{"id":"https://openalex.org/W4402374592","doi":"https://doi.org/10.1136/jnnp-2024-ehdn.132","title":"F014 Handling censored covariates in Huntington disease studies","display_name":"F014 Handling censored covariates in Huntington disease studies","publication_year":2024,"publication_date":"2024-09-01","ids":{"openalex":"https://openalex.org/W4402374592","doi":"https://doi.org/10.1136/jnnp-2024-ehdn.132"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2024-ehdn.132","doi":"https://doi.org/10.1136/jnnp-2024-ehdn.132","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp-2024-ehdn.132","pdf_url":"https://jnnp.bmj.com/content/jnnp/95/Suppl_1/A69.1.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F: Clinical studies: case reports, observational studies and trials","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jnnp.bmj.com/content/jnnp/95/Suppl_1/A69.1.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056272011","display_name":"J. V\u00e1zquez","orcid":"https://orcid.org/0000-0002-3166-1632","observed_orcids":["https://orcid.org/0000-0002-3166-1632"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesus Vazquez","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049086195","display_name":"Marissa C. Ashner","orcid":"https://orcid.org/0000-0002-2936-4161","observed_orcids":["https://orcid.org/0000-0002-2936-4161"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marissa Ashner","raw_affiliation_strings":["Department of Biostatistics and Bioinformatics, Duke University, Durham, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics and Bioinformatics, Duke University, Durham, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067460359","display_name":"Yanyuan Ma B","orcid":"https://orcid.org/0000-0001-6985-0351","observed_orcids":["https://orcid.org/0000-0001-6985-0351","https://orcid.org/0000-0002-7846-0758"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanyuan Ma","raw_affiliation_strings":["Department of Statistics, Penn State University, State College, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Penn State University, State College, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108387150","display_name":"Karen S. Marder","orcid":"https://orcid.org/0000-0003-0117-1429","observed_orcids":["https://orcid.org/0000-0003-0117-1429"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Marder","raw_affiliation_strings":["Department of Neurology, Columbia University Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Columbia University Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113681713","display_name":"Tanya Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Garcia","raw_affiliation_strings":["University of North Carolina at Chapel Hill, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina at Chapel Hill, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A69.1","last_page":"A69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10243","display_name":"Statistical Methods and Bayesian Inference","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.2542000114917755,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.07829999923706055,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/huntington-s-disease","display_name":"Huntington's disease","score":0.9350000023841858},{"id":"https://openalex.org/keywords/informative-censoring","display_name":"informative censoring","score":0.953000009059906},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.906000018119812},{"id":"https://openalex.org/keywords/inverse-probability-weighting","display_name":"inverse probability weighting","score":0.9700000286102295},{"id":"https://openalex.org/keywords/maximum-likelihood-estimation","display_name":"maximum likelihood estimation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/enroll-hd","display_name":"Enroll-HD","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7807267904281616},{"id":"https://openalex.org/C2780647506","wikidata":"https://www.wikidata.org/wiki/Q190564","display_name":"Huntington's disease","level":3,"score":0.6237753033638},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5460051894187927},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5328477025032043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20875221490859985},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.102206289768219},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05595967173576355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jnnp-2024-ehdn.132","doi":"https://doi.org/10.1136/jnnp-2024-ehdn.132","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp-2024-ehdn.132","pdf_url":"https://jnnp.bmj.com/content/jnnp/95/Suppl_1/A69.1.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F: Clinical studies: case reports, observational studies and trials","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jnnp-2024-ehdn.132","doi":"https://doi.org/10.1136/jnnp-2024-ehdn.132","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jnnp-2024-ehdn.132","pdf_url":"https://jnnp.bmj.com/content/jnnp/95/Suppl_1/A69.1.full.pdf","source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F: Clinical studies: case reports, observational studies and trials","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402374592.pdf","grobid_xml":"https://content.openalex.org/works/W4402374592.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7077478930","https://openalex.org/W7118571675","https://openalex.org/W7106304003","https://openalex.org/W7170067169","https://openalex.org/W4403709528","https://openalex.org/W4403593892","https://openalex.org/W4323322888","https://openalex.org/W4386532432","https://openalex.org/W4414541453","https://openalex.org/W4416436448"],"abstract_inverted_index":{"Cognitive":[0],"dysfunction":[1,27],"is":[2,36,91,106,111,125],"a":[3,29,37,59,144,186],"symptom":[4],"of":[5,31,93,113,135,165,170,190,199],"Huntington":[6],"disease":[7],"(HD)":[8],"and":[9,116,139,156,192,197],"can":[10],"serve":[11],"as":[12,28,73,88],"an":[13],"early":[14],"marker":[15],"for":[16,39,62,81],"evaluating":[17],"treatments":[18],"intended":[19],"at":[20,33,64,75],"delaying":[21],"motor":[22],"skill":[23],"decline.":[24],"Understanding":[25],"cognitive":[26],"function":[30],"age":[32,63,74],"clinical":[34,43,65,76],"diagnosis":[35,77],"prerequisite":[38],"their":[40],"use":[41],"in":[42,58,126,168],"trials,":[44],"but":[45],"this":[46],"remains":[47],"challenging":[48],"because":[49],"patients":[50],"drop":[51],"out":[52],"or":[53],"the":[54,98,103,162,194],"study":[55,189],"ends,":[56],"resulting":[57],"censored":[60,89],"value":[61],"diagnosis.":[66],"While":[67],"right-censored":[68],"time-":[69],"to-event":[70],"outcomes":[71],"such":[72],"have":[78],"been":[79],"studied":[80],"decades,":[82],"handling":[83,136],"time-to-event":[84],"covariates,":[85,90],"also":[86],"known":[87],"now":[92],"growing":[94],"interest.":[95],"So":[96],"far,":[97],"literature":[99],"has":[100,117],"assumed":[101],"that":[102],"covariate":[104,123,141],"censoring":[105,114,124],"noninformative,":[107],"i.e.,":[108],"event":[109],"time":[110],"independent":[112],"time,":[115],"yet":[118],"to":[119,184],"establish":[120,161],"methods":[121,133,181],"when":[122,171],"fact":[127],"informative.":[128],"Here,":[129],"we":[130],"present":[131],"five":[132],"capable":[134],"both":[137],"informative":[138],"noninformative":[140],"censoring,":[142],"namely":[143],"complete":[145,152],"case,":[146,153],"inverse":[147],"probability":[148],"weighting":[149],"(IPW),":[150],"augmented":[151,154],"IPW,":[155],"maximum":[157],"likelihood":[158],"estimators.":[159],"We":[160],"robustness":[163],"properties":[164],"these":[166,172],"estimators":[167,173],"terms":[169],"remain":[174],"consistent":[175],"despite":[176],"incorrect":[177],"distributional":[178],"assumptions.":[179],"All":[180],"are":[182],"applied":[183],"ENROLL-HD,":[185],"non-interventional":[187],"observational":[188],"HD,":[191],"compare":[193],"effect":[195],"estimates":[196],"variances":[198],"each":[200],"estimator.":[201]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2024-09-10T00:00:00"}
