{"id":"https://openalex.org/W4402833673","doi":"https://doi.org/10.1109/nss/mic/rtsd57108.2024.10655293","title":"Advanced Positronium Lifetime Imaging Reconstruction Using Two-Component Modeling in Time-of-Flight Positron Emission Tomography","display_name":"Advanced Positronium Lifetime Imaging Reconstruction Using Two-Component Modeling in Time-of-Flight Positron Emission Tomography","publication_year":2024,"publication_date":"2024-09-25","ids":{"openalex":"https://openalex.org/W4402833673","doi":"https://doi.org/10.1109/nss/mic/rtsd57108.2024.10655293"},"language":"en","primary_location":{"id":"doi:10.1109/nss/mic/rtsd57108.2024.10655293","doi":"https://doi.org/10.1109/nss/mic/rtsd57108.2024.10655293","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nss/mic/rtsd57108.2024.10655293","pdf_url":null,"source":{"id":"https://openalex.org/S4363608255","display_name":"IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","issn_l":"1095-7863","issn":["1095-7863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110174060","display_name":"Hsin Hsiung Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.-H. B. Huang","raw_affiliation_strings":["University of Central Florida, Statistics and Data Science,Orlando,Florida,United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Central Florida, Statistics and Data Science,Orlando,Florida,United States of America","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021173522","display_name":"Chien-Min Kao","orcid":"https://orcid.org/0000-0002-8785-5225","observed_orcids":["https://orcid.org/0000-0002-8785-5225"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C.-M. Kao","raw_affiliation_strings":["University of Chicago, Radiology,Chicago,Illinois,United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Radiology,Chicago,Illinois,United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. An","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. An","raw_affiliation_strings":["University of Arizona,Agricultural and Biosystems Engineering,Tucson,Arizona,United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona,Agricultural and Biosystems Engineering,Tucson,Arizona,United States of America","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613563","display_name":"Zhou Chen","orcid":"https://orcid.org/0000-0003-3271-2515","observed_orcids":["https://orcid.org/0000-0003-3271-2515"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Z. Chen","raw_affiliation_strings":["University of Arizona, Mathematics,Tucson,Arizona,United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona, Mathematics,Tucson,Arizona,United States of America","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134441327","display_name":"Slun Booppasiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Booppasiri","raw_affiliation_strings":["University of Central Florida, Statistics and Data Science,Orlando,Florida,United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Central Florida, Statistics and Data Science,Orlando,Florida,United States of America","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36363636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.864300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12579","display_name":"Muon and positron interactions and applications","score":0.07450000196695328,"subfield":{"id":"https://openalex.org/subfields/3104","display_name":"Condensed Matter Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11216","display_name":"Radiation Detection and Scintillator Technologies","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/time-of-flight-positron-emission-tomography","display_name":"time-of-flight positron emission tomography","score":0.9380000233650208},{"id":"https://openalex.org/keywords/maximum-likelihood-estimation","display_name":"maximum likelihood estimation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ortho-positronium-lifetime","display_name":"ortho-positronium lifetime","score":0.8700000047683716},{"id":"https://openalex.org/keywords/tissue-microenvironment","display_name":"tissue microenvironment","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C154726568","wikidata":"https://www.wikidata.org/wiki/Q624990","display_name":"Positronium","level":4,"score":0.8852791786193848},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.7590157985687256},{"id":"https://openalex.org/C98960154","wikidata":"https://www.wikidata.org/wiki/Q3983322","display_name":"Time of flight","level":2,"score":0.6880244016647339},{"id":"https://openalex.org/C37097830","wikidata":"https://www.wikidata.org/wiki/Q1357356","display_name":"Positron emission","level":3,"score":0.5968223810195923},{"id":"https://openalex.org/C202100949","wikidata":"https://www.wikidata.org/wiki/Q3229","display_name":"Positron","level":3,"score":0.5704771280288696},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.5144929885864258},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.5139629244804382},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.45152395963668823},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.42190465331077576},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.2916836142539978},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23281142115592957},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1982925534248352},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.1656259000301361},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0971825122833252},{"id":"https://openalex.org/C147120987","wikidata":"https://www.wikidata.org/wiki/Q2225","display_name":"Electron","level":2,"score":0.06634536385536194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/nss/mic/rtsd57108.2024.10655293","doi":"https://doi.org/10.1109/nss/mic/rtsd57108.2024.10655293","is_oa":false,"landing_page_url":"https://doi.org/10.1109/nss/mic/rtsd57108.2024.10655293","pdf_url":null,"source":{"id":"https://openalex.org/S4363608255","display_name":"IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)","issn_l":"1095-7863","issn":["1095-7863"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W4391351353","https://openalex.org/W4400660452","https://openalex.org/W4406522845"],"related_works":["https://openalex.org/W4400660452","https://openalex.org/W4406522845","https://openalex.org/W4393178078","https://openalex.org/W7024791599","https://openalex.org/W4391351353","https://openalex.org/W4391128777","https://openalex.org/W4389666318","https://openalex.org/W4280572437","https://openalex.org/W4404590570","https://openalex.org/W4402833714"],"abstract_inverted_index":{"Positron":[0],"emission":[1],"tomography":[2],"(PET)":[3],"is":[4],"a":[5,77,84,184],"crucial":[6],"imaging":[7,33],"modality":[8],"for":[9],"the":[10,20,40,101,134,151],"diagnosis":[11],"of":[12,22,153],"diseases":[13],"such":[14],"as":[15],"cancer":[16],"and":[17,123,158],"Alzheimer\u2019s,":[18],"highlighting":[19],"uptake":[21],"radiolabeled":[23],"molecules":[24],"that":[25,118,133,149,171],"target":[26],"specific":[27],"disease":[28],"markers.":[29],"Recently,":[30],"positronium":[31,102],"lifetime":[32,61,103,140,156,179],"(PLI),":[34],"which":[35],"supplements":[36],"PET":[37,53],"by":[38,66],"examining":[39],"tissue":[41],"microenvironment\u2019s":[42],"properties":[43],"beyond":[44],"tracer":[45],"uptake,":[46],"has":[47],"been":[48],"implemented":[49],"using":[50,83],"time-of-flight":[51],"(TOF)":[52],"with":[54,68,167],"non-pure":[55],"positron":[56,163],"emitters.":[57],"However,":[58],"accurately":[59],"reconstructing":[60],"images":[62,157],"from":[63,105,129,161],"data":[64,104,160],"captured":[65],"systems":[67],"limited":[69],"TOF":[70,106],"resolution":[71],"remains":[72],"challenging.":[73],"This":[74],"paper":[75],"presents":[76],"novel":[78],"approach":[79],"to":[80,99],"two-dimensional":[81],"PLI":[82,188],"maximum":[85],"likelihood":[86,121],"estimation":[87],"(MLE)":[88],"method":[89,136],"based":[90],"on":[91],"an":[92,145],"exponentially":[93],"modified":[94],"Gaussian":[95],"(EMG)":[96],"probability":[97],"distribution":[98],"describe":[100],"PET.":[107],"We":[108],"assess":[109],"our":[110,172],"EMG-based":[111],"MLE":[112],"method\u2019s":[113],"effectiveness":[114],"against":[115],"existing":[116,168],"methods":[117],"use":[119],"exponential":[120],"functions":[122],"penalized":[124],"surrogate":[125],"approaches.":[126],"Our":[127],"results":[128],"computer":[130],"simulations":[131],"indicate":[132],"EMG-MLE":[135],"produces":[137],"quantitatively":[138],"precise":[139],"images.":[141],"Moreover,":[142],"we":[143],"introduce":[144],"advanced":[146],"two-component":[147,173],"model":[148,174],"enhances":[150],"accuracy":[152],"ortho-positronium":[154],"(oP)":[155],"accommodates":[159],"multiple":[162],"populations.":[164],"Comparative":[165],"studies":[166],"models":[169],"reveal":[170],"excels":[175],"in":[176,187],"capturing":[177],"complex":[178],"distributions":[180],"more":[181],"accurately,":[182],"marking":[183],"significant":[185],"advancement":[186],"technology.":[189]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-26T00:00:00"}