{"id":"https://openalex.org/W4402200964","doi":"https://doi.org/10.1158/1078-0432.c.7429354","title":"Data from Streamlined Intraoperative Brain Tumor Classification and Molecular Subtyping in Stereotactic Biopsies Using Stimulated Raman Histology and Deep Learning","display_name":"Data from Streamlined Intraoperative Brain Tumor Classification and Molecular Subtyping in Stereotactic Biopsies Using Stimulated Raman Histology and Deep Learning","publication_year":2024,"publication_date":"2024-09-03","ids":{"openalex":"https://openalex.org/W4402200964","doi":"https://doi.org/10.1158/1078-0432.c.7429354"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.7429354","doi":"https://doi.org/10.1158/1078-0432.c.7429354","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7429354","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.7429354","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021311005","display_name":"David Reinecke","orcid":"https://orcid.org/0000-0002-3298-9517","observed_orcids":["https://orcid.org/0000-0002-3298-9517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Reinecke","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3298-9517","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025971193","display_name":"Daniel F. Ruess","orcid":"https://orcid.org/0000-0003-1811-5132","observed_orcids":["https://orcid.org/0000-0003-1811-5132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Ruess","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1811-5132","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102711456","display_name":"Anna-Katharina Mei\u00dfner","orcid":"https://orcid.org/0000-0003-4150-7265","observed_orcids":["https://orcid.org/0000-0003-4150-7265"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna-Katharina Meissner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4150-7265","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024710110","display_name":"Gina F\u00fcrtjes","orcid":"https://orcid.org/0000-0003-3727-9984","observed_orcids":["https://orcid.org/0000-0003-3727-9984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gina F\u00fcrtjes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3727-9984","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056218764","display_name":"Niklas von Spreckelsen","orcid":"https://orcid.org/0000-0002-9873-1711","observed_orcids":["https://orcid.org/0000-0002-9873-1711"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niklas von Spreckelsen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9873-1711","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032755512","display_name":"Adrian Ion\u2010M\u0103rgineanu","orcid":"https://orcid.org/0000-0003-3788-2257","observed_orcids":["https://orcid.org/0000-0003-3788-2257"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrian Ion-Margineanu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3788-2257","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021245110","display_name":"Florian Khalid","orcid":"https://orcid.org/0009-0008-2675-3592","observed_orcids":["https://orcid.org/0009-0008-2675-3592"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florian Khalid","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0008-2675-3592","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026784314","display_name":"Tobias Blau","orcid":"https://orcid.org/0000-0003-0439-971X","observed_orcids":["https://orcid.org/0000-0003-0439-971X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tobias Blau","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0439-971X","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Stehle","orcid":"https://orcid.org/0009-0000-9873-1714","observed_orcids":["https://orcid.org/0009-0000-9873-1714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Stehle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-9873-1714","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114220063","display_name":"Abdulkader Al-Shugri","orcid":"https://orcid.org/0009-0001-4042-011X","observed_orcids":["https://orcid.org/0009-0001-4042-011X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdulkader Al-Shugri","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4042-011X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006712577","display_name":"Reinhard B\u00fcttner","orcid":"https://orcid.org/0000-0001-8806-4786","observed_orcids":["https://orcid.org/0000-0001-8806-4786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard B\u00fcttner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8806-4786","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018453143","display_name":"Roland Goldbrunner","orcid":"https://orcid.org/0000-0002-1927-0022","observed_orcids":["https://orcid.org/0000-0002-1927-0022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roland Goldbrunner","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1927-0022","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081489767","display_name":"Maximilian Ingolf Ruge","orcid":"https://orcid.org/0000-0003-0466-6646","observed_orcids":["https://orcid.org/0000-0003-0466-6646"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maximilian I. Ruge","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0466-6646","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025278993","display_name":"Volker Neuschmelting","orcid":"https://orcid.org/0000-0001-7527-6990","observed_orcids":["https://orcid.org/0000-0001-7527-6990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Volker Neuschmelting","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7527-6990","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.20190000534057617,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulated-raman-histology","display_name":"stimulated Raman histology","score":0.9850000143051147},{"id":"https://openalex.org/keywords/brain-tumor-classification","display_name":"brain tumor classification","score":0.7699999809265137},{"id":"https://openalex.org/keywords/stereotactic-brain-biopsy","display_name":"stereotactic brain biopsy","score":0.8939999938011169},{"id":"https://openalex.org/keywords/intraoperative-diagnosis","display_name":"intraoperative diagnosis","score":0.9079999923706055},{"id":"https://openalex.org/keywords/deep-learning","display_name":"deep learning","score":0.6859999895095825},{"id":"https://openalex.org/keywords/idh-status","display_name":"IDH status","score":0.9670000076293945},{"id":"https://openalex.org/keywords/1p-19q-codeletion","display_name":"1p/19q codeletion","score":0.9309999942779541},{"id":"https://openalex.org/keywords/frozen-section-comparison","display_name":"frozen section comparison","score":0.7549999952316284},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.4830000102519989},{"id":"https://openalex.org/keywords/gliosis","display_name":"gliosis","score":0.6420000195503235},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C83852419","wikidata":"https://www.wikidata.org/wiki/Q2713292","display_name":"Subtyping","level":2,"score":0.9515866041183472},{"id":"https://openalex.org/C57742111","wikidata":"https://www.wikidata.org/wiki/Q7168","display_name":"Histology","level":2,"score":0.697242021560669},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4679989218711853},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.46415767073631287},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4414910078048706},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.43694180250167847},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4334200322628021},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42890673875808716},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38023248314857483},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11197307705879211},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.06728461384773254},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.7429354","doi":"https://doi.org/10.1158/1078-0432.c.7429354","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7429354","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.7429354.v1","doi":"https://doi.org/10.1158/1078-0432.c.7429354.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7429354.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.7429354","doi":"https://doi.org/10.1158/1078-0432.c.7429354","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7429354","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400414019","https://openalex.org/W4404449205","https://openalex.org/W4327609571","https://openalex.org/W4416140217","https://openalex.org/W2998401461","https://openalex.org/W2768043729","https://openalex.org/W7161043745","https://openalex.org/W4309015234","https://openalex.org/W4406833320","https://openalex.org/W7220239486"],"abstract_inverted_index":{"AbstractPurpose:":[0],"Recent":[1],"artificial":[2],"intelligence":[3],"algorithms":[4,20],"aided":[5],"intraoperative":[6,23],"decision-making":[7],"via":[8],"stimulated":[9],"Raman":[10,76],"histology":[11],"(SRH)":[12],"during":[13,248],"craniotomy.":[14],"This":[15],"study":[16,50],"assesses":[17],"deep":[18,80],"learning":[19,81],"for":[21,281],"rapid":[22],"diagnosis":[24],"from":[25,55],"SRH":[26,53,179,200,233],"images":[27,54,180,187,201],"in":[28,162,219,223,242,274],"small":[29,249],"stereotactic-guided":[30,250],"brain":[31,64,163,246],"biopsies.":[32],"It":[33],"defines":[34],"a":[35,72,209,253],"minimum":[36],"tissue":[37,89,152],"sample":[38,212,256],"size":[39,157,257],"threshold":[40],"to":[41,85,238],"ensure":[42],"diagnostic":[43],"accuracy.":[44,155],"Experimental":[45],"Design:":[46],"A":[47],"prospective":[48],"single-center":[49],"examined":[51],"121":[52],"84":[56],"patients":[57],"with":[58,153,178,202],"unclear":[59],"intracranial":[60],"lesions":[61],"undergoing":[62],"stereotactic":[63],"biopsy.":[65],"Unprocessed,":[66],"label-free":[67],"samples":[68],"were":[69,83,136],"imaged":[70],"using":[71],"portable":[73],"fiber":[74],"laser":[75],"scattering":[77],"microscope.":[78],"Three":[79],"models":[82],"tested":[84],"(i)":[86],"identify":[87],"tumorous/nontumorous":[88,151],"as":[90],"qualitative":[91],"biopsy":[92],"control;":[93],"(ii)":[94],"subclassify":[95],"into":[96],"high-grade":[97],"glioma":[98,109,268],"(central":[99,110],"nervous":[100,111],"system":[101,112],"World":[102,113],"Health":[103,114],"Organization":[104,115],"grade":[105],"4),":[106],"diffuse":[107,132,228],"low-grade":[108],"grades":[116],"2\u20133),":[117],"metastases,":[118],"lymphoma,":[119],"or":[120],"gliosis;":[121],"and":[122,127,142,185,208,221,244],"(iii)":[123],"molecularly":[124],"subtype":[125],"IDH":[126],"1p/19q":[128],"statuses":[129],"of":[130,213,226],"adult-type":[131,227],"gliomas.":[133,229],"Model":[134],"predictions":[135],"evaluated":[137],"against":[138],"frozen":[139,170,239,261],"section":[140,240,262],"analysis":[141,235,241],"final":[143],"neuropathologic":[144],"diagnoses.":[145],"Results:":[146],"The":[147],"first":[148],"model":[149],"identified":[150],"91.7%":[154],"Sample":[156],"on":[158],"slides":[159],"impacted":[160],"accuracy":[161,218],"tumor":[164],"subclassification":[165,220],"(81.6%,":[166],"\u03ba":[167,173],"=":[168,174],"0.72":[169],"section;":[171],"73.9%,":[172],"0.61":[175],"second":[176],"model),":[177],"being":[181],"smaller":[182],"than":[183,204],"hematoxylin":[184],"eosin":[186],"(4.1":[188],"\u00b1":[189,194],"2.5":[190],"mm2":[191,215],"vs.":[192],"16.7":[193],"8.2":[195],"mm2,":[196],"P":[197],"<":[198],"0.001).":[199],"more":[203],"140":[205],"high-quality":[206],"patches":[207],"mean":[210],"squeezed":[211,255],"5.26":[214],"yielded":[216],"89.5%":[217],"93.9%":[222],"molecular":[224,267],"subtyping":[225],"Conclusions:":[230],"Artificial":[231],"intelligence\u2013based":[232],"image":[234],"is":[236,258,279],"non-inferior":[237],"detecting":[243],"subclassifying":[245],"tumors":[247],"biopsies":[251],"once":[252],"critical":[254],"reached.":[259],"Beyond":[260],"analysis,":[263],"it":[264],"enables":[265],"valid":[266],"subtyping,":[269],"allowing":[270],"faster":[271],"treatment":[272],"decisions":[273],"the":[275],"future;":[276],"however,":[277],"refinement":[278],"needed":[280],"long-term":[282],"application.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2024-09-04T00:00:00"}