{"id":"https://openalex.org/W4402390401","doi":"https://doi.org/10.1016/j.heliyon.2024.e37741","title":"Integrative analysis of the immunological significances of guanylate binding protein family genes in microsatellite stability colorectal cancer","display_name":"Integrative analysis of the immunological significances of guanylate binding protein family genes in microsatellite stability colorectal cancer","publication_year":2024,"publication_date":"2024-09-01","ids":{"openalex":"https://openalex.org/W4402390401","doi":"https://doi.org/10.1016/j.heliyon.2024.e37741","pmid":"https://pubmed.ncbi.nlm.nih.gov/39315131"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e37741","doi":"https://doi.org/10.1016/j.heliyon.2024.e37741","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e37741","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e37741","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Xin Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ting Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Han","raw_affiliation_strings":["Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022220036","display_name":"Yinchun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinchun Wang","raw_affiliation_strings":["Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103080466","display_name":"Rui Ryan Yang","orcid":"https://orcid.org/0000-0003-1801-6134","observed_orcids":["https://orcid.org/0000-0003-1801-6134"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Yang","raw_affiliation_strings":["Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072018037","display_name":"Qingqiang Yang","orcid":"https://orcid.org/0000-0001-7304-3501","observed_orcids":["https://orcid.org/0000-0001-7304-3501"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqiang Yang","raw_affiliation_strings":["Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100380466","display_name":"Jianxin Li","orcid":"https://orcid.org/0000-0001-9863-6493","observed_orcids":["https://orcid.org/0000-0001-9863-6493","https://orcid.org/0009-0003-9640-5386"]},"institutions":[{"id":"https://openalex.org/I3017480383","display_name":"Southwest Medical University","ror":"https://ror.org/00g2rqs52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I3017480383"]},{"id":"https://openalex.org/I4210086248","display_name":"Affiliated Hospital of Southwest Medical University","ror":"https://ror.org/0014a0n68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianxin Li","raw_affiliation_strings":["Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China"],"raw_orcid":"https://orcid.org/0000-0001-9863-6493","affiliations":[{"raw_affiliation_string":"Department of General Surgery (Gastrointestinal Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China","institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100380466"],"corresponding_institution_ids":["https://openalex.org/I3017480383","https://openalex.org/I4210086248"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.1525,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50176156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"10","issue":"18","first_page":"e37741","last_page":"e37741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7134000062942505,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.25780001282691956,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guanylate-binding-proteins","display_name":"guanylate-binding proteins","score":0.984000027179718},{"id":"https://openalex.org/keywords/microsatellite-stable-colorectal-cancer","display_name":"microsatellite stable colorectal cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.7009999752044678},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interferon-gamma-signaling","display_name":"interferon-gamma signaling","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nod-like-receptor-signaling-pathway","display_name":"NOD-like receptor signaling","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/immune-checkpoint-proteins","display_name":"immune checkpoint molecules","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mhc-molecules","display_name":"MHC molecules","score":0.7929999828338623},{"id":"https://openalex.org/keywords/distant-metastasis","display_name":"distant metastasis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.4180000126361847},{"id":"https://openalex.org/keywords/microsatellite-instability-high","display_name":"microsatellite instability-high","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.8213541507720947},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5254099369049072},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.5018205642700195},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.4878687858581543},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47859856486320496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4551248252391815},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4297838807106018},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3896751403808594},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3710956871509552},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3475358188152313},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e37741","doi":"https://doi.org/10.1016/j.heliyon.2024.e37741","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e37741","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmid:39315131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39315131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11417218","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11417218","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11417218/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:febb44f523ce4463bdaff03191e8bf60","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/febb44f523ce4463bdaff03191e8bf60","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 18, Pp e37741- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e37741","doi":"https://doi.org/10.1016/j.heliyon.2024.e37741","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e37741","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1934094702","https://openalex.org/W1940241680","https://openalex.org/W2009755744","https://openalex.org/W2029795357","https://openalex.org/W2094390470","https://openalex.org/W2137695731","https://openalex.org/W2140683554","https://openalex.org/W2150782426","https://openalex.org/W2162589834","https://openalex.org/W2163104272","https://openalex.org/W2598870398","https://openalex.org/W2752793362","https://openalex.org/W2766263972","https://openalex.org/W2767509615","https://openalex.org/W2788142646","https://openalex.org/W2789762962","https://openalex.org/W2799849968","https://openalex.org/W2884397450","https://openalex.org/W2885569023","https://openalex.org/W2914381860","https://openalex.org/W2920863623","https://openalex.org/W2935748755","https://openalex.org/W2971936647","https://openalex.org/W2981211513","https://openalex.org/W2983813540","https://openalex.org/W3006514782","https://openalex.org/W3008032684","https://openalex.org/W3010538789","https://openalex.org/W3013682272","https://openalex.org/W3015035400","https://openalex.org/W3021442601","https://openalex.org/W3028304854","https://openalex.org/W3033498185","https://openalex.org/W3036095870","https://openalex.org/W3106806530","https://openalex.org/W3121061270","https://openalex.org/W3128646645","https://openalex.org/W3147963921","https://openalex.org/W3185231871","https://openalex.org/W3192263764","https://openalex.org/W4211241149","https://openalex.org/W4220831425","https://openalex.org/W4220872849","https://openalex.org/W4224077408","https://openalex.org/W4225277813","https://openalex.org/W4283783550","https://openalex.org/W4309436817","https://openalex.org/W4317689970","https://openalex.org/W4376226118","https://openalex.org/W6772491042","https://openalex.org/W6808394429"],"related_works":["https://openalex.org/W2412807156","https://openalex.org/W2081783593","https://openalex.org/W2029130118","https://openalex.org/W2299919100","https://openalex.org/W2067665082","https://openalex.org/W2473005840","https://openalex.org/W2969016060","https://openalex.org/W1982747239","https://openalex.org/W4389733843","https://openalex.org/W3190480768"],"abstract_inverted_index":{"Background":[0],"Microsatellite":[1],"stability":[2],"(MSS)":[3],"colorectal":[4],"cancer":[5],"(CRC)":[6],"has":[7],"poor":[8],"sensitivity":[9],"to":[10,56,92,114],"immunotherapy":[11,191,194],"and":[12,38,68,119,136,168,170,179,209],"its":[13],"underlying":[14],"mechanisms":[15],"are":[16,23,88,100,140,151],"still":[17],"unclear.":[18],"Guanylate":[19],"binding":[20],"proteins":[21],"(GBPs)":[22],"a":[24],"family":[25,215],"of":[26,44,71,81,109,149,206,213],"GTPase":[27],"involving":[28],"innate":[29],"immune":[30,158,175],"responses":[31],"by":[32],"providing":[33],"defense":[34],"against":[35],"invading":[36],"microbes":[37],"pathogens.":[39],"However,":[40],"the":[41,59,141,146,204],"immunological":[42],"significances":[43],"GBPs":[45,84,150],"in":[46,75,85,123,193,216],"MSS":[47,76,86,127,219],"CRC":[48,124,217],"remain":[49],"unknown.":[50],"Methods":[51],"We":[52],"utilized":[53],"bioinformatic":[54],"tools":[55],"comprehensively":[57],"analysis":[58,131],"expression":[60,80,108,147,188],"pattern,":[61],"clinical":[62],"relevance,":[63],"prognostic":[64,211],"value,":[65],"biological":[66],"function,":[67],"immunoregulation":[69],"effect":[70],"distinct":[72],"GBP":[73,214],"members":[74],"CRC.":[77],"Results":[78],"The":[79],"all":[82],"seven":[83],"samples":[87],"remarkably":[89,112,152],"decreased":[90],"compared":[91],"microsatellite":[93],"instability-high":[94],"(MSI-H)":[95],"samples.":[96,220],"Among":[97],"them,":[98],"GBP1/2/4/5":[99,187],"obviously":[101],"correlated":[102],"with":[103,126,154,218],"distant":[104],"metastasis":[105],"status.":[106],"High":[107],"GBP1/4/5/6":[110],"was":[111],"related":[113],"favorable":[115],"overall":[116],"survival":[117,121],"(OS)":[118],"progression-free":[120],"(PFS)":[122],"patients":[125],"tumor.":[128],"Subsequent":[129],"enrichment":[130],"revealed":[132],"that":[133],"Interferon-gamma":[134],"(IFN-\u03b3)":[135],"NOD-like":[137],"receptor":[138],"signaling":[139],"most":[142],"relevant":[143],"functions.":[144],"Besides,":[145],"patterns":[148],"associated":[153],"several":[155],"tumor":[156],"infiltrated":[157],"cells":[159],"(e.g.":[160,174],"regulatory":[161],"T":[162,166],"cells,":[163,167],"CD4":[164],"+":[165],"macrophages)":[169],"diverse":[171],"immunoregulatory":[172],"molecules":[173],"checkpoint":[176],"biomarkers":[177,212],"(ICBs)":[178],"major":[180],"histocompatibility":[181],"complex":[182],"(MHC)":[183],"molecules).":[184],"Moreover,":[185],"high":[186],"predicted":[189],"better":[190],"responsiveness":[192],"cohorts.":[195],"Conclusion":[196],"These":[197],"findings":[198],"might":[199],"provide":[200],"novel":[201],"insights":[202],"for":[203],"identification":[205],"therapeutic":[207],"targets":[208],"potential":[210]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}