{"id":"https://openalex.org/W4402217841","doi":"https://doi.org/10.70082/esiculture.vi.711","title":"Comparison of Immunomodulatory Effects of Phyllanthus niruri L. and Toman Fish Albumin Formulations with Phyllanthus urinaria L. and Toman Fish Albumin through Anti-Hepatotoxic Cytokine Regulation Against Male Rattus norvegicus Experiencing CCl4 Toxicity","display_name":"Comparison of Immunomodulatory Effects of Phyllanthus niruri L. and Toman Fish Albumin Formulations with Phyllanthus urinaria L. and Toman Fish Albumin through Anti-Hepatotoxic Cytokine Regulation Against Male Rattus norvegicus Experiencing CCl4 Toxicity","publication_year":2024,"publication_date":"2024-09-02","ids":{"openalex":"https://openalex.org/W4402217841","doi":"https://doi.org/10.70082/esiculture.vi.711"},"language":"en","primary_location":{"id":"doi:10.70082/esiculture.vi.711","doi":"https://doi.org/10.70082/esiculture.vi.711","is_oa":true,"landing_page_url":"http://dx.doi.org/10.70082/esiculture.vi.711","pdf_url":"https://esiculture.com/index.php/esiculture/article/download/711/150","source":{"id":"https://openalex.org/S4210228326","display_name":"Evolutionary Studies in Imaginative Culture","issn_l":"2472-9876","issn":["2472-9876","2472-9884"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EVOLUTIONARY STUDIES IN IMAGINATIVE CULTURE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://esiculture.com/index.php/esiculture/article/download/711/150","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111314866","display_name":"Tutut Puji Lestari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Tutut Puji Lestari","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Jawa Timur, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Jawa Timur, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112019902","display_name":"Mochammad Sasmito Djati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Mochamad Sasmito Djati","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Jawa Timur, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Jawa Timur, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061358082","display_name":"Muhaimin Rifa\u2019i","orcid":"https://orcid.org/0000-0001-5731-2951","observed_orcids":["https://orcid.org/0000-0001-5731-2951"]},"institutions":[{"id":"https://openalex.org/I177055848","display_name":"University of Brawijaya","ror":"https://ror.org/01wk3d929","country_code":"ID","type":"education","lineage":["https://openalex.org/I177055848"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhaimin Rifa'i","raw_affiliation_strings":["Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Jawa Timur, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Jawa Timur, Indonesia","institution_ids":["https://openalex.org/I177055848"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I177055848"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18441412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"561","last_page":"579"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13719","display_name":"Phytochemistry and Bioactivity Studies","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.12229999899864197,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0794999971985817,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phyllanthus-niruri","display_name":"Phyllanthus niruri","score":0.9760000109672546},{"id":"https://openalex.org/keywords/phyllanthus-urinaria","display_name":"Phyllanthus urinaria","score":1.0},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/carbon-tetrachloride-induced-liver-injury","display_name":"carbon tetrachloride-induced liver injury","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9160000085830688},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.6240000128746033},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.4729999899864197},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.5149999856948853},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.7390000224113464},{"id":"https://openalex.org/keywords/herbal-formula","display_name":"herbal formula","score":0.4350000023841858},{"id":"https://openalex.org/keywords/rattus-norvegicus","display_name":"Rattus norvegicus","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C2776718122","wikidata":"https://www.wikidata.org/wiki/Q310927","display_name":"Phyllanthus","level":2,"score":0.9464958906173706},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6562588810920715},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5010175704956055},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.449263334274292},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39424946904182434},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36584246158599854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3314914107322693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.259230375289917},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.1857396960258484}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.70082/esiculture.vi.711","doi":"https://doi.org/10.70082/esiculture.vi.711","is_oa":true,"landing_page_url":"http://dx.doi.org/10.70082/esiculture.vi.711","pdf_url":"https://esiculture.com/index.php/esiculture/article/download/711/150","source":{"id":"https://openalex.org/S4210228326","display_name":"Evolutionary Studies in Imaginative Culture","issn_l":"2472-9876","issn":["2472-9876","2472-9884"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EVOLUTIONARY STUDIES IN IMAGINATIVE CULTURE","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.journal.esiculture.com:article/711","doi":null,"is_oa":true,"landing_page_url":"https://esiculture.com/index.php/esiculture/article/view/711","pdf_url":null,"source":{"id":"https://openalex.org/S4210228326","display_name":"Evolutionary Studies in Imaginative Culture","issn_l":"2472-9876","issn":["2472-9876","2472-9884"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2472-9876","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.70082/esiculture.vi.711","doi":"https://doi.org/10.70082/esiculture.vi.711","is_oa":true,"landing_page_url":"http://dx.doi.org/10.70082/esiculture.vi.711","pdf_url":"https://esiculture.com/index.php/esiculture/article/download/711/150","source":{"id":"https://openalex.org/S4210228326","display_name":"Evolutionary Studies in Imaginative Culture","issn_l":"2472-9876","issn":["2472-9876","2472-9884"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EVOLUTIONARY STUDIES IN IMAGINATIVE CULTURE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402217841.pdf","grobid_xml":"https://content.openalex.org/works/W4402217841.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4256495531","https://openalex.org/W2992764783","https://openalex.org/W2732998902","https://openalex.org/W2610309228","https://openalex.org/W3138919747","https://openalex.org/W1500770553","https://openalex.org/W593781739","https://openalex.org/W2962097165","https://openalex.org/W2371223143","https://openalex.org/W4312418764"],"abstract_inverted_index":{"Impaired":[0],"liver":[1,27,106,247,275],"function":[2],"can":[3,49],"be":[4,291],"seen":[5],"from":[6],"increased":[7],"levels":[8,162,231],"(SGOT-SGPT)":[9],"due":[10],"to":[11,103,220,251,290,296],"proinflammatory":[12,57,180,241],"cytokines":[13,181],"TNF-\u03b1,":[14],"(iL-1)":[15],"and":[16,36,90,121,125,145,174,177,208,239,260,272,283],"(iL-6)":[17],"which":[18],"inhibit":[19],"hormone":[20],"production":[21,55],"(PDGF)":[22],"in":[23,52,229,232,244,274],"the":[24,54,60,169,196,233,255,266,279,288],"process":[25],"of":[26,32,56,69,99,133,179,198,235,258,268,281],"tissue":[28],"regeneration.":[29],"The":[30],"formulation":[31,89],"Phyllanthus":[33,37,199,209],"niruri":[34,115,200],"L.":[35,39,116,124],"urinaria":[38,123,210],"combined":[40],"with":[41,117,165,189,203,213],"toman":[42,204,214],"fish":[43,119,127,205,215],"albumin":[44,206,216],"is":[45],"a":[46,131,166,226],"combination":[47,61,197,280],"that":[48,64,195,278],"work":[50],"synergistically":[51],"suppressing":[53],"molecules,":[58],"because":[59],"contains":[62],"compounds":[63],"are":[65],"antioxidants.":[66],"A":[67],"total":[68],"24":[70],"male":[71,236],"Rattus":[72,237,245],"norvegicus":[73,96,110,238,246],"were":[74,163],"divided":[75],"into":[76],"four":[77],"treatment":[78],"groups,":[79],"namely:":[80],"negative":[81],"control":[82],"(healthy),":[83],"CCl4-induced":[84],"positive":[85],"control,":[86],"dose":[87,91,132,146],"1":[88,134],"2":[92,147],"formulation.":[93],"Male":[94,108],"rattus":[95,109],"induced":[97],"CCl4":[98],"3":[100],"ml/kg":[101],"intraperitoneally,":[102],"describe":[104],"impaired":[105],"function.":[107],"was":[111,187,218],"given":[112,286],"formula":[113,202,212],"(Phyllanthus":[114,122],"Toman":[118,126],"albumin)":[120,128],"orally":[129],"at":[130],"(620":[135],"mg/200":[136,141,149,154],"g":[137,142,150,155],"body":[138,143,151,156],"weight:":[139,152],"62":[140],"weight),":[144],"(1240":[148],"124":[153],"weight)":[157],"for":[158],"14":[159],"days.":[160],"SGOT-SGPT":[161,230],"analyzed":[164],"flowcytometer":[167],"on":[168],"first":[170],"day":[171,175],"after":[172],"acclimatization":[173],"14,":[176],"analysis":[178],"(TNF-\u03b1":[182],"+":[183,185],"iL-1":[184],"iL-6)":[186],"performed":[188],"flow":[190],"cytometry.":[191],"This":[192],"study":[193],"reported":[194],"L":[201,211],"(PNA)":[207],"(PUA)":[217],"able":[219],"show":[221],"striking":[222],"hepatoprotective":[223],"effects":[224],"through":[225],"significant":[227],"decrease":[228],"blood":[234],"decreased":[240],"cytokine":[242],"profiles":[243],"cells":[248],"males":[249],"exposed":[250],"CCl4.":[252],"In":[253],"addition,":[254],"antioxidant":[256],"defenses":[257],"PNA":[259,282],"PUA":[261,284],"formulas":[262,285],"almost":[263],"completely":[264],"prevent":[265],"occurrence":[267],"degeneration,":[269],"necrosis,":[270],"fibrosis":[271],"steatosis":[273],"cells.":[276],"So":[277],"has":[287],"potential":[289],"used":[292],"as":[293],"an":[294],"alternative":[295],"hepatitis":[297],"drugs.":[298]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
