{"id":"https://openalex.org/W4402604697","doi":"https://doi.org/10.1016/j.bioorg.2024.107827","title":"Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation","display_name":"Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation","publication_year":2024,"publication_date":"2024-09-18","ids":{"openalex":"https://openalex.org/W4402604697","doi":"https://doi.org/10.1016/j.bioorg.2024.107827","pmid":"https://pubmed.ncbi.nlm.nih.gov/39321715"},"language":"en","primary_location":{"id":"doi:10.1016/j.bioorg.2024.107827","doi":"https://doi.org/10.1016/j.bioorg.2024.107827","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2024.107827","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053115785","display_name":"Ateyatallah Aljuhani","orcid":"https://orcid.org/0000-0001-7305-8674","observed_orcids":["https://orcid.org/0000-0001-7305-8674"]},"institutions":[{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ateyatallah Aljuhani","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: ateyatallah@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: ateyatallah@hotmail.com","institution_ids":["https://openalex.org/I23075662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030714417","display_name":"Mohamed S. Nafie","orcid":"https://orcid.org/0000-0003-4454-6390","observed_orcids":["https://orcid.org/0000-0003-4454-6390"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]},{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE","EG"],"is_corresponding":true,"raw_author_name":"Mohamed S. Nafie","raw_affiliation_strings":["Department of Chemistry, College of Sciences, University of Sharjah, Sharjah P.O. 27272, United Arab Emirates (UAE); Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, P.O. 41522, Egypt. Electronic address: mohamed.elsayed@sharjah.ac.ae"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Sciences, University of Sharjah, Sharjah P.O. 27272, United Arab Emirates (UAE); Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, P.O. 41522, Egypt. Electronic address: mohamed.elsayed@sharjah.ac.ae","institution_ids":["https://openalex.org/I114794399","https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004553964","display_name":"Nader R. Albujuq","orcid":"https://orcid.org/0000-0002-3089-7037","observed_orcids":["https://orcid.org/0000-0002-3089-7037"]},"institutions":[{"id":"https://openalex.org/I114972647","display_name":"University of Jordan","ror":"https://ror.org/05k89ew48","country_code":"JO","type":"education","lineage":["https://openalex.org/I114972647"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"Nader R. Albujuq","raw_affiliation_strings":["Department of Chemistry, School of Science, The University of Jordan, Amman 11942, Jordan. Electronic address: n.albujuq@ju.edu.jo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, School of Science, The University of Jordan, Amman 11942, Jordan. Electronic address: n.albujuq@ju.edu.jo","institution_ids":["https://openalex.org/I114972647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077186087","display_name":"Wafa Hourani","orcid":"https://orcid.org/0000-0002-2809-741X","observed_orcids":["https://orcid.org/0000-0002-2809-741X"]},"institutions":[{"id":"https://openalex.org/I153921779","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149","country_code":"JO","type":"education","lineage":["https://openalex.org/I153921779"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Wafa Hourani","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan. Electronic address: Whourani@philadelphia.edu.jo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman 19392, Jordan. Electronic address: Whourani@philadelphia.edu.jo","institution_ids":["https://openalex.org/I153921779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068415198","display_name":"Fawzia Faleh Albelwi","orcid":"https://orcid.org/0009-0006-5292-600X","observed_orcids":["https://orcid.org/0009-0006-5292-600X"]},"institutions":[{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Fawzia F. Albelwi","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: fbalawi@taibahu.edu.sa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: fbalawi@taibahu.edu.sa","institution_ids":["https://openalex.org/I23075662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036561963","display_name":"Khaled Mohamed Darwish","orcid":"https://orcid.org/0000-0002-0597-482X","observed_orcids":["https://orcid.org/0000-0002-0597-482X"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]},{"id":"https://openalex.org/I4400009028","display_name":"Galala University","ror":"https://ror.org/04x3ne739","country_code":"EG","type":"education","lineage":["https://openalex.org/I4400009028"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Khaled M. Darwish","raw_affiliation_strings":["Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University, New Galala 43713, Egypt. Electronic address: Khaled_darwish@pharm.suez.edu.eg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University, New Galala 43713, Egypt. Electronic address: Khaled_darwish@pharm.suez.edu.eg","institution_ids":["https://openalex.org/I114794399","https://openalex.org/I4400009028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135407588","display_name":"Aya Samir Ayed","orcid":"https://orcid.org/0000-0002-9371-3274","observed_orcids":["https://orcid.org/0000-0002-9371-3274"]},"institutions":[{"id":"https://openalex.org/I114794399","display_name":"Suez Canal University","ror":"https://ror.org/02m82p074","country_code":"EG","type":"education","lineage":["https://openalex.org/I114794399"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Aya Samir Ayed","raw_affiliation_strings":["Zoology Department, Faculty of Science, Suez Canal University, Ismailia, P.O. 41522, Egypt. Electronic address: Aya_Abdul-Latif@science.suez.edu.eg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Suez Canal University, Ismailia, P.O. 41522, Egypt. Electronic address: Aya_Abdul-Latif@science.suez.edu.eg","institution_ids":["https://openalex.org/I114794399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066603539","display_name":"Mohamed Reda Aouad","orcid":"https://orcid.org/0000-0001-7018-6654","observed_orcids":["https://orcid.org/0000-0001-7018-6654","https://orcid.org/0000-0002-1065-8741"]},"institutions":[{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Mohamed Reda Aouad","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: aouadmohamedreda@yahoo.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: aouadmohamedreda@yahoo.fr","institution_ids":["https://openalex.org/I23075662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017482073","display_name":"Nadjet Rezki","orcid":"https://orcid.org/0000-0001-8330-1738","observed_orcids":["https://orcid.org/0000-0001-8330-1738","https://orcid.org/0000-0002-8747-9848"]},"institutions":[{"id":"https://openalex.org/I23075662","display_name":"Taibah University","ror":"https://ror.org/01xv1nn60","country_code":"SA","type":"education","lineage":["https://openalex.org/I23075662"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Nadjet Rezki","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: nadjetrezki@yahoo.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 41477, Saudi Arabia. Electronic address: nadjetrezki@yahoo.fr","institution_ids":["https://openalex.org/I23075662"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5004553964","https://openalex.org/A5030714417","https://openalex.org/A5066603539"],"corresponding_institution_ids":["https://openalex.org/I114794399","https://openalex.org/I114972647","https://openalex.org/I23075662","https://openalex.org/I29891158"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":1.3742,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.76523697,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"153","issue":null,"first_page":"107827","last_page":"107827"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.850600004196167,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfonamide-derivatives","display_name":"sulfonamide derivatives","score":0.8690000176429749},{"id":"https://openalex.org/keywords/tubulin-polymerization-inhibitors","display_name":"tubulin polymerization inhibitors","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.890999972820282},{"id":"https://openalex.org/keywords/pc-3-cells","display_name":"PC-3 cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/click-chemistry","display_name":"click chemistry","score":0.7080000042915344},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.859000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7080000042915344},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8442983627319336},{"id":"https://openalex.org/C2778522978","wikidata":"https://www.wikidata.org/wiki/Q412784","display_name":"Phthalimide","level":2,"score":0.7906754016876221},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.7622711658477783},{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.6189403533935547},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5629668831825256},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5099261999130249},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4936255216598511},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4840335249900818},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4747645854949951},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.45469748973846436},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34978151321411133},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3406325578689575},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2736157178878784},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2168559432029724},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.19768181443214417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08132514357566833},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06985816359519958},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010797","descriptor_name":"Phthalimides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050257","descriptor_name":"Tubulin Modulators","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D050257","descriptor_name":"Tubulin Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D050257","descriptor_name":"Tubulin Modulators","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bioorg.2024.107827","doi":"https://doi.org/10.1016/j.bioorg.2024.107827","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bioorg.2024.107827","pdf_url":null,"source":{"id":"https://openalex.org/S165482960","display_name":"Bioorganic Chemistry","issn_l":"0045-2068","issn":["0045-2068","1090-2120"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:39321715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39321715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":100,"referenced_works":["https://openalex.org/W1246208357","https://openalex.org/W1431736806","https://openalex.org/W1918363244","https://openalex.org/W1951129168","https://openalex.org/W1964979835","https://openalex.org/W1967072219","https://openalex.org/W1970785155","https://openalex.org/W1977851521","https://openalex.org/W1979555734","https://openalex.org/W1998236197","https://openalex.org/W1999142756","https://openalex.org/W2010490135","https://openalex.org/W2021860357","https://openalex.org/W2025556769","https://openalex.org/W2031242198","https://openalex.org/W2041158925","https://openalex.org/W2051828492","https://openalex.org/W2062458432","https://openalex.org/W2064571598","https://openalex.org/W2068017935","https://openalex.org/W2069386788","https://openalex.org/W2095072642","https://openalex.org/W2100906891","https://openalex.org/W2114918609","https://openalex.org/W2115764471","https://openalex.org/W2134967712","https://openalex.org/W2141528038","https://openalex.org/W2147594462","https://openalex.org/W2160310346","https://openalex.org/W2163339619","https://openalex.org/W2175736881","https://openalex.org/W2294903584","https://openalex.org/W2525848376","https://openalex.org/W2534223538","https://openalex.org/W2575108092","https://openalex.org/W2608143906","https://openalex.org/W2613041741","https://openalex.org/W2732263607","https://openalex.org/W2737167828","https://openalex.org/W2755958285","https://openalex.org/W2796161712","https://openalex.org/W2796186636","https://openalex.org/W2804079332","https://openalex.org/W2883204749","https://openalex.org/W2886512250","https://openalex.org/W2898112932","https://openalex.org/W2898130978","https://openalex.org/W2899039891","https://openalex.org/W2921799967","https://openalex.org/W2927193186","https://openalex.org/W2943520781","https://openalex.org/W2954167186","https://openalex.org/W2972484391","https://openalex.org/W2980186852","https://openalex.org/W2981181140","https://openalex.org/W2990686724","https://openalex.org/W2996972660","https://openalex.org/W2998032090","https://openalex.org/W3013159739","https://openalex.org/W3047741809","https://openalex.org/W3048751077","https://openalex.org/W3080652418","https://openalex.org/W3082162976","https://openalex.org/W3083258145","https://openalex.org/W3087165576","https://openalex.org/W3088336870","https://openalex.org/W3089977222","https://openalex.org/W3094146848","https://openalex.org/W3107158150","https://openalex.org/W3116593879","https://openalex.org/W3120447760","https://openalex.org/W3125875309","https://openalex.org/W3134572664","https://openalex.org/W3137153669","https://openalex.org/W3163093113","https://openalex.org/W3166467481","https://openalex.org/W3199081935","https://openalex.org/W3208675162","https://openalex.org/W4200228992","https://openalex.org/W4200510503","https://openalex.org/W4200556801","https://openalex.org/W4214775203","https://openalex.org/W4220776133","https://openalex.org/W4296098312","https://openalex.org/W4296743093","https://openalex.org/W4306913084","https://openalex.org/W4309046299","https://openalex.org/W4312125591","https://openalex.org/W4318939459","https://openalex.org/W4321376128","https://openalex.org/W4382725084","https://openalex.org/W4384341051","https://openalex.org/W4385497114","https://openalex.org/W4385520939","https://openalex.org/W4386000781","https://openalex.org/W4388734775","https://openalex.org/W4389619340","https://openalex.org/W4390452901","https://openalex.org/W4390597691","https://openalex.org/W4393935425"],"related_works":["https://openalex.org/W2804089639","https://openalex.org/W2994860726","https://openalex.org/W2605478904","https://openalex.org/W1988940287","https://openalex.org/W6977030627","https://openalex.org/W3130413441","https://openalex.org/W4287877617","https://openalex.org/W3137153669","https://openalex.org/W3088336870","https://openalex.org/W3165907462"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2024-09-19T00:00:00"}