{"id":"https://openalex.org/W4402803460","doi":"https://doi.org/10.1158/0008-5472.c.6861233.v2","title":"Data from Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers","display_name":"Data from Abemaciclib is effective in palbociclib-resistant hormone receptor-positive metastatic breast cancers","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402803460","doi":"https://doi.org/10.1158/0008-5472.c.6861233.v2"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.6861233.v2","doi":"https://doi.org/10.1158/0008-5472.c.6861233.v2","is_oa":true,"landing_page_url":"http://doi.org/10.1158/0008-5472.c.6861233.v2","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://doi.org/10.1158/0008-5472.c.6861233.v2","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017644527","display_name":"Juliana Navarro-Yepes","orcid":"https://orcid.org/0000-0003-0393-3773","observed_orcids":["https://orcid.org/0000-0003-0393-3773"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juliana Navarro-Yepes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0393-3773","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026936750","display_name":"Nicole M. Kettner","orcid":"https://orcid.org/0000-0003-2043-4407","observed_orcids":["https://orcid.org/0000-0003-2043-4407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole M. Kettner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2043-4407","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077700916","display_name":"Xiayu Rao","orcid":"https://orcid.org/0000-0001-5245-7449","observed_orcids":["https://orcid.org/0000-0001-5245-7449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiayu Rao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5245-7449","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107385205","display_name":"Cassandra Santaella Bishop","orcid":"https://orcid.org/0000-0001-9153-9615","observed_orcids":["https://orcid.org/0000-0001-9153-9615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cassandra Santaella. Bishop","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9153-9615","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000113218","display_name":"Tuyen N. Bui","orcid":"https://orcid.org/0000-0001-8509-3653","observed_orcids":["https://orcid.org/0000-0001-8509-3653"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tuyen N. Bui","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8509-3653","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052218127","display_name":"Hannah F. Wingate","orcid":"https://orcid.org/0000-0002-1055-8935","observed_orcids":["https://orcid.org/0000-0002-1055-8935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah F. Wingate","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1055-8935","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016698215","display_name":"Akshara Singareeka Raghavendra","orcid":"https://orcid.org/0000-0002-6425-4400","observed_orcids":["https://orcid.org/0000-0002-6425-4400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akshara Singareeka Raghavendra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6425-4400","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057311999","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0001-9566-8975","observed_orcids":["https://orcid.org/0000-0001-9566-8975"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9566-8975","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378341","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0009-0006-4171-5397","https://orcid.org/0000-0002-8911-9555","https://orcid.org/0009-0003-0661-5954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5398-0802","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041098535","display_name":"Ay\u015feg\u00fcl A. \u015eahin","orcid":"https://orcid.org/0000-0001-8259-9624","observed_orcids":["https://orcid.org/0000-0001-8259-9624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aysegul A. Sahin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8259-9624","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076426660","display_name":"Funda Meric\u2010Bernstam","orcid":"https://orcid.org/0000-0001-6816-6072","observed_orcids":["https://orcid.org/0000-0001-6816-6072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Funda Meric-Bernstam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6816-6072","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017411324","display_name":"Kelly K. Hunt","orcid":"https://orcid.org/0000-0001-9156-8723","observed_orcids":["https://orcid.org/0000-0001-9156-8723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kelly K. Hunt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9156-8723","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009582590","display_name":"Senthil Damodaran","orcid":"https://orcid.org/0000-0002-2470-0891","observed_orcids":["https://orcid.org/0000-0002-2470-0891"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Senthil Damodaran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2470-0891","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110083321","display_name":"Debu Tripathy","orcid":"https://orcid.org/0000-0002-5711-2404","observed_orcids":["https://orcid.org/0000-0002-5711-2404"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debu Tripathy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5711-2404","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042960706","display_name":"Khandan Keyomarsi","orcid":"https://orcid.org/0000-0002-5440-0849","observed_orcids":["https://orcid.org/0000-0002-5440-0849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khandan Keyomarsi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5440-0849","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abemaciclib","display_name":"abemaciclib","score":1.0},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cdk4-6-inhibitor-resistance","display_name":"CDK4/6 inhibitor resistance","score":0.9390000104904175},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.921999990940094},{"id":"https://openalex.org/keywords/her2-negative-metastatic-breast-cancer","display_name":"HER2-negative metastatic breast cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.671999990940094},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.6349999904632568},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9010000228881836},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.8880000114440918},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.699999988079071},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.9800000190734863}],"concepts":[{"id":"https://openalex.org/C2779744173","wikidata":"https://www.wikidata.org/wiki/Q15269707","display_name":"Palbociclib","level":5,"score":0.9537178874015808},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5949077606201172},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.5512901544570923},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5493707656860352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5400875210762024},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.507677435874939},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.468467652797699},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4215773940086365},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2671051025390625}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.6861233.v2","doi":"https://doi.org/10.1158/0008-5472.c.6861233.v2","is_oa":true,"landing_page_url":"http://doi.org/10.1158/0008-5472.c.6861233.v2","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.6861233.v2","doi":"https://doi.org/10.1158/0008-5472.c.6861233.v2","is_oa":true,"landing_page_url":"http://doi.org/10.1158/0008-5472.c.6861233.v2","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382541721","https://openalex.org/W4396587858","https://openalex.org/W4282935358","https://openalex.org/W2943341596","https://openalex.org/W3013833338","https://openalex.org/W4229063635","https://openalex.org/W4292866406","https://openalex.org/W4315490807","https://openalex.org/W4205928549","https://openalex.org/W4412974562"],"abstract_inverted_index":{"Abstract":[0],"Cyclin-dependent-kinase-4/6":[1],"inhibitor":[2],"(CDK4/6i)":[3],"plus":[4,27],"endocrine":[5],"therapy":[6,218],"(ET)":[7],"is":[8],"standard":[9],"of":[10,46,81,126,142,195,234],"care":[11],"for":[12,228],"patients":[13,103,162,197,200],"with":[14,33,177,185,201],"hormone":[15],"receptor":[16],"(HR)-positive,":[17],"HER2-negative":[18],"metastatic":[19],"breast":[20,111,160],"cancer":[21,112,161],"(MBC).":[22],"However,":[23],"resistance":[24,68],"to":[25,67,69,123,135,150,165,168,173],"CDK4/6is":[26,41,71],"ET":[28],"remains":[29],"a":[30,193,211,240],"clinical":[31,214,229],"problem":[32],"limited":[34],"therapeutic":[35],"options":[36],"following":[37,237],"disease":[38,61],"progression.":[39,62],"Different":[40],"might":[42],"have":[43],"distinct":[44,115],"mechanisms":[45],"resistance,":[47],"and":[48,73,84,97,109,117,133,148,154],"therefore":[49],"using":[50],"them":[51,122],"sequentially":[52],"or":[53],"targeting":[54],"their":[55],"differentially":[56],"altered":[57],"pathways":[58,65,132],"could":[59],"delay":[60],"To":[63],"understand":[64],"leading":[66],"the":[70,143,226,232],"palbociclib":[72,169],"abemaciclib,":[74,136],"we":[75],"generated":[76],"multiple":[77],"in":[78,92],"vitro":[79],"models":[80,156],"palbociclib-resistant":[82,159],"(PR)":[83],"abemaciclib-resistant":[85],"(AR)":[86],"cell":[87],"lines,":[88],"as":[89,91],"well":[90],"vivo":[93,99],"patient-derived":[94],"xenografts":[95],"(PDX)":[96],"ex":[98],"PDX-derived":[100],"organoids":[101],"from":[102,158,192,216],"who":[104,204],"progressed":[105,205],"on":[106,206,239],"CDK4/6i.":[107,242],"PR":[108,128],"AR":[110,138],"cells":[113,129,139],"exhibited":[114],"transcriptomic":[116],"proteomic":[118],"profiles":[119],"that":[120,199],"sensitized":[121],"different":[124],"classes":[125],"inhibitors;":[127],"upregulated":[130,140],"G2/M":[131],"responded":[134,149],"while":[137,170],"mediators":[141],"oxidative":[144],"phosphorylation":[145],"pathway":[146],"(OXPHOS)":[147],"OXPHOS":[151],"inhibitors.":[152],"PDX":[153],"organoid":[155],"derived":[157],"remained":[163],"responsive":[164],"abemaciclib.":[166],"Resistance":[167],"maintaining":[171],"sensitivity":[172],"abemaciclib":[174,235],"was":[175,182],"associated":[176,184],"pathway-specific":[178],"transcriptional":[179],"activity":[180],"but":[181],"not":[183],"any":[186],"individual":[187],"genetic":[188],"alterations.":[189],"Lastly,":[190],"data":[191],"cohort":[194],"52":[196],"indicated":[198],"HR-positive/HER2-negative":[202],"MBC":[203],"palbociclib-containing":[207],"regimens":[208],"can":[209],"exhibit":[210],"meaningful":[212],"overall":[213],"benefit":[215,233],"abemaciclib-based":[217],"when":[219],"administered":[220],"after":[221],"palbociclib.":[222],"These":[223],"findings":[224],"provide":[225],"rationale":[227],"trials":[230],"evaluating":[231],"treatment":[236],"progression":[238],"prior":[241]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2024-09-25T00:00:00"}