{"id":"https://openalex.org/W4402889409","doi":"https://doi.org/10.7717/peerj.17894","title":"In silico directed evolution of Anabas testudineus AtMP1 antimicrobial peptide to improve in vitro anticancer activity","display_name":"In silico directed evolution of Anabas testudineus AtMP1 antimicrobial peptide to improve in vitro anticancer activity","publication_year":2024,"publication_date":"2024-09-26","ids":{"openalex":"https://openalex.org/W4402889409","doi":"https://doi.org/10.7717/peerj.17894","pmid":"https://pubmed.ncbi.nlm.nih.gov/39346049","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11439379"},"language":"en","primary_location":{"id":"doi:10.7717/peerj.17894","doi":"https://doi.org/10.7717/peerj.17894","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7717/peerj.17894","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.7717/peerj.17894","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056074332","display_name":"Shazrul Fazry","orcid":"https://orcid.org/0000-0002-7072-8609","observed_orcids":["https://orcid.org/0000-0002-7072-8609"]},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Shazrul Fazry","raw_affiliation_strings":["Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia,  Bangi, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia,  Bangi, Selangor, Malaysia","institution_ids":["https://openalex.org/I885383172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022537516","display_name":"Ahmed Abdulkareem Najm","orcid":"https://orcid.org/0000-0003-1206-694X","observed_orcids":["https://orcid.org/0000-0003-1206-694X"]},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Ahmed Abdulkareem Najm","raw_affiliation_strings":["Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia,  Bangi, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia,  Bangi, Selangor, Malaysia","institution_ids":["https://openalex.org/I885383172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108823171","display_name":"Ibrahim Mahmood","orcid":"https://orcid.org/0000-0003-2001-1842","observed_orcids":["https://orcid.org/0000-0003-2001-1842"]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]},{"id":"https://openalex.org/I277213931","display_name":"Alrafidain University College","ror":"https://ror.org/0204z0d18","country_code":"IQ","type":"education","lineage":["https://openalex.org/I277213931"]}],"countries":["IQ","MY"],"is_corresponding":false,"raw_author_name":"Ibrahim Mahmood Mahdi","raw_affiliation_strings":["Dentistry Department, Al-Rafidain University College, Baghad, Iraq","Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dentistry Department, Al-Rafidain University College, Baghad, Iraq","institution_ids":["https://openalex.org/I277213931"]},{"raw_affiliation_string":"Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia","institution_ids":["https://openalex.org/I12649496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065499318","display_name":"Arnold Ang","orcid":"https://orcid.org/0009-0008-0227-1265","observed_orcids":["https://orcid.org/0009-0008-0227-1265"]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Arnold Ang","raw_affiliation_strings":["Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia","institution_ids":["https://openalex.org/I12649496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109790057","display_name":"LiTing Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"LiTing Lee","raw_affiliation_strings":["Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia","institution_ids":["https://openalex.org/I12649496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079793847","display_name":"Choy\u2010Theng Loh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Choy-Theng Loh","raw_affiliation_strings":["Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia","Hangzhou Foreseebio Biotechnology Co., Ltd, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia","institution_ids":["https://openalex.org/I12649496"]},{"raw_affiliation_string":"Hangzhou Foreseebio Biotechnology Co., Ltd, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047765112","display_name":"Sharifah Sakinah Syed Alwi","orcid":"https://orcid.org/0000-0002-6497-706X","observed_orcids":["https://orcid.org/0000-0002-6497-706X"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Sharifah Sakinah Syed Alwi","raw_affiliation_strings":["Department of Biomedical Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114506663","display_name":"Fang Li","orcid":"https://orcid.org/0009-0000-4450-7485","observed_orcids":["https://orcid.org/0009-0000-4450-7485"]},"institutions":[{"id":"https://openalex.org/I4210102741","display_name":"Jiangsu Vocational College of Medicine","ror":"https://ror.org/01jzst437","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210102741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Li","raw_affiliation_strings":["Jiangsu Vocational College of Medicine, Yancheng, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Vocational College of Medicine, Yancheng, China","institution_ids":["https://openalex.org/I4210102741"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012250789","display_name":"Douglas Sie Nguong Law","orcid":"https://orcid.org/0000-0002-7824-3542","observed_orcids":["https://orcid.org/0000-0002-7824-3542"]},"institutions":[{"id":"https://openalex.org/I12649496","display_name":"INTI International University","ror":"https://ror.org/03fj82m46","country_code":"MY","type":"education","lineage":["https://openalex.org/I12649496"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Douglas Law","raw_affiliation_strings":["Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia","institution_ids":["https://openalex.org/I12649496"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5012250789","https://openalex.org/A5022537516"],"corresponding_institution_ids":["https://openalex.org/I12649496","https://openalex.org/I885383172"],"apc_list":{"value":1395,"currency":"USD","value_usd":1395},"apc_paid":{"value":1395,"currency":"USD","value_usd":1395},"fwci":0.6838,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.6167571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"12","issue":null,"first_page":"e17894","last_page":"e17894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9179999828338623},{"id":"https://openalex.org/keywords/anabas-testudineus","display_name":"Anabas testudineus","score":0.906000018119812},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9570000171661377},{"id":"https://openalex.org/keywords/peptide-toxicity-prediction","display_name":"peptide toxicity prediction","score":0.7400000095367432},{"id":"https://openalex.org/keywords/allergenicity-prediction","display_name":"allergenicity prediction","score":0.828000009059906},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/therapeutic-peptides","display_name":"peptide therapeutics","score":0.6179999709129333},{"id":"https://openalex.org/keywords/biological-databases","display_name":"biological databases","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.8158895969390869},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.786588728427887},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.7666072249412537},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7221222519874573},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5380070209503174},{"id":"https://openalex.org/C2781459740","wikidata":"https://www.wikidata.org/wiki/Q10540515","display_name":"Anabas testudineus","level":4,"score":0.48513826727867126},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.43473851680755615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4345170855522156},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.4323032796382904},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4101627469062805},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37441110610961914},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36438584327697754},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.23528629541397095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15328606963157654},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11199185252189636},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.10180279612541199},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2777798493","wikidata":"https://www.wikidata.org/wiki/Q600262","display_name":"Perch","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000089882","descriptor_name":"Antimicrobial Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019020","descriptor_name":"Directed Molecular Evolution","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.7717/peerj.17894","doi":"https://doi.org/10.7717/peerj.17894","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7717/peerj.17894","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11439379","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11439379","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11439379/pdf/peerj-12-17894.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Text"},{"id":"pmid:39346049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39346049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"Journal Article"},{"id":"pmh:oai:psasir.upm.edu.my:116710","doi":null,"is_oa":true,"landing_page_url":"http://psasir.upm.edu.my/id/eprint/116710/1/116710.pdf","pdf_url":"http://psasir.upm.edu.my/id/eprint/116710/1/116710.pdf","source":{"id":"https://openalex.org/S4377196260","display_name":"Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130343225","host_organization_name":"Universiti Putra Malaysia","host_organization_lineage":["https://openalex.org/I130343225"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:e6a129619fad4f41a6c9370faeaeb3d9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6a129619fad4f41a6c9370faeaeb3d9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PeerJ, Vol 12, p e17894 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.7717/peerj.17894","doi":"https://doi.org/10.7717/peerj.17894","is_oa":true,"landing_page_url":"http://dx.doi.org/10.7717/peerj.17894","pdf_url":null,"source":{"id":"https://openalex.org/S1983995261","display_name":"PeerJ","issn_l":"2167-8359","issn":["2167-8359"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320104","host_organization_name":"PeerJ, Inc.","host_organization_lineage":["https://openalex.org/P4310320104"],"host_organization_lineage_names":["PeerJ, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PeerJ","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6674031044","display_name":null,"funder_award_id":"ST-2022-013","funder_id":"https://openalex.org/F4320322699","funder_display_name":"Universiti Kebangsaan Malaysia"}],"funders":[{"id":"https://openalex.org/F4320322699","display_name":"Universiti Kebangsaan Malaysia","ror":"https://ror.org/00bw8d226"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402889409.pdf","grobid_xml":"https://content.openalex.org/works/W4402889409.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1486558210","https://openalex.org/W1494509673","https://openalex.org/W1599749096","https://openalex.org/W1851763797","https://openalex.org/W1974742145","https://openalex.org/W1993474521","https://openalex.org/W1999361661","https://openalex.org/W2015176909","https://openalex.org/W2029625284","https://openalex.org/W2030709958","https://openalex.org/W2040153411","https://openalex.org/W2057164289","https://openalex.org/W2092527324","https://openalex.org/W2096697992","https://openalex.org/W2151932306","https://openalex.org/W2169815691","https://openalex.org/W2170564629","https://openalex.org/W2175270296","https://openalex.org/W2193490462","https://openalex.org/W2306077232","https://openalex.org/W2318098003","https://openalex.org/W2327488668","https://openalex.org/W2395484121","https://openalex.org/W2407564830","https://openalex.org/W2461934594","https://openalex.org/W2564768241","https://openalex.org/W2761938632","https://openalex.org/W2782352040","https://openalex.org/W2793026911","https://openalex.org/W2800819541","https://openalex.org/W2807152882","https://openalex.org/W2940741806","https://openalex.org/W2969598413","https://openalex.org/W3009914931","https://openalex.org/W3040356104","https://openalex.org/W3048798435","https://openalex.org/W3122166379","https://openalex.org/W3133865815","https://openalex.org/W3154258817","https://openalex.org/W3211861476","https://openalex.org/W3217483829","https://openalex.org/W4206722897","https://openalex.org/W4225545453","https://openalex.org/W4226068113","https://openalex.org/W4244736178","https://openalex.org/W4283270742","https://openalex.org/W4285797615"],"related_works":["https://openalex.org/W4384824880","https://openalex.org/W4416956673","https://openalex.org/W4412197625","https://openalex.org/W4406347917","https://openalex.org/W4308274535","https://openalex.org/W3217483829","https://openalex.org/W3155575004","https://openalex.org/W4392871352","https://openalex.org/W4392352514","https://openalex.org/W4327560960"],"abstract_inverted_index":{"Various":[0],"studies":[1],"have":[2],"demonstrated":[3],"that":[4,145,157,230],"directed":[5,18],"evolution":[6,19],"is":[7,158],"a":[8,150],"powerful":[9],"tool":[10],"in":[11,34,106,237],"enhancing":[12],"protein":[13],"properties.":[14],"In":[15],"this":[16],"study,":[17,141],"was":[20,74,143],"used":[21],"to":[22,104,113,183,212,255],"enhance":[23],"the":[24,36,118,135,139,161,169,175,199,204,227,231,238],"efficacy":[25],"of":[26,38,43,49,121,152,160,167,172,198,233],"synthesised":[27],"Anabas":[28],"testudineus":[29],"AtMP1":[30],"antimicrobial":[31,44,69,123,146],"peptides":[32,45,124,147],"(AMPs)":[33,46,125,148],"inhibiting":[35],"proliferation":[37],"cancer":[39],"cells.":[40],"The":[41,99,195,242],"modification":[42],"and":[47,65,97,111,131,177,189,206,218],"prediction":[48],"peptide":[50,70,201,253],"properties":[51,120],"using":[52,58],"bioinformatic":[53],"tools":[54],"were":[55,102,126,181,210],"carried":[56],"out":[57],"four":[59],"databases,":[60,108],"including":[61],"ADP3,":[62],"CAMP-R3,":[63],"AMPfun,":[64],"ANTICP.":[66],"One":[67],"modified":[68],"(AMP),":[71],"ATMP6":[72,173,234],"(THPPTTTTTTTTTTTTTAAPARTT),":[73],"chosen":[75],"based":[76],"on":[77,134],"its":[78],"projected":[79,144],"potent":[80],"anticancer":[81,94],"effect,":[82],"taking":[83],"into":[84],"account":[85],"factors":[86],"such":[87],"as":[88],"amino":[89],"acid":[90],"length,":[91],"net":[92],"charge,":[93],"activity":[95],"score,":[96],"hydrophobicity.":[98],"selected":[100],"AMPs":[101],"subjected":[103],"study":[105],"deep-learning":[107],"namely":[109],"ToxIBTL":[110],"ToxinPred2,":[112],"predict":[114],"their":[115],"toxicity.":[116],"Furthermore,":[117,226],"allergic":[119],"these":[122],"verified":[127],"by":[128],"utilising":[129],"AllerTOP":[130],"AllergenFP.":[132],"Based":[133],"results":[136,228],"obtained":[137],"from":[138],"database":[140],"it":[142],"demonstrate":[149],"lack":[151],"toxicity":[153],"towards":[154],"human":[155],"cells":[156],"indicative":[159],"broader":[162],"population.":[163],"After":[164],"48":[165],"hours":[166],"incubation,":[168],"IC50":[170,196],"values":[171,197],"against":[174,203],"HS27":[176,207],"MDA-MB-231":[178,205,239],"cell":[179,208,240],"lines":[180,209],"found":[182],"be":[184,213],"48.03":[185],"\u00b1":[186,191,215,220],"0.013":[187],"\u00b5g/ml":[188,217],"7.52":[190],"0.027":[192],"\u00b5g/ml,":[193,222],"respectively.":[194],"original":[200],"ATMP1":[202],"determined":[211],"59.6":[214],"0.14":[216,221],"8.25":[219],"respectively,":[223],"when":[224],"compared.":[225],"indicated":[229],"injection":[232],"induced":[235],"apoptosis":[236],"lines.":[241],"present":[243],"investigation":[244],"has":[245],"revealed":[246],"new":[247],"opportunities":[248],"for":[249],"advancing":[250],"novel":[251],"targeted":[252],"therapeutics":[254],"tackle":[256],"cancer.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-27T00:00:00"}
