{"id":"https://openalex.org/W4402804433","doi":"https://doi.org/10.1158/0008-5472.27027566","title":"Supplementary Data from BCA101 is a Tumor-Targeted Bifunctional Fusion Antibody that Simultaneously Inhibits EGFR and TGF-\u03b2 Signalling to Durably Suppress Tumor Growth","display_name":"Supplementary Data from BCA101 is a Tumor-Targeted Bifunctional Fusion Antibody that Simultaneously Inhibits EGFR and TGF-\u03b2 Signalling to Durably Suppress Tumor Growth","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402804433","doi":"https://doi.org/10.1158/0008-5472.27027566"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.27027566","doi":"https://doi.org/10.1158/0008-5472.27027566","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.27027566","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.27027566","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024165763","display_name":"Srinivas Reddy Boreddy","orcid":"https://orcid.org/0000-0002-7074-7498","observed_orcids":["https://orcid.org/0000-0002-7074-7498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srinivas Reddy Boreddy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7074-7498","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073479259","display_name":"Reshmi Nair","orcid":"https://orcid.org/0000-0002-5222-2882","observed_orcids":["https://orcid.org/0000-0002-5222-2882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reshmi Nair","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5222-2882","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056662000","display_name":"Prashant Kumar Pandey","orcid":"https://orcid.org/0000-0002-5306-2948","observed_orcids":["https://orcid.org/0000-0002-5306-2948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashant Kumar. Pandey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5306-2948","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025882503","display_name":"Anshu Kuriakose","orcid":"https://orcid.org/0000-0001-5921-9734","observed_orcids":["https://orcid.org/0000-0001-5921-9734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anshu Kuriakose","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5921-9734","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019736926","display_name":"Shivakumar Bhadravathi Marigowda","orcid":"https://orcid.org/0000-0002-1755-4101","observed_orcids":["https://orcid.org/0000-0002-1755-4101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shivakumar Bhadravathi. Marigowda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1755-4101","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007354190","display_name":"Chaitali Dey","orcid":"https://orcid.org/0000-0002-1216-8738","observed_orcids":["https://orcid.org/0000-0002-1216-8738","https://orcid.org/0009-0009-5927-2442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaitali Dey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1216-8738","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081738593","display_name":"Arindam Banerjee","orcid":"https://orcid.org/0000-0002-9382-5874","observed_orcids":["https://orcid.org/0000-0002-9382-5874"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arindam Banerjee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9382-5874","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063771743","display_name":"Hanumant Kulkarni","orcid":"https://orcid.org/0000-0002-2775-1213","observed_orcids":["https://orcid.org/0000-0002-2775-1213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanumant Kulkarni","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2775-1213","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041441105","display_name":"Milind Sagar","orcid":"https://orcid.org/0000-0001-8976-280X","observed_orcids":["https://orcid.org/0000-0001-8976-280X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Milind Sagar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8976-280X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038278493","display_name":"Shiv Ram Krishn","orcid":"https://orcid.org/0000-0002-4770-6671","observed_orcids":["https://orcid.org/0000-0002-4770-6671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiv Ram Krishn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4770-6671","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076336763","display_name":"Shruthi Rao","orcid":"https://orcid.org/0000-0002-3832-1892","observed_orcids":["https://orcid.org/0000-0002-3832-1892","https://orcid.org/0000-0003-3138-6455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shruthi Rao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3832-1892","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079636482","display_name":"Madhukara AR","orcid":"https://orcid.org/0009-0002-2741-9891","observed_orcids":["https://orcid.org/0009-0002-2741-9891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhukara A R","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-2741-9891","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081932339","display_name":"Vinita Tiwari","orcid":"https://orcid.org/0000-0002-2527-2462","observed_orcids":["https://orcid.org/0000-0002-2527-2462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinita Tiwari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2527-2462","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057631270","display_name":"Bhavna Alke","orcid":"https://orcid.org/0000-0003-4517-5333","observed_orcids":["https://orcid.org/0000-0003-4517-5333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bhavna Alke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4517-5333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045095688","display_name":"Prashantha Kumar MV","orcid":"https://orcid.org/0000-0003-2698-1110","observed_orcids":["https://orcid.org/0000-0003-2698-1110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Prashantha Kumara MV","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2698-1110","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080610600","display_name":"Meena Shri","orcid":"https://orcid.org/0009-0003-9588-6034","observed_orcids":["https://orcid.org/0009-0003-9588-6034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meena Shri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-9588-6034","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054051512","display_name":"Chaitrali Dhamne","orcid":"https://orcid.org/0000-0002-0991-279X","observed_orcids":["https://orcid.org/0000-0002-0991-279X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaitrali Dhamne","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0991-279X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015742558","display_name":"Sonal Patel","orcid":"https://orcid.org/0000-0003-0012-3281","observed_orcids":["https://orcid.org/0000-0003-0012-3281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sonal Patel","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0012-3281","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051676136","display_name":"Pinky Sharma","orcid":"https://orcid.org/0000-0003-0260-1419","observed_orcids":["https://orcid.org/0000-0003-0260-1419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pinky Sharma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0260-1419","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005292378","display_name":"Sankar Periyasamy","orcid":"https://orcid.org/0009-0002-2169-1501","observed_orcids":["https://orcid.org/0009-0002-2169-1501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sankar Periyasamy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-2169-1501","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075535128","display_name":"Jaya Bhatnagar","orcid":"https://orcid.org/0000-0002-9677-3192","observed_orcids":["https://orcid.org/0000-0002-9677-3192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaya Bhatnagar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9677-3192","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085747971","display_name":"Moni Abraham Kuriakose","orcid":"https://orcid.org/0000-0001-7861-9741","observed_orcids":["https://orcid.org/0000-0001-7861-9741"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moni Abraham. Kuriakose","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7861-9741","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052908657","display_name":"Ram Bhupal Reddy","orcid":"https://orcid.org/0000-0002-2884-3590","observed_orcids":["https://orcid.org/0000-0002-2884-3590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ram Bhupal Reddy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2884-3590","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001303284","display_name":"Amritha Suresh","orcid":"https://orcid.org/0000-0002-0785-0054","observed_orcids":["https://orcid.org/0000-0002-0785-0054"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amritha Suresh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0785-0054","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090298450","display_name":"Suma Sreenivas","orcid":"https://orcid.org/0009-0000-6348-5971","observed_orcids":["https://orcid.org/0009-0000-6348-5971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suma Sreenivas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-6348-5971","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009839302","display_name":"Nagaraja Govindappa","orcid":"https://orcid.org/0000-0001-5944-3314","observed_orcids":["https://orcid.org/0000-0001-5944-3314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nagaraja Govindappa","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5944-3314","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025155495","display_name":"Praveen Reddy Moole","orcid":"https://orcid.org/0009-0003-7570-1653","observed_orcids":["https://orcid.org/0009-0003-7570-1653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Praveen Reddy. Moole","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-7570-1653","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064564014","display_name":"Usha Bughani","orcid":"https://orcid.org/0000-0003-4499-0694","observed_orcids":["https://orcid.org/0000-0003-4499-0694"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Usha Bughani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4499-0694","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056210709","display_name":"Seng-Lai Tan","orcid":"https://orcid.org/0009-0003-3150-9213","observed_orcids":["https://orcid.org/0009-0003-3150-9213"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seng-Lai Tan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-3150-9213","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077841973","display_name":"Pradip Nair","orcid":"https://orcid.org/0000-0002-5272-0478","observed_orcids":["https://orcid.org/0000-0002-5272-0478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pradip Nair","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5272-0478","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.24050000309944153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.07289999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-inhibition","display_name":"EGFR inhibition","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8270000219345093},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2780443040","wikidata":"https://www.wikidata.org/wiki/Q3737863","display_name":"Bifunctional","level":3,"score":0.6033280491828918},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5682141184806824},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5628294348716736},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.4951993525028229},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4191516935825348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24343723058700562},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23817172646522522},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22283703088760376},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1652039885520935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1472637951374054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0647445023059845},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06238582730293274},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.27027566","doi":"https://doi.org/10.1158/0008-5472.27027566","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.27027566","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.27027566","doi":"https://doi.org/10.1158/0008-5472.27027566","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.27027566","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379107564","https://openalex.org/W4366351815","https://openalex.org/W4402805774","https://openalex.org/W4379984084","https://openalex.org/W3212553549","https://openalex.org/W3171080294","https://openalex.org/W4410047653","https://openalex.org/W7208169650","https://openalex.org/W4362478953","https://openalex.org/W1986488244"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-09-25T00:00:00"}
