{"id":"https://openalex.org/W4402397601","doi":"https://doi.org/10.1186/s43556-024-00200-3","title":"Gut microbiome influences efficacy of Endostatin combined with PD-1 blockade against colorectal cancer","display_name":"Gut microbiome influences efficacy of Endostatin combined with PD-1 blockade against colorectal cancer","publication_year":2024,"publication_date":"2024-09-10","ids":{"openalex":"https://openalex.org/W4402397601","doi":"https://doi.org/10.1186/s43556-024-00200-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/39251538","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11383918"},"language":"en","primary_location":{"id":"doi:10.1186/s43556-024-00200-3","doi":"https://doi.org/10.1186/s43556-024-00200-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-024-00200-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-024-00200-3.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s43556-024-00200-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108954099","display_name":"Jie Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Xu","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047165914","display_name":"Yaomei Tian","orcid":"https://orcid.org/0000-0002-8979-7970","observed_orcids":["https://orcid.org/0000-0002-8979-7970"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]},{"id":"https://openalex.org/I64852412","display_name":"Sichuan University of Science and Engineering","ror":"https://ror.org/053fzma23","country_code":"CN","type":"education","lineage":["https://openalex.org/I64852412"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaomei Tian","raw_affiliation_strings":["College of Bioengineering, Sichuan University of Science & Engineering, No. 519, Huixing Road, Zigong, Sichuan, 643000, The People's Republic of China","State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-8979-7970","affiliations":[{"raw_affiliation_string":"College of Bioengineering, Sichuan University of Science & Engineering, No. 519, Huixing Road, Zigong, Sichuan, 643000, The People's Republic of China","institution_ids":["https://openalex.org/I64852412"]},{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040018985","display_name":"Binyan Zhao","orcid":"https://orcid.org/0000-0002-6504-8713","observed_orcids":["https://orcid.org/0000-0002-6504-8713"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Binyan Zhao","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100711738","display_name":"Die Hu","orcid":"https://orcid.org/0000-0001-6644-9597","observed_orcids":["https://orcid.org/0000-0001-6644-9597"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Die Hu","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080199657","display_name":"Siwen Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siwen Wu","raw_affiliation_strings":["State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100460558","display_name":"Jing Ma","orcid":"https://orcid.org/0000-0002-9650-2421","observed_orcids":["https://orcid.org/0000-0002-9650-2421","https://orcid.org/0000-0001-9185-7760"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jing ma","raw_affiliation_strings":["Biological Products Inspection Institute of Sichuan Institute of Drug Inspection, Sichuan, The People's Republic of China. scidc_bpl@scsyjs.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Products Inspection Institute of Sichuan Institute of Drug Inspection, Sichuan, The People's Republic of China. scidc_bpl@scsyjs.org","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100612475","display_name":"Li Yang","orcid":"https://orcid.org/0000-0002-7880-2113","observed_orcids":["https://orcid.org/0000-0002-7880-2113"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]},{"id":"https://openalex.org/I4391768003","display_name":"State Key Laboratory of Biotherapy","ror":"https://ror.org/00x43yy22","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768003"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Yang","raw_affiliation_strings":["Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, China. yl.tracy73@gmail.com","State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China. yl.tracy73@gmail.com"],"raw_orcid":"https://orcid.org/0000-0002-7880-2113","affiliations":[{"raw_affiliation_string":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu, 610212, China. yl.tracy73@gmail.com","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, No. 17, West China Hospital, Sichuan University, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, The People's Republic of China. yl.tracy73@gmail.com","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100460558","https://openalex.org/A5100612475"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761","https://openalex.org/I4391768003"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":2.5859,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.91962526,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"5","issue":"1","first_page":"37","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9750000238418579},{"id":"https://openalex.org/keywords/endostatin","display_name":"endostatin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.921999990940094},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9430000185966492},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bacteroides-fragilis","display_name":"Bacteroides fragilis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/isobutyric-acid","display_name":"isobutyric acid","score":0.8930000066757202},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9049999713897705},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6460000276565552},{"id":"https://openalex.org/keywords/mc38-tumor-model","display_name":"MC38 tumor","score":0.6399999856948853},{"id":"https://openalex.org/keywords/microbiota-depletion","display_name":"microbiota depletion","score":0.5070000290870667},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2780246119","wikidata":"https://www.wikidata.org/wiki/Q221817","display_name":"Bacteroides fragilis","level":3,"score":0.8964344263076782},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.684367835521698},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6404074430465698},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6344878077507019},{"id":"https://openalex.org/C75920679","wikidata":"https://www.wikidata.org/wiki/Q359012","display_name":"Endostatin","level":3,"score":0.6123250722885132},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5464127063751221},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5380095839500427},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5335037708282471},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.5157297253608704},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.45049041509628296},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.45038676261901855},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.447521835565567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4236932098865509},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4210854172706604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33643898367881775},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2366161346435547},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2283523976802826},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12375617027282715},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09528487920761108},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s43556-024-00200-3","doi":"https://doi.org/10.1186/s43556-024-00200-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-024-00200-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-024-00200-3.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11383918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11383918","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11383918/pdf/43556_2024_Article_200.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biomed","raw_type":"Text"},{"id":"pmid:39251538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39251538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bbf81cf0381a469caa7c04489c0eb4e1","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bbf81cf0381a469caa7c04489c0eb4e1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Biomedicine, Vol 5, Iss 1, Pp 1-17 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s43556-024-00200-3","doi":"https://doi.org/10.1186/s43556-024-00200-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s43556-024-00200-3","pdf_url":"https://link.springer.com/content/pdf/10.1186/s43556-024-00200-3.pdf","source":{"id":"https://openalex.org/S4210227457","display_name":"Molecular Biomedicine","issn_l":"2662-8651","issn":["2662-8651"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322990","display_name":"Sichuan University","ror":"https://ror.org/011ashp19"},{"id":"https://openalex.org/F4320336042","display_name":"West China Hospital, Sichuan University","ror":"https://ror.org/007mrxy13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402397601.pdf","grobid_xml":"https://content.openalex.org/works/W4402397601.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1982591069","https://openalex.org/W1999906527","https://openalex.org/W2021283639","https://openalex.org/W2041280565","https://openalex.org/W2047477005","https://openalex.org/W2047517931","https://openalex.org/W2060185417","https://openalex.org/W2064228125","https://openalex.org/W2072417345","https://openalex.org/W2081831171","https://openalex.org/W2088322591","https://openalex.org/W2099147393","https://openalex.org/W2116676186","https://openalex.org/W2123558100","https://openalex.org/W2131798870","https://openalex.org/W2139375784","https://openalex.org/W2141643459","https://openalex.org/W2154670252","https://openalex.org/W2165456770","https://openalex.org/W2168033293","https://openalex.org/W2185075416","https://openalex.org/W2301868345","https://openalex.org/W2398894736","https://openalex.org/W2409656339","https://openalex.org/W2436511965","https://openalex.org/W2609317492","https://openalex.org/W2737845433","https://openalex.org/W2739048790","https://openalex.org/W2765314233","https://openalex.org/W2765864836","https://openalex.org/W2766903152","https://openalex.org/W2791926234","https://openalex.org/W2797068438","https://openalex.org/W2800093403","https://openalex.org/W2810666425","https://openalex.org/W2872054593","https://openalex.org/W2884737885","https://openalex.org/W2887471365","https://openalex.org/W2900487160","https://openalex.org/W2913914265","https://openalex.org/W2915010259","https://openalex.org/W2919483263","https://openalex.org/W2924716708","https://openalex.org/W2933419869","https://openalex.org/W2956016709","https://openalex.org/W2963686803","https://openalex.org/W2965568488","https://openalex.org/W2993667306","https://openalex.org/W2995222714","https://openalex.org/W3000419898","https://openalex.org/W3001680293","https://openalex.org/W3096586635","https://openalex.org/W3109885192","https://openalex.org/W3115276438","https://openalex.org/W3116549682","https://openalex.org/W3118419510","https://openalex.org/W3129667909","https://openalex.org/W3175895832","https://openalex.org/W3181800567","https://openalex.org/W3184617699","https://openalex.org/W4220769578","https://openalex.org/W4280574665","https://openalex.org/W4281747334","https://openalex.org/W4283742742","https://openalex.org/W4291786797","https://openalex.org/W4313389004","https://openalex.org/W4313829789","https://openalex.org/W4316506879","https://openalex.org/W4385406583","https://openalex.org/W4389178950","https://openalex.org/W4395447498"],"related_works":["https://openalex.org/W4313829789","https://openalex.org/W4401475745","https://openalex.org/W4211137283","https://openalex.org/W3210439344","https://openalex.org/W4313812066","https://openalex.org/W7128427956","https://openalex.org/W7126174337","https://openalex.org/W4393276328","https://openalex.org/W2740447051","https://openalex.org/W3161836741"],"abstract_inverted_index":{"Abstract":[0],"The":[1,112],"combination":[2,66,122,131,156,210],"of":[3,14,47,67,114,130,138,148,155,211],"anti-angiogenic":[4,68],"drugs":[5,69],"and":[6,39,70,104,158,176,213,227],"immune":[7,48,71,229],"checkpoint":[8,49,72],"inhibitors":[9,73],"(ICIs)":[10],"in":[11,33,35,61,64,117,180,208],"the":[12,36,44,65,127,136,152,181,209],"treatment":[13],"tumors":[15],"is":[16,53],"emerging":[17],"as":[18,85],"a":[19,59,164],"way":[20],"to":[21,163,184],"improve":[22,171],"ICIs-resistant":[23],"tumor":[24,37,110,182,186,224],"therapy.":[25],"In":[26,141],"addition,":[27],"gut":[28,56],"microbes":[29,57,116],"(GMs)":[30],"are":[31,40],"involved":[32,207],"angiogenesis":[34,79],"microenvironment":[38,183],"also":[41],"associated":[42],"with":[43,96,143],"antitumor":[45,128,153,193],"function":[46,63,129,194],"inhibitors.":[50],"However,":[51],"it":[52],"unclear":[54],"whether":[55],"have":[58],"role":[60],"anti-tumor":[62],"for":[74,89,216,223],"cancer":[75,217,228],"treatment.":[76,123],"Endostatin,":[77],"an":[78,86,97],"inhibitor,":[80],"has":[81,220],"been":[82],"widely":[83],"used":[84],"antiangiogenic":[87],"therapy":[88,95,132],"cancer.":[90],"We":[91,124],"showed":[92],"that":[93,126,203],"combined":[94],"adenovirus":[98],"encoding":[99],"human":[100],"endostatin,":[101],"named":[102],"Ad-E,":[103],"PD-1":[105],"blockade":[106],"dramatically":[107],"abrogated":[108],"MC38":[109],"growth.":[111,187],"structure":[113],"intestinal":[115,139],"mice":[118,142],"was":[119,133],"changed":[120],"after":[121,135],"found":[125],"inhibited":[134],"elimination":[137],"microbes.":[140],"depleted":[144],"microbiota,":[145],"oral":[146],"gavage":[147],"Bacteroides":[149,168,189],"fragilis":[150,169,190],"salvaged":[151],"effects":[154],"Ad-E":[157,212],"\u03b1PD-1":[159,214],"monoclonal":[160],"antibody":[161],"(mAb)":[162],"certain":[165],"extent.":[166],"Further,":[167],"could":[170],"CD3+T":[172],"cells,":[173,175],"NK":[174],"IFN\u03b3+CD8+":[177],"T":[178],"cells":[179],"inhibit":[185],"Besides,":[188],"might":[191],"restore":[192],"by":[195],"down-regulating":[196],"isobutyric":[197],"acid":[198],"(IBA).":[199],"Our":[200],"results":[201],"suggested":[202],"GMs":[204],"may":[205],"be":[206],"mAb":[215],"treatment,":[218],"which":[219],"oncological":[221],"implications":[222],"growth":[225],"dynamics":[226],"surveillance.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-11T00:00:00"}
