{"id":"https://openalex.org/W4402147447","doi":"https://doi.org/10.30498/ijb.2024.407148.3762","title":"A Meta-analysis of Transcriptome Data to Investigate the Effect of Soy Isoflavones on Breast Cancer Cell.","display_name":"A Meta-analysis of Transcriptome Data to Investigate the Effect of Soy Isoflavones on Breast Cancer Cell.","publication_year":2024,"publication_date":"2024-04-01","ids":{"openalex":"https://openalex.org/W4402147447","doi":"https://doi.org/10.30498/ijb.2024.407148.3762","pmid":"https://pubmed.ncbi.nlm.nih.gov/39220340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11364926"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11364926","doi":"https://doi.org/10.30498/ijb.2024.407148.3762","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11364926","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11364926/pdf/IJB-22-e3762.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Biotechnol","raw_type":"Text"},"volume":null,"type":"review","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11364926/pdf/IJB-22-e3762.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039819147","display_name":"Elham Ashrafi\u2010Dehkordi","orcid":"https://orcid.org/0000-0002-2811-5876","observed_orcids":["https://orcid.org/0000-0002-2811-5876"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Elham Ashrafi-Dehkordi","raw_affiliation_strings":["Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022939309","display_name":"Ahmad Tahmasebi","orcid":"https://orcid.org/0000-0001-5590-1218","observed_orcids":["https://orcid.org/0000-0001-5590-1218"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ahmad Tahmasebi","raw_affiliation_strings":["Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran","Biotechnology Institute, College of Agriculture, Shiraz University, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]},{"raw_affiliation_string":"Biotechnology Institute, College of Agriculture, Shiraz University, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062228773","display_name":"Habil Zare","orcid":"https://orcid.org/0000-0001-5902-6238","observed_orcids":["https://orcid.org/0000-0001-5902-6238"]},"institutions":[{"id":"https://openalex.org/I13511017","display_name":"Texas State University","ror":"https://ror.org/05h9q1g27","country_code":"US","type":"education","lineage":["https://openalex.org/I13511017"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habil Zare","raw_affiliation_strings":["Department of Computer Science, Texas State University, San Marcos, Texas, 78666, USA","Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, Texas, 78229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Texas State University, San Marcos, Texas, 78666, USA","institution_ids":["https://openalex.org/I13511017"]},{"raw_affiliation_string":"Department of Cell Systems and Anatomy, The University of Texas Health Science Center, San Antonio, Texas, 78229, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042253698","display_name":"Seyed Mohammad Mazloomi","orcid":"https://orcid.org/0000-0002-9672-7743","observed_orcids":["https://orcid.org/0000-0002-9672-7743"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Mohammad Mazloomi","raw_affiliation_strings":["Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Research Center, Department of Food Hygiene and Quality Control, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1384,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.20438206,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"22","issue":"2","first_page":"e3762","last_page":"e3762"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soy-isoflavones","display_name":"soy isoflavones","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phytoestrogens","display_name":"phytoestrogens","score":0.8920000195503235},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6690000295639038},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/purine-metabolism","display_name":"purine metabolism","score":0.8019999861717224},{"id":"https://openalex.org/keywords/estradiol-response","display_name":"estradiol response","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6150000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6269999742507935},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6679999828338623},{"id":"https://openalex.org/keywords/redox-state","display_name":"redox state","score":0.8600000143051147},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C2910376424","wikidata":"https://www.wikidata.org/wiki/Q11006","display_name":"SOY ISOFLAVONES","level":3,"score":0.8682402968406677},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.8140290975570679},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6273443102836609},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5812471508979797},{"id":"https://openalex.org/C2777014122","wikidata":"https://www.wikidata.org/wiki/Q7571993","display_name":"Soy protein","level":2,"score":0.4955357313156128},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.48411500453948975},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41891908645629883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35839781165122986},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.34031498432159424},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3208204507827759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2633535861968994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20119085907936096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10009452700614929},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09754782915115356}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:11364926","doi":"https://doi.org/10.30498/ijb.2024.407148.3762","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11364926","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11364926/pdf/IJB-22-e3762.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Biotechnol","raw_type":"Text"},{"id":"pmid:39220340","doi":"https://doi.org/10.30498/ijb.2024.407148.3762","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39220340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of biotechnology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11364926","doi":"https://doi.org/10.30498/ijb.2024.407148.3762","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11364926","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11364926/pdf/IJB-22-e3762.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iran J Biotechnol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322545","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692"},{"id":"https://openalex.org/F4320323101","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402147447.pdf","grobid_xml":"https://content.openalex.org/works/W4402147447.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2171818686","https://openalex.org/W2415011443"],"related_works":["https://openalex.org/W7155387720","https://openalex.org/W2040998090","https://openalex.org/W4389614364","https://openalex.org/W3215451308","https://openalex.org/W2028140459","https://openalex.org/W2591530387","https://openalex.org/W2137663801","https://openalex.org/W7172004368","https://openalex.org/W2213995755","https://openalex.org/W3149501770"],"abstract_inverted_index":{"Background:":[0],"Breast":[1],"cancer":[2,29,39,62,284],"ranks":[3],"as":[4],"the":[5,77,99,106,141,148,152,186,192,195,247,251,254,257,264,275,280],"second":[6],"highest":[7],"cause":[8],"of":[9,24,169,175,249,253,259,267,282],"cancer-linked":[10],"deaths":[11],"in":[12,185,206,228,263],"women,":[13],"with":[14,233],"varying":[15],"rates":[16],"between":[17],"Western":[18],"and":[19,69,81,84,89,128,138,162,181,214,240,261],"Asian":[20],"countries.":[21],"The":[22,71],"consumption":[23],"phytoestrogens":[25],"can":[26,244,271],"influence":[27],"breast":[28,38,61,283],"occurrence.":[30],"Objective:":[31],"To":[32],"comprehend":[33],"how":[34],"soy":[35,66],"isoflavones":[36,90,160],"impact":[37],"cells,":[40,229],"we":[41,113],"conducted":[42],"a":[43,95,167],"meta-analysis,":[44],"combining":[45],"gene":[46,72,123],"expression":[47,73],"data":[48],"from":[49,76],"multiple":[50],"studies.":[51],"This":[52],"approach":[53],"aimed":[54],"to":[55,65,104,156,173,179,246,286],"identify":[56,105],"crucial":[57],"transcriptional":[58],"characteristics":[59],"driving":[60],"cell":[63,176,207,255],"response":[64,178,281],"phytoestrogens.":[67],"Materials":[68],"Methods:":[70],"profiles":[74],"obtained":[75],"Gene":[78,115],"Expression":[79],"Omnibus":[80],"Array":[82],"Express":[83],"were":[85,140],"grouped":[86],"into":[87,159,197],"control":[88,163],"exposure":[91,161],"conditions.":[92,164],"We":[93,145],"performed":[94,114],"meta-analysis":[96],"based":[97],"on":[98,274],"effect":[100],"size":[101],"combination":[102],"method":[103],"differentially":[107],"expressed":[108],"genes":[109,155,204],"(DEGs).":[110],"In":[111],"addition,":[112],"Ontology":[116],"(GO)":[117],"enrichment":[118],"analysis,":[119,121],"pathway":[120],"weighted":[122],"co-expression":[124],"network":[125],"analysis":[126,219],"(WGCNA)":[127],"recursive":[129],"support":[130],"vector":[131],"machine":[132],"(R-SVM)":[133],"algorithm.":[134],"Results:":[135],"ZF,":[136],"bZIP,":[137],"bHLH":[139],"most":[142,153],"prominent":[143],"families.":[144],"also":[146],"employed":[147],"R-SVM":[149],"for":[150,203],"detecting":[151],"important":[154],"classify":[157],"samples":[158],"It":[165],"identified":[166],"subset":[168],"100":[170],"DEGs":[171,196],"related":[172],"regulation":[174],"growth,":[177],"estradiol,":[180],"intermediate":[182],"ribonucleoside":[183],"monophosphate":[184],"purine":[187],"(IMP)":[188],"metabolic":[189],"process.":[190],"Moreover,":[191],"WGCNA":[193],"separated":[194],"five":[198],"discrete":[199],"modules":[200],"strongly":[201],"enriched":[202],"involved":[205],"division,":[208],"DNA":[209],"replication,":[210],"embryonic":[211],"digit":[212],"morphogenesis,":[213],"cell-cell":[215],"adhesion.":[216],"Conclusion:":[217],"Our":[218],"provides":[220],"evidence":[221],"suggesting":[222],"that":[223,278],"isoflavone":[224],"affects":[225],"various":[226],"mechanisms":[227,277],"including":[230],"pathways":[231],"associated":[232],"NF-\u03baB,":[234],"Akt,":[235],"MAPK,":[236],"Wnt,":[237],"Notch,":[238],"p53,":[239],"AR":[241],"pathways,":[242],"which":[243],"lead":[245],"induction":[248],"apoptosis,":[250],"alteration":[252],"cycle,":[256],"inhibition":[258],"angiogenesis,":[260],"interference":[262],"redox":[265],"state":[266],"cells.":[268],"These":[269],"findings":[270],"shed":[272],"light":[273],"molecular":[276],"underlie":[279],"cells":[285],"isoflavones.":[287]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-03T00:00:00"}