{"id":"https://openalex.org/W4402829248","doi":"https://doi.org/10.1016/j.bbrc.2024.150739","title":"Oct-B: A derivative of L-BAIBA significantly alleviating high-fat diet-induced obesity in mice","display_name":"Oct-B: A derivative of L-BAIBA significantly alleviating high-fat diet-induced obesity in mice","publication_year":2024,"publication_date":"2024-09-25","ids":{"openalex":"https://openalex.org/W4402829248","doi":"https://doi.org/10.1016/j.bbrc.2024.150739","pmid":"https://pubmed.ncbi.nlm.nih.gov/39357338"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2024.150739","doi":"https://doi.org/10.1016/j.bbrc.2024.150739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150739","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.bbrc.2024.150739","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053690863","display_name":"Jianhua Wang","orcid":"https://orcid.org/0000-0002-2858-6029","observed_orcids":["https://orcid.org/0000-0002-2858-6029"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Wang","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China","Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":"https://orcid.org/0000-0002-2858-6029","affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China","institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210136826","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100718148","display_name":"Shanshan Wei","orcid":"https://orcid.org/0000-0003-4185-0346","observed_orcids":["https://orcid.org/0000-0003-4185-0346"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Wei","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Department of Pharmacy, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Department of Pharmacy, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006259146","display_name":"Jinxiu Guo","orcid":"https://orcid.org/0000-0001-6565-8880","observed_orcids":["https://orcid.org/0000-0001-6565-8880"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinxiu Guo","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101916143","display_name":"Xin Xie","orcid":"https://orcid.org/0000-0001-8472-6498","observed_orcids":["https://orcid.org/0000-0001-8472-6498"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Xie","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China","institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010547058","display_name":"Wenxue Sun","orcid":"https://orcid.org/0000-0003-4998-5296","observed_orcids":["https://orcid.org/0000-0003-4998-5296"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenxue Sun","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":"https://orcid.org/0000-0003-4998-5296","affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055145179","display_name":"Shiyuan Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyuan Zhao","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041118359","display_name":"Junjun Meng","orcid":"https://orcid.org/0009-0009-3117-6803","observed_orcids":["https://orcid.org/0009-0009-3117-6803"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjun Meng","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699718","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-4896-0142","observed_orcids":["https://orcid.org/0000-0003-4896-0142"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]},{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China","Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China","institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210136826","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101689758","display_name":"Rong Rong","orcid":"https://orcid.org/0000-0001-6261-9202","observed_orcids":["https://orcid.org/0000-0001-6261-9202"]},"institutions":[{"id":"https://openalex.org/I134738993","display_name":"Shandong University of Traditional Chinese Medicine","ror":"https://ror.org/0523y5c19","country_code":"CN","type":"education","lineage":["https://openalex.org/I134738993"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rong Rong","raw_affiliation_strings":["Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: rosierong@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong University of Traditional Chinese Medicine, Jinan, 250355, China; Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China. Electronic address: rosierong@163.com","institution_ids":["https://openalex.org/I134738993"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102275027","display_name":"Pei Jiang","orcid":"https://orcid.org/0009-0002-7175-6406","observed_orcids":["https://orcid.org/0009-0002-7175-6406"]},"institutions":[{"id":"https://openalex.org/I4210136826","display_name":"Jining First People's Hospital","ror":"https://ror.org/04gs6v336","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136826"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pei Jiang","raw_affiliation_strings":["Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China. Electronic address: jiangpeicsu@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Pharmaceutical Laboratory, Jining First People's Hospital, Shandong First Medical University, Jining, 272000, China; Institute of Translational Pharmacy, Jining Medical Research Academy, Jining, 272000, China. Electronic address: jiangpeicsu@sina.com","institution_ids":["https://openalex.org/I4210136826","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101689758","https://openalex.org/A5102275027"],"corresponding_institution_ids":["https://openalex.org/I134738993","https://openalex.org/I4210136826","https://openalex.org/I4210163399"],"apc_list":{"value":2880,"currency":"USD","value_usd":2880},"apc_paid":{"value":2880,"currency":"USD","value_usd":2880},"fwci":0.4692,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64303962,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"734","issue":null,"first_page":"150739","last_page":"150739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.13529999554157257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-fat-diet-induced-obesity","display_name":"high-fat diet-induced obesity","score":0.8489999771118164},{"id":"https://openalex.org/keywords/obesity-prevention","display_name":"obesity prevention","score":0.6869999766349792},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.5379999876022339},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.6159999966621399},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.8159999847412109},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8299999833106995},{"id":"https://openalex.org/keywords/brown-adipose-tissue","display_name":"brown adipose tissue","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hepatic-lipid-metabolism","display_name":"hepatic lipid metabolism","score":0.5429999828338623},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6277533173561096},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5404875874519348},{"id":"https://openalex.org/C3020571635","wikidata":"https://www.wikidata.org/wiki/Q7551390","display_name":"Anti obesity","level":3,"score":0.4981677532196045},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44601890444755554},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43228620290756226},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4164084196090698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40014171600341797},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3576507866382599},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.1020081639289856},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000621","descriptor_name":"Aminoisobutyric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000621","descriptor_name":"Aminoisobutyric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000621","descriptor_name":"Aminoisobutyric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000621","descriptor_name":"Aminoisobutyric Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2024.150739","doi":"https://doi.org/10.1016/j.bbrc.2024.150739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150739","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:39357338","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39357338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.bbrc.2024.150739","doi":"https://doi.org/10.1016/j.bbrc.2024.150739","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2024.150739","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1001440835","https://openalex.org/W1485719425","https://openalex.org/W1585227915","https://openalex.org/W1967275921","https://openalex.org/W1974559463","https://openalex.org/W2010263368","https://openalex.org/W2036620114","https://openalex.org/W2085397620","https://openalex.org/W2103714496","https://openalex.org/W2116647894","https://openalex.org/W2132358997","https://openalex.org/W2146224145","https://openalex.org/W2163244012","https://openalex.org/W2266900399","https://openalex.org/W2292418975","https://openalex.org/W2325663755","https://openalex.org/W2539166394","https://openalex.org/W2605110590","https://openalex.org/W2780780868","https://openalex.org/W2785863351","https://openalex.org/W2898859410","https://openalex.org/W2917191057","https://openalex.org/W2917520831","https://openalex.org/W3001329756","https://openalex.org/W3034508206","https://openalex.org/W3047633609","https://openalex.org/W3201096757","https://openalex.org/W3203810234","https://openalex.org/W4200295831","https://openalex.org/W4221106992","https://openalex.org/W4280549553","https://openalex.org/W4300167383","https://openalex.org/W4316096801","https://openalex.org/W4382652916","https://openalex.org/W4391507858"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4391375266","https://openalex.org/W1979139803","https://openalex.org/W2037631372","https://openalex.org/W2132898409","https://openalex.org/W3210274271","https://openalex.org/W2011592296","https://openalex.org/W2108923418","https://openalex.org/W2189569609","https://openalex.org/W2352521315"],"abstract_inverted_index":{"The":[0,135],"rising":[1],"prevalence":[2],"of":[3,87,102,128,216],"obesity":[4,24,68,141],"is":[5,187],"a":[6,41,53,164,194,207],"global":[7],"health":[8],"concern.":[9],"Supplementation":[10],"with":[11],"(":[12,16],"S":[13],")-\u03b2-aminoisobutyric":[14],"acid":[15],"L":[17,64,103,168,190,211,226],"-BAIBA)":[18],"has":[19],"shown":[20],"potential":[21],"in":[22,66,69,97,114,120,131,167,171,214,228,238],"preventing":[23,199],"and":[25,36,84,89,91,95,124,155,177,200],"related":[26,151],"metabolic":[27],"disorders":[28],"induced":[29],"by":[30,142],"high-fat":[31,70,202],"diets.":[32],"However,":[33],"developing":[34],"effective":[35],"low-toxicity":[37],"BAIBA":[38,55,208],"derivatives":[39],"remains":[40],"challenging":[42],"yet":[43],"promising":[44,195],"field.":[45],"In":[46],"this":[47],"study,":[48],"we":[49],"introduce":[50],"Oct-B":[51,77,109,139,180,186,220,232,242],",":[52],"novel":[54],"ester":[56],"compound,":[57],"which":[58],"exhibits":[59],"80-fold":[60],"greater":[61,223],"efficacy":[62,224],"than":[63,225],"-BAIBA":[65,169,191,212,227],"alleviating":[67],"diet-fed":[71],"mice.":[72,218],"Our":[73],"results":[74,137],"demonstrate":[75],"that":[76,108,185],"significantly":[78,110],"reduces":[79,93,233],"serum":[80],"TG,":[81],"TC,":[82],"LDL-C,":[83],"the":[85,100,126],"activities":[86],"ALT":[88],"AST,":[90],"also":[92],"TG":[94],"TC":[96],"liver,":[98],"surpassing":[99],"effects":[101],"-BAIBA.":[104],"Histological":[105],"analysis":[106],"shows":[107,221],"decreases":[111],"lipid":[112,234],"accumulation":[113],"liver":[115],"tissues,":[116],"normalizes":[117],"mast":[118],"cells":[119],"white":[121,132,172],"adipose":[122,133,239],"tissue,":[123],"upregulates":[125,236],"expression":[127],"UCP1":[129,237],"protein":[130],"tissue.":[134,240],"qRT-PCR":[136],"indicated":[138],"alleviates":[140],"downregulating":[143],"lipogenic":[144],"genes":[145,152],"(PPAR\u03b3,":[146],"ACC1,":[147],"FAS),":[148],"upregulating":[149],"lipolysis":[150],"(PPAR\u03b1,":[153],"HSL)":[154],"thermogenic":[156,247],"gene":[157],"UCP1.":[158],"Additionally,":[159],"quantitative":[160],"mass":[161],"spectrometry":[162],"reveals":[163],"marked":[165],"increase":[166,210],"levels":[170,213],"fat,":[173,175],"brown":[174],"serum,":[176],"muscle":[178],"following":[179],"administration.":[181],"These":[182],"findings":[183],"suggest":[184],"an":[188],"efficient":[189],"substitute,":[192],"offering":[193],"therapeutic":[196],"approach":[197],"for":[198],"treating":[201],"diet-induced":[203],"obesity.":[204,230],"\u2022":[205,219,231,241],"Oct-B,":[206],"ester,":[209],"tissues":[215],"obese":[217],"80x":[222],"reducing":[229],"accumulation,":[235],"modulates":[243],"lipogenic,":[244],"lipolysis,":[245],"&":[246],"genes.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}