{"id":"https://openalex.org/W4402446597","doi":"https://doi.org/10.1021/acsomega.4c05699","title":"[186Re]Re- and [99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups","display_name":"[186Re]Re- and [99mTc]Tc-Tricarbonyl Metal Complexes with 1,4,7-Triazacyclononane-Based Chelators Bearing Amide, Alcohol, or Ketone Pendent Groups","publication_year":2024,"publication_date":"2024-09-11","ids":{"openalex":"https://openalex.org/W4402446597","doi":"https://doi.org/10.1021/acsomega.4c05699","pmid":"https://pubmed.ncbi.nlm.nih.gov/39346849","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11425660"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.4c05699","doi":"https://doi.org/10.1021/acsomega.4c05699","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.4c05699","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c05699?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c05699?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090363308","display_name":"Rebecca Hoerres","orcid":"https://orcid.org/0000-0001-7845-3841","observed_orcids":["https://orcid.org/0000-0001-7845-3841"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Hoerres","raw_affiliation_strings":["Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109662002","display_name":"Ritin Kamboj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritin Kamboj","raw_affiliation_strings":["Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107129323","display_name":"Nora Pryor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nora Pryor","raw_affiliation_strings":["Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077772306","display_name":"Steven P. Kelley","orcid":"https://orcid.org/0000-0001-6755-4495","observed_orcids":["https://orcid.org/0000-0001-6755-4495"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven P. Kelley","raw_affiliation_strings":["Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States"],"raw_orcid":"https://orcid.org/0000-0001-6755-4495","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037961845","display_name":"Heather M. Hennkens","orcid":"https://orcid.org/0000-0002-3283-8751","observed_orcids":["https://orcid.org/0000-0002-3283-8751"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Heather M. Hennkens","raw_affiliation_strings":["Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States","Research Reactor Center, University of Missouri, 1513 Research Park Drive, Columbia, Missouri 65211, United States"],"raw_orcid":"https://orcid.org/0000-0002-3283-8751","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Missouri, 601 South College Avenue, Columbia, Missouri 65211, United States","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Research Reactor Center, University of Missouri, 1513 Research Park Drive, Columbia, Missouri 65211, United States","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037961845"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.2162,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46462049,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"9","issue":"38","first_page":"39925","last_page":"39935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-4-7-triazacyclononane","display_name":"1,4,7-triazacyclononane","score":0.925000011920929},{"id":"https://openalex.org/keywords/nota","display_name":"NOTA","score":0.746999979019165},{"id":"https://openalex.org/keywords/nodaga","display_name":"NODAGA","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bifunctional-chelators","display_name":"bifunctional chelators","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rhenium-186","display_name":"rhenium-186","score":0.9409999847412109},{"id":"https://openalex.org/keywords/technetium-99m","display_name":"technetium-99m","score":0.9990000128746033},{"id":"https://openalex.org/keywords/radiolabeling-efficiency","display_name":"radiolabeling efficiency","score":0.7599999904632568},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hydrophilicity","display_name":"hydrophilicity","score":0.6520000100135803},{"id":"https://openalex.org/keywords/serum-stability","display_name":"serum stability","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.8947621583938599},{"id":"https://openalex.org/C2777738585","wikidata":"https://www.wikidata.org/wiki/Q170744","display_name":"Ketone","level":2,"score":0.689532458782196},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.6156090497970581},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5957883596420288},{"id":"https://openalex.org/C199978012","wikidata":"https://www.wikidata.org/wiki/Q1273815","display_name":"Bearing (navigation)","level":2,"score":0.5461320877075195},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5443160533905029},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.5102248191833496},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.33536726236343384},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3331751823425293},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23927366733551025},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06630098819732666},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.4c05699","doi":"https://doi.org/10.1021/acsomega.4c05699","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.4c05699","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c05699?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11425660","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11425660","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11425660/pdf/ao4c05699.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmid:39346849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39346849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5241948f5e664df98b8b37646bfd6b09","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5241948f5e664df98b8b37646bfd6b09","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 9, Iss 38, Pp 39925-39935 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.4c05699","doi":"https://doi.org/10.1021/acsomega.4c05699","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.4c05699","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsomega.4c05699?ref=article_openPDF","source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6827879700","display_name":null,"funder_award_id":"31310021M0040","funder_id":"https://openalex.org/F4320308293","funder_display_name":"U.S. Nuclear Regulatory Commission"}],"funders":[{"id":"https://openalex.org/F4320308293","display_name":"U.S. Nuclear Regulatory Commission","ror":"https://ror.org/03nhmbj89"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402446597.pdf","grobid_xml":"https://content.openalex.org/works/W4402446597.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1922636298","https://openalex.org/W1965157982","https://openalex.org/W1966335626","https://openalex.org/W1969360633","https://openalex.org/W1989270330","https://openalex.org/W1993920694","https://openalex.org/W2043377302","https://openalex.org/W2059202671","https://openalex.org/W2059205366","https://openalex.org/W2071142977","https://openalex.org/W2074694755","https://openalex.org/W2092440972","https://openalex.org/W2094240872","https://openalex.org/W2124673635","https://openalex.org/W2142608549","https://openalex.org/W2342326117","https://openalex.org/W2409448913","https://openalex.org/W2623870807","https://openalex.org/W2795139701","https://openalex.org/W2795397166","https://openalex.org/W2899530193","https://openalex.org/W2965362447","https://openalex.org/W3036734631","https://openalex.org/W3041421624","https://openalex.org/W3083147543","https://openalex.org/W4210658251","https://openalex.org/W4251024017","https://openalex.org/W4313245173","https://openalex.org/W4368355755","https://openalex.org/W4386532523"],"related_works":["https://openalex.org/W4386532523","https://openalex.org/W4387769980","https://openalex.org/W4402640338","https://openalex.org/W2032927125","https://openalex.org/W4389370545","https://openalex.org/W1981196346","https://openalex.org/W7062349260","https://openalex.org/W2021793031","https://openalex.org/W2028742373","https://openalex.org/W2007793942"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"1,4,7-Triazacyclononane":[7],"(TACN)-based":[8],"chelators,":[9],"such":[10],"as":[11,19,100,102,171,173],"NOTA":[12],"and":[13,32,46,84,88,107,117,124,146,162,185,197],"NODAGA,":[14],"have":[15,56],"shown":[16],"great":[17],"promise":[18],"bifunctional":[20,79],"chelators":[21,42,80,129],"for":[22,221],"[M(CO)":[23,62,95,135,226],"3":[24,63,96,127,136,227],"]":[25,64,97,137,228],"+":[26,65,98,138,229],"cores":[27,139],"(M":[28,140],"=":[29,141],"99m":[30,144],"Tc":[31],"186":[33,147],"Re)":[34],"in":[35,57,104,167,176,223],"radiopharmaceutical":[36],"development.":[37],"Previous":[38],"investigations":[39],"of":[40,60,109,199,225],"TACN-based":[41,78],"bearing":[43,81],"pendent":[44,54,86],"acid":[45],"ester":[47],"arms":[48,55,87],"demonstrated":[49,164],"the":[50,53,61,68,94,103,110,119,134,150,195],"important":[51],"role":[52],"successful":[58],"coordination":[59],"core":[66,99],"with":[67,93,133],"TACN":[69,205],"backbone":[70],"nitrogens.":[71],"In":[72],"this":[73],"work,":[74],"we":[75],"introduce":[76],"three":[77],"amide,":[82],"alcohol,":[83],"ketone":[85,151],"evaluate":[89],"their":[90,115,219],"(radio)labeling":[91],"efficiency":[92],"well":[101,172],"vitro":[105],"stability":[106,175,198],"hydrophilicity":[108,196],"resulting":[111],"radiometal":[112],"complexes.":[113],"Following":[114],"synthesis":[116],"characterization,":[118],"amide":[120],"(":[121,126,152],"2":[122],")":[123,128,154],"alcohol":[125],"were":[130],"successfully":[131,157],"labeled":[132],"nat":[142],"Re,":[143],"Tc,":[145],"Re),":[148],"while":[149],"4":[153],"was":[155],"not":[156],"labeled.":[158],"Radiometal":[159],"complexes":[160],"M-2":[161],"M-3":[163],"hydrophilic":[165],"character":[166],"logD":[168],"7.4":[169],"studies":[170],"excellent":[174],"phosphate-buffered":[177],"saline":[178],"(pH":[179],"7.4),":[180],"l":[181,183],"-histidine,":[182],"-cysteine,":[184],"rat":[186],"serum":[187],"at":[188],"37":[189],"\u00b0C":[190],"through":[191],"24":[192],"h.":[193],"While":[194],"these":[200],"radiocomplexes":[201],"are":[202],"attractive,":[203],"future":[204],"chelator":[206],"design":[207],"modifications":[208],"to":[209],"increase":[210],"radiolabeling":[211],"yields":[212],"under":[213],"milder":[214],"reaction":[215],"conditions":[216],"would":[217],"improve":[218],"potential":[220],"use":[222],"development":[224],"radiopharmaceuticals.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2024-09-12T00:00:00"}