{"id":"https://openalex.org/W4402806399","doi":"https://doi.org/10.1158/2159-8290.c.6788529.v4","title":"Data from Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer","display_name":"Data from Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402806399","doi":"https://doi.org/10.1158/2159-8290.c.6788529.v4"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.c.6788529.v4","doi":"https://doi.org/10.1158/2159-8290.c.6788529.v4","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6788529.v4","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.c.6788529.v4","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009379815","display_name":"Francesco Facchinetti","orcid":"https://orcid.org/0000-0001-6313-6341","observed_orcids":["https://orcid.org/0000-0001-6313-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Facchinetti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6313-6341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086593040","display_name":"Antoine Hollebecque","orcid":"https://orcid.org/0000-0003-2869-7551","observed_orcids":["https://orcid.org/0000-0003-2869-7551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antoine Hollebecque","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2869-7551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044818787","display_name":"Floriane Bray\u00e9","orcid":"https://orcid.org/0009-0002-3527-6771","observed_orcids":["https://orcid.org/0009-0002-3527-6771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Floriane Braye","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-3527-6771","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075099274","display_name":"Damien Vasseur","orcid":"https://orcid.org/0000-0001-8787-1498","observed_orcids":["https://orcid.org/0000-0001-8787-1498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damien Vasseur","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8787-1498","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083215811","display_name":"Yoann Pradat","orcid":"https://orcid.org/0000-0002-4647-5779","observed_orcids":["https://orcid.org/0000-0002-4647-5779"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yoann Pradat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4647-5779","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045670207","display_name":"Rastislav Bahleda","orcid":"https://orcid.org/0009-0001-8245-0544","observed_orcids":["https://orcid.org/0009-0001-8245-0544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rastislav Bahleda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-8245-0544","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025502682","display_name":"C\u00e9dric Pobel","orcid":"https://orcid.org/0000-0001-6251-622X","observed_orcids":["https://orcid.org/0000-0001-6251-622X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cedric Pobel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6251-622X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072899659","display_name":"Ludovic Bigot","orcid":"https://orcid.org/0009-0009-0820-5370","observed_orcids":["https://orcid.org/0009-0009-0820-5370"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ludovic Bigot","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-0820-5370","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058013683","display_name":"Olivier D\u00e9as","orcid":"https://orcid.org/0000-0001-7355-3632","observed_orcids":["https://orcid.org/0000-0001-7355-3632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Deas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7355-3632","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020436377","display_name":"Juan David Florez Arango","orcid":"https://orcid.org/0009-0004-4531-6495","observed_orcids":["https://orcid.org/0009-0004-4531-6495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan David Florez Arango","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-4531-6495","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048627770","display_name":"Giorgia Guaitoli","orcid":"https://orcid.org/0000-0001-8671-9910","observed_orcids":["https://orcid.org/0000-0001-8671-9910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgia Guaitoli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8671-9910","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050932527","display_name":"Hayato Mizuta","orcid":"https://orcid.org/0009-0006-3553-9091","observed_orcids":["https://orcid.org/0009-0006-3553-9091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hayato Mizuta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-3553-9091","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010103730","display_name":"David Combarel","orcid":"https://orcid.org/0000-0003-2935-2782","observed_orcids":["https://orcid.org/0000-0003-2935-2782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Combarel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2935-2782","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057151895","display_name":"Lambros Tselikas","orcid":"https://orcid.org/0000-0002-8878-4916","observed_orcids":["https://orcid.org/0000-0002-8878-4916","https://orcid.org/0000-0001-7732-6293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lambros Tselikas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8878-4916","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062814767","display_name":"Stefan Michiels","orcid":"https://orcid.org/0000-0002-6963-2968","observed_orcids":["https://orcid.org/0000-0002-6963-2968"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stefan Michiels","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6963-2968","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002994486","display_name":"Sergey I. Nikolaev","orcid":"https://orcid.org/0000-0001-8587-2307","observed_orcids":["https://orcid.org/0000-0001-8587-2307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey I. Nikolaev","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8587-2307","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042575799","display_name":"Jean\u2010Yves Scoazec","orcid":"https://orcid.org/0000-0003-1604-6823","observed_orcids":["https://orcid.org/0000-0003-1604-6823"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Yves Scoazec","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1604-6823","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044751755","display_name":"Santiago Ponce-Aix","orcid":"https://orcid.org/0000-0002-2289-4709","observed_orcids":["https://orcid.org/0000-0002-2289-4709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santiago Ponce-Aix","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2289-4709","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023794502","display_name":"Benjamin Besse","orcid":"https://orcid.org/0000-0001-5090-8189","observed_orcids":["https://orcid.org/0000-0001-5090-8189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Besse","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5090-8189","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033733948","display_name":"Ken Andr\u00e9 Olaussen","orcid":"https://orcid.org/0000-0002-3115-8914","observed_orcids":["https://orcid.org/0000-0002-3115-8914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ken A. Olaussen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3115-8914","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027991868","display_name":"Yohann Loriot","orcid":"https://orcid.org/0000-0002-8338-1739","observed_orcids":["https://orcid.org/0000-0002-8338-1739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yohann Loriot","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8338-1739","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025583232","display_name":"Luc Friboulet","orcid":"https://orcid.org/0000-0002-1129-4978","observed_orcids":["https://orcid.org/0000-0002-1129-4978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luc Friboulet","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1129-4978","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.6640999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.29739999771118164,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8100000023841858},{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":0.7369999885559082},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pi3k-mtor-pathway","display_name":"PI3K/mTOR pathway","score":0.9179999828338623},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tsc1-2","display_name":"TSC1/2","score":0.7979999780654907},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.753000020980835},{"id":"https://openalex.org/keywords/erdafitinib","display_name":"erdafitinib","score":0.8840000033378601},{"id":"https://openalex.org/keywords/pictilisib","display_name":"pictilisib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9539999961853027},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7200000286102295},{"id":"https://openalex.org/keywords/patient-derived-models","display_name":"patient-derived models","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.7868707180023193},{"id":"https://openalex.org/C3020745361","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial cancer","level":4,"score":0.7453728318214417},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5161153078079224},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.45180264115333557},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42853161692619324},{"id":"https://openalex.org/C3019882237","wikidata":"https://www.wikidata.org/wiki/Q2501186","display_name":"Urothelial carcinoma","level":4,"score":0.42721399664878845},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28297674655914307},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.28088945150375366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.251922607421875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22527995705604553},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.19767320156097412},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08697611093521118},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/2159-8290.c.6788529.v4","doi":"https://doi.org/10.1158/2159-8290.c.6788529.v4","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6788529.v4","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.c.6788529.v4","doi":"https://doi.org/10.1158/2159-8290.c.6788529.v4","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.c.6788529.v4","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382344454","https://openalex.org/W4362593906","https://openalex.org/W4386470457","https://openalex.org/W4386470682","https://openalex.org/W3082675720","https://openalex.org/W4386470071","https://openalex.org/W4405492323","https://openalex.org/W4397013168","https://openalex.org/W3022883047","https://openalex.org/W2572663347"],"abstract_inverted_index":{"Abstract":[0],"Several":[1],"FGFR":[2,41,58,96],"inhibitors":[3,42],"are":[4],"approved":[5],"or":[6],"in":[7,56,62,76,103,131],"clinical":[8],"development":[9],"for":[10],"the":[11,57,104,132],"treatment":[12],"of":[13,20,91,134],"FGFR-driven":[14,34],"urothelial":[15,35],"cancer,":[16],"and":[17,43,73],"molecular":[18],"mechanisms":[19],"resistance":[21,145],"leading":[22],"to":[23,93,142],"patient":[24],"relapses":[25],"have":[26],"not":[27],"been":[28],"fully":[29],"explored.":[30],"We":[31,52],"identified":[32],"21":[33],"cancer":[36],"patients":[37,65,100],"treated":[38],"with":[39,129],"selective":[40,95],"analyzed":[44],"post-progression":[45],"tissue":[46],"and/or":[47],"circulating":[48],"tumor":[49],"DNA":[50],"(ctDNA).":[51],"detected":[53],"single":[54],"mutations":[55,75],"tyrosine":[59],"kinase":[60],"domain":[61],"seven":[63],"(33%)":[64],"(FGFR3":[66,80],"N540K,":[67,81],"V553L/M,":[68],"V555L/M,":[69],"E587Q;":[70],"FGFR2":[71],"L551F)":[72],"multiple":[74,94],"one":[77],"(5%)":[78],"case":[79],"V555L,":[82],"L608V).":[83],"Using":[84],"Ba/F3":[85],"cells,":[86],"we":[87],"defined":[88],"their":[89],"spectrum":[90],"resistance/sensitivity":[92],"inhibitors.":[97],"Eleven":[98],"(52%)":[99],"harbored":[101],"alterations":[102],"PI3K-mTOR":[105],"pathway":[106],"(n":[107],"=":[108,112,116,120],"5":[109,113],"TSC1/2,":[110],"n":[111,115,119],"PIK3CA,":[114],"1":[117,121],"NF2,":[118],"PTEN).":[122],"In":[123],"patient-derived":[124],"models,":[125],"erdafitinib":[126],"was":[127,140],"synergic":[128],"pictilisib":[130],"presence":[133],"PIK3CA":[135],"E545K,":[136],"while":[137],"erdafitinib-gefitinib":[138],"combination":[139],"able":[141],"overcome":[143],"bypass":[144],"mediated":[146],"by":[147],"EGFR":[148],"activation.":[149]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2024-09-25T00:00:00"}