{"id":"https://openalex.org/W4402818409","doi":"https://doi.org/10.1158/1078-0432.27033286.v1","title":"Supplementary Figure S6 from Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma.","display_name":"Supplementary Figure S6 from Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma.","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402818409","doi":"https://doi.org/10.1158/1078-0432.27033286.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.27033286.v1","doi":"https://doi.org/10.1158/1078-0432.27033286.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.27033286.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.27033286.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013925872","display_name":"Eileen Mary Boyle","orcid":"https://orcid.org/0000-0001-8791-1744","observed_orcids":["https://orcid.org/0000-0001-8791-1744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eileen M. Boyle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8791-1744","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059413757","display_name":"Patrick Blaney","orcid":"https://orcid.org/0000-0002-9319-8866","observed_orcids":["https://orcid.org/0000-0002-9319-8866"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Blaney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9319-8866","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073186841","display_name":"James Hart Stoeckle","orcid":"https://orcid.org/0000-0003-3377-5120","observed_orcids":["https://orcid.org/0000-0003-3377-5120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James H. Stoeckle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3377-5120","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001885140","display_name":"Yubao Wang","orcid":"https://orcid.org/0000-0002-8063-6628","observed_orcids":["https://orcid.org/0000-0002-8063-6628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yubao Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8063-6628","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062629241","display_name":"Hussein Ghamlouch","orcid":"https://orcid.org/0000-0002-2932-1081","observed_orcids":["https://orcid.org/0000-0002-2932-1081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hussein Ghamlouch","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2932-1081","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028857786","display_name":"Dylan C. Gagler","orcid":"https://orcid.org/0000-0003-0333-3989","observed_orcids":["https://orcid.org/0000-0003-0333-3989"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dylan Gagler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0333-3989","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011258393","display_name":"Marc Justin Braunstein","orcid":"https://orcid.org/0000-0002-0859-7257","observed_orcids":["https://orcid.org/0000-0002-0859-7257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Braunstein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0859-7257","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091049442","display_name":"Louis S. Williams","orcid":"https://orcid.org/0000-0001-6680-4608","observed_orcids":["https://orcid.org/0000-0001-6680-4608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis Williams","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6680-4608","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051825099","display_name":"Avital Tenenbaum","orcid":"https://orcid.org/0009-0001-1215-1178","observed_orcids":["https://orcid.org/0009-0001-1215-1178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avital Tenenbaum","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-1215-1178","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032742535","display_name":"Ariel Siegel","orcid":"https://orcid.org/0000-0002-2475-6393","observed_orcids":["https://orcid.org/0000-0002-2475-6393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariel Siegel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2475-6393","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042756133","display_name":"Xiaoyi Chen","orcid":"https://orcid.org/0000-0001-6394-4744","observed_orcids":["https://orcid.org/0000-0001-6394-4744"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaoyi Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6394-4744","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031847721","display_name":"Gaurav Varma","orcid":"https://orcid.org/0000-0002-1903-9170","observed_orcids":["https://orcid.org/0000-0002-1903-9170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gaurav Varma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1903-9170","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092469450","display_name":"Jason I. Avigan","orcid":"https://orcid.org/0009-0003-2470-5451","observed_orcids":["https://orcid.org/0009-0003-2470-5451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Avigan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-2470-5451","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041824418","display_name":"Alexander Li","orcid":"https://orcid.org/0009-0003-9852-0855","observed_orcids":["https://orcid.org/0009-0003-9852-0855"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-9852-0855","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092469451","display_name":"Monica Jinsi","orcid":"https://orcid.org/0009-0001-4161-0521","observed_orcids":["https://orcid.org/0009-0001-4161-0521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monica Jinsi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4161-0521","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077741348","display_name":"David Kaminetzky","orcid":"https://orcid.org/0000-0003-4949-6951","observed_orcids":["https://orcid.org/0000-0003-4949-6951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Kaminetzky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4949-6951","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001192882","display_name":"Arnaldo Arbini","orcid":"https://orcid.org/0000-0003-0345-4174","observed_orcids":["https://orcid.org/0000-0003-0345-4174"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnaldo Arbini","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0345-4174","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087428292","display_name":"Lydia Montes","orcid":"https://orcid.org/0000-0003-3854-4209","observed_orcids":["https://orcid.org/0000-0003-3854-4209","https://orcid.org/0009-0002-9621-825X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lydia Montes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3854-4209","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030565933","display_name":"Jill Corre","orcid":"https://orcid.org/0000-0003-1580-6106","observed_orcids":["https://orcid.org/0000-0003-1580-6106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill Corre","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1580-6106","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044130554","display_name":"Even Holth Rustad","orcid":"https://orcid.org/0000-0002-9320-4963","observed_orcids":["https://orcid.org/0000-0002-9320-4963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Even H. Rustad","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9320-4963","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082004555","display_name":"Ola Landgren","orcid":"https://orcid.org/0000-0001-6485-4839","observed_orcids":["https://orcid.org/0000-0001-6485-4839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ola Landgren","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6485-4839","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091566972","display_name":"Francesco Maura","orcid":"https://orcid.org/0000-0002-5017-1620","observed_orcids":["https://orcid.org/0000-0002-5017-1620","https://orcid.org/0000-0001-6233-4864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Maura","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5017-1620","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042516164","display_name":"Brian A. Walker","orcid":"https://orcid.org/0000-0002-8615-6254","observed_orcids":["https://orcid.org/0000-0002-8615-6254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian A. Walker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8615-6254","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007618693","display_name":"Michael Bauer","orcid":"https://orcid.org/0000-0003-2498-7295","observed_orcids":["https://orcid.org/0000-0003-2498-7295"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Bauer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2498-7295","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038143009","display_name":"Benedetto Bruno","orcid":"https://orcid.org/0000-0002-7299-6770","observed_orcids":["https://orcid.org/0000-0002-7299-6770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benedetto Bruno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7299-6770","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051845185","display_name":"Aristotelis Tsirigos","orcid":"https://orcid.org/0000-0002-7512-8477","observed_orcids":["https://orcid.org/0000-0002-7512-8477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aristotelis Tsirigos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7512-8477","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034560778","display_name":"Faith E. Davies","orcid":"https://orcid.org/0000-0002-3971-2393","observed_orcids":["https://orcid.org/0000-0002-3971-2393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faith E. Davies","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3971-2393","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100632493","display_name":"Gareth John Morgan","orcid":"https://orcid.org/0000-0002-4271-6360","observed_orcids":["https://orcid.org/0000-0002-4271-6360","https://orcid.org/0000-0002-1275-2010","https://orcid.org/0000-0001-7073-2723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gareth J. Morgan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4271-6360","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.6850000023841858},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.8550000190734863},{"id":"https://openalex.org/keywords/human-chromosome-1","display_name":"chromosome 1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/chromatin-state","display_name":"chromatin state","score":0.8949999809265137},{"id":"https://openalex.org/keywords/1p36","display_name":"1p36","score":0.6060000061988831},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.6549999713897705},{"id":"https://openalex.org/keywords/u266","display_name":"U266","score":0.7170000076293945},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.5770000219345093},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5182183384895325},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.44396060705184937},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4298117160797119},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41142863035202026},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4095652997493744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40927982330322266},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1614381968975067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.056071311235427856}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.27033286.v1","doi":"https://doi.org/10.1158/1078-0432.27033286.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.27033286.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/27033286","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S6_from_Multiomic_mapping_of_acquired_chromosome_1_copy_number_and_structural_variants_to_identify_therapeutic_vulnerabilities_in_multiple_myeloma_/27033286","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.27033286.v1","doi":"https://doi.org/10.1158/1078-0432.27033286.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.27033286.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3213857571"],"abstract_inverted_index":{"Chromatin":[0],"state":[1],"of":[2,13],"different":[3],"SV":[4],"regions.":[5],"The":[6],"CT1":[7],"region":[8,54],"at":[9,21,35],"1p36.11-1p34.3":[10],"is":[11],"comprised":[12],"greater":[14,41],"than":[15],"74%":[16],"A-compartment":[17,45],"(range":[18,26,31,59,70],"74-100%);":[19],"CT2":[20],"1p33-1p32.3":[22],"comprises":[23],"both":[24],"inactive":[25],"35-59%)":[27],"and":[28,61],"active":[29,68],"chromatin":[30],"41-65%)":[32],"and,":[33],"CT3":[34],"1p13.3-1p12,":[36],"overlaps":[37],"with":[38,43],"TI1,":[39],"had":[40],"variability":[42],"86%":[44],"in":[46,51,57,64],"U266":[47],"while":[48],"only":[49],"1%":[50],"KMS11.":[52],"TI1":[53],"predominantly":[55],"laid":[56],"B-compartment":[58],"63-73%)":[60],"TI2":[62],"lay":[63],"an":[65],"almost":[66],"entirely":[67],"compartment":[69],"91-100%).":[71],"NBC=Na\u00efve":[72],"B-cell,":[73,75,78],"MBC=Memory":[74],"GCBC=Germinal":[76],"Center":[77],"PC=plasma":[79],"cell.":[80]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-09-25T00:00:00"}