{"id":"https://openalex.org/W4402309062","doi":"https://doi.org/10.1016/j.critrevonc.2024.104499","title":"Management of peripheral neuropathy associated with brentuximab vedotin in the frontline treatment of classical Hodgkin lymphoma","display_name":"Management of peripheral neuropathy associated with brentuximab vedotin in the frontline treatment of classical Hodgkin lymphoma","publication_year":2024,"publication_date":"2024-09-06","ids":{"openalex":"https://openalex.org/W4402309062","doi":"https://doi.org/10.1016/j.critrevonc.2024.104499","pmid":"https://pubmed.ncbi.nlm.nih.gov/39244180"},"language":"en","primary_location":{"id":"doi:10.1016/j.critrevonc.2024.104499","doi":"https://doi.org/10.1016/j.critrevonc.2024.104499","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.critrevonc.2024.104499","pdf_url":null,"source":{"id":"https://openalex.org/S185233701","display_name":"Critical Reviews in Oncology/Hematology","issn_l":"1040-8428","issn":["1040-8428","1879-0461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oncology/Hematology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.critrevonc.2024.104499","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002103749","display_name":"Jeremy S. Abramson","orcid":"https://orcid.org/0000-0001-8467-9257","observed_orcids":["https://orcid.org/0000-0001-8467-9257"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeremy S. Abramson","raw_affiliation_strings":["Massachusetts General Hospital,\u00a0Boston,\u00a0MA,\u00a0United States. Electronic address: jabramson@mgh.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital,\u00a0Boston,\u00a0MA,\u00a0United States. Electronic address: jabramson@mgh.harvard.edu","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086976880","display_name":"Robert N. Stuver","orcid":"https://orcid.org/0000-0003-0991-5170","observed_orcids":["https://orcid.org/0000-0003-0991-5170"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Stuver","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center,\u00a0New York,\u00a0NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center,\u00a0New York,\u00a0NY,\u00a0United States","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030788778","display_name":"Alex Francisco Herrera","orcid":"https://orcid.org/0000-0002-9665-7415","observed_orcids":["https://orcid.org/0000-0002-9665-7415"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex Herrera","raw_affiliation_strings":["City of Hope,\u00a0Duarte,\u00a0CA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope,\u00a0Duarte,\u00a0CA,\u00a0United States","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075972955","display_name":"Emily S. Patterson","orcid":"https://orcid.org/0000-0002-4514-2075","observed_orcids":["https://orcid.org/0000-0002-4514-2075"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Patterson","raw_affiliation_strings":["Massachusetts General Hospital,\u00a0Boston,\u00a0MA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital,\u00a0Boston,\u00a0MA,\u00a0United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031910275","display_name":"Yi-Ping Wen","orcid":"https://orcid.org/0009-0009-8683-595X","observed_orcids":["https://orcid.org/0009-0009-8683-595X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Ping Wen","raw_affiliation_strings":["City of Hope,\u00a0Duarte,\u00a0CA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Hope,\u00a0Duarte,\u00a0CA,\u00a0United States","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062879857","display_name":"Alison J. Moskowitz","orcid":"https://orcid.org/0000-0002-3408-050X","observed_orcids":["https://orcid.org/0000-0002-3408-050X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alison Moskowitz","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center,\u00a0New York,\u00a0NY,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center,\u00a0New York,\u00a0NY,\u00a0United States","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5002103749"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":0.4422,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.47072331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"204","issue":null,"first_page":"104499","last_page":"104499"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.8154000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.13040000200271606,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brentuximab-vedotin","display_name":"brentuximab vedotin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/classical-hodgkin-lymphoma","display_name":"classical Hodgkin lymphoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.875},{"id":"https://openalex.org/keywords/dacarbazine","display_name":"dacarbazine","score":0.968999981880188},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neuropathy-management","display_name":"neuropathy management","score":0.6869999766349792},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C2778191690","wikidata":"https://www.wikidata.org/wiki/Q422324","display_name":"Brentuximab vedotin","level":4,"score":0.9799550771713257},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.8845874071121216},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.8842533230781555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8370001316070557},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.7624790072441101},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.6521384716033936},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5366365909576416},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5361172556877136},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5153164863586426},{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.49765685200691223},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4296642243862152},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.34837469458580017},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.05619019269943237},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000079963","descriptor_name":"Brentuximab Vedotin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000079963","descriptor_name":"Brentuximab Vedotin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006689","descriptor_name":"Hodgkin Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.critrevonc.2024.104499","doi":"https://doi.org/10.1016/j.critrevonc.2024.104499","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.critrevonc.2024.104499","pdf_url":null,"source":{"id":"https://openalex.org/S185233701","display_name":"Critical Reviews in Oncology/Hematology","issn_l":"1040-8428","issn":["1040-8428","1879-0461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oncology/Hematology","raw_type":"journal-article"},{"id":"pmid:39244180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39244180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in oncology/hematology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.critrevonc.2024.104499","doi":"https://doi.org/10.1016/j.critrevonc.2024.104499","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.critrevonc.2024.104499","pdf_url":null,"source":{"id":"https://openalex.org/S185233701","display_name":"Critical Reviews in Oncology/Hematology","issn_l":"1040-8428","issn":["1040-8428","1879-0461"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Oncology/Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W2023049866","https://openalex.org/W2057662279","https://openalex.org/W2062486240","https://openalex.org/W2073796788","https://openalex.org/W2090907917","https://openalex.org/W2155256323","https://openalex.org/W2207853596","https://openalex.org/W2277951273","https://openalex.org/W2529762417","https://openalex.org/W2603453366","https://openalex.org/W2775803967","https://openalex.org/W2797608577","https://openalex.org/W2803000479","https://openalex.org/W2887926439","https://openalex.org/W2913945163","https://openalex.org/W2923697933","https://openalex.org/W2954226397","https://openalex.org/W2981960459","https://openalex.org/W2996841369","https://openalex.org/W2999168705","https://openalex.org/W3043680095","https://openalex.org/W3045813318","https://openalex.org/W3112219413","https://openalex.org/W3130671713","https://openalex.org/W3151555262","https://openalex.org/W3154950152","https://openalex.org/W3165566500","https://openalex.org/W3205072810","https://openalex.org/W4200395413","https://openalex.org/W4229083035","https://openalex.org/W4283071085","https://openalex.org/W4284894213","https://openalex.org/W4294300762","https://openalex.org/W4296460105","https://openalex.org/W4308146252","https://openalex.org/W4310114233","https://openalex.org/W4327618055","https://openalex.org/W4379981929","https://openalex.org/W4380081689","https://openalex.org/W4385897258","https://openalex.org/W4385971596","https://openalex.org/W4386022324","https://openalex.org/W4386248178","https://openalex.org/W4399305336"],"related_works":["https://openalex.org/W4385971596","https://openalex.org/W4379281403","https://openalex.org/W4380083392","https://openalex.org/W4310103743","https://openalex.org/W4200395413","https://openalex.org/W2899283766","https://openalex.org/W4402670104","https://openalex.org/W7222844006","https://openalex.org/W2140902687","https://openalex.org/W2603453366"],"abstract_inverted_index":{"The":[0],"ECHELON-1":[1],"trial":[2],"demonstrated":[3],"the":[4,51],"effectiveness":[5],"of":[6,40,53],"brentuximab":[7],"vedotin":[8],"(BV)":[9],"in":[10,22,36],"combination":[11],"with":[12,32],"doxorubicin,":[13],"vinblastine,":[14,72],"and":[15,78,88],"dacarbazine":[16],"as":[17],"a":[18],"frontline":[19],"treatment":[20],"regimen":[21],"classical":[23],"Hodgkin":[24],"lymphoma.":[25],"However,":[26],"peripheral":[27,83],"neuropathy":[28],"(PN)":[29],"is":[30],"common":[31],"this":[33],"regimen,":[34],"occurring":[35],"up":[37],"to":[38],"two-thirds":[39],"patients.":[41],"While":[42],"standard":[43],"prescribing":[44],"information":[45],"recommends":[46],"BV":[47],"dose":[48,67,89],"modification":[49],"at":[50],"onset":[52],"grade":[54],"2":[55],"PN,":[56],"management":[57],"strategies":[58],"for":[59,81],"PN":[60],"are":[61],"not":[62],"well-defined.":[63],"Most":[64],"commonly,":[65],"clinicians":[66],"reduce":[68],"or":[69,73],"discontinue":[70],"BV,":[71],"both.":[74],"We":[75],"review":[76],"evidence-based":[77],"practical":[79],"approaches":[80],"managing":[82],"neuropathy,":[84],"emphasizing":[85],"early":[86],"detection":[87],"modification.":[90]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-07T00:00:00"}