{"id":"https://openalex.org/W4402395863","doi":"https://doi.org/10.1002/adhm.202402337","title":"Immuno\u2010Rolling Circle Amplification (Immuno\u2010RCA): Biosensing Strategies, Practical Applications, and Future Perspectives","display_name":"Immuno\u2010Rolling Circle Amplification (Immuno\u2010RCA): Biosensing Strategies, Practical Applications, and Future Perspectives","publication_year":2024,"publication_date":"2024-09-10","ids":{"openalex":"https://openalex.org/W4402395863","doi":"https://doi.org/10.1002/adhm.202402337","pmid":"https://pubmed.ncbi.nlm.nih.gov/39252654"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.202402337","doi":"https://doi.org/10.1002/adhm.202402337","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.202402337","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100415158","display_name":"Limei Zhang","orcid":"https://orcid.org/0000-0001-9522-790X","observed_orcids":["https://orcid.org/0000-0001-9522-790X"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limei Zhang","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052759327","display_name":"Hao Bai","orcid":"https://orcid.org/0000-0002-0916-5755","observed_orcids":["https://orcid.org/0000-0002-0916-5755"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Bai","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":"https://orcid.org/0000-0002-0916-5755","affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069626327","display_name":"Jie Zou","orcid":"https://orcid.org/0000-0001-6041-1125","observed_orcids":["https://orcid.org/0000-0001-6041-1125"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Zou","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089045549","display_name":"Chuyan Zhang","orcid":"https://orcid.org/0000-0002-9667-846X","observed_orcids":["https://orcid.org/0000-0002-9667-846X","https://orcid.org/0000-0003-3674-8830"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuyan Zhang","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":"https://orcid.org/0000-0003-3674-8830","affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054789980","display_name":"Weihua Zhuang","orcid":"https://orcid.org/0000-0003-0492-7527","observed_orcids":["https://orcid.org/0000-0003-0492-7527"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihua Zhuang","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":"https://orcid.org/0000-0003-0492-7527","affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013067279","display_name":"Jie Hong Hu","orcid":"https://orcid.org/0000-0002-6137-9064","observed_orcids":["https://orcid.org/0000-0002-6137-9064"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Hu","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084708809","display_name":"Yongchao Yao","orcid":"https://orcid.org/0000-0002-8210-7121","observed_orcids":["https://orcid.org/0000-0002-8210-7121"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongchao Yao","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":"https://orcid.org/0000-0002-8210-7121","affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016591821","display_name":"Walter W. Hu","orcid":"https://orcid.org/0000-0002-6748-1916","observed_orcids":["https://orcid.org/0000-0002-6748-1916","https://orcid.org/0009-0004-9610-6957"]},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]},{"id":"https://openalex.org/I4210089761","display_name":"West China Hospital of Sichuan University","ror":"https://ror.org/007mrxy13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210089761"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenchuang (Walter) Hu","raw_affiliation_strings":["Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China"],"raw_orcid":"https://orcid.org/0000-0002-6748-1916","affiliations":[{"raw_affiliation_string":"Precision Medicine Translational Research Center (PMTRC) Department of Laboratory Medicine West China Hospital Sichuan University  Chengdu Sichuan 610041 China","institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016591821"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I2800091995","https://openalex.org/I4210089761"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":0.8427,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.65648427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"32","first_page":"e2402337","last_page":"e2402337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rolling-circle-amplification","display_name":"rolling circle amplification","score":0.9629999995231628},{"id":"https://openalex.org/keywords/signal-amplification","display_name":"signal amplification","score":0.8489999771118164},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.9240000247955322},{"id":"https://openalex.org/keywords/biosensors","display_name":"biosensors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/biomarker-detection","display_name":"biomarker detection","score":0.8930000066757202},{"id":"https://openalex.org/keywords/single-molecule-detection","display_name":"single-molecule detection","score":0.9290000200271606},{"id":"https://openalex.org/keywords/circular-dna-templates","display_name":"circular DNA templates","score":0.7350000143051147},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.781000018119812},{"id":"https://openalex.org/keywords/diagnostics","display_name":"diagnostics","score":0.5210000276565552},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"biomarker discovery","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C7452308","wikidata":"https://www.wikidata.org/wiki/Q3112822","display_name":"Rolling circle replication","level":4,"score":0.8808663487434387},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6676669120788574},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.6481912732124329},{"id":"https://openalex.org/C66782513","wikidata":"https://www.wikidata.org/wiki/Q864601","display_name":"Biomedicine","level":2,"score":0.6422091722488403},{"id":"https://openalex.org/C49853544","wikidata":"https://www.wikidata.org/wiki/Q206229","display_name":"Biomolecule","level":2,"score":0.5899436473846436},{"id":"https://openalex.org/C137535248","wikidata":"https://www.wikidata.org/wiki/Q4914691","display_name":"Bioanalysis","level":2,"score":0.5385438203811646},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46373477578163147},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4146891236305237},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24357792735099792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24308434128761292},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2168509066104889},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1933853030204773},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0775085985660553},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004270","descriptor_name":"DNA, Circular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D021141","descriptor_name":"Nucleic Acid Amplification Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.202402337","doi":"https://doi.org/10.1002/adhm.202402337","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.202402337","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:39252654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39252654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G42593620","display_name":null,"funder_award_id":"ZYGX2022YGRH002","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":190,"referenced_works":["https://openalex.org/W14671359","https://openalex.org/W750794043","https://openalex.org/W1530960824","https://openalex.org/W1708866424","https://openalex.org/W1972221830","https://openalex.org/W1972790909","https://openalex.org/W1974399372","https://openalex.org/W1976785971","https://openalex.org/W1996538021","https://openalex.org/W2001559409","https://openalex.org/W2016943398","https://openalex.org/W2025956077","https://openalex.org/W2027001273","https://openalex.org/W2034630077","https://openalex.org/W2035951630","https://openalex.org/W2038744035","https://openalex.org/W2040172043","https://openalex.org/W2043691999","https://openalex.org/W2050352631","https://openalex.org/W2050387685","https://openalex.org/W2053320202","https://openalex.org/W2055108575","https://openalex.org/W2069913772","https://openalex.org/W2077292423","https://openalex.org/W2081221548","https://openalex.org/W2082754436","https://openalex.org/W2084272002","https://openalex.org/W2090462692","https://openalex.org/W2091298788","https://openalex.org/W2106781930","https://openalex.org/W2109445702","https://openalex.org/W2117659678","https://openalex.org/W2118903707","https://openalex.org/W2133930954","https://openalex.org/W2145303234","https://openalex.org/W2146719101","https://openalex.org/W2257067466","https://openalex.org/W2293363147","https://openalex.org/W2318872441","https://openalex.org/W2329887558","https://openalex.org/W2403311782","https://openalex.org/W2460997937","https://openalex.org/W2480468978","https://openalex.org/W2527391297","https://openalex.org/W2552535243","https://openalex.org/W2611288605","https://openalex.org/W2613116661","https://openalex.org/W2745417210","https://openalex.org/W2770101695","https://openalex.org/W2786202610","https://openalex.org/W2794387057","https://openalex.org/W2800916479","https://openalex.org/W2801981871","https://openalex.org/W2802350433","https://openalex.org/W2895690595","https://openalex.org/W2938518143","https://openalex.org/W2969837995","https://openalex.org/W2977861177","https://openalex.org/W2982988696","https://openalex.org/W2997502283","https://openalex.org/W3000172394","https://openalex.org/W3004391246","https://openalex.org/W3004781275","https://openalex.org/W3005104290","https://openalex.org/W3012221854","https://openalex.org/W3021076897","https://openalex.org/W3025896955","https://openalex.org/W3029499190","https://openalex.org/W3034026674","https://openalex.org/W3039872457","https://openalex.org/W3045499237","https://openalex.org/W3099594428","https://openalex.org/W3101476137","https://openalex.org/W3107282776","https://openalex.org/W3115848604","https://openalex.org/W3122790855","https://openalex.org/W3131708419","https://openalex.org/W3134197002","https://openalex.org/W3138350580","https://openalex.org/W3146292195","https://openalex.org/W3149073958","https://openalex.org/W3165934065","https://openalex.org/W3177853972","https://openalex.org/W3178761710","https://openalex.org/W3198942202","https://openalex.org/W3200368306","https://openalex.org/W3205925041","https://openalex.org/W3206153956","https://openalex.org/W3207443835","https://openalex.org/W3209285056","https://openalex.org/W3210580612","https://openalex.org/W4200187549","https://openalex.org/W4205155921","https://openalex.org/W4213200965","https://openalex.org/W4213230287","https://openalex.org/W4213373251","https://openalex.org/W4220771053","https://openalex.org/W4221061687","https://openalex.org/W4224311399","https://openalex.org/W4226030257","https://openalex.org/W4230564751","https://openalex.org/W4281666356","https://openalex.org/W4283453434","https://openalex.org/W4283793647","https://openalex.org/W4285490702","https://openalex.org/W4294068858","https://openalex.org/W4294989754","https://openalex.org/W4295464110","https://openalex.org/W4296381520","https://openalex.org/W4301185173","https://openalex.org/W4306412530","https://openalex.org/W4306831767","https://openalex.org/W4310462733","https://openalex.org/W4313655700","https://openalex.org/W4318539592","https://openalex.org/W4318542373","https://openalex.org/W4361215673","https://openalex.org/W4361224134","https://openalex.org/W4361292562","https://openalex.org/W4365457377","https://openalex.org/W4366609834","https://openalex.org/W4377029875","https://openalex.org/W4380986663","https://openalex.org/W4382931004","https://openalex.org/W4385201617","https://openalex.org/W4385260298","https://openalex.org/W4385923954","https://openalex.org/W4386003509","https://openalex.org/W4387515960","https://openalex.org/W4387573881","https://openalex.org/W4387660867","https://openalex.org/W4387692962","https://openalex.org/W4388153544","https://openalex.org/W4388821870","https://openalex.org/W4389513514","https://openalex.org/W4389720828","https://openalex.org/W4391654428","https://openalex.org/W4391691932","https://openalex.org/W4391745947","https://openalex.org/W4391821974","https://openalex.org/W4391884040","https://openalex.org/W4392129281","https://openalex.org/W4392361227","https://openalex.org/W4392661681","https://openalex.org/W4392666146","https://openalex.org/W4392717486","https://openalex.org/W4392915942","https://openalex.org/W4393130087","https://openalex.org/W4393188922","https://openalex.org/W4393388783","https://openalex.org/W4394569179","https://openalex.org/W4394698108","https://openalex.org/W4394758821","https://openalex.org/W4394769978","https://openalex.org/W4395465306","https://openalex.org/W4395664325","https://openalex.org/W4396721421","https://openalex.org/W4398141029","https://openalex.org/W4399070192","https://openalex.org/W4399093990","https://openalex.org/W4399104954","https://openalex.org/W6600005967","https://openalex.org/W6600031136","https://openalex.org/W6600103761","https://openalex.org/W6600137863","https://openalex.org/W6600210674","https://openalex.org/W6600238479","https://openalex.org/W6600423979","https://openalex.org/W6600651459","https://openalex.org/W6600797165","https://openalex.org/W6601280837","https://openalex.org/W6601403687","https://openalex.org/W6601487527","https://openalex.org/W6601603263","https://openalex.org/W6603514168","https://openalex.org/W6603860191","https://openalex.org/W6606133544","https://openalex.org/W6607343888","https://openalex.org/W6607666538","https://openalex.org/W6607733250","https://openalex.org/W6607950872","https://openalex.org/W6609822380","https://openalex.org/W6630149902","https://openalex.org/W6634580229","https://openalex.org/W6680303759","https://openalex.org/W6704017408","https://openalex.org/W6733074214","https://openalex.org/W6829606992","https://openalex.org/W6830796964","https://openalex.org/W6840230124"],"related_works":["https://openalex.org/W2555579645","https://openalex.org/W3115456245","https://openalex.org/W2040172043","https://openalex.org/W4282834715","https://openalex.org/W2802350433","https://openalex.org/W4414161523","https://openalex.org/W2527391297","https://openalex.org/W4283453434","https://openalex.org/W3138350580","https://openalex.org/W2166996651"],"abstract_inverted_index":{"In":[0],"the":[1,41,118,127,136,151],"rapidly":[2],"evolving":[3],"field":[4],"of":[5,25,43,101,135,143],"life":[6],"sciences":[7],"and":[8,13,32,40,53,112,123,139,157,183],"biomedicine,":[9],"detecting":[10,146],"low-abundance":[11],"biomolecules,":[12],"ultraweak":[14],"biosignals":[15],"presents":[16],"significant":[17],"challenges.":[18],"This":[19,76,130,165],"has":[20],"spurred":[21],"a":[22,47,80,85,97,102,169],"rapid":[23],"development":[24],"analytical":[26],"techniques":[27],"aiming":[28],"for":[29,161,172],"increased":[30],"sensitivity":[31],"specificity.":[33],"These":[34],"advancements,":[35],"including":[36],"signal":[37,72,115],"amplification":[38,64,73,111],"strategies":[39],"integration":[42],"biorecognition":[44],"events,":[45],"mark":[46],"transformative":[48],"era":[49],"in":[50,145,175],"bioanalytical":[51],"precision":[52],"accuracy.":[54],"A":[55],"prominent":[56],"method":[57],"among":[58],"these":[59,155],"innovations":[60],"is":[61,121],"immuno-rolling":[62],"circle":[63],"(immuno-RCA)":[65],"technology,":[66],"which":[67],"effectively":[68],"combines":[69],"immunoassays":[70],"with":[71],"via":[74],"RCA.":[75],"process":[77],"starts":[78],"when":[79],"targeted":[81],"biomolecule,":[82],"such":[83,178],"as":[84,168,179],"protein":[86],"or":[87,94],"cell,":[88],"binds":[89],"to":[90,109,154],"an":[91,133],"immobilized":[92],"antibody":[93],"probe":[95],"on":[96],"substrate.":[98],"The":[99],"introduction":[100],"circular":[103],"DNA":[104],"template":[105],"triggers":[106],"RCA,":[107],"leading":[108],"exponential":[110],"significantly":[113],"enhanced":[114],"intensity,":[116],"thus":[117],"target":[119],"molecule":[120],"detectable":[122],"quantifiable":[124],"even":[125],"at":[126],"single-molecule":[128],"level.":[129],"review":[131,166],"provides":[132],"overview":[134],"biosensing":[137],"strategy":[138],"extensive":[140],"practical":[141],"applications":[142],"immuno-RCA":[144,174],"biomarkers.":[147],"Furthermore,":[148],"it":[149],"scrutinizes":[150],"limitations":[152],"inherent":[153],"sensors":[156],"sets":[158],"forth":[159],"expectations":[160],"their":[162],"future":[163],"trajectory.":[164],"serves":[167],"valuable":[170],"reference":[171],"advancing":[173],"various":[176],"domains,":[177],"diagnostics,":[180],"biomarker":[181],"discovery,":[182],"molecular":[184],"imaging.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-11T00:00:00"}