{"id":"https://openalex.org/W4402829263","doi":"https://doi.org/10.3390/molecules29194548","title":"Discovery of Cinnamic Acid Derivatives as Potent Anti-H. pylori Agents","display_name":"Discovery of Cinnamic Acid Derivatives as Potent Anti-H. pylori Agents","publication_year":2024,"publication_date":"2024-09-25","ids":{"openalex":"https://openalex.org/W4402829263","doi":"https://doi.org/10.3390/molecules29194548","pmid":"https://pubmed.ncbi.nlm.nih.gov/39407478","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11477721"},"language":"en","primary_location":{"id":"doi:10.3390/molecules29194548","doi":"https://doi.org/10.3390/molecules29194548","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29194548","pdf_url":"https://www.mdpi.com/1420-3049/29/19/4548/pdf?version=1727254342","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1420-3049/29/19/4548/pdf?version=1727254342","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031644464","display_name":"Yonglian Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yonglian Li","raw_affiliation_strings":["Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","School of Eco-Environment Technology, Guangdong Industry Polytechnic University, Guangzhou 510300, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I139024713"]},{"raw_affiliation_string":"School of Eco-Environment Technology, Guangdong Industry Polytechnic University, Guangzhou 510300, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022769855","display_name":"Kun Zhao","orcid":"https://orcid.org/0000-0002-4947-2418","observed_orcids":["https://orcid.org/0000-0002-4947-2418"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhao","raw_affiliation_strings":["Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080028689","display_name":"Zhidi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhidi Wu","raw_affiliation_strings":["Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024191444","display_name":"Yujun George Zheng","orcid":"https://orcid.org/0000-0001-7116-3067","observed_orcids":["https://orcid.org/0000-0001-7116-3067","https://orcid.org/0000-0001-9974-2917"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujun Zheng","raw_affiliation_strings":["Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072972048","display_name":"Jialin Yu","orcid":"https://orcid.org/0000-0003-2881-4658","observed_orcids":["https://orcid.org/0000-0003-2881-4658"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jialin Yu","raw_affiliation_strings":["School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109788911","display_name":"Sikun Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sikun Wu","raw_affiliation_strings":["Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I139024713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004387618","display_name":"Vincent Kam Wai Wong","orcid":"https://orcid.org/0000-0002-2951-8108","observed_orcids":["https://orcid.org/0000-0002-2951-8108"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]}],"countries":["MO"],"is_corresponding":false,"raw_author_name":"Vincent Kam Wai Wong","raw_affiliation_strings":["Neher\u2019s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China"],"raw_orcid":"https://orcid.org/0000-0002-2951-8108","affiliations":[{"raw_affiliation_string":"Neher\u2019s Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China","institution_ids":["https://openalex.org/I111950717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337191","display_name":"Min Chen","orcid":"https://orcid.org/0000-0001-8167-7707","observed_orcids":["https://orcid.org/0000-0001-8167-7707","https://orcid.org/0000-0001-8716-4400"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Chen","raw_affiliation_strings":["School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013640324","display_name":"Wenfeng Liu","orcid":"https://orcid.org/0000-0002-7169-843X","observed_orcids":["https://orcid.org/0000-0002-7169-843X"]},"institutions":[{"id":"https://openalex.org/I4210151615","display_name":"Wuyi University","ror":"https://ror.org/0488wz367","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210151615"]},{"id":"https://openalex.org/I98834328","display_name":"Wuyi University","ror":"https://ror.org/059djzq42","country_code":"CN","type":"education","lineage":["https://openalex.org/I98834328"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenfeng Liu","raw_affiliation_strings":["School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China"],"raw_orcid":"https://orcid.org/0000-0002-7169-843X","affiliations":[{"raw_affiliation_string":"School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China","institution_ids":["https://openalex.org/I4210151615","https://openalex.org/I98834328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072268022","display_name":"Suqing Zhao","orcid":"https://orcid.org/0000-0002-9457-3787","observed_orcids":["https://orcid.org/0000-0002-9457-3787"]},"institutions":[{"id":"https://openalex.org/I139024713","display_name":"Guangdong University of Technology","ror":"https://ror.org/04azbjn80","country_code":"CN","type":"education","lineage":["https://openalex.org/I139024713"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Suqing Zhao","raw_affiliation_strings":["Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, China","institution_ids":["https://openalex.org/I139024713"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013640324","https://openalex.org/A5072268022"],"corresponding_institution_ids":["https://openalex.org/I139024713","https://openalex.org/I4210151615","https://openalex.org/I98834328"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3069},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3069},"fwci":0.2564,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49458949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"29","issue":"19","first_page":"4548","last_page":"4548"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.8306000232696533,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cinnamic-acid-derivatives","display_name":"cinnamic acid derivatives","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.8619999885559082},{"id":"https://openalex.org/keywords/4-methoxyphenol","display_name":"4-methoxyphenol","score":0.9769999980926514},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.7519999742507935},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gastritis","display_name":"gastritis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.703000009059906},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2778831176","wikidata":"https://www.wikidata.org/wiki/Q164785","display_name":"Cinnamic acid","level":2,"score":0.8526153564453125},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7790180444717407},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.7456014156341553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7165009379386902},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.48797816038131714},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4684472382068634},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3437940776348114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34036847949028015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14105188846588135},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/molecules29194548","doi":"https://doi.org/10.3390/molecules29194548","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29194548","pdf_url":"https://www.mdpi.com/1420-3049/29/19/4548/pdf?version=1727254342","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11477721","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11477721","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11477721/pdf/molecules-29-04548.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"Text"},{"id":"pmid:39407478","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39407478","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:12ce2bf94e534a8f8d187c5f6b241ef0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/12ce2bf94e534a8f8d187c5f6b241ef0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecules, Vol 29, Iss 19, p 4548 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/molecules29194548","doi":"https://doi.org/10.3390/molecules29194548","is_oa":true,"landing_page_url":"https://doi.org/10.3390/molecules29194548","pdf_url":"https://www.mdpi.com/1420-3049/29/19/4548/pdf?version=1727254342","source":{"id":"https://openalex.org/S108911230","display_name":"Molecules","issn_l":"1420-3049","issn":["1420-3049","1433-1373"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6204936779","display_name":null,"funder_award_id":"2019WGALH01","funder_id":"https://openalex.org/F4320324310","funder_display_name":"Wuyi University"}],"funders":[{"id":"https://openalex.org/F4320324310","display_name":"Wuyi University","ror":"https://ror.org/059djzq42"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402829263.pdf","grobid_xml":"https://content.openalex.org/works/W4402829263.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1964647898","https://openalex.org/W2007785330","https://openalex.org/W2022948175","https://openalex.org/W2044056603","https://openalex.org/W2044917757","https://openalex.org/W2046588215","https://openalex.org/W2047732604","https://openalex.org/W2114040986","https://openalex.org/W2159653017","https://openalex.org/W2170855291","https://openalex.org/W2174597817","https://openalex.org/W2199203801","https://openalex.org/W2337669303","https://openalex.org/W2410959088","https://openalex.org/W2527848138","https://openalex.org/W2591054253","https://openalex.org/W2790522681","https://openalex.org/W2802672006","https://openalex.org/W2883870923","https://openalex.org/W2890880302","https://openalex.org/W3012615718","https://openalex.org/W3047987759","https://openalex.org/W3048978573","https://openalex.org/W3082465759","https://openalex.org/W3104270240","https://openalex.org/W3120759438","https://openalex.org/W3150114898","https://openalex.org/W3162032752","https://openalex.org/W3176266860","https://openalex.org/W3197004581","https://openalex.org/W4211017205","https://openalex.org/W4296329299","https://openalex.org/W4317721780"],"related_works":["https://openalex.org/W7167500845","https://openalex.org/W2883870923","https://openalex.org/W1982958274","https://openalex.org/W2950765959","https://openalex.org/W1978973147","https://openalex.org/W2171871589","https://openalex.org/W10425101","https://openalex.org/W7203629155","https://openalex.org/W2173050388","https://openalex.org/W2952869100"],"abstract_inverted_index":{"Antibiotics":[0],"are":[1],"currently":[2],"used":[3],"for":[4,45,47,74],"the":[5,17,24,56,123,126,134,157,162,173],"treatment":[6],"of":[7,20,27,59,64,101,125,152],"Helicobacter":[8],"pylori":[9,52,76,95,120,154,186,191],"(H.":[10],"pylori),":[11],"which":[12],"is":[13,41],"confirmed":[14],"to":[15,122,168,188],"be":[16,181],"major":[18],"cause":[19],"gastric":[21],"disorders.":[22],"However,":[23],"long-term":[25],"consumption":[26],"antibiotics":[28],"has":[29],"already":[30],"caused":[31],"antibiotic":[32],"resistance":[33],"and":[34,49,72,113],"side":[35],"effects":[36],"in":[37,137,148],"vivo.":[38],"Therefore,":[39],"there":[40],"an":[42,98,149],"emerging":[43],"need":[44],"searching":[46],"safe":[48],"effective":[50],"anti-H.":[51,185],"agents.":[53],"Inspired":[54],"by":[55],"excellent":[57,93],"bioactivities":[58],"cinnamic":[60,65,87,138],"acid,":[61],"a":[62,85,115,183],"series":[63],"acid":[66,88,139,146],"derivatives":[67],"(compounds":[68],"1\u201330)":[69],"were":[70],"synthesized":[71],"determined":[73],"H.":[75,94,119,153,190],"inhibition.":[77],"The":[78],"initial":[79],"screening":[80],"revealed":[81,132],"that":[82,107,133,177],"compound":[83,108,169,178],"23,":[84],"2,4-dinitro":[86,135],"derivative":[89],"containing":[90],"4-methoxyphenol,":[91],"showed":[92,110],"inhibition":[96],"with":[97,144],"MIC":[99],"value":[100],"4":[102],"\u03bcM.":[103],"Further":[104],"studies":[105],"indicated":[106],"23":[109,179],"anti-bacterial":[111],"activity":[112],"had":[114],"bactericidal":[116],"effect":[117],"on":[118],"due":[121],"destruction":[124],"bacterial":[127],"structure.":[128],"Molecular":[129],"docking":[130],"analysis":[131],"groups":[136],"moiety":[140,159],"formed":[141],"hydrogen":[142],"bonding":[143],"amino":[145],"residues":[147],"active":[150],"pocket":[151],"protein.":[155],"Interestingly,":[156],"ester":[158],"fitted":[160],"into":[161],"hydrophobic":[163],"pocket,":[164],"attaining":[165],"additional":[166],"stability":[167],"23.":[170],"Above":[171],"all,":[172],"present":[174],"study":[175],"reveals":[176],"could":[180],"considered":[182],"promising":[184],"agent":[187],"treat":[189],"causing":[192],"gastritis.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-26T00:00:00"}