page":"1592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-necrotizing-pancreatitis","display_name":"acute necrotizing pancreatitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/timing-of-intervention","display_name":"intervention timing","score":0.9150000214576721},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.7429999709129333},{"id":"https://openalex.org/keywords/delayed-intervention","display_name":"delayed intervention","score":0.9940000176429749},{"id":"https://openalex.org/keywords/percutaneous-drainage","display_name":"percutaneous drainage","score":0.7990000247955322},{"id":"https://openalex.org/keywords/endoscopic-drainage","display_name":"endoscopic drainage","score":0.9929999709129333},{"id":"https://openalex.org/keywords/surgical-drainage","display_name":"surgical drainage","score":0.7929999828338623},{"id":"https://openalex.org/keywords/post-pancreatitis-complications","display_name":"post-pancreatitis complications","score":0.753000020980835},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7940000295639038},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.843999981880188},{"id":"https://openalex.org/keywords/icu-length-of-stay","display_name":"ICU length of stay","score":0.40299999713897705},{"id":"https://openalex.org/keywords/pancreatic-fistula","display_name":"pancreatic fistula","score":0.699999988079071},{"id":"https://openalex.org/keywords/gastrointestinal-fistula","display_name":"gastrointestinal fistula","score":0.6579999923706055},{"id":"https://openalex.org/keywords/endocrine-pancreatic-insufficiency","display_name":"endocrine pancreatic insufficiency","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C2910062394","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Necrotizing pancreatitis","level":3,"score":0.8809254169464111},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.7062007188796997},{"id":"https://openalex.org/C199033989","wikidata":"https://www.wikidata.org/wiki/Q1318295","display_name":"Narrative","level":2,"score":0.6924898624420166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5783728361129761},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5690609216690063},{"id":"https://openalex.org/C2776670229","wikidata":"https://www.wikidata.org/wiki/Q854573","display_name":"Acute pancreatitis","level":2,"score":0.5248113870620728},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.5043429136276245},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.4558994472026825},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.17461538314819336},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16322898864746094},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.05278459191322327},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004322","descriptor_name":"Drainage","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019283","descriptor_name":"Pancreatitis, Acute Necrotizing","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019283","descriptor_name":"Pancreatitis, Acute Necrotizing","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D061665","descriptor_name":"Time-to-Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/medicina60101592","doi":"https://doi.org/10.3390/medicina60101592","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina60101592","pdf_url":"https://www.mdpi.com/1648-9144/60/10/1592/pdf?version=1727591219","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11509130","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11509130","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11509130/pdf/medicina-60-01592.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas)","raw_type":"Text"},{"id":"pmid:39459378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39459378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina (Kaunas, Lithuania)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2a7eed1c1ff646d69820cfe6f06be982","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2a7eed1c1ff646d69820cfe6f06be982","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicina, Vol 60, Iss 10, p 1592 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/medicina60101592","doi":"https://doi.org/10.3390/medicina60101592","is_oa":true,"landing_page_url":"https://doi.org/10.3390/medicina60101592","pdf_url":"https://www.mdpi.com/1648-9144/60/10/1592/pdf?version=1727591219","source":{"id":"https://openalex.org/S1008817457","display_name":"Medicina","issn_l":"1010-660X","issn":["1010-660X","1648-9144"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402919331.pdf","grobid_xml":"https://content.openalex.org/works/W4402919331.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W77612229","https://openalex.org/W141783472","https://openalex.org/W206079558","https://openalex.org/W272477196","https://openalex.org/W1528638673","https://openalex.org/W1544299356","https://openalex.org/W1972516036","https://openalex.org/W1975926180","https://openalex.org/W1981237335","https://openalex.org/W1992280222","https://openalex.org/W2003533296","https://openalex.org/W2013439125","https://openalex.org/W2016152308","https://openalex.org/W2017531370","https://openalex.org/W2021797735","https://openalex.org/W2026082407","https://openalex.org/W2030714032","https://openalex.org/W2048110056","https://openalex.org/W2048835849","https://openalex.org/W2050133462","https://openalex.org/W2052118586","https://openalex.org/W2053311274","https://openalex.org/W2070073194","https://openalex.org/W2086471516","https://openalex.org/W2088730523","https://openalex.org/W2093455309","https://openalex.org/W2094759691","https://openalex.org/W2103509799","https://openalex.org/W2109057101","https://openalex.org/W2110617812","https://openalex.org/W2113453694","https://openalex.org/W2116812720","https://openalex.org/W2119496770","https://openalex.org/W2119841679","https://openalex.org/W2125332073","https://openalex.org/W2134811461","https://openalex.org/W2136196992","https://openalex.org/W2145758369","https://openalex.org/W2147227928","https://openalex.org/W2148010522","https://openalex.org/W2163524757","https://openalex.org/W2186129387","https://openalex.org/W2216723602","https://openalex.org/W2272867491","https://openalex.org/W2275911709","https://openalex.org/W2289658851","https://openalex.org/W2295491798","https://openalex.org/W2310609224","https://openalex.org/W2353700738","https://openalex.org/W2546001063","https://openalex.org/W2579826027","https://openalex.org/W2609777439","https://openalex.org/W2727721722","https://openalex.org/W2752023293","https://openalex.org/W2755524842","https://openalex.org/W2777138253","https://openalex.org/W2789180182","https://openalex.org/W2792549632","https://openalex.org/W2797697368","https://openalex.org/W2799455904","https://openalex.org/W2807603780","https://openalex.org/W2888424775","https://openalex.org/W2895270450","https://openalex.org/W2895654324","https://openalex.org/W2898869070","https://openalex.org/W2900453203","https://openalex.org/W2900812208","https://openalex.org/W2900864502","https://openalex.org/W2907972929","https://openalex.org/W2910053234","https://openalex.org/W2912275002","https://openalex.org/W2947617969","https://openalex.org/W2949891360","https://openalex.org/W2970272373","https://openalex.org/W2991484780","https://openalex.org/W3000345340","https://openalex.org/W3014845852","https://openalex.org/W3035952700","https://openalex.org/W3086386450","https://openalex.org/W3095060976","https://openalex.org/W3097840774","https://openalex.org/W3119876960","https://openalex.org/W3123195699","https://openalex.org/W3126301173","https://openalex.org/W3129944423","https://openalex.org/W3158216686","https://openalex.org/W3171353859","https://openalex.org/W3182067484","https://openalex.org/W3182658126","https://openalex.org/W3189861662","https://openalex.org/W3204102881","https://openalex.org/W3206018307","https://openalex.org/W4211022384","https://openalex.org/W4226043090","https://openalex.org/W4230382211","https://openalex.org/W4240986128","https://openalex.org/W4253451268","https://openalex.org/W4253878229","https://openalex.org/W4280517228","https://openalex.org/W4282553315","https://openalex.org/W4283739384","https://openalex.org/W4283805796","https://openalex.org/W4287509719","https://openalex.org/W4291321802","https://openalex.org/W4293503400","https://openalex.org/W4294958489","https://openalex.org/W4317434657","https://openalex.org/W4318926537","https://openalex.org/W4318932571","https://openalex.org/W4372330428","https://openalex.org/W4384295917","https://openalex.org/W6676993913"],"related_works":["https://openalex.org/W4226043090","https://openalex.org/W6962564004","https://openalex.org/W2017531370","https://openalex.org/W4414371172","https://openalex.org/W4304014608","https://openalex.org/W4412434443","https://openalex.org/W3119876960","https://openalex.org/W4383302095","https://openalex.org/W3138490573","https://openalex.org/W4319337070"],"abstract_inverted_index":{"Introduction:":[0],"Acute":[1],"necrotizing":[2],"pancreatitis":[3],"(ANP)":[4],"is":[5,57,160,166,174,190,228,251],"the":[6,41,60,85,137,148,151,154,168,182,186,223],"acute":[7],"inflammation":[8],"of":[9,31,54,98,116,132,139,153,195],"pancreatic":[10,202,207],"parenchyma,":[11],"most":[12],"commonly":[13],"due":[14],"to":[15,58,243],"alcohol":[16],"abuse":[17],"or":[18,26,46,107,125],"cholelithiasis.":[19],"The":[20,52,130],"treatment":[21],"can":[22,120],"be":[23,44,50,121,237,244],"either":[24,123],"conservative":[25],"invasive,":[27],"including":[28],"a":[29],"variety":[30],"techniques;":[32],"however,":[33],"it":[34,48,189,250],"has":[35],"not":[36],"yet":[37],"been":[38],"established":[39],"if":[40,47],"intervention":[42,64,111,140,159,173,214,227,234,241],"should":[43,49,236],"early":[45,88,158,233,240],"delayed.":[51],"aim":[53],"this":[55,133],"review":[56,134],"investigate":[59],"optimal":[61],"time":[62,138],"for":[63,82,141],"in":[65,73,147,216,220],"ANP.":[66],"Methods:":[67],"A":[68],"literature":[69],"search":[70],"was":[71],"conducted":[72,122],"PubMed":[74],"and":[75,89,150,209,222,235,247,249],"Scopus":[76],"from":[77],"inception":[78],"until":[79],"September":[80],"2024":[81],"studies":[83],"reporting":[84],"comparison":[86],"between":[87],"late":[90],"intervention.":[91,187],"Results:":[92],"Early":[93],"intervention,":[94],"within":[95],"4":[96,114],"weeks":[97,115],"symptom":[99,117],"onset,":[100],"often":[101],"involves":[102],"drainage":[103],"via":[104,126],"percutaneous,":[105],"endoscopic,":[106],"combined":[108],"methods.":[109],"Delayed":[110,172,226],"occurs":[112],"after":[113],"onset.":[118],"This":[119],"surgically":[124],"minimally":[127],"invasive":[128],"means.":[129],"results":[131,215],"reveal":[135],"that":[136],"ANP":[142],"plays":[143],"an":[144],"important":[145],"role":[146],"prognosis":[149],"course":[152],"disease.":[155],"In":[156],"particular,":[157],"associated":[161,184],"with":[162,185],"higher":[163],"mortality,":[164],"which":[165],"also":[167,175],"primary":[169],"clinical":[170,179],"outcome.":[171],"superior":[176],"regarding":[177],"secondary":[178],"outcomes,":[180],"specifically":[181],"complications":[183],"Thus,":[188],"accompanied":[191],"by":[192],"fewer":[193],"episodes":[194],"new-onset":[196],"organ":[197],"failure,":[198],"bleeding,":[199],"gastrointestinal":[200],"fistula,":[201,203],"wound":[204],"infection,":[205],"endocrine":[206],"insufficiency,":[208],"other":[210],"complications.":[211],"Finally,":[212],"delayed":[213],"shorter":[217],"stays,":[218],"both":[219,245],"hospitals":[221],"ICU.":[224],"Conclusions:":[225],"clearly":[229],"more":[230],"effective":[231],"than":[232],"preferred.":[238],"However,":[239],"appears":[242],"safe":[246],"effective,":[248],"feasible.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2024-09-28T00:00:00"}