{"id":"https://openalex.org/W4402837293","doi":"https://doi.org/10.4239/wjd.v15.i10.2022","title":"Immunotherapy in type 1 diabetes: Novel pathway to the future ahead","display_name":"Immunotherapy in type 1 diabetes: Novel pathway to the future ahead","publication_year":2024,"publication_date":"2024-09-26","ids":{"openalex":"https://openalex.org/W4402837293","doi":"https://doi.org/10.4239/wjd.v15.i10.2022","pmid":"https://pubmed.ncbi.nlm.nih.gov/39493558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11525730"},"language":"en","primary_location":{"id":"doi:10.4239/wjd.v15.i10.2022","doi":"https://doi.org/10.4239/wjd.v15.i10.2022","is_oa":true,"landing_page_url":"https://doi.org/10.4239/wjd.v15.i10.2022","pdf_url":"https://rcastoragev2.blob.core.windows.net/f8c1847afadda0ea79d41f594654da60/PMC5776665.pdf","source":{"id":"https://openalex.org/S9864596","display_name":"World Journal of Diabetes","issn_l":"1948-9358","issn":["1948-9358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Diabetes","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://rcastoragev2.blob.core.windows.net/f8c1847afadda0ea79d41f594654da60/PMC5776665.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113689884","display_name":"Sayantan Ray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117092","display_name":"All India Institute of Medical Sciences Bhubaneswar","ror":"https://ror.org/029mnbn96","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210117092"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sayantan Ray","raw_affiliation_strings":["Department of Endocrinology, All India Institute of Medical Sciences, Bhubaneswar 751019, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, All India Institute of Medical Sciences, Bhubaneswar 751019, India","institution_ids":["https://openalex.org/I4210117092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003893543","display_name":"Rajan Palui","orcid":"https://orcid.org/0000-0002-2429-3595","observed_orcids":["https://orcid.org/0000-0002-2429-3595"]},"institutions":[{"id":"https://openalex.org/I4210124299","display_name":"Mission Hospital Durgapur","ror":"https://ror.org/032yhrq65","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210124299"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajan Palui","raw_affiliation_strings":["Department of Endocrinology, The Mission Hospital, Durgapur 713212, India. rajanpalui@gmail.com. rajanpalui@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The Mission Hospital, Durgapur 713212, India. rajanpalui@gmail.com. rajanpalui@gmail.com","institution_ids":["https://openalex.org/I4210124299"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"10","first_page":"2022","last_page":"2035"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/teplizumab","display_name":"teplizumab","score":0.8259999752044678},{"id":"https://openalex.org/keywords/islet-autoimmunity","display_name":"islet autoimmunity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/t-cell-depletion","display_name":"T cell depletion","score":0.46399998664855957},{"id":"https://openalex.org/keywords/b-cell-depletion","display_name":"B-cell depletion","score":0.8510000109672546},{"id":"https://openalex.org/keywords/cytokine-antagonists","display_name":"cytokine antagonists","score":0.847000002861023},{"id":"https://openalex.org/keywords/stem-cell-therapy","display_name":"stem cell therapy","score":0.8410000205039978},{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/disease-prevention","display_name":"disease prevention","score":0.597000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8654175996780396},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.7185826301574707},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6216418743133545},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.548895001411438},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.43519651889801025},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.43011415004730225},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2912178337574005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06487864255905151},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4239/wjd.v15.i10.2022","doi":"https://doi.org/10.4239/wjd.v15.i10.2022","is_oa":true,"landing_page_url":"https://doi.org/10.4239/wjd.v15.i10.2022","pdf_url":"https://rcastoragev2.blob.core.windows.net/f8c1847afadda0ea79d41f594654da60/PMC5776665.pdf","source":{"id":"https://openalex.org/S9864596","display_name":"World Journal of Diabetes","issn_l":"1948-9358","issn":["1948-9358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11525730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11525730","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11525730/pdf/WJD-15-2022.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Diabetes","raw_type":"Text"},{"id":"pmid:39493558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39493558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of diabetes","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.4239/wjd.v15.i10.2022","doi":"https://doi.org/10.4239/wjd.v15.i10.2022","is_oa":true,"landing_page_url":"https://doi.org/10.4239/wjd.v15.i10.2022","pdf_url":"https://rcastoragev2.blob.core.windows.net/f8c1847afadda0ea79d41f594654da60/PMC5776665.pdf","source":{"id":"https://openalex.org/S9864596","display_name":"World Journal of Diabetes","issn_l":"1948-9358","issn":["1948-9358"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-2"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402837293.pdf","grobid_xml":"https://content.openalex.org/works/W4402837293.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W1935873314","https://openalex.org/W1942296996","https://openalex.org/W1981093904","https://openalex.org/W1983670702","https://openalex.org/W1983720572","https://openalex.org/W2006920670","https://openalex.org/W2043452201","https://openalex.org/W2048488933","https://openalex.org/W2053411009","https://openalex.org/W2055299834","https://openalex.org/W2064431167","https://openalex.org/W2064663954","https://openalex.org/W2081903402","https://openalex.org/W2092512708","https://openalex.org/W2094345654","https://openalex.org/W2098954537","https://openalex.org/W2099862791","https://openalex.org/W2106218189","https://openalex.org/W2109121747","https://openalex.org/W2109886432","https://openalex.org/W2114603595","https://openalex.org/W2123592823","https://openalex.org/W2124812894","https://openalex.org/W2133076779","https://openalex.org/W2135484010","https://openalex.org/W2138589314","https://openalex.org/W2146664729","https://openalex.org/W2154247668","https://openalex.org/W2154694193","https://openalex.org/W2158735251","https://openalex.org/W2165394699","https://openalex.org/W2208591348","https://openalex.org/W2252442238","https://openalex.org/W2504401193","https://openalex.org/W2525595583","https://openalex.org/W2541443144","https://openalex.org/W2554650020","https://openalex.org/W2734739784","https://openalex.org/W2743949118","https://openalex.org/W2772728378","https://openalex.org/W2798226476","https://openalex.org/W2851535791","https://openalex.org/W2883621086","https://openalex.org/W2895067267","https://openalex.org/W2898408097","https://openalex.org/W2898492815","https://openalex.org/W2904763939","https://openalex.org/W2935961302","https://openalex.org/W2948104235","https://openalex.org/W2968469734","https://openalex.org/W2991077754","https://openalex.org/W3081020556","https://openalex.org/W3087414342","https://openalex.org/W3094947891","https://openalex.org/W3099245374","https://openalex.org/W3101325924","https://openalex.org/W3111538429","https://openalex.org/W3122624768","https://openalex.org/W3123611756","https://openalex.org/W3134851073","https://openalex.org/W3140852949","https://openalex.org/W3175547923","https://openalex.org/W3191407259","https://openalex.org/W3208091844","https://openalex.org/W3214753991","https://openalex.org/W3214819015","https://openalex.org/W4207008708","https://openalex.org/W4220917002","https://openalex.org/W4224223069","https://openalex.org/W4280495960","https://openalex.org/W4283259537","https://openalex.org/W4283751393","https://openalex.org/W4293694993","https://openalex.org/W4295694326","https://openalex.org/W4311666650","https://openalex.org/W4312007200","https://openalex.org/W4313280480","https://openalex.org/W4324128834","https://openalex.org/W4324305894","https://openalex.org/W4372335371","https://openalex.org/W4375955997","https://openalex.org/W4376637888","https://openalex.org/W4379469356","https://openalex.org/W4386365603","https://openalex.org/W4386564605","https://openalex.org/W4387730476","https://openalex.org/W4389376234","https://openalex.org/W4390791027","https://openalex.org/W4391252960","https://openalex.org/W4391486222","https://openalex.org/W4392975504","https://openalex.org/W4395464411","https://openalex.org/W4395479965","https://openalex.org/W4397013706"],"related_works":["https://openalex.org/W4391486222","https://openalex.org/W4229449299","https://openalex.org/W4416918957","https://openalex.org/W4403306327","https://openalex.org/W4408133845","https://openalex.org/W2905186764","https://openalex.org/W4403393589","https://openalex.org/W4406886929","https://openalex.org/W3216511429","https://openalex.org/W2975864454"],"abstract_inverted_index":{"Since":[0],"the":[1,9,14,32,55,66,76,84,109,116,130,141,153,159],"discovery":[2],"of":[3,11,16,28,34,37,58,69,75,127,132,161,169,185],"insulin":[4],"over":[5],"100":[6],"years":[7],"ago,":[8],"focus":[10],"research":[12,163],"in":[13,42,50,124,140,158,164],"management":[15,27],"type":[17],"1":[18],"diabetes":[19],"(T1D)":[20],"has":[21,46],"centered":[22],"around":[23],"glycemic":[24],"control":[25],"and":[26,112],"complications":[29],"rather":[30],"than":[31],"prevention":[33,182],"autoimmune":[35],"destruction":[36],"pancreatic":[38,100],"\u03b2":[39,101],"cells.":[40],"Fortunately,":[41],"recent":[43,156],"years,":[44],"there":[45],"been":[47],"significant":[48],"advancement":[49],"immune-targeted":[51,61],"pharmacotherapy":[52],"to":[53,64,99,120,134,176],"halt":[54],"natural":[56],"progression":[57],"T1D.":[59,128,165,186],"The":[60,79],"intervention":[62],"aims":[63],"alter":[65],"underlying":[67],"pathogenesis":[68],"T1D":[70],"by":[71],"targeting":[72],"different":[73],"aspects":[74],"immune":[77,85],"system.":[78],"immunotherapy":[80,118,162],"can":[81],"either":[82],"antagonize":[83],"mediators":[86],"like":[87],"T":[88],"cells,":[89],"B":[90],"cells":[91,102],"or":[92,96,105,183],"cytokines":[93],"(antibody-based":[94],"therapy),":[95],"reinduce":[97],"self-tolerance":[98],"(antigen-based":[103],"therapy)":[104],"stem-cell":[106],"treatment.":[107],"Recently,":[108],"US":[110],"Food":[111],"Drug":[113],"Administration":[114],"approved":[115,138],"first":[117],"teplizumab":[119],"be":[121],"used":[122],"only":[123],"stage":[125],"2":[126],"However,":[129,166],"window":[131],"opportunity":[133],"practically":[135],"implement":[136],"this":[137,148],"molecule":[139],"selected":[142],"target":[143],"population":[144],"is":[145],"limited.":[146],"In":[147],"Editorial,":[149],"we":[150],"briefly":[151],"discuss":[152],"various":[154],"promising":[155],"developments":[157],"field":[160],"further":[167],"studies":[168],"these":[170],"newer":[171],"therapeutic":[172],"agents":[173],"are":[174],"needed":[175],"explore":[177],"their":[178],"true":[179],"potential":[180],"for":[181],"cure":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-26T00:00:00"}
