{"id":"https://openalex.org/W4402223441","doi":"https://doi.org/10.1158/1541-7786.c.7431569.v1","title":"Data from miR-497 Target Gene Regulatory Network in Angiosarcoma","display_name":"Data from miR-497 Target Gene Regulatory Network in Angiosarcoma","publication_year":2024,"publication_date":"2024-09-04","ids":{"openalex":"https://openalex.org/W4402223441","doi":"https://doi.org/10.1158/1541-7786.c.7431569.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.c.7431569.v1","doi":"https://doi.org/10.1158/1541-7786.c.7431569.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.7431569.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1541-7786.c.7431569.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025635296","display_name":"Annaleigh Benton","orcid":"https://orcid.org/0000-0001-6322-9994","observed_orcids":["https://orcid.org/0000-0001-6322-9994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annaleigh Benton","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6322-9994","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092935732","display_name":"Noah M. Moriarty","orcid":"https://orcid.org/0000-0002-6022-9769","observed_orcids":["https://orcid.org/0000-0002-6022-9769"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noah M. Moriarty","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6022-9769","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018730837","display_name":"Emma Terwilliger","orcid":"https://orcid.org/0009-0000-8381-7902","observed_orcids":["https://orcid.org/0009-0000-8381-7902"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Terwilliger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-8381-7902","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066396136","display_name":"Bozhi Liu","orcid":"https://orcid.org/0009-0007-1631-3158","observed_orcids":["https://orcid.org/0009-0007-1631-3158"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bozhi Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-1631-3158","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027892220","display_name":"Ant Murphy","orcid":"https://orcid.org/0009-0002-2467-4491","observed_orcids":["https://orcid.org/0009-0002-2467-4491"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ant Murphy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-2467-4491","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092935733","display_name":"Hannah Maluvac","orcid":"https://orcid.org/0009-0002-1028-5209","observed_orcids":["https://orcid.org/0009-0002-1028-5209"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah Maluvac","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-1028-5209","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039017005","display_name":"Mae Shu","orcid":"https://orcid.org/0000-0001-9661-2244","observed_orcids":["https://orcid.org/0000-0001-9661-2244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mae Shu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9661-2244","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092935734","display_name":"Lauren E. Gartenhaus","orcid":"https://orcid.org/0009-0003-9173-7242","observed_orcids":["https://orcid.org/0009-0003-9173-7242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lauren E. Gartenhaus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-9173-7242","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026623309","display_name":"Nimod D. Janson","orcid":"https://orcid.org/0009-0004-8795-4030","observed_orcids":["https://orcid.org/0009-0004-8795-4030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nimod D. Janson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-8795-4030","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088669266","display_name":"Claire M. Pfeffer","orcid":"https://orcid.org/0000-0003-0045-2333","observed_orcids":["https://orcid.org/0000-0003-0045-2333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claire M. Pfeffer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0045-2333","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081241043","display_name":"Sagar M. Utturkar","orcid":"https://orcid.org/0000-0002-3453-1948","observed_orcids":["https://orcid.org/0000-0002-3453-1948"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sagar M. Utturkar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3453-1948","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091889496","display_name":"Elizabeth I. Parkinson","orcid":"https://orcid.org/0000-0002-3665-5522","observed_orcids":["https://orcid.org/0000-0002-3665-5522"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth I. Parkinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3665-5522","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026862562","display_name":"Nadia A. Lanman","orcid":"https://orcid.org/0000-0002-1819-7070","observed_orcids":["https://orcid.org/0000-0002-1819-7070"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadia A. Lanman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1819-7070","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022466829","display_name":"Jason A. Hanna","orcid":"https://orcid.org/0000-0001-7253-7964","observed_orcids":["https://orcid.org/0000-0001-7253-7964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason A. Hanna","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7253-7964","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.034299999475479126,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiosarcoma","display_name":"angiosarcoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mir-497-5p","display_name":"miR-497-5p","score":0.9380000233650208},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7799999713897705},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dicer1","display_name":"DICER1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6126589179039001},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5243332982063293},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5193063616752625},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5144922733306885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41789817810058594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3896143436431885},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32415497303009033},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21307304501533508}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1541-7786.c.7431569.v1","doi":"https://doi.org/10.1158/1541-7786.c.7431569.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.7431569.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1541-7786.c.7431569.v1","doi":"https://doi.org/10.1158/1541-7786.c.7431569.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1541-7786.c.7431569.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4398183919","https://openalex.org/W6907749639","https://openalex.org/W2804409946","https://openalex.org/W2755579458","https://openalex.org/W4404348988","https://openalex.org/W2264724828","https://openalex.org/W2515838410","https://openalex.org/W7131681122","https://openalex.org/W7120640129","https://openalex.org/W2800031203"],"abstract_inverted_index":{"Abstract":[0],"Angiosarcoma":[1],"is":[2,7,25,59,156],"a":[3,71,114,208],"vascular":[4],"sarcoma":[5],"that":[6,35,56,86,160,176],"highly":[8],"aggressive":[9],"and":[10,95,130,144,168,211],"metastatic.":[11],"Because":[12],"of":[13,38,48,102,116,139,152,179,198,217,222,228],"its":[14,205],"rarity,":[15],"treatment":[16],"options":[17],"for":[18,204],"patients":[19,127],"are":[20],"limited.":[21],"Therefore,":[22],"more":[23],"research":[24],"needed":[26],"to":[27,69,90,164],"identify":[28],"possible":[29],"therapeutic":[30,209],"vulnerabilities.":[31],"We":[32,83,134],"previously":[33,67],"found":[34,85],"conditional":[36],"deletion":[37],"Dicer1":[39],"drives":[40],"angiosarcoma":[41,62,121,188],"development":[42],"in":[43,50,61,74,104,119,170,200],"mice.":[44],"Given":[45],"the":[46,100,182,194,215,223],"role":[47,73],"DICER1":[49],"canonical":[51],"miRNA":[52,57],"biogenesis,":[53],"this":[54],"suggests":[55],"loss":[58],"important":[60],"development.":[63],"After":[64],"testing":[65],"miRNAs":[66],"suggested":[68,163],"have":[70],"tumor-suppressive":[72,196],"angiosarcoma,":[75,129,201],"miRNA-497-5p":[76],"(miR-497)":[77],"suppressed":[78],"cell":[79,93,122,166],"viability":[80],"most":[81],"significantly.":[82],"also":[84],"miR-497":[87,103,136,199],"overexpression":[88],"led":[89],"significantly":[91],"reduced":[92],"migration":[94,167],"tumor":[96,105,218],"formation.":[97],"To":[98],"understand":[99],"mechanism":[101],"suppression,":[106],"we":[107,174],"identified":[108],"clinically":[109],"relevant":[110],"target":[111,131,224],"genes":[112],"using":[113],"combination":[115],"RNA-sequencing":[117],"data":[118,125],"an":[120,157],"line,":[123],"expression":[124],"from":[126],"with":[128,181],"prediction":[132],"algorithms.":[133],"validated":[135],"direct":[137],"regulation":[138],"cyclin-D2,":[140],"cyclin-dependent":[141],"kinase":[142],"6,":[143],"vesicle":[145],"amine":[146],"transport":[147],"protein":[148,159],"1":[149],"(VAT1).":[150],"One":[151],"these":[153],"genes,":[154],"VAT1,":[155],"understudied":[158],"has":[161],"been":[162],"promote":[165],"metastasis":[169],"other":[171],"cancers.":[172],"Indeed,":[173],"find":[175],"pharmacologic":[177],"inhibition":[178],"VAT1":[180],"natural":[183],"product":[184],"neocarzilin":[185],"A":[186],"reduces":[187],"migration.":[189],"Implications:":[190],"This":[191],"work":[192],"supports":[193],"potent":[195],"abilities":[197],"providing":[202],"evidence":[203],"potential":[206],"as":[207],"agent,":[210],"provides":[212],"insight":[213],"into":[214],"mechanisms":[216],"suppression":[219],"through":[220],"analysis":[221],"gene":[225],"regulatory":[226],"network":[227],"miR-497.":[229]},"counts_by_year":[],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2024-09-05T00:00:00"}