{"id":"https://openalex.org/W4402522993","doi":"https://doi.org/10.1080/1750743x.2024.2390819","title":"Bioengineering MSCs for untapped therapeutic potential","display_name":"Bioengineering MSCs for untapped therapeutic potential","publication_year":2024,"publication_date":"2024-08-21","ids":{"openalex":"https://openalex.org/W4402522993","doi":"https://doi.org/10.1080/1750743x.2024.2390819","pmid":"https://pubmed.ncbi.nlm.nih.gov/39268677","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11486229"},"language":"en","primary_location":{"id":"doi:10.1080/1750743x.2024.2390819","doi":"https://doi.org/10.1080/1750743x.2024.2390819","is_oa":true,"landing_page_url":"https://doi.org/10.1080/1750743x.2024.2390819","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/1750743X.2024.2390819?needAccess=true","source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/1750743X.2024.2390819?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048214136","display_name":"Olivia L. Sirpilla","orcid":"https://orcid.org/0000-0002-0634-407X","observed_orcids":["https://orcid.org/0000-0002-0634-407X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Sirpilla","raw_affiliation_strings":["Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA","Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA","Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN\u00a055905, USA","T Cell Engineering, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":"https://orcid.org/0000-0002-0634-407X","affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN\u00a055905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054196868","display_name":"Saad S. Kenderian","orcid":"https://orcid.org/0000-0003-2767-3830","observed_orcids":["https://orcid.org/0000-0003-2767-3830"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Saad S Kenderian","raw_affiliation_strings":["Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA","Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA","T Cell Engineering, Mayo Clinic, Rochester, MN 55905, USA"],"raw_orcid":"https://orcid.org/0000-0003-2767-3830","affiliations":[{"raw_affiliation_string":"Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Division of Hematology, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"T Cell Engineering, Mayo Clinic, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054196868"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"14-15","first_page":"907","last_page":"911"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cell-engineering","display_name":"cell engineering","score":0.5009999871253967},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.5350000262260437},{"id":"https://openalex.org/keywords/multilineage-differentiation","display_name":"multilineage differentiation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.9800000190734863},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.4385494291782379},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3983333110809326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38131922483444214},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3425002694129944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33595675230026245},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14641600847244263}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057005","descriptor_name":"Bioengineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1080/1750743x.2024.2390819","doi":"https://doi.org/10.1080/1750743x.2024.2390819","is_oa":true,"landing_page_url":"https://doi.org/10.1080/1750743x.2024.2390819","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/1750743X.2024.2390819?needAccess=true","source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11486229","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11486229/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11486229/pdf/IIMY_16_2390819.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"Text"},{"id":"pmid:39268677","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39268677","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1080/1750743x.2024.2390819","doi":"https://doi.org/10.1080/1750743x.2024.2390819","is_oa":true,"landing_page_url":"https://doi.org/10.1080/1750743x.2024.2390819","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/1750743X.2024.2390819?needAccess=true","source":{"id":"https://openalex.org/S71887004","display_name":"Immunotherapy","issn_l":"1750-743X","issn":["1750-743X","1750-7448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunotherapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4027895822","display_name":"Simultaneous Thermal and Osmotic Stresses in Tumor Ablation: Imaging and Biology","funder_award_id":"R01CA201127","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000881388","display_name":"Paul Calabresi Program in Clinical/Translational Research at Mayo Clinic","funder_award_id":"K12CA090628","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000882466","display_name":"Engineered Mesenchymal Stromal Cells for Enhanced Immunosuppression","funder_award_id":"R01AI179974","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000893657","display_name":"Towards Safer and More Effective CART Cell Therapy Through the Modulation of Myeloid Cytokines","funder_award_id":"R37CA266344","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333659","display_name":"Center for Individualized Medicine, Mayo Clinic","ror":"https://ror.org/03zzw1w08"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402522993.pdf","grobid_xml":"https://content.openalex.org/works/W4402522993.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1995286643","https://openalex.org/W2155299920","https://openalex.org/W2163899718","https://openalex.org/W2529992186","https://openalex.org/W2609187335","https://openalex.org/W2783211174","https://openalex.org/W2792588868","https://openalex.org/W2804434142","https://openalex.org/W2805892376","https://openalex.org/W2943031177","https://openalex.org/W2994755337","https://openalex.org/W3001265605","https://openalex.org/W3004044398","https://openalex.org/W3007974384","https://openalex.org/W3035553552","https://openalex.org/W3043861550","https://openalex.org/W3044491460","https://openalex.org/W3127853020","https://openalex.org/W3135234497","https://openalex.org/W3203882066","https://openalex.org/W4376112532","https://openalex.org/W4376642306","https://openalex.org/W4387305217","https://openalex.org/W4387421950","https://openalex.org/W4390058241","https://openalex.org/W4393380449"],"related_works":["https://openalex.org/W1988188397","https://openalex.org/W2192685765","https://openalex.org/W2372783730","https://openalex.org/W2399253540","https://openalex.org/W2469349462","https://openalex.org/W3030824308","https://openalex.org/W2389990751","https://openalex.org/W2616129176","https://openalex.org/W2069724639","https://openalex.org/W2378360429"],"abstract_inverted_index":{"Mesenchymal":[0],"stromal":[1],"cells":[2,23],"(MSCs)":[3],"are":[4],"multipotent":[5],"homeostatic":[6],"regulators":[7],"of":[8],"the":[9],"body":[10],"that":[11],"have":[12],"both":[13],"multilineage":[14],"differentiation":[15],"potential":[16],"and":[17],"self-renewal":[18],"capabilities":[19],"[1].":[20],"These":[21],"\u2019stem-like\u2019":[22],"...":[24]},"counts_by_year":[{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-14T00:00:00"}