{"id":"https://openalex.org/W4402798019","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v4","title":"Data from Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC)Unveils New Actionable Genomic Aberrations in PACC","display_name":"Data from Comparative Genomic Analysis of Pancreatic Acinar Cell Carcinoma (PACC) and Pancreatic Ductal Adenocarcinoma (PDAC)Unveils New Actionable Genomic Aberrations in PACC","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402798019","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v4"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6715507.v4","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v4","is_oa":true,"landing_page_url":"http://doi.org/10.1158/1078-0432.c.6715507.v4","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://doi.org/10.1158/1078-0432.c.6715507.v4","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043773782","display_name":"Vaia Florou","orcid":"https://orcid.org/0000-0001-5558-753X","observed_orcids":["https://orcid.org/0000-0001-5558-753X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vaia Florou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5558-753X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029537789","display_name":"Andrew Elliott","orcid":"https://orcid.org/0000-0001-8494-8031","observed_orcids":["https://orcid.org/0000-0001-8494-8031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Elliott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8494-8031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051591843","display_name":"Matthew H. Bailey","orcid":"https://orcid.org/0000-0003-4526-9727","observed_orcids":["https://orcid.org/0000-0003-4526-9727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew H. Bailey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4526-9727","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David Stone","orcid":"https://orcid.org/0009-0008-1368-3687","observed_orcids":["https://orcid.org/0009-0008-1368-3687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Stone","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-1368-3687","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001580260","display_name":"Kajsa E. Affolter","orcid":"https://orcid.org/0000-0002-1703-0535","observed_orcids":["https://orcid.org/0000-0002-1703-0535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kajsa Affolter","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1703-0535","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054848065","display_name":"Heloisa Prado Soares","orcid":"https://orcid.org/0000-0002-5185-2583","observed_orcids":["https://orcid.org/0000-0002-5185-2583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heloisa P. Soares","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5185-2583","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080264243","display_name":"Chris Nevala-Plagemann","orcid":"https://orcid.org/0000-0003-4048-2692","observed_orcids":["https://orcid.org/0000-0003-4048-2692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chris Nevala-Plagemann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4048-2692","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053671455","display_name":"Courtney L. Scaife","orcid":"https://orcid.org/0000-0003-2497-4961","observed_orcids":["https://orcid.org/0000-0003-2497-4961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney Scaife","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2497-4961","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061883893","display_name":"Phillip Walker","orcid":"https://orcid.org/0009-0009-5324-6219","observed_orcids":["https://orcid.org/0009-0009-5324-6219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phillip Walker","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5324-6219","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040325455","display_name":"Wolfgang Michael Korn","orcid":"https://orcid.org/0000-0002-0124-6841","observed_orcids":["https://orcid.org/0000-0002-0124-6841"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Michael Korn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0124-6841","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062667375","display_name":"Emil Lou","orcid":"https://orcid.org/0000-0002-1607-1386","observed_orcids":["https://orcid.org/0000-0002-1607-1386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emil Lou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1607-1386","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012936802","display_name":"Rachna T. Shroff","orcid":"https://orcid.org/0000-0003-0066-2672","observed_orcids":["https://orcid.org/0000-0003-0066-2672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachna T. Shroff","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0066-2672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065012486","display_name":"Peter J. Hosein","orcid":"https://orcid.org/0000-0001-8537-6397","observed_orcids":["https://orcid.org/0000-0001-8537-6397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Hosein","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8537-6397","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029563022","display_name":"Ignacio Garrido\u2010Laguna","orcid":"https://orcid.org/0000-0003-2273-9028","observed_orcids":["https://orcid.org/0000-0003-2273-9028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio Garrido-Laguna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2273-9028","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-acinar-cell-carcinoma","display_name":"pancreatic acinar cell carcinoma","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.7630000114440918},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.8109999895095825},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/brca1","display_name":"BRCA1","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":1.0},{"id":"https://openalex.org/keywords/palb2","display_name":"PALB2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/braf-v600e-mutation","display_name":"BRAF V600E mutation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/encorafenib","display_name":"encorafenib","score":0.9359999895095825},{"id":"https://openalex.org/keywords/binimetinib","display_name":"binimetinib","score":1.0},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.8859999775886536},{"id":"https://openalex.org/keywords/actionable-genomic-alterations","display_name":"actionable genomic alterations","score":0.7089999914169312},{"id":"https://openalex.org/keywords/intertumoral-heterogeneity","display_name":"intertumoral heterogeneity","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.852802038192749},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5249207615852356},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.5113091468811035},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4725484549999237},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41362032294273376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39594751596450806},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.2533116936683655},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12855106592178345}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6715507.v4","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v4","is_oa":true,"landing_page_url":"http://doi.org/10.1158/1078-0432.c.6715507.v4","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6715507.v4","doi":"https://doi.org/10.1158/1078-0432.c.6715507.v4","is_oa":true,"landing_page_url":"http://doi.org/10.1158/1078-0432.c.6715507.v4","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4379095614","https://openalex.org/W7122380883","https://openalex.org/W7221715579","https://openalex.org/W7118293589","https://openalex.org/W7162695819","https://openalex.org/W2093232036","https://openalex.org/W4399564816","https://openalex.org/W7169733909","https://openalex.org/W2773109548","https://openalex.org/W4362705680"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Pure":[2,153],"pancreatic":[3,88],"acinar":[4],"cell":[5,148,228],"carcinomas":[6],"(PACC)":[7],"are":[8,211],"rare":[9],"malignancies":[10],"with":[11,21,101,118,161,192],"no":[12],"established":[13],"treatment.":[14,245],"PACC":[15,43,56,102,127,140,154,215,236],"demonstrates":[16],"significant":[17],"genetic":[18],"intertumoral":[19],"heterogeneity":[20],"multiple":[22],"pathways":[23],"involved,":[24],"suggesting":[25],"using":[26],"targeted":[27],"cancer":[28],"therapeutics":[29],"to":[30,44,151,158],"treat":[31],"this":[32,187],"disease.":[33],"We":[34,79,120],"aggregated":[35],"one":[36,175],"of":[37,41,63,83,87,134,204,220,234],"the":[38,46,131,169,221],"largest":[39],"datasets":[40],"pure":[42,126,135,235],"examine":[45],"genomic":[47,85,156,232],"variability":[48],"and":[49,70,128,145,166,200,216,225],"explore":[50],"patient-specific":[51],"therapeutic":[52],"targets.":[53],"Experimental":[54],"Design:":[55],"specimens":[57],"(n=51)":[58],"underwent":[59],"next-generation":[60],"sequencing":[61],"(NGS)":[62],"DNA":[64],"(n=29)":[65],"or":[66],"whole":[67],"exome":[68],"[n=22])":[69],"RNA":[71],"(whole":[72],"transcriptome,":[73],"n=29)":[74],"at":[75,104,173],"a":[76,84,97,177,181],"commercial":[77],"laboratory.":[78],"performed":[80],"comparative":[81],"analyses":[82],"cohort":[86],"ductal":[89],"adenocarcinomas":[90],"(PDAC,":[91],"n=4205).":[92],"In":[93,230],"parallel,":[94],"we":[95],"conducted":[96],"retrospective":[98],"review":[99],"patients":[100,117,171],"treated":[103,172,191],"Huntsman":[105],"Cancer":[106],"Institute":[107],"(HCI).":[108],"Results:":[109],"The":[110],"real-world":[111],"dataset":[112],"included":[113],"samples":[114],"from":[115],"51":[116],"PACC.":[119,136],"found":[121],"key":[122],"molecular":[123],"differences":[124,138,213],"between":[125,214],"PDAC,":[129,217],"highlighting":[130],"unique":[132],"characteristics":[133],"Major":[137],"in":[139,163],"include":[141],"lower":[142],"MAPK":[143,222],"signaling":[144,223],"less":[146,226],"stromal":[147,227],"abundance":[149],"compared":[150],"PDAC.":[152],"showed":[155],"loss-of-heterozygosity":[157],"largely":[159],"coincide":[160],"mutations":[162],"BRCA1,":[164],"BRCA2,":[165],"PALB2.":[167],"Of":[168],"seven":[170],"HCI,":[174],"had":[176],"tumor":[178],"that":[179],"harbored":[180],"BRAF-V600E":[182],"mutation.":[183],"Leveraging":[184],"precision":[185],"oncology,":[186],"patient":[188,244],"is":[189],"being":[190],"encorafenib":[193],"plus":[194],"binimetinib,":[195],"achieving":[196],"an":[197],"exceptionally":[198],"durable":[199],"ongoing":[201],"complete":[202],"response":[203],"more":[205],"than":[206],"three":[207],"years.":[208],"Conclusions:":[209],"There":[210],"major":[212],"including":[218],"downregulation":[219],"pathway,":[224],"abundance.":[229],"addition,":[231],"characterization":[233],"revealed":[237],"frequent":[238],"targetable":[239],"alterations,":[240],"which":[241],"can":[242],"guide":[243]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2024-09-25T00:00:00"}
