{"id":"https://openalex.org/W4402551985","doi":"https://doi.org/10.1186/s13287-024-03820-2","title":"Proteomic analysis of cerebrospinal fluid of amyotrophic lateral sclerosis patients in the presence of autologous bone marrow derived mesenchymal stem cells","display_name":"Proteomic analysis of cerebrospinal fluid of amyotrophic lateral sclerosis patients in the presence of autologous bone marrow derived mesenchymal stem cells","publication_year":2024,"publication_date":"2024-09-15","ids":{"openalex":"https://openalex.org/W4402551985","doi":"https://doi.org/10.1186/s13287-024-03820-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/39278909","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11403799"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-024-03820-2","doi":"https://doi.org/10.1186/s13287-024-03820-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-024-03820-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13287-024-03820-2.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4402551985"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13287-024-03820-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063478617","display_name":"Ana Luiza Guimar\u00e3es Reis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Luiza Guimar\u00e3es Reis","raw_affiliation_strings":["FMUSP: Universidade de Sao Paulo Faculdade de Medicina","Laboratorio de Neurologia Translacional, Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMUSP: Universidade de Sao Paulo Faculdade de Medicina","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laboratorio de Neurologia Translacional, Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037615244","display_name":"J\u00e9ssica Ruivo Maximino","orcid":"https://orcid.org/0000-0002-3955-206X","observed_orcids":["https://orcid.org/0000-0002-3955-206X"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jessica Ruivo Maximino","raw_affiliation_strings":["FMUSP: Universidade de Sao Paulo Faculdade de Medicina","Laboratorio de Neurologia Translacional, Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMUSP: Universidade de Sao Paulo Faculdade de Medicina","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laboratorio de Neurologia Translacional, Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076223036","display_name":"Lu\u00eds Alberto de P\u00e1dua Covas Lage","orcid":"https://orcid.org/0000-0002-9228-3276","observed_orcids":["https://orcid.org/0000-0002-9228-3276"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luis Alberto de Padua Covas Lage","raw_affiliation_strings":["USP HC: Universidade de Sao Paulo Hospital das Clinicas","LIM-31, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP HC: Universidade de Sao Paulo Hospital das Clinicas","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"LIM-31, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082797985","display_name":"H\u00e9lio Rodrigues Gomes","orcid":"https://orcid.org/0000-0003-4461-0305","observed_orcids":["https://orcid.org/0000-0003-4461-0305"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"H\u00e9lio Rodrigues Gomes","raw_affiliation_strings":["USP HC: Universidade de Sao Paulo Hospital das Clinicas","Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP HC: Universidade de Sao Paulo Hospital das Clinicas","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003883532","display_name":"Juliana C. Pereira","orcid":"https://orcid.org/0000-0002-0655-2821","observed_orcids":["https://orcid.org/0000-0002-0655-2821","https://orcid.org/0009-0005-7379-9022"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Juliana Pereira","raw_affiliation_strings":["USP HC: Universidade de Sao Paulo Hospital das Clinicas","LIM-31, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP HC: Universidade de Sao Paulo Hospital das Clinicas","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"LIM-31, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085814995","display_name":"Paulo Roberto Slud Brofman","orcid":"https://orcid.org/0000-0001-6401-782X","observed_orcids":["https://orcid.org/0000-0001-6401-782X"]},"institutions":[{"id":"https://openalex.org/I176838256","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1","ror":"https://ror.org/02x1vjk79","country_code":"BR","type":"education","lineage":["https://openalex.org/I176838256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Roberto Slud Brofman","raw_affiliation_strings":["PUCPR: Pontificia Universidade Catolica do Parana","Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PUCPR: Pontificia Universidade Catolica do Parana","institution_ids":["https://openalex.org/I176838256"]},{"raw_affiliation_string":"Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil","institution_ids":["https://openalex.org/I176838256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022453340","display_name":"Alexandra Cristina Senegaglia","orcid":"https://orcid.org/0000-0002-8052-6357","observed_orcids":["https://orcid.org/0000-0002-8052-6357"]},"institutions":[{"id":"https://openalex.org/I176838256","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1","ror":"https://ror.org/02x1vjk79","country_code":"BR","type":"education","lineage":["https://openalex.org/I176838256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alexandra Cristina Senegaglia","raw_affiliation_strings":["PUCPR: Pontificia Universidade Catolica do Parana","Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PUCPR: Pontificia Universidade Catolica do Parana","institution_ids":["https://openalex.org/I176838256"]},{"raw_affiliation_string":"Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil","institution_ids":["https://openalex.org/I176838256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023420874","display_name":"C\u00e1rmen L\u00facia Kuniyoshi Rebelatto","orcid":"https://orcid.org/0000-0003-1407-0416","observed_orcids":["https://orcid.org/0000-0003-1407-0416"]},"institutions":[{"id":"https://openalex.org/I176838256","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1","ror":"https://ror.org/02x1vjk79","country_code":"BR","type":"education","lineage":["https://openalex.org/I176838256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carmen L\u00facia Kuniyoshi Rebelatto","raw_affiliation_strings":["PUCPR: Pontificia Universidade Catolica do Parana","Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PUCPR: Pontificia Universidade Catolica do Parana","institution_ids":["https://openalex.org/I176838256"]},{"raw_affiliation_string":"Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil","institution_ids":["https://openalex.org/I176838256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005761824","display_name":"D\u00e9bora Regina Daga","orcid":"https://orcid.org/0000-0003-2241-4442","observed_orcids":["https://orcid.org/0000-0003-2241-4442"]},"institutions":[{"id":"https://openalex.org/I176838256","display_name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1","ror":"https://ror.org/02x1vjk79","country_code":"BR","type":"education","lineage":["https://openalex.org/I176838256"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Debora Regina Daga","raw_affiliation_strings":["PUCPR: Pontificia Universidade Catolica do Parana","Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PUCPR: Pontificia Universidade Catolica do Parana","institution_ids":["https://openalex.org/I176838256"]},{"raw_affiliation_string":"Core for Cell Technology, School of Medicine and Life Sciences, Pontif\u00edcia Universidade Catolica do Parana, Curitiba, PR, 80215-901, Brazil","institution_ids":["https://openalex.org/I176838256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029831221","display_name":"Wellingson Silva Paiva","orcid":"https://orcid.org/0000-0002-5165-7040","observed_orcids":["https://orcid.org/0000-0002-5165-7040"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wellingson Silva Paiva","raw_affiliation_strings":["USP HC: Universidade de Sao Paulo Hospital das Clinicas","Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP HC: Universidade de Sao Paulo Hospital das Clinicas","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil","institution_ids":["https://openalex.org/I4210145268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014723606","display_name":"Giuseppe Palmisano","orcid":"https://orcid.org/0000-0003-1336-6151","observed_orcids":["https://orcid.org/0000-0003-1336-6151"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4210145268","display_name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo","ror":"https://ror.org/03se9eg94","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210145268"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giuseppe Palmisano","raw_affiliation_strings":["USP ICB: Universidade de Sao Paulo Instituto de Ciencias Biomedicas","Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil. gerchadi@usp.br","Laboratorio de Neurologia Translacional, Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil. gerchadi@usp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USP ICB: Universidade de Sao Paulo Instituto de Ciencias Biomedicas","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Departamento de Neurologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil. gerchadi@usp.br","institution_ids":["https://openalex.org/I4210145268"]},{"raw_affiliation_string":"Laboratorio de Neurologia Translacional, Departamento de Neurologia, Hospital das Clinicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, SP, 01246-903, Brazil. gerchadi@usp.br","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4210145268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084620097","display_name":"Gerson Chadi","orcid":"https://orcid.org/0000-0002-9667-0716","observed_orcids":["https://orcid.org/0000-0002-9667-0716"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gerson Chadi","raw_affiliation_strings":["FMUSP: Universidade de Sao Paulo Faculdade de Medicina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FMUSP: Universidade de Sao Paulo Faculdade de Medicina","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":2.3692,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.88323395,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"15","issue":"1","first_page":"301","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/bone-marrow-derived-mesenchymal-stem-cells","display_name":"bone marrow-derived mesenchymal stem cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/autologous-stem-cell-therapy","display_name":"autologous stem cell therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-proteome","display_name":"cerebrospinal fluid proteome","score":0.8949999809265137},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9100000262260437},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":1.0},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.5},{"id":"https://openalex.org/keywords/apolipoproteins","display_name":"apolipoproteins","score":0.765999972820282},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.6470000147819519},{"id":"https://openalex.org/keywords/plasminogen","display_name":"plasminogen","score":0.8050000071525574},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8653932809829712},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7483283877372742},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.6583042144775391},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6364228129386902},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6111345291137695},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5695538520812988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46341389417648315},{"id":"https://openalex.org/C13685319","wikidata":"https://www.wikidata.org/wiki/Q7607302","display_name":"Stem cell transplantation for articular cartilage repair","level":5,"score":0.4279382824897766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35053494572639465},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.26979658007621765},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23604848980903625},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.14513510465621948},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0926479697227478},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D016632","descriptor_name":"Apolipoprotein A-I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13287-024-03820-2","doi":"https://doi.org/10.1186/s13287-024-03820-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-024-03820-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13287-024-03820-2.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-3665197/v1","doi":"https://doi.org/10.21203/rs.3.rs-3665197/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3665197/v1","pdf_url":"https://www.researchsquare.com/article/rs-3665197/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:11403799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11403799","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11403799/pdf/13287_2024_Article_3820.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmid:39278909","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39278909","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Clinical Trial, Phase I"},{"id":"pmh:oai:doaj.org/article:15b73e097e494ce6b2633b7b2d896a55","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/15b73e097e494ce6b2633b7b2d896a55","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-024-03820-2","doi":"https://doi.org/10.1186/s13287-024-03820-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-024-03820-2","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13287-024-03820-2.pdf","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2399465108","display_name":null,"funder_award_id":"401922/2014-6","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3338629646","display_name":null,"funder_award_id":"2014-6","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G7921119479","display_name":null,"funder_award_id":"1701/22","funder_id":"https://openalex.org/F4320322904","funder_display_name":"Financiadora de Estudos e Projetos"},{"id":"https://openalex.org/G7982349281","display_name":null,"funder_award_id":"836458/2016","funder_id":"https://openalex.org/F4320323916","funder_display_name":"Minist\u00e9rio da Sa\u00fade"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"},{"id":"https://openalex.org/F4320323140","display_name":"Brock University","ror":"https://ror.org/056am2717"},{"id":"https://openalex.org/F4320323339","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748"},{"id":"https://openalex.org/F4320323916","display_name":"Minist\u00e9rio da Sa\u00fade","ror":"https://ror.org/02y7p0749"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402551985.pdf","grobid_xml":"https://content.openalex.org/works/W4402551985.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W1521143540","https://openalex.org/W1969353942","https://openalex.org/W1971102239","https://openalex.org/W1989277387","https://openalex.org/W2004628180","https://openalex.org/W2006240877","https://openalex.org/W2016879629","https://openalex.org/W2021931341","https://openalex.org/W2022009847","https://openalex.org/W2036321220","https://openalex.org/W2043759616","https://openalex.org/W2047101604","https://openalex.org/W2069351132","https://openalex.org/W2070334783","https://openalex.org/W2070542281","https://openalex.org/W2073880678","https://openalex.org/W2080752012","https://openalex.org/W2096936673","https://openalex.org/W2102955851","https://openalex.org/W2112513984","https://openalex.org/W2121589895","https://openalex.org/W2123991169","https://openalex.org/W2129100373","https://openalex.org/W2129390057","https://openalex.org/W2145041062","https://openalex.org/W2158217645","https://openalex.org/W2177289690","https://openalex.org/W2234902113","https://openalex.org/W2239366382","https://openalex.org/W2536901227","https://openalex.org/W2593678637","https://openalex.org/W2607420694","https://openalex.org/W2617071147","https://openalex.org/W2767062265","https://openalex.org/W2774136216","https://openalex.org/W2774526315","https://openalex.org/W2800010511","https://openalex.org/W2807099927","https://openalex.org/W2810654871","https://openalex.org/W2884205788","https://openalex.org/W2890187093","https://openalex.org/W2892972723","https://openalex.org/W2921829638","https://openalex.org/W2922090299","https://openalex.org/W2924784269","https://openalex.org/W2943517835","https://openalex.org/W2978880851","https://openalex.org/W2981786395","https://openalex.org/W2984082855","https://openalex.org/W2987229198","https://openalex.org/W2991416247","https://openalex.org/W3000985212","https://openalex.org/W3003318258","https://openalex.org/W3007126308","https://openalex.org/W3007638452","https://openalex.org/W3014032715","https://openalex.org/W3036634556","https://openalex.org/W3043861550","https://openalex.org/W3049279227","https://openalex.org/W3080729671","https://openalex.org/W3081311131","https://openalex.org/W3089175271","https://openalex.org/W3105671367","https://openalex.org/W3110692113","https://openalex.org/W3111592494","https://openalex.org/W3128951324","https://openalex.org/W3132226537","https://openalex.org/W3134834933","https://openalex.org/W3134918276","https://openalex.org/W3137195984","https://openalex.org/W3138150943","https://openalex.org/W3155271432","https://openalex.org/W3168339355","https://openalex.org/W3175360324","https://openalex.org/W3178764441","https://openalex.org/W3183368521","https://openalex.org/W3183929054","https://openalex.org/W3187190181","https://openalex.org/W3193463226","https://openalex.org/W3201041141","https://openalex.org/W3201502209","https://openalex.org/W3208688355","https://openalex.org/W3208691473","https://openalex.org/W3209592917","https://openalex.org/W4200320029","https://openalex.org/W4214950145","https://openalex.org/W4220659756","https://openalex.org/W4220676470","https://openalex.org/W4220730224","https://openalex.org/W4220831425","https://openalex.org/W4220915974","https://openalex.org/W4220954898","https://openalex.org/W4224262903","https://openalex.org/W4231254854","https://openalex.org/W4253523674","https://openalex.org/W4281485069","https://openalex.org/W4285491068","https://openalex.org/W4285586726","https://openalex.org/W4287921716","https://openalex.org/W4289979044","https://openalex.org/W4292332855","https://openalex.org/W4294678212","https://openalex.org/W4294953579","https://openalex.org/W4307658314","https://openalex.org/W4308834828","https://openalex.org/W4309506674","https://openalex.org/W4309520608","https://openalex.org/W4312045033","https://openalex.org/W4313382384","https://openalex.org/W4316362745","https://openalex.org/W4317868056","https://openalex.org/W4365142160","https://openalex.org/W4366828670","https://openalex.org/W4383710767","https://openalex.org/W4386592045","https://openalex.org/W4386845720"],"related_works":["https://openalex.org/W4399104481","https://openalex.org/W2097921156","https://openalex.org/W2790511031","https://openalex.org/W2744921233","https://openalex.org/W2263595714","https://openalex.org/W4366828670","https://openalex.org/W2287396155","https://openalex.org/W4223511898","https://openalex.org/W7166148191"],"abstract_inverted_index":{"BACKGROUND:":[0],"Amyotrophic":[1],"lateral":[2],"sclerosis":[3],"(ALS)":[4],"is":[5],"a":[6],"fatal":[7],"and":[8,124,142,155],"rapidly":[9],"progressive":[10],"motoneuron":[11],"degenerative":[12],"disorder.":[13],"There":[14],"are":[15,83],"still":[16],"no":[17],"drugs":[18],"capable":[19],"of":[20,28,56,65,72,98,121,147,171,176],"slowing":[21],"disease":[22],"evolution":[23],"or":[24],"improving":[25],"life":[26],"quality":[27],"ALS":[29,66,99,150,177],"patients.":[30,178],"Thus,":[31],"autologous":[32,73,172],"stem":[33],"cell":[34,80,148,156],"therapy":[35],"has":[36],"emerged":[37,167],"as":[38,128,130,159,161,168],"an":[39],"alternative":[40],"treatment":[41],"regime":[42],"to":[43,105,113],"be":[44],"investigated":[45,60],"in":[46,52,61,96,144,174],"clinical":[47],"ALS.":[48],"METHOD:":[49],"cells/kg,":[50],"intrathecally":[51],"the":[53,57,109,145],"lumbar":[54],"region":[55],"spine)":[58],"were":[59],"cerebrospinal":[62],"fluid":[63],"(CSF)":[64],"patients":[67,111],"who":[68],"received":[69],"intrathecal":[70],"infusions":[71],"bone":[74],"marrow-derived":[75],"MSCs":[76,103,114,173],"thirty":[77],"days":[78],"after":[79],"therapy.":[81],"Data":[82],"available":[84],"via":[85],"ProteomeXchange":[86],"with":[87,102],"identifier":[88,182],"PXD053129.":[89],"RESULTS:":[90],"Proteomics":[91],"revealed":[92],"220":[93],"deregulated":[94],"proteins":[95],"CSF":[97,106,146,175],"subjects":[100],"treated":[101,149],"compared":[104],"collected":[107],"from":[108],"same":[110],"prior":[112],"infusion.":[115],"Bioinformatics":[116],"enriched":[117],"analyses":[118],"highlighted":[119,164],"events":[120],"Extracellular":[122,153],"matrix":[123,154],"Cell":[125],"adhesion":[126,157],"molecules":[127,158],"well":[129,160],"related":[131,163],"key":[132,169],"targets":[133,170],"APOA1,":[134],"APOE,":[135],"APP,":[136],"C4A,":[137],"C5,":[138],"FGA,":[139],"FGB,":[140],"FGG":[141],"PLG":[143],"subjects.":[151],"CONCLUSIONS:":[152],"their":[162],"components":[165],"have":[166],"TRIAL":[179],"REGISTRATION:":[180],"Clinicaltrial.gov":[181],"NCT0291768.":[183],"Registered":[184],"28":[185],"September":[186],"2016.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2024-09-16T00:00:00"}
