{"id":"https://openalex.org/W4402803026","doi":"https://doi.org/10.1158/2159-8290.27025610","title":"Supplementary Table S1 from FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer","display_name":"Supplementary Table S1 from FH variant pathogenicity promotes purine salvage pathway dependence in kidney cancer","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402803026","doi":"https://doi.org/10.1158/2159-8290.27025610"},"language":"en","primary_location":{"id":"doi:10.1158/2159-8290.27025610","doi":"https://doi.org/10.1158/2159-8290.27025610","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.27025610","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2159-8290.27025610","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021478900","display_name":"Blake R. Wilde","orcid":"https://orcid.org/0000-0002-8372-3954","observed_orcids":["https://orcid.org/0000-0002-8372-3954"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Blake R. Wilde","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8372-3954","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025428634","display_name":"Nishma Chakraborty","orcid":"https://orcid.org/0000-0003-2100-5428","observed_orcids":["https://orcid.org/0000-0003-2100-5428"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nishma Chakraborty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2100-5428","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062370039","display_name":"Nedas Matulionis","orcid":"https://orcid.org/0000-0001-7624-3090","observed_orcids":["https://orcid.org/0000-0001-7624-3090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nedas Matulionis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7624-3090","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009888248","display_name":"Stephanie Hernandez","orcid":"https://orcid.org/0009-0004-1355-7331","observed_orcids":["https://orcid.org/0009-0004-1355-7331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie Hernandez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-1355-7331","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068839347","display_name":"Daiki Ueno","orcid":"https://orcid.org/0009-0002-3574-4264","observed_orcids":["https://orcid.org/0009-0002-3574-4264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daiki Ueno","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-3574-4264","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033569354","display_name":"Michayla E. Gee","orcid":"https://orcid.org/0009-0001-5005-6710","observed_orcids":["https://orcid.org/0009-0001-5005-6710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michayla E. Gee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5005-6710","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003631861","display_name":"Edward D. Esplin","orcid":"https://orcid.org/0000-0001-9205-3756","observed_orcids":["https://orcid.org/0000-0001-9205-3756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward D. Esplin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9205-3756","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009964370","display_name":"Karen Ouyang","orcid":"https://orcid.org/0009-0009-5748-1451","observed_orcids":["https://orcid.org/0009-0009-5748-1451"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Ouyang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5748-1451","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064218126","display_name":"Keith Nykamp","orcid":"https://orcid.org/0000-0002-1389-5320","observed_orcids":["https://orcid.org/0000-0002-1389-5320"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Nykamp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1389-5320","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022014477","display_name":"Brian M. Shuch","orcid":"https://orcid.org/0000-0003-2065-3570","observed_orcids":["https://orcid.org/0000-0003-2065-3570"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Shuch","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2065-3570","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5031437834","display_name":"Heather R. Christofk","orcid":"https://orcid.org/0000-0002-8662-4425","observed_orcids":["https://orcid.org/0000-0002-8662-4425"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather R. Christofk","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8662-4425","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.3075999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.045099999755620956,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fumarate-hydratase","display_name":"fumarate hydratase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/purine-salvage-pathway","display_name":"purine salvage pathway","score":0.9470000267028809},{"id":"https://openalex.org/keywords/kidney-cancer","display_name":"kidney cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/catalytic-efficiency","display_name":"catalytic efficiency","score":0.9129999876022339},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.925000011920929},{"id":"https://openalex.org/keywords/population-frequency","display_name":"population frequency","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.6763473153114319},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.5528185963630676},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.5149434208869934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4611073136329651},{"id":"https://openalex.org/C2776476023","wikidata":"https://www.wikidata.org/wiki/Q188261","display_name":"Purine","level":3,"score":0.4266999661922455},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3810630142688751},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3781971335411072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35055166482925415},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.21978986263275146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12778571248054504},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.10805845260620117},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08689373731613159},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.06598153710365295}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/2159-8290.27025610","doi":"https://doi.org/10.1158/2159-8290.27025610","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.27025610","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2159-8290.27025610.v1","doi":"https://doi.org/10.1158/2159-8290.27025610.v1","is_oa":true,"landing_page_url":"http://doi.org/10.1158/2159-8290.27025610.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/27025610","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Supplementary_Table_S1_from_FH_variant_pathogenicity_promotes_purine_salvage_pathway_dependence_in_kidney_cancer/27025610","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/2159-8290.27025610","doi":"https://doi.org/10.1158/2159-8290.27025610","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2159-8290.27025610","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385303605","https://openalex.org/W4378782285","https://openalex.org/W3203660586","https://openalex.org/W4391645268","https://openalex.org/W7221343377","https://openalex.org/W3024547843","https://openalex.org/W2969336029","https://openalex.org/W7167477519","https://openalex.org/W3188622615","https://openalex.org/W7160906570"],"abstract_inverted_index":{"Supplementary":[0],"Table":[1],"S1:":[2],"FH":[3],"variants":[4],"with":[5],"population":[6],"frequencies,":[7],"interpretations":[8],"of":[9],"pathogenicity,":[10],"catalytic":[11],"efficiencies,":[12],"and":[13],"multimerization":[14],"states":[15]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-25T00:00:00"}