{"id":"https://openalex.org/W4402797261","doi":"https://doi.org/10.1158/1078-0432.c.6563227.v3","title":"Data from Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer","display_name":"Data from Reversal of lactate and PD-1-mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402797261","doi":"https://doi.org/10.1158/1078-0432.c.6563227.v3"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6563227.v3","doi":"https://doi.org/10.1158/1078-0432.c.6563227.v3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6563227.v3","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6563227.v3","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081681820","display_name":"Kiranj Kishor Chaudagar","orcid":"https://orcid.org/0000-0002-8113-8516","observed_orcids":["https://orcid.org/0000-0002-8113-8516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kiranj Chaudagar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8113-8516","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016000403","display_name":"Hanna M. Hieromnimon","orcid":"https://orcid.org/0000-0001-8727-5290","observed_orcids":["https://orcid.org/0000-0001-8727-5290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanna M. Hieromnimon","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8727-5290","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049543850","display_name":"Rimpi Khurana","orcid":"https://orcid.org/0000-0002-0493-6266","observed_orcids":["https://orcid.org/0000-0002-0493-6266"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rimpi Khurana","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0493-6266","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082558529","display_name":"Brian William Labadie","orcid":"https://orcid.org/0000-0002-3648-4663","observed_orcids":["https://orcid.org/0000-0002-3648-4663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Labadie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3648-4663","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049507860","display_name":"Taghreed Hirz","orcid":"https://orcid.org/0000-0001-9230-1756","observed_orcids":["https://orcid.org/0000-0001-9230-1756"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taghreed Hirz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9230-1756","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006481328","display_name":"Shenglin Mei","orcid":"https://orcid.org/0000-0001-8258-5898","observed_orcids":["https://orcid.org/0000-0001-8258-5898"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shenglin Mei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8258-5898","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082246777","display_name":"Raisa Hasan","orcid":"https://orcid.org/0000-0002-5065-3363","observed_orcids":["https://orcid.org/0000-0002-5065-3363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raisa Hasan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5065-3363","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006555178","display_name":"Jordan S. Shafran","orcid":"https://orcid.org/0000-0001-6946-3060","observed_orcids":["https://orcid.org/0000-0001-6946-3060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan Shafran","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6946-3060","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057608003","display_name":"Anne Kelley","orcid":"https://orcid.org/0000-0003-2496-8967","observed_orcids":["https://orcid.org/0000-0003-2496-8967"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Kelley","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2496-8967","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052468195","display_name":"Eva Apostolov","orcid":"https://orcid.org/0000-0001-9516-1672","observed_orcids":["https://orcid.org/0000-0001-9516-1672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Apostolov","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9516-1672","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081791257","display_name":"Ghamdan Al\u2010Eryani","orcid":"https://orcid.org/0000-0002-1137-1726","observed_orcids":["https://orcid.org/0000-0002-1137-1726"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ghamdan Al-Eryani","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1137-1726","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026516999","display_name":"Kate Harvey","orcid":"https://orcid.org/0000-0002-2155-5203","observed_orcids":["https://orcid.org/0000-0002-2155-5203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Harvey","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2155-5203","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014932117","display_name":"Srikrishnan Rameshbabu","orcid":"https://orcid.org/0000-0002-9952-2591","observed_orcids":["https://orcid.org/0000-0002-9952-2591"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srikrishnan Rameshbabu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9952-2591","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075152000","display_name":"Mayme Loyd","orcid":"https://orcid.org/0000-0002-5540-4884","observed_orcids":["https://orcid.org/0000-0002-5540-4884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mayme Loyd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5540-4884","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073680897","display_name":"Kaela M. Bynoe","orcid":"https://orcid.org/0000-0002-8748-0531","observed_orcids":["https://orcid.org/0000-0002-8748-0531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaela Bynoe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8748-0531","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086185350","display_name":"Catherine Drovetsky","orcid":"https://orcid.org/0000-0002-1209-7538","observed_orcids":["https://orcid.org/0000-0002-1209-7538"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Drovetsky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1209-7538","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068814417","display_name":"Ani Solanki","orcid":"https://orcid.org/0000-0002-7190-7852","observed_orcids":["https://orcid.org/0000-0002-7190-7852"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ani Solanki","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7190-7852","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085739244","display_name":"Erica J. Markiewicz","orcid":"https://orcid.org/0000-0002-4247-8948","observed_orcids":["https://orcid.org/0000-0002-4247-8948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica Markiewicz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4247-8948","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061774893","display_name":"Marta A. Zamora","orcid":"https://orcid.org/0000-0001-6311-5663","observed_orcids":["https://orcid.org/0000-0001-6311-5663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Zamora","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6311-5663","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089826782","display_name":"Xiaobing Fan","orcid":"https://orcid.org/0000-0001-9004-029X","observed_orcids":["https://orcid.org/0000-0001-9004-029X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaobing Fan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9004-029X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013636406","display_name":"Stephan C. Sch\u00fcrer","orcid":"https://orcid.org/0000-0001-7180-0978","observed_orcids":["https://orcid.org/0000-0001-7180-0978","https://orcid.org/0000-0002-5615-5576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephan Sch\u00fcrer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7180-0978","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038076681","display_name":"Alexander Swarbrick","orcid":"https://orcid.org/0000-0002-3051-5676","observed_orcids":["https://orcid.org/0000-0002-3051-5676"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Swarbrick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3051-5676","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088797237","display_name":"David B. Sykes","orcid":"https://orcid.org/0000-0002-9788-0221","observed_orcids":["https://orcid.org/0000-0002-9788-0221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David B. Sykes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9788-0221","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068014441","display_name":"Akash Patnaik","orcid":"https://orcid.org/0000-0001-5306-0208","observed_orcids":["https://orcid.org/0000-0001-5306-0208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akash Patnaik","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5306-0208","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.6553000211715698,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1662999987602234,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.16329999268054962,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9160000085830688},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/lactate","display_name":"lactate","score":0.8240000009536743},{"id":"https://openalex.org/keywords/histone-lactylation","display_name":"histone lactylation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.7020000219345093},{"id":"https://openalex.org/keywords/androgen-deprivation-therapy","display_name":"androgen deprivation therapy","score":0.9819999933242798},{"id":"https://openalex.org/keywords/copanlisib","display_name":"copanlisib","score":0.9179999828338623},{"id":"https://openalex.org/keywords/immunometabolism","display_name":"immunometabolism","score":0.8100000023841858},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7279999852180481},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2780252810","wikidata":"https://www.wikidata.org/wiki/Q1455316","display_name":"Immunosuppression","level":2,"score":0.8255929946899414},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7806543111801147},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.7564454078674316},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5337181091308594},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5058712363243103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4781242907047272},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.4355057179927826},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.405611515045166},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39060795307159424},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.38541173934936523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2336631417274475},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.21563205122947693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08212316036224365},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.07235586643218994},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.05540648102760315}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6563227.v3","doi":"https://doi.org/10.1158/1078-0432.c.6563227.v3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6563227.v3","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6563227.v3","doi":"https://doi.org/10.1158/1078-0432.c.6563227.v3","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6563227.v3","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4322758461","https://openalex.org/W4386817476","https://openalex.org/W4308385956","https://openalex.org/W4389226657","https://openalex.org/W7147269324","https://openalex.org/W4286295324","https://openalex.org/W3140761655","https://openalex.org/W4416256715","https://openalex.org/W2752010057","https://openalex.org/W2741158063"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"PTEN":[2,29],"loss-of-function":[3,30],"occurs":[4],"in":[5,47,146,174,191,213,240,247],"~50%":[6],"of":[7,56,74,152,164,207],"metastatic,":[8],"castrate-resistant":[9],"prostate":[10],"cancer":[11],"(mCRPC)":[12],"patients,":[13],"and":[14,19,24,37,62,112,118,123,202,226,236],"associated":[15],"with":[16,84,95,242],"poor":[17],"prognosis":[18],"responsiveness":[20],"to":[21,53,58,63,68,166,170],"standard-of-care":[22],"therapies":[23],"immune":[25],"checkpoint":[26],"inhibitors.":[27],"While":[28],"hyperactivates":[31],"PI3K":[32,99],"signaling,":[33],"combinatorial":[34,66],"PI3K/AKT":[35],"pathway":[36],"androgen":[38],"deprivation":[39],"therapy":[40],"(ADT)":[41],"has":[42],"demonstrated":[43],"limited":[44],"anti-cancer":[45,175,193],"efficacy":[46],"clinical":[48],"trials.":[49],"Here,":[50],"we":[51],"aimed":[52],"elucidate":[54],"mechanism(s)":[55],"resistance":[57],"ADT/PI3K-AKT":[59],"axis":[60],"blockade,":[61],"develop":[64],"rational":[65],"strategies":[67,232],"effectively":[69],"treat":[70],"this":[71],"molecular":[72],"subset":[73],"mCRPC.":[75],"Experimental":[76],"design:":[77],"Prostate-specific":[78],"PTEN/p53-deficient":[79,147],"genetically":[80],"engineered":[81],"mice":[82],"(GEM)":[83],"established":[85],"150-200":[86],"mm3":[87],"tumors,":[88],"as":[89,106],"assessed":[90],"by":[91,116,199,204],"ultrasound,":[92],"were":[93,114],"treated":[94],"either":[96],"ADT":[97],"(degarelix),":[98],"inhibitor":[100],"(copanlisib),":[101],"or":[102,109,126],"anti-PD-1":[103],"antibody":[104],"(aPD-1),":[105],"single":[107],"agents":[108],"their":[110,192],"combinations,":[111],"tumors":[113],"monitored":[115],"MRI":[117],"harvested":[119],"for":[120],"immune,":[121],"transcriptomic":[122],"proteomic":[124],"profiling,":[125],"ex":[127],"vivo":[128],"co-culture":[129],"studies.":[130],"Single-cell":[131,210],"RNAseq":[132],"on":[133],"human":[134],"mCRPC":[135,214,249],"samples":[136,217],"was":[137,197],"performed":[138],"using":[139],"10X":[140],"Genomics":[141],"platform.":[142],"Results:":[143],"Co-clinical":[144],"trials":[145],"GEM":[148],"revealed":[149,218],"that":[150,233],"recruitment":[151],"PD-1-expressing":[153],"tumor-associated":[154],"macrophages":[155],"(TAM)":[156],"thwarts":[157],"ADT/PI3Ki":[158,167],"combination-induced":[159],"tumor":[160,183],"control.":[161],"The":[162],"addition":[163],"aPD-1":[165],"combination":[168,241],"led":[169],"TAM-dependent":[171],"~3-fold":[172],"increase":[173],"responses.":[176],"Mechanistically,":[177],"decreased":[178],"lactate":[179,235],"production":[180],"from":[181],"PI3Ki-treated":[182],"cells":[184],"suppressed":[185],"histone":[186],"lactylation":[187],"within":[188],"TAM,":[189],"resulting":[190],"phagocytic":[194],"activation,":[195],"which":[196],"augmented":[198],"ADT/aPD-1":[200],"treatment":[201],"abrogated":[203],"feedback":[205],"activation":[206],"Wnt/\u03b2-catenin":[208],"pathway.":[209],"RNA-sequencing":[211],"analysis":[212],"patient":[215],"biopsy":[216],"a":[219],"direct":[220],"correlation":[221],"between":[222],"high":[223],"glycolytic":[224],"activity":[225],"TAM":[227,238],"phagocytosis":[228],"suppression.":[229],"Conclusions:":[230],"Immunometabolic":[231],"reverse":[234],"PD-1-mediated":[237],"immunosuppression,":[239],"ADT,":[243],"warrant":[244],"further":[245],"investigation":[246],"PTEN-deficient":[248],"patients.":[250]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2024-09-25T00:00:00"}