{"id":"https://openalex.org/W4402425170","doi":"https://doi.org/10.57237/j.cmrd.2024.02.002","title":"Exploring the Possible Mechanism of Combination of Polygonati rhizoma and Angelicae sinensis in Preventing Alzheimer\u2019s Disease","display_name":"Exploring the Possible Mechanism of Combination of Polygonati rhizoma and Angelicae sinensis in Preventing Alzheimer\u2019s Disease","publication_year":2024,"publication_date":"2024-09-09","ids":{"openalex":"https://openalex.org/W4402425170","doi":"https://doi.org/10.57237/j.cmrd.2024.02.002"},"language":"en","primary_location":{"id":"doi:10.57237/j.cmrd.2024.02.002","doi":"https://doi.org/10.57237/j.cmrd.2024.02.002","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57237/j.cmrd.2024.02.002","pdf_url":"http://article.isciencegroup.com/pdf/10690059.pdf","source":{"id":"https://openalex.org/S5407054161","display_name":"Chinese Medicine Research and Development","issn_l":"2995-553X","issn":["2995-553X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine Research and Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://article.isciencegroup.com/pdf/10690059.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101887202","display_name":"Shengdong Wang","orcid":"https://orcid.org/0000-0003-4070-9623","observed_orcids":["https://orcid.org/0000-0003-4070-9623"]},"institutions":[{"id":"https://openalex.org/I1315279114","display_name":"Zhejiang Wanli University","ror":"https://ror.org/00rjdhd62","country_code":"CN","type":"education","lineage":["https://openalex.org/I1315279114"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengdong Wang","raw_affiliation_strings":["College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China;","institution_ids":["https://openalex.org/I1315279114"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xu Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315279114","display_name":"Zhejiang Wanli University","ror":"https://ror.org/00rjdhd62","country_code":"CN","type":"education","lineage":["https://openalex.org/I1315279114"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Xu","raw_affiliation_strings":["College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China;","institution_ids":["https://openalex.org/I1315279114"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100352440","display_name":"Liping Liu","orcid":"https://orcid.org/0000-0002-5853-7236","observed_orcids":["https://orcid.org/0000-0002-5853-7236","https://orcid.org/0000-0002-8890-8587"]},"institutions":[{"id":"https://openalex.org/I1315279114","display_name":"Zhejiang Wanli University","ror":"https://ror.org/00rjdhd62","country_code":"CN","type":"education","lineage":["https://openalex.org/I1315279114"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liping Liu","raw_affiliation_strings":["College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biological & Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China;","institution_ids":["https://openalex.org/I1315279114"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100352440"],"corresponding_institution_ids":["https://openalex.org/I1315279114"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1754184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7378000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.21639999747276306,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.02370000071823597,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9750000238418579},{"id":"https://openalex.org/keywords/angelica-sinensis","display_name":"Angelica sinensis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/baicalin","display_name":"baicalin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/glycyrrhizin","display_name":"glycyrrhizin","score":0.9679999947547913},{"id":"https://openalex.org/keywords/stigmasterol","display_name":"stigmasterol","score":0.9800000190734863},{"id":"https://openalex.org/keywords/diosgenin","display_name":"diosgenin","score":0.996999979019165},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.7089999914169312},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.9919999837875366},{"id":"https://openalex.org/keywords/app","display_name":"APP","score":0.8650000095367432},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.8299999833106995},{"id":"https://openalex.org/keywords/esr1","display_name":"ESR1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/amyloid-beta-aggregation","display_name":"amyloid-beta aggregation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tau-hyperphosphorylation","display_name":"tau hyperphosphorylation","score":0.9129999876022339},{"id":"https://openalex.org/keywords/multi-target-drug-mechanism","display_name":"multi-target drug mechanism","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C4941483","wikidata":"https://www.wikidata.org/wiki/Q25272","display_name":"Ampere","level":3,"score":0.5907948613166809},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.52166748046875},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.48819977045059204},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32725727558135986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3256007432937622},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23476696014404297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1138867735862732},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09456765651702881},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.57237/j.cmrd.2024.02.002","doi":"https://doi.org/10.57237/j.cmrd.2024.02.002","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57237/j.cmrd.2024.02.002","pdf_url":"http://article.isciencegroup.com/pdf/10690059.pdf","source":{"id":"https://openalex.org/S5407054161","display_name":"Chinese Medicine Research and Development","issn_l":"2995-553X","issn":["2995-553X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine Research and Development","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.57237/j.cmrd.2024.02.002","doi":"https://doi.org/10.57237/j.cmrd.2024.02.002","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57237/j.cmrd.2024.02.002","pdf_url":"http://article.isciencegroup.com/pdf/10690059.pdf","source":{"id":"https://openalex.org/S5407054161","display_name":"Chinese Medicine Research and Development","issn_l":"2995-553X","issn":["2995-553X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese Medicine Research and Development","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402425170.pdf","grobid_xml":"https://content.openalex.org/works/W4402425170.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Alzheimer's":[0,126,176],"disease":[1,127,177],"(AD)":[2],"is":[3,54],"a":[4,14,55,170],"neurodegenerative":[5],"disorder,":[6],"mainly":[7],"manifested":[8],"by":[9,81,109,178],"cognitive":[10],"and":[11,19,29,41,48,63,72,77,84,106,142,146,174,181],"behavioral":[12],"impairments,":[13],"serious":[15],"threat":[16],"to":[17,34,134],"life,":[18],"without":[20],"specific":[21],"therapeutic":[22],"drugs.":[23],"The":[24,88],"combination":[25],"of":[26,37,50,57,138,150,161],"Polygonati":[27],"rhizoma":[28],"Angelicae":[30],"sinensis":[31],"(CPA)":[32],"conforms":[33],"the":[35,46,69,136,147,158,162],"principle":[36],"Chinese":[38],"medicine":[39],"formulation":[40],"has":[42],"good":[43,153],"effect":[44,62],"on":[45,59],"prevention":[47],"treatment":[49,188],"AD,":[51],"but":[52],"there":[53],"lack":[56],"discussion":[58],"its":[60],"target":[61],"clinical":[64,192],"mechanism.":[65],"In":[66],"this":[67],"study,":[68],"core":[70,148,159],"targets":[71,112,160],"key":[73,111],"pathways":[74,123],"between":[75],"CPA":[76,95,151,168],"AD":[78],"were":[79],"analyzed":[80],"network":[82],"pharmacology":[83],"molecular":[85,154],"docking":[86,155],"methods.":[87],"results":[89,165,184],"showed":[90],"that":[91,167],"active":[92],"compounds":[93],"in":[94,120,172],"(such":[96,113,124],"as":[97,114,125],"baicalin,":[98],"glycyrrhizin,":[99],"stigmasterol,":[100],"diosgenin,":[101],"cis-ligustilide,":[102],"etc.)":[103,119],"played":[104,169],"anti-inflammatory":[105],"anti-apoptotic":[107],"effects":[108],"regulating":[110,179],"APP,":[115],"EGFR,":[116],"ESR1,":[117],"PTGS2,":[118],"related":[121],"signaling":[122,130],"pathway,":[128],"NF-kB":[129],"pathways,":[131],"etc.":[132],")":[133],"reduce":[135],"aggregation":[137],"\u03b2":[139],"amyloid":[140],"protein":[141],"inhibit":[143],"Tau":[144],"hyperphosphorylation,":[145],"components":[149],"had":[152],"activity":[156],"with":[157],"pathway.":[163],"These":[164,183],"indicated":[166],"role":[171],"preventing":[173],"improving":[175],"multi-target":[180],"multi-channel.":[182],"will":[185],"provide":[186],"effective":[187],"basis":[189],"for":[190],"future":[191],"research.":[193]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-10T00:00:00"}
