{"id":"https://openalex.org/W4402561401","doi":"https://doi.org/10.1016/j.annonc.2024.08.864","title":"813MO Phase I trial of a personalized multi-peptide vaccine combined with the TLR1/2 ligand XS15 under Bruton-Tyrosine-Kinase inhibitor (BTKi) treatment in chronic lymphocytic leukemia (CLL) patients","display_name":"813MO Phase I trial of a personalized multi-peptide vaccine combined with the TLR1/2 ligand XS15 under Bruton-Tyrosine-Kinase inhibitor (BTKi) treatment in chronic lymphocytic leukemia (CLL) patients","publication_year":2024,"publication_date":"2024-09-01","ids":{"openalex":"https://openalex.org/W4402561401","doi":"https://doi.org/10.1016/j.annonc.2024.08.864"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2024.08.864","doi":"https://doi.org/10.1016/j.annonc.2024.08.864","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2024.08.864","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(24)02383-4/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annalsofoncology.org/article/S0923-7534(24)02383-4/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084829554","display_name":"Christopher Hackenbruch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Hackenbruch","raw_affiliation_strings":["Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039927433","display_name":"Jonas S. Heitmann","orcid":"https://orcid.org/0000-0002-7305-8620","observed_orcids":["https://orcid.org/0000-0002-7305-8620"]},"institutions":[{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J.S. Heitmann","raw_affiliation_strings":["Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064734982","display_name":"S.S. Jung","orcid":"https://orcid.org/0009-0000-8640-349X","observed_orcids":["https://orcid.org/0009-0000-8640-349X"]},"institutions":[{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Jung","raw_affiliation_strings":["Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008873049","display_name":"Yacine Maringer","orcid":"https://orcid.org/0000-0002-2197-8740","observed_orcids":["https://orcid.org/0000-0002-2197-8740"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Y. Maringer","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Wacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Wacker","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037039636","display_name":"Annika Nelde","orcid":"https://orcid.org/0000-0001-8504-8481","observed_orcids":["https://orcid.org/0000-0001-8504-8481"]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Nelde","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063729578","display_name":"Maddalena Marconato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Marconato","raw_affiliation_strings":["Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020968623","display_name":"Lisa Zieschang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"L. Zieschang","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091290762","display_name":"Christoph Kammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Kammer","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M.T. \u00d6zbek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M.T. \u00d6zbek","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074873185","display_name":"Marion Richter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Richter","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":null,"display_name":"M. Denk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094118","display_name":"Universit\u00e4tsklinikum T\u00fcbingen","ror":"https://ror.org/00pjgxh97","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210094118"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Denk","raw_affiliation_strings":["Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Immunology, Department of Peptide-based Immunotherapy, University Hospital T\u00fcbingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I4210094118"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026255080","display_name":"Helmut Rainer Salih","orcid":"https://orcid.org/0000-0002-6719-1847","observed_orcids":["https://orcid.org/0000-0002-6719-1847"]},"institutions":[{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H.R. Salih","raw_affiliation_strings":["Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015470086","display_name":"J.S. Walz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J.S. Walz","raw_affiliation_strings":["Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Clinical Collaboration Unit Translational Immunology, University Hospital T\u00fcbingen, German Cancer Consortium (DKTK), Tuebingen, Germany","institution_ids":["https://openalex.org/I4391767962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":0.2885,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.49626784,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"35","issue":null,"first_page":"S601","last_page":"S602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.9330000281333923},{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.9620000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8828588724136353},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.7240129709243774},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5259616374969482},{"id":"https://openalex.org/C2776789287","wikidata":"https://www.wikidata.org/wiki/Q7166532","display_name":"Peptide vaccine","level":4,"score":0.4535941481590271},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4255495071411133},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.42538982629776},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4227831959724426},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.42273059487342834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3839191794395447},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27629584074020386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.16319352388381958},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.13897418975830078},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1279798448085785},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2024.08.864","doi":"https://doi.org/10.1016/j.annonc.2024.08.864","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2024.08.864","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(24)02383-4/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2024.08.864","doi":"https://doi.org/10.1016/j.annonc.2024.08.864","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2024.08.864","pdf_url":"https://www.annalsofoncology.org/article/S0923-7534(24)02383-4/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402561401.pdf","grobid_xml":"https://content.openalex.org/works/W4402561401.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282942227","https://openalex.org/W4401868474","https://openalex.org/W4390594993","https://openalex.org/W4391102158","https://openalex.org/W4379508879","https://openalex.org/W4412907854","https://openalex.org/W4392590787","https://openalex.org/W7215108031","https://openalex.org/W3213579475","https://openalex.org/W4411653743"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-18T00:00:00"}
