{"id":"https://openalex.org/W4402882796","doi":"https://doi.org/10.1016/j.humimm.2024.111144","title":"Blockade of store-operated calcium entry by BTP2 preserves anti-inflammatory gene expression in human peripheral blood mononuclear cells","display_name":"Blockade of store-operated calcium entry by BTP2 preserves anti-inflammatory gene expression in human peripheral blood mononuclear cells","publication_year":2023,"publication_date":"2023-03-13","ids":{"openalex":"https://openalex.org/W4402882796","doi":"https://doi.org/10.1016/j.humimm.2024.111144","pmid":"https://pubmed.ncbi.nlm.nih.gov/36993646","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10055512"},"language":"en","primary_location":{"id":"doi:10.1016/j.humimm.2024.111144","doi":"https://doi.org/10.1016/j.humimm.2024.111144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.humimm.2024.111144","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Human Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.humimm.2024.111144","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022776708","display_name":"Divya Shankaranarayanan","orcid":"https://orcid.org/0009-0006-8028-9618","observed_orcids":["https://orcid.org/0009-0006-8028-9618"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Shankaranarayanan","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004575873","display_name":"Madhav Mantri","orcid":"https://orcid.org/0000-0001-9844-7852","observed_orcids":["https://orcid.org/0000-0001-9844-7852"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madhav Mantri","raw_affiliation_strings":["Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109471584","display_name":"Mila Lagman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mila Lagman","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037032270","display_name":"Carol Y. Li","orcid":"https://orcid.org/0000-0002-0576-2181","observed_orcids":["https://orcid.org/0000-0002-0576-2181"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol Li","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Vijay K. Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vijay K. Sharma","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009885369","display_name":"Thangamani Muthukumar","orcid":"https://orcid.org/0000-0002-0294-6209","observed_orcids":["https://orcid.org/0000-0002-0294-6209"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thangamani Muthukumar","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036954977","display_name":"Jenny Xiang","orcid":"https://orcid.org/0000-0003-0484-2769","observed_orcids":["https://orcid.org/0000-0003-0484-2769"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny Z. Xiang","raw_affiliation_strings":["Genomics Resources Core Facility, Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Resources Core Facility, Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027216516","display_name":"Iwijn De Vlaminck","orcid":"https://orcid.org/0000-0001-6085-7311","observed_orcids":["https://orcid.org/0000-0001-6085-7311"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iwijn De Vlaminck","raw_affiliation_strings":["Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055037292","display_name":"Khaled Machaca","orcid":"https://orcid.org/0000-0001-6215-2411","observed_orcids":["https://orcid.org/0000-0001-6215-2411"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I92528248","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05","country_code":"QA","type":"funder","lineage":["https://openalex.org/I92528248"]}],"countries":["QA","US"],"is_corresponding":false,"raw_author_name":"Khaled Machaca","raw_affiliation_strings":["Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Calcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210152471","https://openalex.org/I4387153466","https://openalex.org/I92528248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073533672","display_name":"Manikkam Suthanthiran","orcid":"https://orcid.org/0000-0001-6894-0486","observed_orcids":["https://orcid.org/0000-0001-6894-0486"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Manikkam Suthanthiran","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA. Electronic address: msuthan@med.cornell.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA; Department of Transplantation Medicine, NewYork-Presbyterian Hospital-Weill Cornell Medicine, New York, NY, USA. Electronic address: msuthan@med.cornell.edu","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5073533672"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466","https://openalex.org/I4405272987"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.1771,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.4615771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"85","issue":"6","first_page":"111144","last_page":"111144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9990000128746033},{"id":"https://openalex.org/keywords/btp2","display_name":"BTP2","score":0.9819999933242798},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9570000171661377},{"id":"https://openalex.org/keywords/anti-inflammatory-gene-expression","display_name":"anti-inflammatory gene expression","score":0.7559999823570251},{"id":"https://openalex.org/keywords/proinflammatory-gene-expression","display_name":"pro-inflammatory gene expression","score":0.9670000076293945},{"id":"https://openalex.org/keywords/t-cell-clonal-expansion","display_name":"T cell clonal expansion","score":0.7820000052452087},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7620000243186951},{"id":"https://openalex.org/keywords/organ-transplantation","display_name":"organ transplantation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/phytohemagglutinin-stimulation","display_name":"phytohemagglutinin stimulation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.640999972820282},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":0.921999990940094},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8140000104904175},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7950000166893005},{"id":"https://openalex.org/keywords/granzyme-b","display_name":"granzyme B","score":0.9419999718666077}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.9037548303604126},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.5987170934677124},{"id":"https://openalex.org/C3017910909","wikidata":"https://www.wikidata.org/wiki/Q618363","display_name":"Peripheral blood","level":2,"score":0.5852226614952087},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5228050947189331},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.47090792655944824},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45952990651130676},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4473688006401062},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4038999676704407},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3331444263458252},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3293479084968567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32145896553993225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2662736177444458},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.136027991771698},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13007491827011108},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0959315299987793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08419916033744812}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.humimm.2024.111144","doi":"https://doi.org/10.1016/j.humimm.2024.111144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.humimm.2024.111144","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Human Immunology","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2618144/v1","doi":"https://doi.org/10.21203/rs.3.rs-2618144/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2618144/v1","pdf_url":"https://www.researchsquare.com/article/rs-2618144/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11637971","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11637971/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11637971/pdf/nihms-2025997.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hum Immunol","raw_type":"Text"},{"id":"pmid:36993646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36993646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Preprint"},{"id":"pmid:39332042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39332042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human immunology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11377411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11637971","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10055512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10055512","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10055512/pdf/nihpp-rs2618144v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Res Sq","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.humimm.2024.111144","doi":"https://doi.org/10.1016/j.humimm.2024.111144","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.humimm.2024.111144","pdf_url":null,"source":{"id":"https://openalex.org/S6860681","display_name":"Human Immunology","issn_l":"0198-8859","issn":["0198-8859","1879-1166"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Human Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2165940234","display_name":null,"funder_award_id":"NPRP12S\u20100212\u2010190074","funder_id":"https://openalex.org/F4320332753","funder_display_name":"Qatar National Research Fund"},{"id":"https://openalex.org/G2432297286","display_name":"Cell-Free DNA in Peritoneal Fluid as a Novel and Versatile Analyte for Monitoring Peritonitis","funder_award_id":"R21AI164093","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2894603144","display_name":null,"funder_award_id":"NPRP12S-","funder_id":"https://openalex.org/F4320332753","funder_display_name":"Qatar National Research Fund"},{"id":"https://openalex.org/G7057546020","display_name":"Biomolecular Markers for Safe Minimization of Immunosuppression","funder_award_id":"R37AI051652","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7158380036","display_name":"Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantation","funder_award_id":"R01AI151059","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7542782345","display_name":null,"funder_award_id":"R37 NIH MERIT AI051652","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7605775006","display_name":null,"funder_award_id":"MERIT AI051652","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8234290779","display_name":null,"funder_award_id":"NPRP12S-0212-190074","funder_id":"https://openalex.org/F4320309815","funder_display_name":"Qatar Foundation"},{"id":"https://openalex.org/G904291458","display_name":"Urine mRNA Profiling for Renal Allograft Surveillance","funder_award_id":"R01AI051652","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309815","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320332753","display_name":"Qatar National Research Fund","ror":"https://ror.org/01svaqq28"},{"id":"https://openalex.org/F4320334416","display_name":"Weill Cornell Medicine - Qatar","ror":"https://ror.org/05v5hg569"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402882796.pdf","grobid_xml":"https://content.openalex.org/works/W4402882796.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1490870966","https://openalex.org/W1545637885","https://openalex.org/W1606523019","https://openalex.org/W1650401181","https://openalex.org/W1934528477","https://openalex.org/W1974313653","https://openalex.org/W1977144608","https://openalex.org/W1977764086","https://openalex.org/W1978593035","https://openalex.org/W1993051112","https://openalex.org/W1997093700","https://openalex.org/W2004106131","https://openalex.org/W2005571837","https://openalex.org/W2008245136","https://openalex.org/W2009503875","https://openalex.org/W2013172050","https://openalex.org/W2019239845","https://openalex.org/W2019453182","https://openalex.org/W2020754776","https://openalex.org/W2029953646","https://openalex.org/W2036413106","https://openalex.org/W2042953533","https://openalex.org/W2049049472","https://openalex.org/W2068877244","https://openalex.org/W2073580835","https://openalex.org/W2086131781","https://openalex.org/W2098465830","https://openalex.org/W2104959557","https://openalex.org/W2106160458","https://openalex.org/W2106719152","https://openalex.org/W2110437412","https://openalex.org/W2132781656","https://openalex.org/W2144017515","https://openalex.org/W2144608950","https://openalex.org/W2146512944","https://openalex.org/W2155160447","https://openalex.org/W2163789582","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2215051438","https://openalex.org/W2323330456","https://openalex.org/W2329336046","https://openalex.org/W2587341909","https://openalex.org/W2793860566","https://openalex.org/W2795553403","https://openalex.org/W2801918257","https://openalex.org/W2836363664","https://openalex.org/W2884255979","https://openalex.org/W2898554275","https://openalex.org/W2908770791","https://openalex.org/W2925007462","https://openalex.org/W2950221693","https://openalex.org/W3135268773","https://openalex.org/W3159506168","https://openalex.org/W4294349031","https://openalex.org/W4296382398","https://openalex.org/W4298326598","https://openalex.org/W4382345215","https://openalex.org/W6671737827","https://openalex.org/W6854490266"],"related_works":["https://openalex.org/W4324028600","https://openalex.org/W7128787201","https://openalex.org/W2086131781","https://openalex.org/W2300072685","https://openalex.org/W7043002786","https://openalex.org/W3116796164","https://openalex.org/W3091457582","https://openalex.org/W1966994683","https://openalex.org/W2028530728","https://openalex.org/W590902547"],"abstract_inverted_index":{"Abstract":[0],"Calcium":[1],"is":[2],"a":[3],"critical":[4],"signaling":[5],"molecule":[6],"in":[7,26,42,96,149,165,180],"many":[8],"cell":[9,131,136],"types":[10],"including":[11],"immune":[12,27],"cells.":[13],"The":[14],"calcium-release":[15],"activated":[16,88,93,181],"calcium":[17,23],"channels":[18],"(CRAC)":[19],"responsible":[20],"for":[21,112],"store-operated":[22],"entry":[24],"(SOCE)":[25],"cells":[28,59],"are":[29],"gated":[30],"by":[31,129,178],"STIM":[32],"family":[33],"members":[34],"functioning":[35],"as":[36],"sensors":[37],"of":[38,50,99,152,168],"Ca2+":[39],"store":[40],"content":[41],"the":[43,48,63,77,97,102,141,150,166,174],"endoplasmic":[44],"reticulum.":[45],"We":[46,67,122],"investigated":[47],"effect":[49],"SOCE":[51],"blocker":[52],"BTP2":[53,134,144,158,179],"on":[54],"human":[55,183],"peripheral":[56],"blood":[57],"mononuclear":[58],"(PBMC)":[60],"stimulated":[61],"with":[62,89,94],"mitogen":[64],"phytohemagglutinin":[65],"(PHA).":[66],"performed":[68,123],"RNA":[69],"sequencing":[70],"(RNA-seq)":[71],"to":[72,186],"query":[73],"gene":[74],"expression":[75,138],"at":[76,140],"whole":[78],"transcriptome":[79],"level":[80],"and":[81,91,127,191],"identified":[82],"genes":[83,108],"differentially":[84,103],"expressed":[85,104],"between":[86],"PBMC":[87,92,184],"PHA":[90,95],"presence":[98],"BTP2.":[100],"Among":[101],"genes,":[105],"we":[106],"prioritized":[107],"encoding":[109,154,170],"immunoregulatory":[110],"proteins":[111],"validation":[113],"using":[114],"preamplification":[115],"enhanced":[116],"real":[117],"time":[118],"quantitative":[119],"PCR":[120],"assays.":[121],"multiparameter":[124],"flow":[125],"cytometry":[126],"validated":[128],"single":[130],"analysis":[132],"that":[133],"inhibits":[135],"surface":[137],"CD25":[139],"protein":[142],"level.":[143],"reduced":[145],"significantly":[146,162],"PHA-induced":[147,163],"increase":[148,164],"abundance":[151,167],"mRNAs":[153,169],"proinflammatory":[155],"proteins.":[156,172],"Surprisingly,":[157],"did":[159],"not":[160],"reduce":[161],"anti-inflammatory":[171],"Collectively,":[173],"molecular":[175],"signature":[176],"elicited":[177],"normal":[182],"appears":[185],"be":[187],"tipped":[188],"towards":[189],"tolerance":[190],"away":[192],"from":[193],"inflammation.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2024-09-27T00:00:00"}