{"id":"https://openalex.org/W4402126178","doi":"https://doi.org/10.1111/1751-7915.14525","title":"Strangers in a foreign land: \u2018Yeastizing\u2019 plant enzymes","display_name":"Strangers in a foreign land: \u2018Yeastizing\u2019 plant enzymes","publication_year":2024,"publication_date":"2024-09-01","ids":{"openalex":"https://openalex.org/W4402126178","doi":"https://doi.org/10.1111/1751-7915.14525","pmid":"https://pubmed.ncbi.nlm.nih.gov/39222378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11368087"},"language":"en","primary_location":{"id":"doi:10.1111/1751-7915.14525","doi":"https://doi.org/10.1111/1751-7915.14525","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1751-7915.14525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.14525","source":{"id":"https://openalex.org/S4210238104","display_name":"Microbial Biotechnology","issn_l":"1751-7915","issn":["1751-7915","1751-7907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["arxiv","crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.14525","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036655676","display_name":"Kristen Van Gelder","orcid":"https://orcid.org/0000-0001-8745-802X","observed_orcids":["https://orcid.org/0000-0001-8745-802X"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen Van\u00a0Gelder","raw_affiliation_strings":["Horticultural Sciences Department, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Horticultural Sciences Department, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014885322","display_name":"Steffen N. Lindner","orcid":"https://orcid.org/0000-0003-3226-3043","observed_orcids":["https://orcid.org/0000-0003-3226-3043"]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I4210105972","display_name":"Max Planck Institute of Molecular Plant Physiology","ror":"https://ror.org/01fbde567","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210105972"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen N. Lindner","raw_affiliation_strings":["Department of Biochemistry Charit\u00e9 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t  Berlin Germany","Department of Systems and Synthetic Metabolism, Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry Charit\u00e9 Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t  Berlin Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I75951250","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Department of Systems and Synthetic Metabolism, Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany","institution_ids":["https://openalex.org/I4210105972"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043335302","display_name":"Andrew D. Hanson","orcid":"https://orcid.org/0000-0003-2585-9340","observed_orcids":["https://orcid.org/0000-0003-2585-9340"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew D. Hanson","raw_affiliation_strings":["Horticultural Sciences Department, University of Florida, Gainesville, Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Horticultural Sciences Department, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073206868","display_name":"Juannan Zhou","orcid":"https://orcid.org/0000-0002-1373-4746","observed_orcids":["https://orcid.org/0000-0002-1373-4746"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juannan Zhou","raw_affiliation_strings":["Department of Biology, University of Florida, Gainesville, Florida, USA"],"raw_orcid":"https://orcid.org/0000-0002-1373-4746","affiliations":[{"raw_affiliation_string":"Department of Biology, University of Florida, Gainesville, Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073206868"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":0.4721,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.44714451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"9","first_page":"e14525","last_page":"e14525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.6958000063896179,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yeast-expression-system","display_name":"yeast expression system","score":0.609000027179718},{"id":"https://openalex.org/keywords/protein-sequence-features","display_name":"protein sequence features","score":0.6890000104904175},{"id":"https://openalex.org/keywords/design-build-test-cycle","display_name":"design-build-test cycle","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.7238073348999023},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5120366215705872},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4990074634552002},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4762568473815918},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.47410067915916443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45911070704460144},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.45431989431381226},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4385008215904236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3844963312149048},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.34831756353378296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.267654687166214},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.17789104580879211},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1111/1751-7915.14525","doi":"https://doi.org/10.1111/1751-7915.14525","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1751-7915.14525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.14525","source":{"id":"https://openalex.org/S4210238104","display_name":"Microbial Biotechnology","issn_l":"1751-7915","issn":["1751-7915","1751-7907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11368087","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11368087","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11368087/pdf/MBT2-17-e14525.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Biotechnol","raw_type":"Text"},{"id":"pmid:39222378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39222378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:2403.12912","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2403.12912","pdf_url":"https://arxiv.org/pdf/2403.12912","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c0b81b56f8d34dddb2d1333f73ff0ed8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c0b81b56f8d34dddb2d1333f73ff0ed8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Microbial Biotechnology, Vol 17, Iss 9, Pp n/a-n/a (2024)","raw_type":"article"},{"id":"pmh:oai:osti.gov:2439084","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/2439084","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:2439085","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/2439085","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:osti.gov:2472246","doi":null,"is_oa":false,"landing_page_url":"https://www.osti.gov/biblio/2472246","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.48550/arxiv.2403.12912","doi":"https://doi.org/10.48550/arxiv.2403.12912","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2403.12912","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1111/1751-7915.14525","doi":"https://doi.org/10.1111/1751-7915.14525","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1751-7915.14525","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.14525","source":{"id":"https://openalex.org/S4210238104","display_name":"Microbial Biotechnology","issn_l":"1751-7915","issn":["1751-7915","1751-7907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1020086576","display_name":null,"funder_award_id":"DE-SC0020153","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G376713357","display_name":"UNDERSTANDING THE MECHANISM AND PROPERTIES OF CATALYTIC THI4 PROTEINS","funder_award_id":"DESC0020153","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6073810273","display_name":null,"funder_award_id":"FLA-HOS-005796","funder_id":"https://openalex.org/F4320306114","funder_display_name":"U.S. Department of Agriculture"},{"id":"https://openalex.org/G709032760","display_name":null,"funder_award_id":"FLA\u2010HOS\u2010005796","funder_id":"https://openalex.org/F4320332299","funder_display_name":"National Institute of Food and Agriculture"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320332299","display_name":"National Institute of Food and Agriculture","ror":"https://ror.org/05qx3fv49"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320333506","display_name":"College of Liberal Arts and Sciences, University of Florida","ror":null},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402126178.pdf","grobid_xml":"https://content.openalex.org/works/W4402126178.grobid-xml"},"referenced_works_count":102,"referenced_works":["https://openalex.org/W1487878063","https://openalex.org/W1516116810","https://openalex.org/W1540714253","https://openalex.org/W1567318028","https://openalex.org/W1760665500","https://openalex.org/W1964600118","https://openalex.org/W1971948874","https://openalex.org/W1988620524","https://openalex.org/W1990027795","https://openalex.org/W1990226486","https://openalex.org/W2004674004","https://openalex.org/W2023806904","https://openalex.org/W2024793354","https://openalex.org/W2025214889","https://openalex.org/W2026674566","https://openalex.org/W2036099201","https://openalex.org/W2037861389","https://openalex.org/W2038335468","https://openalex.org/W2042650553","https://openalex.org/W2045201404","https://openalex.org/W2057351000","https://openalex.org/W2063779182","https://openalex.org/W2066829062","https://openalex.org/W2072499238","https://openalex.org/W2075868340","https://openalex.org/W2089047063","https://openalex.org/W2092122738","https://openalex.org/W2099763917","https://openalex.org/W2109036608","https://openalex.org/W2112689874","https://openalex.org/W2120772351","https://openalex.org/W2120971204","https://openalex.org/W2121891865","https://openalex.org/W2127497651","https://openalex.org/W2129095580","https://openalex.org/W2131339809","https://openalex.org/W2137335580","https://openalex.org/W2148734328","https://openalex.org/W2152458080","https://openalex.org/W2152873168","https://openalex.org/W2155115398","https://openalex.org/W2166323054","https://openalex.org/W2169768603","https://openalex.org/W2169805130","https://openalex.org/W2171667988","https://openalex.org/W2187089797","https://openalex.org/W2238393485","https://openalex.org/W2413156691","https://openalex.org/W2625702416","https://openalex.org/W2626778328","https://openalex.org/W2776563109","https://openalex.org/W2790018487","https://openalex.org/W2790456375","https://openalex.org/W2795396508","https://openalex.org/W2795780418","https://openalex.org/W2799756983","https://openalex.org/W2800329064","https://openalex.org/W2811140905","https://openalex.org/W2901121611","https://openalex.org/W2903648433","https://openalex.org/W2909363712","https://openalex.org/W2917202476","https://openalex.org/W2938901849","https://openalex.org/W2945456477","https://openalex.org/W2947525207","https://openalex.org/W2947716560","https://openalex.org/W2952856897","https://openalex.org/W2981543307","https://openalex.org/W3003633836","https://openalex.org/W3015295562","https://openalex.org/W3017013227","https://openalex.org/W3024267968","https://openalex.org/W3028694781","https://openalex.org/W3037033469","https://openalex.org/W3039721477","https://openalex.org/W3082772719","https://openalex.org/W3083874241","https://openalex.org/W3088109935","https://openalex.org/W3093282046","https://openalex.org/W3123596475","https://openalex.org/W3137117380","https://openalex.org/W3146944767","https://openalex.org/W3166928479","https://openalex.org/W3176264499","https://openalex.org/W3177828909","https://openalex.org/W3179485843","https://openalex.org/W3183172800","https://openalex.org/W3196499982","https://openalex.org/W3201075817","https://openalex.org/W3202228291","https://openalex.org/W3202848468","https://openalex.org/W3208914146","https://openalex.org/W3217031179","https://openalex.org/W4220708277","https://openalex.org/W4226162236","https://openalex.org/W4235129366","https://openalex.org/W4280539826","https://openalex.org/W4280634382","https://openalex.org/W4283712126","https://openalex.org/W4293792996","https://openalex.org/W4296801599","https://openalex.org/W4375858802"],"related_works":["https://openalex.org/W4416950699","https://openalex.org/W4313479123","https://openalex.org/W4289520417","https://openalex.org/W7099707306","https://openalex.org/W2170764254","https://openalex.org/W4387297077","https://openalex.org/W7165979471","https://openalex.org/W3083514086","https://openalex.org/W3213999762","https://openalex.org/W4307897321"],"abstract_inverted_index":{"Expressing":[0],"plant":[1,16,30,63,92,113,131],"metabolic":[2],"pathways":[3,93],"in":[4,32,65,94],"microbial":[5],"platforms":[6],"is":[7,73,125],"an":[8],"efficient,":[9],"cost-effective":[10,108],"solution":[11],"for":[12,59,82,115],"producing":[13],"many":[14],"desired":[15],"compounds.":[17],"As":[18],"eukaryotic":[19],"organisms,":[20],"yeasts":[21],"are":[22,42,76,140],"often":[23],"the":[24,40,46,55,89,104,119,174,178],"preferred":[25],"platform.":[26],"However,":[27],"expression":[28],"of":[29,62,70,91,106],"enzymes":[31,41,64,114,134],"a":[33,107,148,183],"yeast":[34,48,120,133],"frequently":[35],"leads":[36],"to":[37,45,99,111,118,154,168,176],"failure":[38],"because":[39],"poorly":[43],"adapted":[44],"foreign":[47],"cellular":[49,95,121],"environment.":[50],"Here,":[51],"we":[52,102,146,172],"first":[53],"summarize":[54],"current":[56],"engineering":[57],"approaches":[58,72],"optimizing":[60],"performance":[61],"yeast.":[66],"A":[67],"critical":[68],"limitation":[69],"these":[71],"that":[74,130,139],"they":[75],"labour-intensive":[77],"and":[78,132],"must":[79],"be":[80,165],"customized":[81],"each":[83],"individual":[84],"enzyme,":[85],"which":[86,163],"significantly":[87],"hinders":[88],"establishment":[90],"factories.":[96],"In":[97],"response":[98],"this":[100],"challenge,":[101],"propose":[103],"development":[105],"computational":[109],"pipeline":[110],"redesign":[112],"better":[116],"adaptation":[117],"milieu.":[122],"This":[123],"proposition":[124],"underpinned":[126],"by":[127],"compelling":[128],"evidence":[129],"exhibit":[135],"distinct":[136],"sequence":[137,161],"features":[138],"generalizable":[141],"across":[142],"enzyme":[143],"families.":[144],"Consequently,":[145],"introduce":[147],"data-driven":[149],"machine":[150,179],"learning":[151,180],"framework":[152],"designed":[153],"extract":[155],"'yeastizing'":[156],"rules":[157],"from":[158],"natural":[159],"protein":[160],"variations,":[162],"can":[164],"broadly":[166],"applied":[167],"all":[169],"enzymes.":[170],"Additionally,":[171],"discuss":[173],"potential":[175],"integrate":[177],"model":[181],"into":[182],"full":[184],"design-build-test":[185],"cycle.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-09-03T00:00:00"}