{"id":"https://openalex.org/W4402890899","doi":"https://doi.org/10.2174/0118715273329531240911075309","title":"Revolutionising Neurological Therapeutics: Investigating Drug Repurposing Strategies","display_name":"Revolutionising Neurological Therapeutics: Investigating Drug Repurposing Strategies","publication_year":2024,"publication_date":"2024-09-26","ids":{"openalex":"https://openalex.org/W4402890899","doi":"https://doi.org/10.2174/0118715273329531240911075309","pmid":"https://pubmed.ncbi.nlm.nih.gov/39323347"},"language":"en","primary_location":{"id":"doi:10.2174/0118715273329531240911075309","doi":"https://doi.org/10.2174/0118715273329531240911075309","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715273329531240911075309","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & Neurological Disorders - Drug Targets","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4402890899"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092554044","display_name":"Meenakshi Attri","orcid":"https://orcid.org/0000-0003-1605-177X","observed_orcids":["https://orcid.org/0000-0003-1605-177X"]},"institutions":[{"id":"https://openalex.org/I4210114149","display_name":"KR Mangalam University","ror":"https://ror.org/026b9sf88","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210114149"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Meenakshi Attri","raw_affiliation_strings":["School of Medical & Allied Sciences, K.R. Mangalam University, Gurugram, Haryana 122103, India"],"raw_orcid":"https://orcid.org/0000-0003-1605-177X","affiliations":[{"raw_affiliation_string":"School of Medical & Allied Sciences, K.R. Mangalam University, Gurugram, Haryana 122103, India","institution_ids":["https://openalex.org/I4210114149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092554045","display_name":"Asha Raghav","orcid":"https://orcid.org/0000-0002-5724-6912","observed_orcids":["https://orcid.org/0000-0002-5724-6912"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Asha Raghav","raw_affiliation_strings":["Department of\nPharmaceutics, School of Health Sciences, Sushant University, Gurugram, Haryana 122003, India"],"raw_orcid":"https://orcid.org/0000-0002-5724-6912","affiliations":[{"raw_affiliation_string":"Department of\nPharmaceutics, School of Health Sciences, Sushant University, Gurugram, Haryana 122003, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026960276","display_name":"Jyoti Sinha","orcid":"https://orcid.org/0009-0007-9032-1412","observed_orcids":["https://orcid.org/0009-0007-9032-1412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jyoti Sinha","raw_affiliation_strings":["Department of\nPharmaceutics, School of Health Sciences, Sushant University, Gurugram, Haryana 122003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of\nPharmaceutics, School of Health Sciences, Sushant University, Gurugram, Haryana 122003, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5092554045"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0259,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02772277,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"24","issue":"2","first_page":"115","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8550000190734863},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8970000147819519},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.5759999752044678},{"id":"https://openalex.org/keywords/proteomics","display_name":"proteomics","score":0.8640000224113464},{"id":"https://openalex.org/keywords/network-analysis","display_name":"network analysis","score":0.5899999737739563},{"id":"https://openalex.org/keywords/genomics","display_name":"genomics","score":0.7279999852180481},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"virtual screening","score":0.9279999732971191},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.9446725845336914},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.9304139614105225},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5854990482330322},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.573681652545929},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5073637366294861},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49848222732543945},{"id":"https://openalex.org/C2777494893","wikidata":"https://www.wikidata.org/wiki/Q4781752","display_name":"Approved drug","level":3,"score":0.46693816781044006},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45641592144966125},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4358375072479248},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3621114194393158},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3295783996582031},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31239092350006104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17156213521957397},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09239846467971802},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/0118715273329531240911075309","doi":"https://doi.org/10.2174/0118715273329531240911075309","is_oa":false,"landing_page_url":"https://doi.org/10.2174/0118715273329531240911075309","pdf_url":null,"source":{"id":"https://openalex.org/S148418319","display_name":"CNS & Neurological Disorders - Drug Targets","issn_l":"1568-007X","issn":["1568-007X","1871-5273","1996-3181","2212-5299"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & Neurological Disorders - Drug Targets","raw_type":"journal-article"},{"id":"pmid:39323347","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39323347","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS & neurological disorders drug targets","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":209,"referenced_works":["https://openalex.org/W22857079","https://openalex.org/W150733228","https://openalex.org/W174236887","https://openalex.org/W189445517","https://openalex.org/W1567880561","https://openalex.org/W1576999553","https://openalex.org/W1592341435","https://openalex.org/W1656802472","https://openalex.org/W1828947725","https://openalex.org/W1893459668","https://openalex.org/W1904458203","https://openalex.org/W1926532831","https://openalex.org/W1940519961","https://openalex.org/W1963605907","https://openalex.org/W1965968130","https://openalex.org/W1967645451","https://openalex.org/W1968217711","https://openalex.org/W1968779484","https://openalex.org/W1971336706","https://openalex.org/W1974879622","https://openalex.org/W1977936721","https://openalex.org/W1978486653","https://openalex.org/W1984615306","https://openalex.org/W1985270532","https://openalex.org/W1988884203","https://openalex.org/W1989750506","https://openalex.org/W1991248698","https://openalex.org/W1991629471","https://openalex.org/W1993251792","https://openalex.org/W1994658365","https://openalex.org/W1995817686","https://openalex.org/W1996548604","https://openalex.org/W1996980138","https://openalex.org/W1997854589","https://openalex.org/W1998959104","https://openalex.org/W2000292092","https://openalex.org/W2002313452","https://openalex.org/W2003095583","https://openalex.org/W2003674452","https://openalex.org/W2006241298","https://openalex.org/W2006333161","https://openalex.org/W2008176593","https://openalex.org/W2008620264","https://openalex.org/W2009405916","https://openalex.org/W2011726136","https://openalex.org/W2016149155","https://openalex.org/W2016864853","https://openalex.org/W2017061363","https://openalex.org/W2018522439","https://openalex.org/W2020132970","https://openalex.org/W2020605686","https://openalex.org/W2025285868","https://openalex.org/W2026816336","https://openalex.org/W2027195572","https://openalex.org/W2028273867","https://openalex.org/W2028279608","https://openalex.org/W2030028063","https://openalex.org/W2030672557","https://openalex.org/W2032625286","https://openalex.org/W2033541126","https://openalex.org/W2037939651","https://openalex.org/W2041679053","https://openalex.org/W2041906544","https://openalex.org/W2043950794","https://openalex.org/W2046330571","https://openalex.org/W2047219680","https://openalex.org/W2048356178","https://openalex.org/W2048629875","https://openalex.org/W2049892216","https://openalex.org/W2050755008","https://openalex.org/W2052214665","https://openalex.org/W2052792709","https://openalex.org/W2053957040","https://openalex.org/W2055031312","https://openalex.org/W2060045688","https://openalex.org/W2060333462","https://openalex.org/W2061747153","https://openalex.org/W2061914766","https://openalex.org/W2062907730","https://openalex.org/W2065812641","https://openalex.org/W2069728700","https://openalex.org/W2071485896","https://openalex.org/W2073486423","https://openalex.org/W2074042142","https://openalex.org/W2074156945","https://openalex.org/W2075958435","https://openalex.org/W2076771365","https://openalex.org/W2078261272","https://openalex.org/W2079870772","https://openalex.org/W2080405711","https://openalex.org/W2087601089","https://openalex.org/W2088303467","https://openalex.org/W2089329334","https://openalex.org/W2092243607","https://openalex.org/W2093602450","https://openalex.org/W2095253562","https://openalex.org/W2100929382","https://openalex.org/W2101348366","https://openalex.org/W2102491186","https://openalex.org/W2105341103","https://openalex.org/W2105562985","https://openalex.org/W2106052836","https://openalex.org/W2107621750","https://openalex.org/W2108155748","https://openalex.org/W2110506701","https://openalex.org/W2112163143","https://openalex.org/W2112946624","https://openalex.org/W2115504770","https://openalex.org/W2117991078","https://openalex.org/W2120526231","https://openalex.org/W2124213159","https://openalex.org/W2126114791","https://openalex.org/W2126274301","https://openalex.org/W2130735976","https://openalex.org/W2131142034","https://openalex.org/W2135364779","https://openalex.org/W2135808678","https://openalex.org/W2138305199","https://openalex.org/W2139560421","https://openalex.org/W2140239055","https://openalex.org/W2140822113","https://openalex.org/W2147048440","https://openalex.org/W2147371111","https://openalex.org/W2148286123","https://openalex.org/W2151092952","https://openalex.org/W2156034369","https://openalex.org/W2159368029","https://openalex.org/W2162294150","https://openalex.org/W2163480486","https://openalex.org/W2163754658","https://openalex.org/W2166221624","https://openalex.org/W2167912995","https://openalex.org/W2168882620","https://openalex.org/W2170146596","https://openalex.org/W2173696128","https://openalex.org/W2254386269","https://openalex.org/W2261425654","https://openalex.org/W2268589829","https://openalex.org/W2273267066","https://openalex.org/W2317696784","https://openalex.org/W2318810208","https://openalex.org/W2321248858","https://openalex.org/W2341574236","https://openalex.org/W2405860079","https://openalex.org/W2463280158","https://openalex.org/W2463901487","https://openalex.org/W2499640845","https://openalex.org/W2520107693","https://openalex.org/W2522083379","https://openalex.org/W2522186216","https://openalex.org/W2528080441","https://openalex.org/W2544079919","https://openalex.org/W2556164933","https://openalex.org/W2562737870","https://openalex.org/W2565611518","https://openalex.org/W2588146368","https://openalex.org/W2604002407","https://openalex.org/W2604975863","https://openalex.org/W2607350503","https://openalex.org/W2681380026","https://openalex.org/W2729684734","https://openalex.org/W2732803752","https://openalex.org/W2734505834","https://openalex.org/W2736137960","https://openalex.org/W2753953057","https://openalex.org/W2765985736","https://openalex.org/W2767683865","https://openalex.org/W2767891136","https://openalex.org/W2769604672","https://openalex.org/W2773987374","https://openalex.org/W2776803885","https://openalex.org/W2781273307","https://openalex.org/W2783076969","https://openalex.org/W2787229753","https://openalex.org/W2794356742","https://openalex.org/W2799817815","https://openalex.org/W2801804034","https://openalex.org/W2803364980","https://openalex.org/W2810388850","https://openalex.org/W2884418830","https://openalex.org/W2884430236","https://openalex.org/W2885096695","https://openalex.org/W2892123052","https://openalex.org/W2896002881","https://openalex.org/W2897474378","https://openalex.org/W2901303766","https://openalex.org/W2905002184","https://openalex.org/W2943504484","https://openalex.org/W2950612086","https://openalex.org/W2968671948","https://openalex.org/W2972368830","https://openalex.org/W2973727587","https://openalex.org/W2996672198","https://openalex.org/W3004386025","https://openalex.org/W3011853967","https://openalex.org/W3012707556","https://openalex.org/W3019897091","https://openalex.org/W3037874056","https://openalex.org/W3044296243","https://openalex.org/W3112212292","https://openalex.org/W3124325052","https://openalex.org/W3128618129","https://openalex.org/W3199000899","https://openalex.org/W4200594722","https://openalex.org/W4235875658","https://openalex.org/W4243153132","https://openalex.org/W4288707390","https://openalex.org/W4323306606","https://openalex.org/W4376136225"],"related_works":["https://openalex.org/W4393857300","https://openalex.org/W4393906247","https://openalex.org/W7118017535","https://openalex.org/W3037874056","https://openalex.org/W2920028299","https://openalex.org/W4401956972","https://openalex.org/W4387041633","https://openalex.org/W4398194466","https://openalex.org/W2299074827","https://openalex.org/W4407752410"],"abstract_inverted_index":{"Repurposing":[0],"drugs":[1,54],"(DR)":[2],"has":[3],"become":[4],"a":[5,170],"viable":[6],"approach":[7],"to":[8,34,63,121,129,143],"hasten":[9],"the":[10,45,74,114,131],"search":[11],"for":[12,14,38,55,111,156,179],"cures":[13],"neurodegenerative":[15],"diseases":[16],"(NDs).":[17],"This":[18,125],"review":[19,72],"examines":[20],"different":[21],"off-target":[22],"and":[23,28,78,88,91,105,118,142,164,177],"on-target":[24,58],"drug":[25,109,134,173],"discovery":[26],"techniques":[27],"how":[29],"they":[30],"might":[31],"be":[32,67],"used":[33],"find":[35],"possible":[36,162],"treatments":[37],"non-diagnostic":[39],"depressions.":[40],"Off-target":[41],"strategies":[42,59],"look":[43],"at":[44,103,108],"known":[46],"or":[47],"unknown":[48],"side":[49],"effects":[50],"of":[51,76,116,133,147,172],"currently":[52],"approved":[53],"repositioning,":[56],"whereas":[57],"connect":[60],"disease":[61],"pathways":[62],"targets":[64],"that":[65,150],"can":[66],"treated":[68],"with":[69,160],"drugs.":[70],"The":[71],"highlights":[73],"potential":[75],"experimental":[77],"computational":[79],"methodologies,":[80],"such":[81],"as":[82],"machine":[83],"learning,":[84],"proteomic":[85],"techniques,":[86],"network":[87],"genomics-based":[89],"approaches,":[90],"in":[92,95,136],"silico":[93],"screening,":[94],"uncovering":[96],"new":[97],"drug-disease":[98],"correlations.":[99],"It":[100],"also":[101],"looks":[102],"difficulties":[104,178],"failed":[106],"attempts":[107],"repurposing":[110,135,148,174],"NDs,":[112],"highlighting":[113],"necessity":[115],"exact":[117],"standardised":[119],"procedures":[120],"increase":[122],"success":[123],"rates.":[124],"review's":[126],"objectives":[127],"are":[128,151],"address":[130],"purpose":[132],"human":[137],"disorders,":[138],"particularly":[139],"neurological":[140,157],"diseases,":[141],"provide":[144],"an":[145],"overview":[146],"candidates":[149],"presently":[152],"undergoing":[153],"clinical":[154],"trials":[155],"conditions,":[158],"along":[159],"any":[161],"causes":[163],"early":[165],"findings.":[166],"We":[167],"then":[168],"include":[169],"list":[171],"strategies,":[175],"restrictions,":[176],"upcoming":[180],"research.":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-09-27T00:00:00"}