{"id":"https://openalex.org/W4402632748","doi":"https://doi.org/10.1016/j.biopsych.2024.09.009","title":"Noradrenergic Mechanisms and Circuitry of Hyperkatifeia in Alcohol Use Disorder","display_name":"Noradrenergic Mechanisms and Circuitry of Hyperkatifeia in Alcohol Use Disorder","publication_year":2024,"publication_date":"2024-09-19","ids":{"openalex":"https://openalex.org/W4402632748","doi":"https://doi.org/10.1016/j.biopsych.2024.09.009","pmid":"https://pubmed.ncbi.nlm.nih.gov/39304172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11839382"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2024.09.009","doi":"https://doi.org/10.1016/j.biopsych.2024.09.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2024.09.009","pdf_url":"https://www.biologicalpsychiatryjournal.com/article/S0006-3223(24)01609-3/pdf","source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.biologicalpsychiatryjournal.com/article/S0006-3223(24)01609-3/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067528131","display_name":"Florence P. Varodayan","orcid":"https://orcid.org/0009-0000-1644-9767","observed_orcids":["https://orcid.org/0009-0000-1644-9767"]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Florence P. Varodayan","raw_affiliation_strings":["Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University, SUNY, Binghamton, New York. Electronic address: fvaroday@binghamton.edu","Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA. Electronic address: fvaroday@binghamton.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University, SUNY, Binghamton, New York. Electronic address: fvaroday@binghamton.edu","institution_ids":["https://openalex.org/I123946342"]},{"raw_affiliation_string":"Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA. Electronic address: fvaroday@binghamton.edu","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029649378","display_name":"Chloe Michelle Erikson","orcid":"https://orcid.org/0009-0007-1993-1752","observed_orcids":["https://orcid.org/0009-0007-1993-1752"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chloe M. Erikson","raw_affiliation_strings":["Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California","Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107605407","display_name":"Marcis V. Scroger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123946342","display_name":"Binghamton University","ror":"https://ror.org/008rmbt77","country_code":"US","type":"education","lineage":["https://openalex.org/I123946342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcis V. Scroger","raw_affiliation_strings":["Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University, SUNY, Binghamton, New York","Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University, SUNY, Binghamton, New York","institution_ids":["https://openalex.org/I123946342"]},{"raw_affiliation_string":"Developmental Exposure Alcohol Research Center and Behavioral Neuroscience Program, Department of Psychology, Binghamton University - SUNY, 4400 Vestal Parkway East, Binghamton, NY, 13902, USA","institution_ids":["https://openalex.org/I123946342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060479945","display_name":"Marisa Roberto","orcid":"https://orcid.org/0000-0003-0729-3961","observed_orcids":["https://orcid.org/0000-0003-0729-3961"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marisa Roberto","raw_affiliation_strings":["Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California. Electronic address: mroberto@scripps.edu","Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. Electronic address: mroberto@scripps.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California. Electronic address: mroberto@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. Electronic address: mroberto@scripps.edu","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060479945","https://openalex.org/A5067528131"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I123946342"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":0.8234,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.64221364,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"97","issue":"6","first_page":"580","last_page":"589"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.6601999998092651,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.3174000084400177,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.996999979019165},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/noradrenergic-dysfunction","display_name":"noradrenergic dysfunction","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alcohol-withdrawal-syndrome","display_name":"alcohol withdrawal","score":0.9440000057220459},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.7960000038146973},{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"sexual dimorphism","score":0.6340000033378601},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6019999980926514},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.718999981880188},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5557469725608826},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5505488514900208},{"id":"https://openalex.org/C2779442783","wikidata":"https://www.wikidata.org/wiki/Q15326","display_name":"Alcohol use disorder","level":3,"score":0.5497888326644897},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4218064844608307},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.32362574338912964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14069929718971252},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.biopsych.2024.09.009","doi":"https://doi.org/10.1016/j.biopsych.2024.09.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2024.09.009","pdf_url":"https://www.biologicalpsychiatryjournal.com/article/S0006-3223(24)01609-3/pdf","source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11839382","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11839382/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11839382/pdf/nihms-2038268.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biol Psychiatry","raw_type":"Text"},{"id":"pmid:39304172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39304172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biopsych.2024.09.009","doi":"https://doi.org/10.1016/j.biopsych.2024.09.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2024.09.009","pdf_url":"https://www.biologicalpsychiatryjournal.com/article/S0006-3223(24)01609-3/pdf","source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G170229325","display_name":null,"funder_award_id":"AA025408","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G1902745206","display_name":null,"funder_award_id":"R37-AA017447","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G194875419","display_name":null,"funder_award_id":"AA017447","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G1990489264","display_name":"Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependence","funder_award_id":"R01AA021491","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5294059471","display_name":"Alcohol-induced neuroadapation of prefrontal cortical projections","funder_award_id":"R00AA025408","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G6766161928","display_name":"Neuroimmune mechanisms in stress and alcohol comorbidity","funder_award_id":"R01AA027700","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7445688726","display_name":"Neuroimmune mechanisms of adult chronic ethanol consumption","funder_award_id":"R21AA031101","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7483800461","display_name":"Alcohol-induced neuroadapation of prefrontal cortical projections","funder_award_id":"K99AA025408","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8526286588","display_name":"Gene-environment interaction: the brain CRF system in alcohol preferring msP rats","funder_award_id":"R01AA017447","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000858503","display_name":"9/10 Electrophysiology of Alcohol in Extended Amygdala","funder_award_id":"U01AA013498","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000861062","display_name":"Synaptic Mechanisms underlying sex-differences in alcohol use disorder","funder_award_id":"R01AA029841","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000880038","display_name":"NEUROPSYCHOPHARMACOLOGY: MULTIDISCIPLINARY TRAINING","funder_award_id":"T32AA007456","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000910499","display_name":"Gene-environment interaction: the brain CRF system in alcohol preferring msP rats","funder_award_id":"5r37aa017447-15","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000913995","display_name":"Developmental Exposure Alcohol Research Center","funder_award_id":"P50AA017823","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G9000917812","display_name":"CNS Effects of Alcohol: Cellular Neurobiology","funder_award_id":"P60AA006420","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402632748.pdf","grobid_xml":"https://content.openalex.org/works/W4402632748.grobid-xml"},"referenced_works_count":144,"referenced_works":["https://openalex.org/W286021848","https://openalex.org/W580921785","https://openalex.org/W1488246691","https://openalex.org/W1506979081","https://openalex.org/W1516025158","https://openalex.org/W1546738173","https://openalex.org/W1603807626","https://openalex.org/W1604468358","https://openalex.org/W1731924710","https://openalex.org/W1745700293","https://openalex.org/W1770093059","https://openalex.org/W1805631454","https://openalex.org/W1812829056","https://openalex.org/W1860129028","https://openalex.org/W1890045606","https://openalex.org/W1922402201","https://openalex.org/W1967100996","https://openalex.org/W1970210021","https://openalex.org/W1971245339","https://openalex.org/W1974383964","https://openalex.org/W1974784105","https://openalex.org/W1975327913","https://openalex.org/W1978125276","https://openalex.org/W1980680669","https://openalex.org/W1980751228","https://openalex.org/W1982713269","https://openalex.org/W1983095834","https://openalex.org/W1985339809","https://openalex.org/W1989623523","https://openalex.org/W1993426894","https://openalex.org/W1996880759","https://openalex.org/W2002071549","https://openalex.org/W2004680767","https://openalex.org/W2006974405","https://openalex.org/W2009870425","https://openalex.org/W2011829440","https://openalex.org/W2024398740","https://openalex.org/W2027285935","https://openalex.org/W2030325164","https://openalex.org/W2030839682","https://openalex.org/W2033749889","https://openalex.org/W2039548603","https://openalex.org/W2041163143","https://openalex.org/W2053805891","https://openalex.org/W2054401586","https://openalex.org/W2066788685","https://openalex.org/W2068763397","https://openalex.org/W2069798616","https://openalex.org/W2072492572","https://openalex.org/W2080894664","https://openalex.org/W2084664557","https://openalex.org/W2085425790","https://openalex.org/W2086278380","https://openalex.org/W2093672376","https://openalex.org/W2098508105","https://openalex.org/W2101795926","https://openalex.org/W2114960819","https://openalex.org/W2115084317","https://openalex.org/W2123753609","https://openalex.org/W2123808389","https://openalex.org/W2134015193","https://openalex.org/W2136636160","https://openalex.org/W2137803188","https://openalex.org/W2144929234","https://openalex.org/W2146478352","https://openalex.org/W2147748411","https://openalex.org/W2153131480","https://openalex.org/W2157643754","https://openalex.org/W2166059093","https://openalex.org/W2176880930","https://openalex.org/W2177596836","https://openalex.org/W2181055835","https://openalex.org/W2181462941","https://openalex.org/W2193305094","https://openalex.org/W2193828563","https://openalex.org/W2235063867","https://openalex.org/W2236348940","https://openalex.org/W2283360045","https://openalex.org/W2288850542","https://openalex.org/W2303872853","https://openalex.org/W2336009356","https://openalex.org/W2528260044","https://openalex.org/W2551270820","https://openalex.org/W2584847302","https://openalex.org/W2587859190","https://openalex.org/W2604282481","https://openalex.org/W2614277232","https://openalex.org/W2741261712","https://openalex.org/W2774966835","https://openalex.org/W2791932649","https://openalex.org/W2793137269","https://openalex.org/W2798178492","https://openalex.org/W2799706425","https://openalex.org/W2802439163","https://openalex.org/W2804904418","https://openalex.org/W2884197960","https://openalex.org/W2887258867","https://openalex.org/W2889479634","https://openalex.org/W2894909937","https://openalex.org/W2898914644","https://openalex.org/W2899845017","https://openalex.org/W2904305025","https://openalex.org/W2914644197","https://openalex.org/W2976862480","https://openalex.org/W2992043281","https://openalex.org/W3032283791","https://openalex.org/W3037055231","https://openalex.org/W3037468054","https://openalex.org/W3044084373","https://openalex.org/W3082075382","https://openalex.org/W3097574686","https://openalex.org/W3111225216","https://openalex.org/W3118534613","https://openalex.org/W3130287913","https://openalex.org/W3130482867","https://openalex.org/W3135741627","https://openalex.org/W3155878774","https://openalex.org/W3174230726","https://openalex.org/W3179970520","https://openalex.org/W3182120581","https://openalex.org/W3184619240","https://openalex.org/W3197859851","https://openalex.org/W3199212347","https://openalex.org/W3215163921","https://openalex.org/W3216214053","https://openalex.org/W4205700827","https://openalex.org/W4213123346","https://openalex.org/W4213391849","https://openalex.org/W4221005088","https://openalex.org/W4221071133","https://openalex.org/W4224041854","https://openalex.org/W4293758661","https://openalex.org/W4294203095","https://openalex.org/W4297973302","https://openalex.org/W4313246624","https://openalex.org/W4315486433","https://openalex.org/W4366224705","https://openalex.org/W4367185513","https://openalex.org/W4383603011","https://openalex.org/W4387917629","https://openalex.org/W4387937652","https://openalex.org/W4392869087","https://openalex.org/W4404415684","https://openalex.org/W6842520769"],"related_works":["https://openalex.org/W4413765407","https://openalex.org/W7165163077","https://openalex.org/W2793137269","https://openalex.org/W2802439163","https://openalex.org/W4224041854","https://openalex.org/W7133570246","https://openalex.org/W2358967852","https://openalex.org/W3092102654","https://openalex.org/W4225493849","https://openalex.org/W2506728349"],"abstract_inverted_index":{"Hyperkatifeia,":[0],"the":[1,15,50,67,88,94,134,143,154,170,179,188,198,206],"manifestation":[2],"of":[3,26,52,61,64,69,96,109,147,169,181,190,200],"emotional":[4,123],"distress":[5],"or":[6,34,213,219],"pain,":[7],"is":[8,29,66,108,114],"a":[9],"conceptual":[10],"framework":[11],"gaining":[12],"traction":[13],"throughout":[14],"alcohol":[16,46,54],"and":[17,48,98,122,124,145,151,160,176,197],"other":[18],"substance":[19],"use":[20,55],"fields":[21],"as":[22,41],"an":[23,53],"important":[24],"driver":[25],"addiction.":[27],"It":[28],"well":[30,76],"known":[31],"that":[32,91,137,203],"previous":[33],"current":[35,155],"negative":[36],"life":[37],"experiences":[38],"can":[39,74,100],"serve":[40],"powerful":[42],"motivators":[43],"for":[44],"excessive":[45],"consumption":[47],"precipitate":[49],"development":[51,144,193],"disorder":[56],"(AUD).":[57],"A":[58],"major":[59],"hallmark":[60],"later":[62],"stages":[63],"AUD":[65,99,148,171,196,201],"emergence":[68],"hyperkatifeia":[70,97],"during":[71],"withdrawal,":[72],"which":[73],"persist":[75],"into":[77],"protracted":[78],"abstinence":[79],"to":[80,140,194],"drive":[81],"relapse.":[82],"Given":[83],"these":[84,185,209],"complex":[85],"interactions,":[86],"understanding":[87],"specific":[89],"neuroadaptations":[90],"lie":[92],"at":[93,166],"intersection":[95],"inform":[101],"ongoing":[102],"therapeutic":[103],"development.":[104],"The":[105],"monoamine":[106],"norepinephrine":[107],"particular":[110],"interest.":[111],"Noradrenergic":[112],"dysfunction":[113],"implicated":[115],"in":[116,149],"AUD,":[117],"anxiety,":[118],"chronic":[119,217],"stress,":[120],"depression,":[121],"physical":[125],"pain.":[126],"Importantly,":[127],"there":[128],"are":[129,138],"key":[130],"sexual":[131],"dimorphisms":[132],"within":[133],"noradrenergic":[135,164],"system":[136],"thought":[139],"differentially":[141],"impact":[142],"trajectory":[146],"women":[150,212],"men.":[152],"In":[153],"review,":[156],"we":[157],"discuss":[158],"past":[159],"recent":[161],"work":[162],"on":[163],"influences":[165],"each":[167],"stage":[168],"cycle":[172],"(binge/intoxication,":[173],"withdrawal/negative":[174],"affect,":[175],"preoccupation/anticipation)":[177],"through":[178],"lens":[180],"hyperkatifeia.":[182],"Evidence":[183],"from":[184,208],"studies":[186],"support":[187],"prioritization":[189],"norepinephrine-specific":[191],"drug":[192],"treat":[195],"identification":[199],"subpopulations":[202],"may":[204],"benefit":[205],"most":[207],"therapies":[210],"(e.g.,":[211],"people":[214],"with":[215],"comorbid":[216],"pain":[218],"anxiety/stress":[220],"disorders).":[221]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-09-20T00:00:00"}