{"id":"https://openalex.org/W4402600971","doi":"https://doi.org/10.1007/s00535-024-02150-7","title":"CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study","display_name":"CRAFITY score as a predictive marker for refractoriness to atezolizumab plus bevacizumab therapy in hepatocellular carcinoma: a multicenter retrospective study","publication_year":2024,"publication_date":"2024-09-18","ids":{"openalex":"https://openalex.org/W4402600971","doi":"https://doi.org/10.1007/s00535-024-02150-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/39289234","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11541291"},"language":"en","primary_location":{"id":"doi:10.1007/s00535-024-02150-7","doi":"https://doi.org/10.1007/s00535-024-02150-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00535-024-02150-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00535-024-02150-7.pdf","source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00535-024-02150-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083177175","display_name":"Masayuki Ueno","orcid":"https://orcid.org/0000-0002-2497-9327","observed_orcids":["https://orcid.org/0000-0002-2497-9327"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Ueno","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki, Japan"],"raw_orcid":"https://orcid.org/0000-0002-2497-9327","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki, Japan","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000486174","display_name":"Haruhiko Takeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruhiko Takeda","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053697171","display_name":"Atsushi Takai","orcid":"https://orcid.org/0000-0002-5233-4120","observed_orcids":["https://orcid.org/0000-0002-5233-4120"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Takai","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. atsushit@kuhp.kyoto-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-5233-4120","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan. atsushit@kuhp.kyoto-u.ac.jp","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077106327","display_name":"Hiroki Morimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210151887","display_name":"Osaka Red Cross Hospital","ror":"https://ror.org/05h4q5j46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210151887"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Morimura","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210151887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113966906","display_name":"Norihiro Nishijima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283158","display_name":"Meiwa Hospital","ror":"https://ror.org/0141nsn41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283158"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norihiro Nishijima","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Meiwa Hospital, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Meiwa Hospital, Nishinomiya, Japan","institution_ids":["https://openalex.org/I4405283158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026181571","display_name":"Satoru Iwamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017590076","display_name":"Kyoto Medical Center","ror":"https://ror.org/045kb1d14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3017590076","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoru Iwamoto","raw_affiliation_strings":["Department of Gastroenterology, Kyoto Medical Center, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Kyoto Medical Center, Kyoto, Japan","institution_ids":["https://openalex.org/I3017590076"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shunsuke Okuyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shunsuke Okuyama","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki, Japan","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Makoto Umeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134765","display_name":"Hyogo Prefectural Amagasaki General Medical Center","ror":"https://ror.org/04e8mq383","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210134765"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Umeda","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan","institution_ids":["https://openalex.org/I4210134765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032526114","display_name":"Takeshi Seta","orcid":"https://orcid.org/0000-0002-3057-6284","observed_orcids":["https://orcid.org/0000-0002-3057-6284"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4210156364","display_name":"Japanese Red Cross Society Wakayama Medical Center","ror":"https://ror.org/05ajyt645","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210156364"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Seta","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan","Department of Health Informatics, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan","institution_ids":["https://openalex.org/I4210156364"]},{"raw_affiliation_string":"Department of Health Informatics, Graduate School of Medicine and School of Public Health, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084454250","display_name":"Atsuyuki Ikeda","orcid":"https://orcid.org/0000-0002-0933-3106","observed_orcids":["https://orcid.org/0000-0002-0933-3106"]},"institutions":[{"id":"https://openalex.org/I4210140509","display_name":"Kyoto Katsura Hospital","ror":"https://ror.org/04w3ve464","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210140509"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsuyuki Ikeda","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Kyoto Katsura Hospital, Kyoto, Japan","institution_ids":["https://openalex.org/I4210140509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084965625","display_name":"Tomoyuki Got\u014d","orcid":"https://orcid.org/0000-0003-0754-4724","observed_orcids":["https://orcid.org/0000-0003-0754-4724","https://orcid.org/0009-0000-0972-2067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tomoyuki Goto","raw_affiliation_strings":["Department of Medical Oncology, Shiga General Hospital, Moriyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Shiga General Hospital, Moriyama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036937060","display_name":"Shin\u2019ichi Miyamoto","orcid":"https://orcid.org/0000-0003-2298-0970","observed_orcids":["https://orcid.org/0000-0003-2298-0970"]},"institutions":[{"id":"https://openalex.org/I3017590076","display_name":"Kyoto Medical Center","ror":"https://ror.org/045kb1d14","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I3017590076","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shin\u2019ichi Miyamoto","raw_affiliation_strings":["Department of Gastroenterology, Kyoto Medical Center, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Kyoto Medical Center, Kyoto, Japan","institution_ids":["https://openalex.org/I3017590076"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031550720","display_name":"Takahisa Kayahara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089671","display_name":"Kurashiki Central Hospital","ror":"https://ror.org/00947s692","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210089671"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahisa Kayahara","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, Kurashiki, Japan","institution_ids":["https://openalex.org/I4210089671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056549460","display_name":"Yoshito Uenoyama","orcid":"https://orcid.org/0000-0003-4967-0059","observed_orcids":["https://orcid.org/0000-0003-4967-0059"]},"institutions":[{"id":"https://openalex.org/I4210156364","display_name":"Japanese Red Cross Society Wakayama Medical Center","ror":"https://ror.org/05ajyt645","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210156364"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshito Uenoyama","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan","institution_ids":["https://openalex.org/I4210156364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114041602","display_name":"Kazuyoshi Matsumura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuyoshi Matsumura","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Shiga General Hospital, Moriyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Shiga General Hospital, Moriyama, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014352823","display_name":"Shigeharu Nakano","orcid":"https://orcid.org/0000-0002-1008-459X","observed_orcids":["https://orcid.org/0000-0002-1008-459X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeharu Nakano","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006225276","display_name":"Masako Mishima","orcid":"https://orcid.org/0000-0001-6997-2084","observed_orcids":["https://orcid.org/0000-0001-6997-2084"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Mishima","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967342","display_name":"Tadashi Inuzuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Inuzuka","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001467370","display_name":"Yuji Eso","orcid":"https://orcid.org/0000-0003-4426-1491","observed_orcids":["https://orcid.org/0000-0003-4426-1491"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Eso","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101682699","display_name":"Ken Takahashi","orcid":"https://orcid.org/0000-0002-9592-4200","observed_orcids":["https://orcid.org/0000-0002-9592-4200"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405286405","display_name":"Center for Cancer Immunotherapy and Immunobiology, Kyoto University","ror":"https://ror.org/02246td81","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405286405"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Takahashi","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","Division of Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Division of Cancer Immunotherapy, Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405286405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080250007","display_name":"Hiroyuki Marusawa","orcid":"https://orcid.org/0000-0002-4286-2712","observed_orcids":["https://orcid.org/0000-0002-4286-2712"]},"institutions":[{"id":"https://openalex.org/I4210151887","display_name":"Osaka Red Cross Hospital","ror":"https://ror.org/05h4q5j46","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2799517759","https://openalex.org/I4210151887"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Marusawa","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210151887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054300830","display_name":"Yukio Osaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405283158","display_name":"Meiwa Hospital","ror":"https://ror.org/0141nsn41","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4405283158"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukio Osaki","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Meiwa Hospital, Nishinomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Meiwa Hospital, Nishinomiya, Japan","institution_ids":["https://openalex.org/I4405283158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056173852","display_name":"Etsuro Hatano","orcid":"https://orcid.org/0000-0003-3407-1918","observed_orcids":["https://orcid.org/0000-0003-3407-1918"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Etsuro Hatano","raw_affiliation_strings":["Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepato-Biliary-Pancreatic Surgery and Transplantation, Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008788188","display_name":"Hiroshi Seno","orcid":"https://orcid.org/0000-0002-8509-8128","observed_orcids":["https://orcid.org/0000-0002-8509-8128"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Seno","raw_affiliation_strings":["Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5053697171"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":3.7336,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.95113386,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"59","issue":"12","first_page":"1107","last_page":"1118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":1.0},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/treatment-refractoriness","display_name":"treatment refractoriness","score":0.8920000195503235},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8989999890327454},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.847000002861023},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9010000228881836},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6919999718666077},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9140580892562866},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.9004374742507935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7641323804855347},{"id":"https://openalex.org/C70616116","wikidata":"https://www.wikidata.org/wiki/Q1736732","display_name":"Refractory period","level":2,"score":0.7190619707107544},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6498555541038513},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.625709056854248},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5625259876251221},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.5584109425544739},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.43222346901893616},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3840515613555908},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.3113698363304138},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30965107679367065},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2459205687046051},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1265260875225067},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007564","descriptor_name":"Japan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s00535-024-02150-7","doi":"https://doi.org/10.1007/s00535-024-02150-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00535-024-02150-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00535-024-02150-7.pdf","source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11541291","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11541291","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11541291/pdf/535_2024_Article_2150.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gastroenterol","raw_type":"Text"},{"id":"pmid:39289234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39289234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01221:0006479516","doi":null,"is_oa":true,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/79b8ccbe-08c7-45b5-a9bf-b454f0bac948/download","pdf_url":"https://repository.kulib.kyoto-u.ac.jp/bitstreams/79b8ccbe-08c7-45b5-a9bf-b454f0bac948/download","source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/290050","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/290050","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1007/s00535-024-02150-7","doi":"https://doi.org/10.1007/s00535-024-02150-7","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00535-024-02150-7","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00535-024-02150-7.pdf","source":{"id":"https://openalex.org/S41046285","display_name":"Journal of Gastroenterology","issn_l":"0944-1174","issn":["0944-1174","1435-5922"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G5439159808","display_name":"\u708e\u75c7\u6027\u809d\u767a\u764c\u904e\u7a0b\u306b\u304a\u3051\u308bDNA\u8131\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u306e\u6a5f\u80fd\u7684\u5f79\u5272\u3068\u5206\u5b50\u6a5f\u5e8f\u306e\u89e3\u660e","funder_award_id":"22K07983","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402600971.pdf","grobid_xml":"https://content.openalex.org/works/W4402600971.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1828082159","https://openalex.org/W1920582150","https://openalex.org/W2019607817","https://openalex.org/W2123105952","https://openalex.org/W2275737843","https://openalex.org/W2414810833","https://openalex.org/W2560499218","https://openalex.org/W2759920579","https://openalex.org/W2787358630","https://openalex.org/W2809889937","https://openalex.org/W2908573150","https://openalex.org/W2969846817","https://openalex.org/W3025022288","https://openalex.org/W3128646645","https://openalex.org/W3205595708","https://openalex.org/W3205914248","https://openalex.org/W3212192415","https://openalex.org/W3213332409","https://openalex.org/W4200162927","https://openalex.org/W4200388794","https://openalex.org/W4205601742","https://openalex.org/W4213154232","https://openalex.org/W4226196287","https://openalex.org/W4281645619","https://openalex.org/W4281695324","https://openalex.org/W4283395775","https://openalex.org/W4283819452","https://openalex.org/W4292756365","https://openalex.org/W4294904355","https://openalex.org/W4295088736","https://openalex.org/W4297227823","https://openalex.org/W4307886382","https://openalex.org/W4310172261","https://openalex.org/W4310597858","https://openalex.org/W4310962190","https://openalex.org/W4316341624","https://openalex.org/W4319222008","https://openalex.org/W4323534329","https://openalex.org/W4323812864","https://openalex.org/W4324262440","https://openalex.org/W4327571871","https://openalex.org/W4380291390","https://openalex.org/W4385514156","https://openalex.org/W4385563349","https://openalex.org/W4386324839","https://openalex.org/W4386725961","https://openalex.org/W4388562853","https://openalex.org/W4390616448"],"related_works":["https://openalex.org/W7116975631","https://openalex.org/W4283819452","https://openalex.org/W3215532914","https://openalex.org/W4380448821","https://openalex.org/W4413092623","https://openalex.org/W7222920664","https://openalex.org/W3205914248","https://openalex.org/W7163011490","https://openalex.org/W4414162629","https://openalex.org/W4283395775"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"atezolizumab":[2],"plus":[3],"bevacizumab":[4],"(Atezo/Bev)":[5],"therapy":[6,65],"has":[7],"been":[8],"used":[9],"as":[10,80,106],"the":[11,51,164,170,175,190,199],"preferred":[12],"first-line":[13,52,176,239],"treatment":[14,165],"for":[15,37,44],"advanced":[16],"hepatocellular":[17],"carcinoma":[18],"(HCC),":[19],"up":[20],"to":[21,46,159,238],"26%":[22],"of":[23,85,96,108,116,135,206,234],"patients":[24,59,183,235],"do":[25],"not":[26],"achieve":[27],"disease":[28,87,90,113],"control,":[29],"suggesting":[30],"alternative":[31],"treatments":[32],"might":[33],"be":[34],"more":[35],"beneficial":[36],"such":[38],"patients.":[39],"We":[40,55],"investigated":[41],"key":[42],"predictors":[43],"refractoriness":[45],"Atezo/Bev":[47,64,240],"therapy,":[48],"particularly":[49],"in":[50,75,148,194,211,248],"setting.":[53],"METHODS:":[54],"retrospectively":[56],"analyzed":[57],"302":[58],"with":[60,114,203],"HCC":[61],"who":[62],"received":[63],"between":[66,131,163],"October":[67],"2020":[68],"and":[69,91,122,139,167,192,209,214,222],"September":[70],"2022":[71],"across":[72],"nine":[73],"hospitals":[74],"Japan.":[76],"Refractoriness":[77,145],"was":[78,104,146],"defined":[79,105],"best":[81,200],"overall":[82,136],"response":[83,110],"(BOR)":[84],"progressive":[86],"or":[88,111],"stable":[89,112],"a":[92,160],"progression-free":[93],"survival":[94,137],"(PFS)":[95],"<":[97,219],"180":[98,118],"days":[99],"(RECIST":[100],"v1.1).":[101],"Clinical":[102],"benefit":[103],"BOR":[107],"partial/complete":[109],"PFS":[115,140,223],"\u2265":[117],"days.":[119],"Baseline":[120],"characteristics":[121],"potential":[123,188],"predictors,":[124,189],"identified":[125],"through":[126],"literature":[127],"review,":[128],"were":[129,141,224,236],"compared":[130],"these":[132],"groups.":[133],"Stratifications":[134],"(OS),":[138],"also":[142,225],"assessed.":[143],"RESULTS:":[144],"observed":[147],"126":[149],"(41.7%)":[150],"patients,":[151,216],"while":[152],"154":[153],"(51.0%)":[154],"achieved":[155],"clinical":[156],"benefit.":[157],"Due":[158],"significant":[161],"association":[162],"line":[166],"refractory":[168,204,237],"rate,":[169],"subsequent":[171],"analysis":[172],"focused":[173],"on":[174],"cohort":[177],"(n":[178],"=":[179],"214;":[180],"72":[181],"[33.6%]":[182],"showed":[184],"refractoriness).":[185],"Among":[186],"13":[187],"CRP":[191],"AFP":[193],"immunotherapy":[195],"(CRAFITY)":[196],"score":[197,244],"had":[198],"predictive":[201],"performance,":[202],"rates":[205],"24.6%,":[207],"44.6%,":[208],"57.9%":[210],"CRAFITY-0,":[212],"1,":[213],"2":[215],"respectively":[217],"(p":[218],"0.001).":[220],"OS":[221],"well-stratified":[226],"by":[227],"this":[228],"scoring":[229],"system.":[230],"CONCLUSIONS:":[231],"Approximately":[232],"one-third":[233],"therapy.":[241],"The":[242],"CRAFITY":[243],"demonstrated":[245],"superior":[246],"performance":[247],"predicting":[249],"refractoriness.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-19T00:00:00"}