{"id":"https://openalex.org/W4402776402","doi":"https://doi.org/10.1016/j.bbadis.2024.167395","title":"How does the natural compound 7\u03b1-acetoxy-6\u03b2-hydroxyroyleanone (Roy) modulates glioblastoma cells autophagy?","display_name":"How does the natural compound 7\u03b1-acetoxy-6\u03b2-hydroxyroyleanone (Roy) modulates glioblastoma cells autophagy?","publication_year":2024,"publication_date":"2024-09-16","ids":{"openalex":"https://openalex.org/W4402776402","doi":"https://doi.org/10.1016/j.bbadis.2024.167395"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbadis.2024.167395","doi":"https://doi.org/10.1016/j.bbadis.2024.167395","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2024.167395","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.bbadis.2024.167395","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063998179","display_name":"Mariana Magalh\u00e3es","orcid":"https://orcid.org/0000-0002-1874-1611","observed_orcids":["https://orcid.org/0000-0002-1874-1611"]},"institutions":[{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Mariana Magalh\u00e3es","raw_affiliation_strings":["CIBB/UCoimbra, Portugal","CNC/UCoimbra, Portugal","PhD Programme in Experimental Biology and Biomedicine, III/UC, Portugal","iCBR/CACC/FMUC, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBB/UCoimbra, Portugal","institution_ids":["https://openalex.org/I4405252802"]},{"raw_affiliation_string":"CNC/UCoimbra, Portugal","institution_ids":[]},{"raw_affiliation_string":"PhD Programme in Experimental Biology and Biomedicine, III/UC, Portugal","institution_ids":[]},{"raw_affiliation_string":"iCBR/CACC/FMUC, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041812249","display_name":"Pedro A. Dion\u00edsio","orcid":"https://orcid.org/0000-0003-2756-1863","observed_orcids":["https://orcid.org/0000-0003-2756-1863"]},"institutions":[{"id":"https://openalex.org/I4405255207","display_name":"Multidisciplinary Institute of Ageing","ror":"https://ror.org/02r0v5a32","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255207","https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro D\u00edonisio","raw_affiliation_strings":["MIA-Portugal, UCoimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIA-Portugal, UCoimbra, Portugal","institution_ids":["https://openalex.org/I4405255207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100747732","display_name":"Paulo Jorge Oliveira","orcid":"https://orcid.org/0000-0002-5201-9948","observed_orcids":["https://orcid.org/0000-0002-5201-9948"]},"institutions":[{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paulo J. Oliveira","raw_affiliation_strings":["CIBB/UCoimbra, Portugal","CNC/UCoimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBB/UCoimbra, Portugal","institution_ids":["https://openalex.org/I4405252802"]},{"raw_affiliation_string":"CNC/UCoimbra, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033575797","display_name":"Thomas Efferth","orcid":"https://orcid.org/0000-0002-2637-1681","observed_orcids":["https://orcid.org/0000-0002-2637-1681"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Efferth","raw_affiliation_strings":["Johannes Gutenberg University, Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johannes Gutenberg University, Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012111165","display_name":"Patr\u00edcia  Mendonca Rijo","orcid":"https://orcid.org/0000-0001-7992-8343","observed_orcids":["https://orcid.org/0000-0001-7992-8343"]},"institutions":[{"id":"https://openalex.org/I4405254910","display_name":"Centro de Investiga\u00e7\u00e3o em Bioci\u00eancias e Tecnologias da Sa\u00fade","ror":"https://ror.org/02cpgaz56","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405254910","https://openalex.org/I88596544"]},{"id":"https://openalex.org/I88596544","display_name":"Universidade Lus\u00f3fona","ror":"https://ror.org/05xxfer42","country_code":"PT","type":"education","lineage":["https://openalex.org/I88596544"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Patr\u00edcia Rijo","raw_affiliation_strings":["CBIOS\u2014Universidade Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, Lisbon, Portugal","Faculty of Pharmacy, iMed.ULisboa, ULisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CBIOS\u2014Universidade Lus\u00f3fona\u2019s Research Center for Biosciences & Health Technologies, Lisbon, Portugal","institution_ids":["https://openalex.org/I4405254910","https://openalex.org/I88596544"]},{"raw_affiliation_string":"Faculty of Pharmacy, iMed.ULisboa, ULisbon, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006141192","display_name":"Nuno Raimundo","orcid":"https://orcid.org/0000-0002-5988-9129","observed_orcids":["https://orcid.org/0000-0002-5988-9129"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]},{"id":"https://openalex.org/I4405255207","display_name":"Multidisciplinary Institute of Ageing","ror":"https://ror.org/02r0v5a32","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4405255207","https://openalex.org/I76903346"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Nuno Raimundo","raw_affiliation_strings":["MIA-Portugal, UCoimbra, Portugal","Penn State College of Medicine, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIA-Portugal, UCoimbra, Portugal","institution_ids":["https://openalex.org/I4405255207"]},{"raw_affiliation_string":"Penn State College of Medicine, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046438933","display_name":"C\u00e9lia Cabral","orcid":"https://orcid.org/0000-0003-4562-6683","observed_orcids":["https://orcid.org/0000-0003-4562-6683"]},"institutions":[{"id":"https://openalex.org/I4405252802","display_name":"Centro de Inova\u00e7\u00e3o em Biomedicina e Biotecnologia","ror":"https://ror.org/01t5ta457","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252802","https://openalex.org/I76903346"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"C\u00e9lia Cabral","raw_affiliation_strings":["CFE/UCoimbra, Portugal","CIBB/UCoimbra, Portugal","iCBR/CACC/FMUC, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CFE/UCoimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"CIBB/UCoimbra, Portugal","institution_ids":["https://openalex.org/I4405252802"]},{"raw_affiliation_string":"iCBR/CACC/FMUC, Portugal","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5063998179"],"corresponding_institution_ids":["https://openalex.org/I4405252802"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1870","issue":"8","first_page":"167395","last_page":"167395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/royleanone","display_name":"royleanone","score":0.7590000033378601},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.875},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8259999752044678},{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.8230000138282776},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6169999837875366},{"id":"https://openalex.org/keywords/autophagy-modulation","display_name":"autophagy modulation","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9242371916770935},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.8771694898605347},{"id":"https://openalex.org/C2993469326","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural compound","level":2,"score":0.4946865737438202},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.4892425537109375},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4516351819038391},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4394341707229614},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3252601623535156},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24392816424369812},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19082647562026978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16972237825393677},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10358846187591553},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.0856630802154541},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.bbadis.2024.167395","doi":"https://doi.org/10.1016/j.bbadis.2024.167395","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2024.167395","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.bbadis.2024.167395","doi":"https://doi.org/10.1016/j.bbadis.2024.167395","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bbadis.2024.167395","pdf_url":null,"source":{"id":"https://openalex.org/S4210173099","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","issn_l":"0925-4439","issn":["0925-4439","1879-260X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7371858053","display_name":"Targeting glioblastoma: a novel therapeutic approach based on natural products","funder_award_id":"SFRH/BD/146441/2019","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408444376","https://openalex.org/W7128784894","https://openalex.org/W4405611745","https://openalex.org/W4401526145","https://openalex.org/W1980687166","https://openalex.org/W2972273695","https://openalex.org/W7096868621","https://openalex.org/W6946416671","https://openalex.org/W1494447887","https://openalex.org/W3111489325"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-25T00:00:00"}