{"id":"https://openalex.org/W4402832736","doi":"https://doi.org/10.1007/s43657-025-00272-3","title":"A Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Knee Pain in the UK Biobank (n = 439,743)","display_name":"A Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Knee Pain in the UK Biobank (n = 439,743)","publication_year":2026,"publication_date":"2026-05-14","ids":{"openalex":"https://openalex.org/W4402832736","doi":"https://doi.org/10.1007/s43657-025-00272-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/42953296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13713951"},"language":"en","primary_location":{"id":"doi:10.1007/s43657-025-00272-3","doi":"https://doi.org/10.1007/s43657-025-00272-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s43657-025-00272-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210180626","display_name":"Phenomics","issn_l":"2730-583X","issn":["2730-583X","2730-5848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pubmed.ncbi.nlm.nih.gov/42953296/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071824322","display_name":"Yiwen Tao","orcid":"https://orcid.org/0009-0000-0102-4205","observed_orcids":["https://orcid.org/0009-0000-0102-4205"]},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Tao","raw_affiliation_strings":["Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China"],"raw_orcid":"https://orcid.org/0009-0000-0102-4205","affiliations":[{"raw_affiliation_string":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101522452","display_name":"Qi Pan","orcid":"https://orcid.org/0000-0003-0135-9122","observed_orcids":["https://orcid.org/0000-0003-0135-9122"]},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Pan","raw_affiliation_strings":["Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China"],"raw_orcid":"https://orcid.org/0000-0003-0135-9122","affiliations":[{"raw_affiliation_string":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032507794","display_name":"Tengda Cai","orcid":"https://orcid.org/0000-0003-1617-506X","observed_orcids":["https://orcid.org/0000-0003-1617-506X"]},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengda Cai","raw_affiliation_strings":["Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China"],"raw_orcid":"https://orcid.org/0000-0003-1617-506X","affiliations":[{"raw_affiliation_string":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003659487","display_name":"Luning Yang","orcid":"https://orcid.org/0000-0001-9056-5950","observed_orcids":["https://orcid.org/0000-0001-9056-5950"]},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luning Yang","raw_affiliation_strings":["Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China"],"raw_orcid":"https://orcid.org/0000-0001-9056-5950","affiliations":[{"raw_affiliation_string":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050955198","display_name":"Mainul Haque","orcid":"https://orcid.org/0000-0003-1836-8076","observed_orcids":["https://orcid.org/0000-0003-1836-8076"]},"institutions":[{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mainul Haque","raw_affiliation_strings":["School of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, 315100 China"],"raw_orcid":"https://orcid.org/0000-0003-1836-8076","affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences, University of Nottingham Ningbo China, Ningbo, 315100 China","institution_ids":["https://openalex.org/I13591777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005779337","display_name":"Tania Dottorini","orcid":"https://orcid.org/0000-0001-7733-906X","observed_orcids":["https://orcid.org/0000-0001-7733-906X"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tania Dottorini","raw_affiliation_strings":["School of Veterinary Medicine and Science, University of Nottingham, Nottingham, LE12 5RD UK"],"raw_orcid":"https://orcid.org/0000-0001-7733-906X","affiliations":[{"raw_affiliation_string":"School of Veterinary Medicine and Science, University of Nottingham, Nottingham, LE12 5RD UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023337880","display_name":"Weihua Meng","orcid":"https://orcid.org/0000-0001-5388-8494","observed_orcids":["https://orcid.org/0000-0001-5388-8494"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]},{"id":"https://openalex.org/I13591777","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428","country_code":"CN","type":"education","lineage":["https://openalex.org/I13591777","https://openalex.org/I142263535"]},{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I2802526638","display_name":"Ninewells Hospital","ror":"https://ror.org/039c6rk82","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800860831","https://openalex.org/I2802526638"]}],"countries":["CN","GB"],"is_corresponding":true,"raw_author_name":"Weihua Meng","raw_affiliation_strings":["Center for Public Health, Faculty of Medicine, Health and Life Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, BT12 6BA UK","Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD2 4BF UK","Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China"],"raw_orcid":"https://orcid.org/0000-0001-5388-8494","affiliations":[{"raw_affiliation_string":"Center for Public Health, Faculty of Medicine, Health and Life Sciences, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, BT12 6BA UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD2 4BF UK","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I2802526638"]},{"raw_affiliation_string":"Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100 China","institution_ids":["https://openalex.org/I13591777"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023337880"],"corresponding_institution_ids":["https://openalex.org/I126231945","https://openalex.org/I13591777","https://openalex.org/I177639307","https://openalex.org/I2802526638"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00181934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4","first_page":"439","last_page":"455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.5903000235557556,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.35910001397132874,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-pain","display_name":"knee pain","score":1.0},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7020000219345093},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gdf5","display_name":"GDF5","score":0.8889999985694885},{"id":"https://openalex.org/keywords/novel-genetic-loci","display_name":"novel genetic loci","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sex-specific-genetic-association","display_name":"sex-specific genetic association","score":0.8339999914169312},{"id":"https://openalex.org/keywords/musculoskeletal-pain","display_name":"musculoskeletal pain","score":0.6650000214576721},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.9721918106079102},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6489027738571167},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.48112955689430237},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4722924828529358},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.42091384530067444},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4159424304962158},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40772324800491333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3301589787006378},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32709041237831116},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2302367389202118},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.21180281043052673},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1436954140663147},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.13642415404319763},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1007/s43657-025-00272-3","doi":"https://doi.org/10.1007/s43657-025-00272-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s43657-025-00272-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210180626","display_name":"Phenomics","issn_l":"2730-583X","issn":["2730-583X","2730-5848"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenomics","raw_type":"journal-article"},{"id":"pmid:42953296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenomics (Cham, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13713951","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953296/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenomics","raw_type":"Text"},{"id":"pmh:oai:discovery.dundee.ac.uk:openaire/eb01f291-3f87-44f1-b886-505d2ac39683","doi":null,"is_oa":true,"landing_page_url":"https://discovery.dundee.ac.uk/en/publications/eb01f291-3f87-44f1-b886-505d2ac39683","pdf_url":null,"source":{"id":"https://openalex.org/S4306400523","display_name":"Discovery Research Portal (University of Dundee)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177639307","host_organization_name":"University of Dundee","host_organization_lineage":["https://openalex.org/I177639307"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Tao, Y, Pan, Q, Cai, T, Yang, L, Haque, M, Dottorini, T & Meng, W 2026, 'A Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Knee Pain in the UK Biobank (n = 439,743)', Phenomics. https://doi.org/10.1007/s43657-025-00272-3","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13713951","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42953296/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phenomics","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320324","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58"},{"id":"https://openalex.org/F4320337088","display_name":"University of Nottingham Ningbo China","ror":"https://ror.org/03y4dt428"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1559467286","https://openalex.org/W1981797382","https://openalex.org/W1996144339","https://openalex.org/W2007888083","https://openalex.org/W2011216735","https://openalex.org/W2012428888","https://openalex.org/W2033151532","https://openalex.org/W2056710407","https://openalex.org/W2088921319","https://openalex.org/W2092831145","https://openalex.org/W2103695168","https://openalex.org/W2109478944","https://openalex.org/W2113670619","https://openalex.org/W2118996750","https://openalex.org/W2140513563","https://openalex.org/W2153860431","https://openalex.org/W2159890589","https://openalex.org/W2163013660","https://openalex.org/W2181281524","https://openalex.org/W2264585211","https://openalex.org/W2527834482","https://openalex.org/W2607998356","https://openalex.org/W2770092353","https://openalex.org/W2783974895","https://openalex.org/W2786399160","https://openalex.org/W2883663896","https://openalex.org/W2883802793","https://openalex.org/W2905536256","https://openalex.org/W2911999331","https://openalex.org/W2950103694","https://openalex.org/W2969810988","https://openalex.org/W2969996045","https://openalex.org/W2970281210","https://openalex.org/W3023626738","https://openalex.org/W3111335358","https://openalex.org/W3165316471","https://openalex.org/W3197364483","https://openalex.org/W4210780562","https://openalex.org/W4224938995","https://openalex.org/W4293089684","https://openalex.org/W4308942497","https://openalex.org/W4317390883","https://openalex.org/W4378574677","https://openalex.org/W4384830282"],"related_works":["https://openalex.org/W7213035435","https://openalex.org/W3162611871","https://openalex.org/W2970281210","https://openalex.org/W4406687986","https://openalex.org/W4411290461","https://openalex.org/W4409783084","https://openalex.org/W4393022186","https://openalex.org/W3209211130","https://openalex.org/W4407271621","https://openalex.org/W3014536739"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-26T00:00:00"}