{"id":"https://openalex.org/W4402551908","doi":"https://doi.org/10.1158/1538-7445.pancreatic24-b044","title":"Abstract B044: Durable T-cell-mediated anti-tumor immune response to pancreatic cancer cells overexpressing interleukin 6","display_name":"Abstract B044: Durable T-cell-mediated anti-tumor immune response to pancreatic cancer cells overexpressing interleukin 6","publication_year":2024,"publication_date":"2024-09-15","ids":{"openalex":"https://openalex.org/W4402551908","doi":"https://doi.org/10.1158/1538-7445.pancreatic24-b044"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.pancreatic24-b044","doi":"https://doi.org/10.1158/1538-7445.pancreatic24-b044","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.pancreatic24-b044","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017768166","display_name":"Paige C. Arneson\u2010Wissink","orcid":"https://orcid.org/0000-0002-2706-9652","observed_orcids":["https://orcid.org/0000-0002-2706-9652"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paige C Arneson-Wissink","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027555031","display_name":"Alexandra Q. Bartlett","orcid":"https://orcid.org/0000-0001-7912-6084","observed_orcids":["https://orcid.org/0000-0001-7912-6084"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Q Bartlett","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001677357","display_name":"Heike Mendez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heike Mendez","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002708668","display_name":"Xinxia Zhu","orcid":"https://orcid.org/0009-0009-4041-1561","observed_orcids":["https://orcid.org/0009-0009-4041-1561"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinxia Zhu","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020646269","display_name":"Jessica Dickie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Dickie","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthew McWhorter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew McWhorter","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048749219","display_name":"Peter R. Levasseur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter R Levasseur","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024041826","display_name":"Parham Diba","orcid":"https://orcid.org/0000-0003-1014-510X","observed_orcids":["https://orcid.org/0000-0003-1014-510X"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parham Diba","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023887178","display_name":"Katelyn T. Byrne","orcid":"https://orcid.org/0000-0002-2459-9041","observed_orcids":["https://orcid.org/0000-0002-2459-9041"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn T Byrne","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073686225","display_name":"Gregory David Scott","orcid":"https://orcid.org/0000-0003-0830-5557","observed_orcids":["https://orcid.org/0000-0003-0830-5557"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory D Scott","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042431372","display_name":"Robert L Eil","orcid":"https://orcid.org/0000-0003-3030-9327","observed_orcids":["https://orcid.org/0000-0003-3030-9327"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Eil","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045078700","display_name":"Aaron J. Grossberg","orcid":"https://orcid.org/0000-0003-4690-4948","observed_orcids":["https://orcid.org/0000-0003-4690-4948"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J Grossberg","raw_affiliation_strings":["Oregon Health and Science University, Portland, OR. 1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health and Science University, Portland, OR. 1","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165690674"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"17_Supplement_2","first_page":"B044","last_page":"B044"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5234000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1881999969482422,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.14470000565052032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9509999752044678},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-immune-resistance","display_name":"tumor immune resistance","score":0.6510000228881836},{"id":"https://openalex.org/keywords/antitumor-t-cells","display_name":"antitumor T cells","score":0.75},{"id":"https://openalex.org/keywords/tumor-clearance","display_name":"tumor clearance","score":0.6100000143051147},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.7329999804496765},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.8690000176429749},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/splenomegaly","display_name":"splenomegaly","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6745008230209351},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6489353179931641},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5205898284912109},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4877184331417084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46966588497161865},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4371093511581421},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3707857131958008},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17944207787513733}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.pancreatic24-b044","doi":"https://doi.org/10.1158/1538-7445.pancreatic24-b044","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1158/1538-7445.pancreatic24-b044","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012081960","https://openalex.org/W2079105677","https://openalex.org/W3160432000","https://openalex.org/W2971868466","https://openalex.org/W3028147324","https://openalex.org/W3201399084","https://openalex.org/W4221015902","https://openalex.org/W2348276370","https://openalex.org/W2072687151","https://openalex.org/W3038917638"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"immune":[2,207,214,228,349,421,491],"resistance":[3],"contributes":[4],"to":[5,55,79,159,219,322,330,388,439,493],"low":[6],"survivorship":[7],"in":[8,43,60,181,185,190,212,252,260,362,424,446,508,512],"patients":[9],"with":[10,170,303],"pancreatic":[11,38,494],"ductal":[12],"adenocarcinoma":[13],"(PDAC).":[14],"To":[15,209],"understand":[16],"how":[17],"tumor-secreted":[18],"factors":[19],"might":[20],"impact":[21],"anti-tumor":[22,206,292,310,348,391,490],"immunity,":[23],"we":[24,147,222,240],"developed":[25,70],"a":[26,34,142,153,224,299],"model":[27,51],"of":[28,37,144,201,227,273,325,332,346,364,366,383,404,419,434,503],"PDAC":[29,46,81,284],"tumor":[30,58,163,171,213,220,238,267,285,301,340,454],"overexpressing":[31,497],"interleukin-6":[32],"(IL-6),":[33],"known":[35,438],"driver":[36,143],"tumorigenesis":[39,441],"and":[40,63,112,146,233,244,249,269,353,371,397,409,442,444],"cancer":[41,47,495],"cachexia,":[42,145,443],"orthotopically":[44],"implanted":[45],"cells":[48,59,229,248,251,257,279,336,357,408,413,496],"(OT-PDACIL6).":[49],"This":[50,306,427],"utilized":[52],"codon-optimized":[53],"IL6":[54],"accurately":[56],"detect":[57],"the":[61,80,162,291,309,338,344,347,400,420,431,450,504],"pancreas":[62],"distal":[64],"organs":[65],"via":[66],"qPCR.":[67],"OT-PDACIL6":[68,90,134,150,182,191,253,261,274,318,425],"tumors":[69,91,135,151,319],"poorly-":[71],"differentiated,":[72],"infiltrative":[73],"carcinomas,":[74],"which":[75,436],"were":[76,85,92,116,203,258,358],"histologically":[77],"similar":[78],"cell":[82,294,312,393],"line":[83],"they":[84],"derived":[86],"from":[87],"(OT-PDACparental).":[88],"Surprisingly,":[89],"present":[93],"at":[94,119,128,368,374],"5":[95,174],"days":[96,107,121],"post":[97,108],"implantation,":[98],"but":[99,188],"undetectable":[100,189],"by":[101,105,315,360],"histology":[102],"or":[103],"qPCR":[104,361],"10":[106],"implantation.":[109],"OT-":[110,123],"PDACIL6":[111,356],"sham":[113],"mouse":[114],"survival":[115,272],"equivalent":[117],"(87.5%)":[118],"76":[120],"post-implantation.":[122],"PDACparental":[124,304],"mortality":[125],"was":[126,164,178,296,320],"100%":[127],"day":[129,369,375],"13.":[130],"We":[131,196,287,342,377],"concluded":[132],"that":[133,149,157,198,216,277,308,355,379,395],"resolve":[136,160],"spontaneously.":[137],"IL-6":[138,167,177,202,385],"is":[139,437,449],"well-established":[140],"as":[141,161],"saw":[148],"induced":[152],"rapid":[154],"cachexia":[155],"phenotype":[156],"began":[158],"cleared.":[165],"Plasma":[166],"levels":[168,200,382],"tracked":[169],"burden.":[172],"At":[173,236],"days,":[175],"plasma":[176],"100-fold":[179],"higher":[180],"mice":[183,192,316,367],"than":[184],"OT-PDACparental":[186,326],"mice,":[187,275],"after":[193],"12":[194],"days.":[195],"hypothesized":[197],"high":[199,381],"driving":[204,451],"an":[205,390],"response.":[208],"assess":[210],"changes":[211],"infiltrate":[215],"could":[217],"lead":[218],"clearance,":[221],"measured":[223],"broad":[225],"range":[226],"using":[230,298],"flow":[231],"cytometry":[232],"immunofluorescent":[234],"histology.":[235],"peak":[237],"burden,":[239],"observed":[241,423],"exacerbated":[242],"splenomegaly,":[243],"increased":[245,405],"tumor-infiltrating":[246,406],"T":[247,255,278,293,311,335,392,407,411,478],"NK":[250],"mice.":[254,426],"regulatory":[256,412],"decreased":[259,271,410],"tumors.":[262],"CD4/CD8":[263],"antibody-based":[264],"depletion":[265],"prevented":[266],"clearance":[268],"significantly":[270],"indicating":[276],"are":[280,386,414],"necessary":[281],"for":[282],"IL-6-driven":[283],"clearance.":[286,455],"then":[288],"tested":[289],"whether":[290],"response":[295,313,350,394,422,492],"durable":[297],"secondary":[300],"challenge":[302],"cells.":[305],"revealed":[307],"elicited":[314],"bearing":[317],"sufficient":[321,387],"prevent":[323],"development":[324],"tumors,":[327],"likely":[328,415],"due":[329],"induction":[331],"long-term":[333],"memory":[334],"during":[337],"initial":[339],"challenge.":[341],"assessed":[343],"effect":[345],"on":[351],"metastases":[352],"found":[354],"detected":[359,373],"lungs":[363],"58%":[365],"5,":[370],"not":[372],"12.":[376],"conclude":[378],"extremely":[380],"tumor-derived":[384],"drive":[389],"rapidly":[396],"durably":[398],"clears":[399],"tumor.":[401],"The":[402],"combination":[403],"both":[416],"important":[417],"aspects":[418],"surprising":[428],"finding":[429],"highlights":[430],"pleiotropic":[432],"effects":[433],"IL-6,":[435],"promote":[440],"yet,":[445],"this":[447],"work,":[448],"force":[452],"underlying":[453],"Citation":[456],"Format:":[457],"Paige":[458],"C":[459],"Arneson-Wissink,":[460],"Alexandra":[461],"Q":[462],"Bartlett,":[463],"Heike":[464],"Mendez,":[465],"Xinxia":[466],"Zhu,":[467],"Jessica":[468],"Dickie,":[469],"Matthew":[470],"McWhorter,":[471],"Peter":[472],"R":[473],"Levasseur,":[474],"Parham":[475],"Diba,":[476],"Katelyn":[477],"Byrne,":[479],"Gregory":[480],"D":[481],"Scott,":[482],"Robert":[483],"Eil,":[484],"Aaron":[485],"J":[486],"Grossberg.":[487],"Durable":[488],"T-cell-mediated":[489],"interleukin":[498],"6":[499],"[abstract].":[500],"In:":[501],"Proceedings":[502],"AACR":[505],"Special":[506],"Conference":[507],"Cancer":[509,514,524],"Research:":[510],"Advances":[511],"Pancreatic":[513],"Research;":[515],"2024":[516],"Sep":[517],"15-18;":[518],"Boston,":[519],"MA.":[520],"Philadelphia":[521],"(PA):":[522],"AACR;":[523],"Res":[525],"2024;84(17":[526],"Suppl_2):Abstract":[527],"nr":[528],"B044.":[529]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}