{"id":"https://openalex.org/W4402221908","doi":"https://doi.org/10.12688/f1000research.145101.2","title":"Exploring the Synergistic Potential of Pectin-Chitosan Composites for Advanced Drug Delivery and Biomedical Implant Applications: A Comprehensive Review and Future Perspectives","display_name":"Exploring the Synergistic Potential of Pectin-Chitosan Composites for Advanced Drug Delivery and Biomedical Implant Applications: A Comprehensive Review and Future Perspectives","publication_year":2024,"publication_date":"2024-03-21","ids":{"openalex":"https://openalex.org/W4402221908","doi":"https://doi.org/10.12688/f1000research.145101.2"},"language":"en","primary_location":{"id":"doi:10.12688/f1000research.145101.2","doi":"https://doi.org/10.12688/f1000research.145101.2","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.145101.2","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.12688/f1000research.145101.2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103191580","display_name":"Mohammed Hussein M. Alsharbaty","orcid":"https://orcid.org/0000-0003-4977-8713","observed_orcids":["https://orcid.org/0000-0003-4977-8713"]},"institutions":[{"id":"https://openalex.org/I135120706","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I135120706"]},{"id":"https://openalex.org/I4405264678","display_name":"University of Al-Ameed","ror":"https://ror.org/02mpwke65","country_code":"IQ","type":"education","lineage":["https://openalex.org/I4405264678"]}],"countries":["IQ"],"is_corresponding":true,"raw_author_name":"Mohammed Hussein M. Alsharbaty","raw_affiliation_strings":["Branch of Prosthodontics, College of Dentistry, University of Al-Ameed, Karbala","Department of Prosthodontics, College of Dentistry, University of Baghdad, Baghdad, Baghdad Governorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Branch of Prosthodontics, College of Dentistry, University of Al-Ameed, Karbala","institution_ids":["https://openalex.org/I4405264678"]},{"raw_affiliation_string":"Department of Prosthodontics, College of Dentistry, University of Baghdad, Baghdad, Baghdad Governorate","institution_ids":["https://openalex.org/I135120706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030750183","display_name":"Ghassan Abdul-Hamid Naji","orcid":"https://orcid.org/0000-0001-6221-4213","observed_orcids":["https://orcid.org/0000-0001-6221-4213","https://orcid.org/0000-0003-4972-3990"]},"institutions":[{"id":"https://openalex.org/I135120706","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I135120706"]},{"id":"https://openalex.org/I3131779051","display_name":"Iraqi University","ror":"https://ror.org/01wfhkb67","country_code":"IQ","type":"education","lineage":["https://openalex.org/I3131779051"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Ghassan A. Naji","raw_affiliation_strings":["College of Dentistry, The Iraqia University, Baghdad","Department of Prosthodontics, College of Dentistry, University of Baghdad, Baghdad, Baghdad Governorate"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Dentistry, The Iraqia University, Baghdad","institution_ids":["https://openalex.org/I3131779051"]},{"raw_affiliation_string":"Department of Prosthodontics, College of Dentistry, University of Baghdad, Baghdad, Baghdad Governorate","institution_ids":["https://openalex.org/I135120706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053665490","display_name":"Sameh Samir Ali","orcid":"https://orcid.org/0000-0002-7033-8387","observed_orcids":["https://orcid.org/0000-0002-7033-8387"]},"institutions":[{"id":"https://openalex.org/I115592961","display_name":"Jiangsu University","ror":"https://ror.org/03jc41j30","country_code":"CN","type":"education","lineage":["https://openalex.org/I115592961"]},{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["CN","EG"],"is_corresponding":false,"raw_author_name":"Sameh S. Ali","raw_affiliation_strings":["Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu","Botany Department, Tanta University, Tanta, Gharbia Governorate, 31527"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biofuels Institute, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu","institution_ids":["https://openalex.org/I115592961"]},{"raw_affiliation_string":"Botany Department, Tanta University, Tanta, Gharbia Governorate, 31527","institution_ids":["https://openalex.org/I21376657"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103191580"],"corresponding_institution_ids":["https://openalex.org/I135120706","https://openalex.org/I4405264678"],"apc_list":{"value":1350,"currency":"USD","value_usd":1350},"apc_paid":{"value":1350,"currency":"USD","value_usd":1350},"fwci":0.1638,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39041565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"13","issue":null,"first_page":"209","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9214000105857849,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10488","display_name":"Nanocomposite Films for Food Packaging","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pectin","display_name":"pectin","score":0.949999988079071},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":1.0},{"id":"https://openalex.org/keywords/polysaccharide-composites","display_name":"polysaccharide composites","score":0.9760000109672546},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7940000295639038},{"id":"https://openalex.org/keywords/biomedical-implants","display_name":"biomedical implants","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dental-implants","display_name":"dental implants","score":0.9179999828338623},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.9729999899864197},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.7409999966621399},{"id":"https://openalex.org/keywords/biodegradation","display_name":"biodegradation","score":0.5590000152587891},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.7710000276565552},{"id":"https://openalex.org/keywords/implant-surface-modification","display_name":"implant surface modification","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7566728591918945},{"id":"https://openalex.org/C2983643791","wikidata":"https://www.wikidata.org/wiki/Q1999993","display_name":"Open peer review","level":3,"score":0.6530272960662842},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6449952125549316},{"id":"https://openalex.org/C2780756937","wikidata":"https://www.wikidata.org/wiki/Q188154","display_name":"Pectin","level":2,"score":0.6447519063949585},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5375909805297852},{"id":"https://openalex.org/C2992936677","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Plant biology","level":2,"score":0.5263572931289673},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4496578872203827},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.42396241426467896},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41604992747306824},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3283533453941345},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2864198684692383},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2374851107597351},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18976569175720215},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13089674711227417},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.08576950430870056},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.08182406425476074},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.12688/f1000research.145101.2","doi":"https://doi.org/10.12688/f1000research.145101.2","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.145101.2","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},{"id":"doi:10.12688/f1000research.145101.1","doi":"https://doi.org/10.12688/f1000research.145101.1","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.145101.1","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.12688/f1000research.145101.2","doi":"https://doi.org/10.12688/f1000research.145101.2","is_oa":true,"landing_page_url":"https://doi.org/10.12688/f1000research.145101.2","pdf_url":null,"source":{"id":"https://openalex.org/S4210239046","display_name":"F1000Research","issn_l":"2046-1402","issn":["2046-1402"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320357","host_organization_name":"Faculty of 1000","host_organization_lineage":["https://openalex.org/P4310320357","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Faculty of 1000","Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"F1000Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328486","display_name":"Narodowy Instytut Lek\u00f3w","ror":"https://ror.org/05m2pwn60"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W43478737","https://openalex.org/W1147480412","https://openalex.org/W1541522407","https://openalex.org/W1563293563","https://openalex.org/W1867255464","https://openalex.org/W1966323697","https://openalex.org/W1969119815","https://openalex.org/W1969621678","https://openalex.org/W1977800073","https://openalex.org/W1978399979","https://openalex.org/W1981028981","https://openalex.org/W1987357900","https://openalex.org/W1990469519","https://openalex.org/W1990578091","https://openalex.org/W1997360122","https://openalex.org/W1997491556","https://openalex.org/W1999346310","https://openalex.org/W2003563263","https://openalex.org/W2004755519","https://openalex.org/W2004957965","https://openalex.org/W2006554458","https://openalex.org/W2006614581","https://openalex.org/W2019729163","https://openalex.org/W2023705609","https://openalex.org/W2025601595","https://openalex.org/W2030644946","https://openalex.org/W2033941018","https://openalex.org/W2038388301","https://openalex.org/W2043502318","https://openalex.org/W2044231361","https://openalex.org/W2046703536","https://openalex.org/W2050732989","https://openalex.org/W2051884496","https://openalex.org/W2052563823","https://openalex.org/W2056241845","https://openalex.org/W2058658344","https://openalex.org/W2059368890","https://openalex.org/W2062703580","https://openalex.org/W2064142674","https://openalex.org/W2064301088","https://openalex.org/W2067237899","https://openalex.org/W2069892982","https://openalex.org/W2070457379","https://openalex.org/W2070996892","https://openalex.org/W2074257817","https://openalex.org/W2075592400","https://openalex.org/W2077541358","https://openalex.org/W2081590341","https://openalex.org/W2081719294","https://openalex.org/W2088034452","https://openalex.org/W2089527692","https://openalex.org/W2090296204","https://openalex.org/W2092036201","https://openalex.org/W2092567809","https://openalex.org/W2107706626","https://openalex.org/W2108031998","https://openalex.org/W2112151320","https://openalex.org/W2113980864","https://openalex.org/W2121712767","https://openalex.org/W2123749835","https://openalex.org/W2131945662","https://openalex.org/W2133578093","https://openalex.org/W2135579715","https://openalex.org/W2146363147","https://openalex.org/W2148817782","https://openalex.org/W2151799684","https://openalex.org/W2152276464","https://openalex.org/W2157089487","https://openalex.org/W2161899697","https://openalex.org/W2165790223","https://openalex.org/W2168886197","https://openalex.org/W2169751391","https://openalex.org/W2170405502","https://openalex.org/W2183495099","https://openalex.org/W2223724969","https://openalex.org/W2296610173","https://openalex.org/W2343645038","https://openalex.org/W2375823798","https://openalex.org/W2486270894","https://openalex.org/W2489754848","https://openalex.org/W2571156027","https://openalex.org/W2592480992","https://openalex.org/W2745204920","https://openalex.org/W2913995584","https://openalex.org/W2950361059","https://openalex.org/W2953326698","https://openalex.org/W2956927427","https://openalex.org/W2988193748","https://openalex.org/W3007714212","https://openalex.org/W3012203377","https://openalex.org/W3016055222","https://openalex.org/W3023068841","https://openalex.org/W3042371181","https://openalex.org/W3084084147","https://openalex.org/W3097541165","https://openalex.org/W3101498202","https://openalex.org/W3133970531","https://openalex.org/W3164197022","https://openalex.org/W3169826941","https://openalex.org/W3182574867","https://openalex.org/W3190677692","https://openalex.org/W3215839618","https://openalex.org/W4200106175","https://openalex.org/W4210547625","https://openalex.org/W4210605879","https://openalex.org/W4220799812","https://openalex.org/W4224325063","https://openalex.org/W4234731933","https://openalex.org/W4239562518","https://openalex.org/W4248031042","https://openalex.org/W4289639916","https://openalex.org/W4289644953","https://openalex.org/W4311032399","https://openalex.org/W4311577550","https://openalex.org/W4317393944","https://openalex.org/W4327494773","https://openalex.org/W4365816221","https://openalex.org/W4378974679","https://openalex.org/W4380318591","https://openalex.org/W4389742291","https://openalex.org/W4390826796"],"related_works":["https://openalex.org/W4386512838","https://openalex.org/W4414371304","https://openalex.org/W4296051885","https://openalex.org/W4414542981","https://openalex.org/W2966674436","https://openalex.org/W2135579715","https://openalex.org/W4285731968","https://openalex.org/W4408851425","https://openalex.org/W2267956374","https://openalex.org/W4389381748"],"abstract_inverted_index":{"The":[0,30],"polysaccharides":[1],"pectin":[2],"and":[3,11,15,20,35,47,64,86,112,130],"chitosan":[4,48],"are":[5,49],"derived":[6],"from":[7],"the":[8,33,62,94,122,125,136],"fruit":[9],"peels":[10],"exoskeletons":[12],"of":[13,32,37,67,74,96,103,117],"crustaceans":[14],"insects,":[16],"respectively.":[17],"Their":[18],"biocompatibility":[19],"renewability":[21],"make":[22],"them":[23],"suitable":[24],"for":[25],"use":[26,95],"in":[27],"food":[28],"products.":[29],"size":[31],"swelling":[34],"degradation":[36],"these":[38],"cells":[39],"can":[40,57],"be":[41,58,133],"controlled":[42],"using":[43],"different":[44],"combinations.":[45],"Pectin":[46],"useful":[50],"as":[51,77],"medication":[52],"delivery":[53,88],"systems,":[54],"where":[55],"they":[56],"integrated":[59],"to":[60,121,135],"control":[61],"dosages":[63],"residence":[65],"times":[66],"pharmaceuticals.":[68],"They":[69],"have":[70],"a":[71,100,115],"wide":[72],"range":[73],"applications":[75],"such":[76],"wound":[78],"dressings,":[79],"body":[80],"fat":[81],"reducers,":[82],"tissue":[83],"engineering":[84],"agents,":[85],"drug":[87],"agents.":[89],"Addressing":[90],"teeth":[91],"loss":[92],"with":[93,139],"dental":[97,104],"implants":[98],"is":[99,110],"critical":[101],"element":[102],"care.":[105],"In":[106],"most":[107],"cases,":[108],"healing":[109,126],"time-consuming":[111],"painful.":[113],"As":[114],"result":[116],"adding":[118],"new":[119],"materials":[120],"implant":[123,137],"surface,":[124],"process":[127],"would":[128,132],"accelerate,":[129],"medications":[131],"delivered":[134],"site":[138],"greater":[140],"efficiency.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2024-09-05T00:00:00"}