{"id":"https://openalex.org/W4402783289","doi":"https://doi.org/10.1016/j.bbadis.2024.167419","title":"How Impaired lysosomal acidification regulates mitochondrial activity and how this crosstalk interferes with aging process","display_name":"How Impaired lysosomal acidification regulates mitochondrial activity and how this crosstalk interferes with aging process","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402783289","doi":"https://doi.org/10.1016/j.bbadis.2024.167419"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbadis.2024.167419","doi":"https://doi.org/10.1016/j.bbadis.2024.167419","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2024.167419","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bbadis.2024.167419","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020520139","display_name":"Vilma A. Sard\u00e3o","orcid":"https://orcid.org/0000-0001-7014-4614","observed_orcids":["https://orcid.org/0000-0001-7014-4614"]},"institutions":[{"id":"https://openalex.org/I4394709155","display_name":"Centro de Neuroci\u00eancias e Biologia Celular","ror":"https://ror.org/01nzkd566","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I4405255207","display_name":"Multidisciplinary Institute of Ageing","ror":"https://ror.org/02r0v5a32","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255207","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Vilma A. Sard\u00e3o","raw_affiliation_strings":["CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal","Multidisciplinary Institute of Aging (MIA-Portugal), University of Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Portugal","institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Multidisciplinary Institute of Aging (MIA-Portugal), University of Coimbra, Portugal","institution_ids":["https://openalex.org/I4405255207","https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006141192","display_name":"Nuno Raimundo","orcid":"https://orcid.org/0000-0002-5988-9129","observed_orcids":["https://orcid.org/0000-0002-5988-9129"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4405255207","display_name":"Multidisciplinary Institute of Ageing","ror":"https://ror.org/02r0v5a32","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255207","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Nuno Raimundo","raw_affiliation_strings":["Multidisciplinary Institute of Aging (MIA-Portugal), University of Coimbra, Portugal","Penn State College of Medicine, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Multidisciplinary Institute of Aging (MIA-Portugal), University of Coimbra, Portugal","institution_ids":["https://openalex.org/I4405255207","https://openalex.org/I76903346"]},{"raw_affiliation_string":"Penn State College of Medicine, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5020520139"],"corresponding_institution_ids":["https://openalex.org/I4394709155","https://openalex.org/I4405255207","https://openalex.org/I76903346"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1870","issue":"8","first_page":"167419","last_page":"167419"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysosomal-acidification","display_name":"lysosomal acidification","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lysosomal-storage-disorders","display_name":"lysosomal storage disease","score":0.8019999861717224},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.597000002861023},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7729418277740479},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6038820743560791},{"id":"https://openalex.org/C19829342","wikidata":"https://www.wikidata.org/wiki/Q855711","display_name":"Ocean acidification","level":3,"score":0.47259029746055603},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.47016188502311707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4384925961494446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2846167981624603},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06791123747825623},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.06584939360618591},{"id":"https://openalex.org/C132651083","wikidata":"https://www.wikidata.org/wiki/Q7942","display_name":"Climate change","level":2,"score":0.060189396142959595},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbadis.2024.167419","doi":"https://doi.org/10.1016/j.bbadis.2024.167419","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2024.167419","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbadis.2024.167419","doi":"https://doi.org/10.1016/j.bbadis.2024.167419","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2024.167419","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G475319455","display_name":null,"funder_award_id":"2022.09311","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3096357470","https://openalex.org/W4402784469","https://openalex.org/W2986554413","https://openalex.org/W7162812298","https://openalex.org/W4401881069","https://openalex.org/W2037118367","https://openalex.org/W2580445004","https://openalex.org/W4390081886","https://openalex.org/W2413097616","https://openalex.org/W167617745"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-22T17:25:34.749102","created_date":"2024-09-25T00:00:00"}