{"id":"https://openalex.org/W4402067228","doi":"https://doi.org/10.1007/s00726-024-03409-2","title":"Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance","display_name":"Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance","publication_year":2024,"publication_date":"2024-08-30","ids":{"openalex":"https://openalex.org/W4402067228","doi":"https://doi.org/10.1007/s00726-024-03409-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/39212734"},"language":"en","primary_location":{"id":"doi:10.1007/s00726-024-03409-2","doi":"https://doi.org/10.1007/s00726-024-03409-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-024-03409-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00726-024-03409-2.pdf","source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1007/s00726-024-03409-2.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100390122","display_name":"Xiaoguang Liu","orcid":"https://orcid.org/0000-0003-0183-2100","observed_orcids":["https://orcid.org/0000-0003-0183-2100"]},"institutions":[{"id":"https://openalex.org/I3130633384","display_name":"Guangzhou Sport University","ror":"https://ror.org/046r6pk12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130633384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoguang Liu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, China","School of Sport and Health, Guangzhou Sport University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, China","institution_ids":["https://openalex.org/I3130633384"]},{"raw_affiliation_string":"School of Sport and Health, Guangzhou Sport University, Guangzhou, China","institution_ids":["https://openalex.org/I3130633384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667705","display_name":"Lin Zhu","orcid":"https://orcid.org/0000-0002-4546-2896","observed_orcids":["https://orcid.org/0000-0002-4546-2896","https://orcid.org/0009-0000-5005-9455"]},"institutions":[{"id":"https://openalex.org/I3130633384","display_name":"Guangzhou Sport University","ror":"https://ror.org/046r6pk12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130633384"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Zhu","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, China. 11251@gzsport.edu.cn","School of Sport and Health, Guangzhou Sport University, Guangzhou, China. 11251@gzsport.edu.cn","School of Sport and Health, Guangzhou Sport University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion, Guangzhou Sport University, Guangzhou, China. 11251@gzsport.edu.cn","institution_ids":["https://openalex.org/I3130633384"]},{"raw_affiliation_string":"School of Sport and Health, Guangzhou Sport University, Guangzhou, China. 11251@gzsport.edu.cn","institution_ids":["https://openalex.org/I3130633384"]},{"raw_affiliation_string":"School of Sport and Health, Guangzhou Sport University, Guangzhou, China","institution_ids":["https://openalex.org/I3130633384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089715826","display_name":"Jingxin Liu","orcid":"https://orcid.org/0000-0003-4880-9346","observed_orcids":["https://orcid.org/0000-0003-4880-9346"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingxin Liu","raw_affiliation_strings":["Physical education and sports school, Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical education and sports school, Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zichen Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zichen Nie","raw_affiliation_strings":["Harbin Institute of Technology, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, Shenzhen, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wenjun Qiu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94357780","display_name":"Zhongkai University of Agriculture and Engineering","ror":"https://ror.org/000b7ms85","country_code":"CN","type":"education","lineage":["https://openalex.org/I94357780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjun Qiu","raw_affiliation_strings":["Zhongkai University of Agriculture and Engineering, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongkai University of Agriculture and Engineering, Guangzhou, China","institution_ids":["https://openalex.org/I94357780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101667705"],"corresponding_institution_ids":["https://openalex.org/I3130633384"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":0.5888,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.61122286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"56","issue":"1","first_page":"54","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.08290000259876251,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.049800001084804535,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-obesity","display_name":"childhood obesity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9940000176429749},{"id":"https://openalex.org/keywords/weight-loss-interventions","display_name":"weight loss interventions","score":0.968999981880188},{"id":"https://openalex.org/keywords/metabolomic-signatures","display_name":"metabolomic signatures","score":0.7570000290870667},{"id":"https://openalex.org/keywords/plasma-metabolites","display_name":"plasma metabolites","score":0.9589999914169312},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7379999756813049},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.6169999837875366},{"id":"https://openalex.org/keywords/type-2-diabetes-prevention","display_name":"type 2 diabetes prevention","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7659589052200317},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7443098425865173},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.5375655889511108},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5014998912811279},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4422151446342468},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4328187108039856},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.43093788623809814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42520684003829956},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4239833950996399},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4125733971595764},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36057281494140625},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34626278281211853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2890452742576599},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23315206170082092},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07935139536857605},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061217","descriptor_name":"Weight Reduction Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061217","descriptor_name":"Weight Reduction Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061217","descriptor_name":"Weight Reduction Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061217","descriptor_name":"Weight Reduction Programs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D063766","descriptor_name":"Pediatric Obesity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s00726-024-03409-2","doi":"https://doi.org/10.1007/s00726-024-03409-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-024-03409-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00726-024-03409-2.pdf","source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},{"id":"pmid:39212734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39212734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino acids","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11364699","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39212734/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11364699/pdf/726_2024_Article_3409.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Amino Acids","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:028a3696c0a34d28b7dfea4f301d4fa3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/028a3696c0a34d28b7dfea4f301d4fa3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Amino Acids, Vol 56, Iss 1, Pp 1-13 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/s00726-024-03409-2","doi":"https://doi.org/10.1007/s00726-024-03409-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00726-024-03409-2","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00726-024-03409-2.pdf","source":{"id":"https://openalex.org/S13895637","display_name":"Amino Acids","issn_l":"0939-4451","issn":["0939-4451","1438-2199"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Amino Acids","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402067228.pdf","grobid_xml":"https://content.openalex.org/works/W4402067228.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1519785014","https://openalex.org/W1657478053","https://openalex.org/W1778593387","https://openalex.org/W1979503314","https://openalex.org/W1981460639","https://openalex.org/W2069619326","https://openalex.org/W2109941637","https://openalex.org/W2113468195","https://openalex.org/W2152007541","https://openalex.org/W2302016601","https://openalex.org/W2405416127","https://openalex.org/W2538544078","https://openalex.org/W2766147673","https://openalex.org/W2766519476","https://openalex.org/W2772308155","https://openalex.org/W2795013773","https://openalex.org/W2805376596","https://openalex.org/W2888597016","https://openalex.org/W2888795926","https://openalex.org/W2895911941","https://openalex.org/W2936569839","https://openalex.org/W2974767039","https://openalex.org/W3005849052","https://openalex.org/W3005953879","https://openalex.org/W3007114336","https://openalex.org/W3014942687","https://openalex.org/W3040383747","https://openalex.org/W3087264013","https://openalex.org/W3087802816","https://openalex.org/W3112016412","https://openalex.org/W3115725152","https://openalex.org/W3118997615","https://openalex.org/W3142605790","https://openalex.org/W3161593331","https://openalex.org/W3201660281","https://openalex.org/W4200215705","https://openalex.org/W4205488723","https://openalex.org/W4206284799","https://openalex.org/W4206970153","https://openalex.org/W4207017140","https://openalex.org/W4210581174","https://openalex.org/W4360830344","https://openalex.org/W4377028102"],"related_works":["https://openalex.org/W4283390424","https://openalex.org/W2137270828","https://openalex.org/W1976072307","https://openalex.org/W4205440119","https://openalex.org/W1561393703","https://openalex.org/W3153348389","https://openalex.org/W2040768604","https://openalex.org/W4292104203","https://openalex.org/W3045530230","https://openalex.org/W2096576371"],"abstract_inverted_index":{"The":[0],"obesity":[1],"epidemic":[2],"among":[3],"children":[4,48,53,176,195,234],"has":[5,20],"become":[6],"a":[7],"major":[8,223],"public":[9],"health":[10,67],"issue,":[11],"and":[12,76,98,106,137,149,160,168,180,247],"the":[13,25,37,59,94,117,126,132,146,155,205,244],"presence":[14],"of":[15,27,83,135],"childhood":[16],"insulin":[17],"resistance":[18],"(IR)":[19],"been":[21],"demonstrated":[22],"prior":[23],"to":[24,93,115,144,153],"onset":[26],"type":[28],"2":[29],"diabetes":[30],"mellitus.":[31],"However,":[32],"it":[33],"is":[34,40],"unclear":[35],"whether":[36],"metabolomic":[38,230],"signature":[39],"associated":[41,221],"with":[42,49,54,125,177,196,222,235],"weight":[43,60,78,182,186,238,252],"loss":[44,61,79,183,187,239,253],"interventions":[45],"in":[46,104,131,174,193,232,251],"obese":[47,52,175,194,233],"IR.":[50,197],"Thirty-six":[51],"IR":[55,178,236],"were":[56,73,113,171,201,219],"selected":[57],"from":[58],"camp":[62],"(Shenzhen":[63],"Sunshine":[64],"Xing":[65],"Yada":[66],"Technology":[68],"Co.,":[69],"LTD).":[70],"Clinical":[71],"parameters":[72,167,246],"collected":[74],"before":[75,179],"after":[77,181,237],"intervention.":[80,184],"Targeted":[81],"metabolomics":[82],"plasma":[84],"samples":[85],"was":[86,123],"performed":[87],"by":[88],"ultra-performance":[89],"liquid":[90],"chromatography":[91],"coupled":[92],"tandem":[95],"mass":[96],"spectrometry,":[97],"principal":[99],"component":[100],"analysis,":[101],"variable":[102],"importance":[103],"projection,":[105],"orthogonal":[107],"partial":[108],"least":[109],"squares":[110],"discriminant":[111],"analysis":[112,122,152],"used":[114,140],"obtain":[116,145],"differentially":[118],"expressed":[119],"metabolites.":[120],"Pathway":[121],"conducted":[124],"Homo":[127],"sapiens":[128],"(HSA)":[129],"sets":[130],"Kyoto":[133],"Encyclopedia":[134],"Genes":[136],"Genomes.":[138],"We":[139,163],"machine":[141,206],"learning":[142,207],"algorithms":[143],"potential":[147,158,212,217],"biomarkers":[148,159,218],"Spearman":[150],"correlation":[151],"clarify":[154],"association":[156],"between":[157],"clinical":[161,166,224,245],"parameters.":[162,225],"found":[164,209],"that":[165],"metabolite":[169,248],"clusters":[170],"significantly":[172,189,202],"changed":[173,190],"Mechanistically,":[185],"intervention":[188],"61":[191],"metabolites":[192],"Furthermore,":[198],"12":[199],"pathways":[200],"changed.":[203],"Moreover,":[204],"algorithm":[208],"6":[210],"important":[211],"biomarkers.":[213],"In":[214],"addition,":[215],"these":[216],"strongly":[220],"These":[226],"data":[227],"indicate":[228],"different":[229],"profiles":[231],"intervention,":[240],"providing":[241],"insights":[242],"into":[243],"mechanisms":[249],"involved":[250],"programs.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}