{"id":"https://openalex.org/W4402843166","doi":"https://doi.org/10.1152/ajplung.00250.2024","title":"Disruption of immune responses by type 1 diabetes exacerbates SARS-CoV-2 mediated lung injury","display_name":"Disruption of immune responses by type 1 diabetes exacerbates SARS-CoV-2 mediated lung injury","publication_year":2024,"publication_date":"2024-09-25","ids":{"openalex":"https://openalex.org/W4402843166","doi":"https://doi.org/10.1152/ajplung.00250.2024","pmid":"https://pubmed.ncbi.nlm.nih.gov/39320093","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11684958"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00250.2024","doi":"https://doi.org/10.1152/ajplung.00250.2024","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajplung.00250.2024","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1152/ajplung.00250.2024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044940090","display_name":"Sara Kass-Gergi","orcid":"https://orcid.org/0000-0003-3437-2147","observed_orcids":["https://orcid.org/0000-0003-3437-2147"]},"institutions":[{"id":"https://openalex.org/I4210143392","display_name":"University of Pennsylvania Health System","ror":"https://ror.org/04h81rw26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Kass-Gergi","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I4210143392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100939206","display_name":"Zhao Gan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gan Zhao","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078668350","display_name":"Joanna Wong","orcid":"https://orcid.org/0000-0002-8836-0363","observed_orcids":["https://orcid.org/0000-0002-8836-0363"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna Wong","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":"https://orcid.org/0000-0002-8836-0363","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081559752","display_name":"Aaron I. Weiner","orcid":"https://orcid.org/0000-0003-3618-5548","observed_orcids":["https://orcid.org/0000-0003-3618-5548"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron I. Weiner","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056189721","display_name":"Stephanie Adams\u2010Tzivelekidis","orcid":"https://orcid.org/0000-0002-5642-7439","observed_orcids":["https://orcid.org/0000-0002-5642-7439"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Adams Tzivelekidis","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005858229","display_name":"Maria Elena Gentile","orcid":"https://orcid.org/0000-0001-9138-1053","observed_orcids":["https://orcid.org/0000-0001-9138-1053"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria E. Gentile","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113401828","display_name":"Meryl Mendoza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meryl Mendoza","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067624546","display_name":"Nicolas P. Holcomb","orcid":"https://orcid.org/0009-0004-3517-4745","observed_orcids":["https://orcid.org/0009-0004-3517-4745"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicolas P. Holcomb","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663167","display_name":"Xinyuan Li","orcid":"https://orcid.org/0000-0002-6746-8367","observed_orcids":["https://orcid.org/0000-0002-6746-8367"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinyuan Li","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101370579","display_name":"Madeline Singh","orcid":"https://orcid.org/0009-0000-5254-0875","observed_orcids":["https://orcid.org/0009-0000-5254-0875"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline Singh","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":"https://orcid.org/0009-0000-5254-0875","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104083339","display_name":"Yuru Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuru Huang","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020891588","display_name":"Alena Klochkova","orcid":"https://orcid.org/0000-0001-6138-7497","observed_orcids":["https://orcid.org/0000-0001-6138-7497"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alena Klochkova","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016422217","display_name":"Andrew E. Vaughan","orcid":"https://orcid.org/0000-0001-5740-643X","observed_orcids":["https://orcid.org/0000-0001-5740-643X"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew E. Vaughan","raw_affiliation_strings":["Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States"],"raw_orcid":"https://orcid.org/0000-0001-5740-643X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Penn Lung Biology Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, PA, United States","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016422217"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.849,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.85360387,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"327","issue":"6","first_page":"L839","last_page":"L851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.8895999789237976,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.10140000283718109,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9089999794960022},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.8259999752044678},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6359999775886536},{"id":"https://openalex.org/keywords/adaptive-immune-response","display_name":"adaptive immune response","score":0.8240000009536743},{"id":"https://openalex.org/keywords/t-cell-recruitment","display_name":"T cell recruitment","score":0.9959999918937683},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/respiratory-failure","display_name":"respiratory failure","score":0.492000013589859},{"id":"https://openalex.org/keywords/tissue-digestion","display_name":"tissue digestion","score":0.30300000309944153},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4300000071525574}],"concepts":[{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.6342482566833496},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.617286205291748},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5361530780792236},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5335728526115417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4833228588104248},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4830061197280884},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4519996643066406},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43110841512680054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39561182260513306},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28965574502944946},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11189576983451843}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D055370","descriptor_name":"Lung Injury","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajplung.00250.2024","doi":"https://doi.org/10.1152/ajplung.00250.2024","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajplung.00250.2024","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"doi:10.1101/2024.05.31.596857","doi":"https://doi.org/10.1101/2024.05.31.596857","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2024.05.31.596857","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2024/05/31/2024.05.31.596857.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11684958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11684958","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},{"id":"pmid:39320093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39320093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1152/ajplung.00250.2024","doi":"https://doi.org/10.1152/ajplung.00250.2024","is_oa":true,"landing_page_url":"https://doi.org/10.1152/ajplung.00250.2024","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1110324277","display_name":null,"funder_award_id":"5T32-HL007586-38","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7047764377","display_name":null,"funder_award_id":"5T32-HL007586-38","funder_id":"https://openalex.org/F4320338421","funder_display_name":"NHLBI Division of Intramural Research"},{"id":"https://openalex.org/G9000915062","display_name":"TRAINING IN PULMONARY IMMUNOLOGY","funder_award_id":"T32HL007586","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320338421","display_name":"NHLBI Division of Intramural Research","ror":"https://ror.org/023ny1p48"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402843166.pdf","grobid_xml":"https://content.openalex.org/works/W4402843166.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1961511910","https://openalex.org/W1979281993","https://openalex.org/W2023419926","https://openalex.org/W2049173505","https://openalex.org/W2060085753","https://openalex.org/W2074552958","https://openalex.org/W2079463609","https://openalex.org/W2134897227","https://openalex.org/W2186824108","https://openalex.org/W2482698601","https://openalex.org/W2782746707","https://openalex.org/W2928665623","https://openalex.org/W2954198684","https://openalex.org/W2963522010","https://openalex.org/W3014040695","https://openalex.org/W3024541652","https://openalex.org/W3046920367","https://openalex.org/W3048686971","https://openalex.org/W3048704086","https://openalex.org/W3112860625","https://openalex.org/W3113369914","https://openalex.org/W3162123223","https://openalex.org/W3164692211","https://openalex.org/W4206069520","https://openalex.org/W4210792795","https://openalex.org/W4213453160","https://openalex.org/W4221027163","https://openalex.org/W4307804964","https://openalex.org/W4311668129","https://openalex.org/W4311668684","https://openalex.org/W4318485191","https://openalex.org/W4323057707","https://openalex.org/W4323348088","https://openalex.org/W4361011506","https://openalex.org/W4376117783","https://openalex.org/W4376225677","https://openalex.org/W4389670732"],"related_works":["https://openalex.org/W4365811195","https://openalex.org/W3160590358","https://openalex.org/W3209765937","https://openalex.org/W3173253954","https://openalex.org/W3034475813","https://openalex.org/W4399053870","https://openalex.org/W3093049374","https://openalex.org/W4367599554","https://openalex.org/W3062098675","https://openalex.org/W3112035689"],"abstract_inverted_index":{"ABSTRACT":[0],"COVID-19":[1,60,270],"commonly":[2],"presents":[3],"as":[4,25,156,158],"pneumonia,":[5],"with":[6,22,67,194],"those":[7,116],"most":[8],"severely":[9],"affected":[10],"progressing":[11],"to":[12,17,28,83,115,121,131,140,221,250],"respiratory":[13,217],"failure.":[14],"Patient":[15],"responses":[16,290],"SARS-CoV-2":[18],"infection":[19,198,245],"are":[20],"varied,":[21],"comorbidities":[23],"acting":[24],"major":[26,35],"contributors":[27],"varied":[29],"outcomes.":[30],"Focusing":[31],"on":[32,269,328],"one":[33],"such":[34],"comorbidity,":[36],"we":[37,134,312],"assessed":[38],"whether":[39],"pharmacological":[40],"induction":[41],"of":[42,52,59,103,111,117,170,176,263],"Type":[43,264],"I":[44,265],"Diabetes":[45,266],"Mellitus":[46,267],"(T1DM)":[47,268],"would":[48],"increase":[49],"the":[50,104,109,123,174,189,195,213,228,260],"severity":[51,272],"lung":[53,95],"injury":[54],"in":[55,81,108,188,240,273,291],"a":[56,100,137,146,182,206,241,314],"murine":[57],"model":[58],"pneumonia":[61,271],"utilizing":[62],"wild":[63],"type":[64],"mice":[65,71,113,200,276],"infected":[66],"mouse-adapted":[68],"SARS-CoV-2.":[69],"Hyperglycemic":[70,275],"exhibited":[72],"increased":[73,278],"weight":[74,279],"loss":[75,280],"and":[76,165,246,281,297,306,324],"reduced":[77,282,302],"blood":[78],"oxygen":[79,283],"saturation":[80],"comparison":[82],"their":[84],"euglycemic":[85],"counterparts,":[86],"suggesting":[87],"that":[88,192,216],"these":[89,199],"animals":[90],"indeed":[91],"experienced":[92,201,277],"more":[93,196,243],"severe":[94,197,244,253],"injury.":[96],"Transcriptomic":[97,285],"analysis":[98,129,155,286,323],"revealed":[99,181,287],"significant":[101,223],"impairment":[102],"adaptive":[105],"immune":[106,289],"response":[107],"lungs":[110,175],"diabetic":[112,190,292],"compared":[114],"control.":[118],"In":[119],"order":[120],"expand":[122],"limited":[124],"options":[125],"available":[126],"for":[127,152,209,227,317],"tissue":[128,144,318,331],"due":[130],"biosafety":[132],"restrictions,":[133],"also":[135],"employed":[136],"novel":[138,315],"technique":[139,316],"digest":[141],"highly":[142,184,329],"fixed":[143,330],"into":[145,173,205,236],"single":[147,159],"cell":[148,160,304],"suspension,":[149],"which":[150],"allowed":[151],"flow":[153,295,321],"cytometric":[154,322],"well":[157],"RNA":[161,299,326],"sequencing.":[162],"Flow":[163],"immunophenotyping":[164],"scRNA-Seq":[166,180],"confirmed":[167,301],"impaired":[168,288],"recruitment":[169,305],"T":[171,303],"cells":[172],"T1DM":[177,238],"animals.":[178],"Additionally,":[179,311],"distinct,":[183],"inflammatory":[185,308],"macrophage":[186,309],"profile":[187],"cohort":[191],"correlates":[193],"clinically,":[202],"allowing":[203],"insight":[204],"possible":[207,248],"mechanism":[208],"this":[210],"phenomenon.":[211],"Recognizing":[212],"near":[214],"certainty":[215],"viruses":[218],"will":[219],"continue":[220],"present":[222],"public":[224],"health":[225],"concerns":[226],"foreseeable":[229],"future,":[230],"our":[231],"study":[232],"provides":[233],"key":[234],"insights":[235],"how":[237],"results":[239],"much":[242],"identifies":[247],"targets":[249],"ameliorate":[251],"comorbidity-associated":[252],"disease.":[254],"NEW":[255],"AND":[256],"NOTEWORTHY":[257],"We":[258],"define":[259],"exacerbating":[261],"effects":[262],"mice.":[274],"saturation.":[284],"mice,":[293],"while":[294],"cytometry":[296],"single-cell":[298,325],"sequencing":[300,327],"an":[307],"profile.":[310],"introduced":[313],"analysis,":[319],"enabling":[320],"samples.":[332]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-09-26T00:00:00"}