{"id":"https://openalex.org/W4402038416","doi":"https://doi.org/10.1016/j.heliyon.2024.e37230","title":"SZ-685C inhibits the growth of non-functioning pituitary adenoma by down-regulating miR-340-3p and inducing autophagy","display_name":"SZ-685C inhibits the growth of non-functioning pituitary adenoma by down-regulating miR-340-3p and inducing autophagy","publication_year":2024,"publication_date":"2024-08-30","ids":{"openalex":"https://openalex.org/W4402038416","doi":"https://doi.org/10.1016/j.heliyon.2024.e37230","pmid":"https://pubmed.ncbi.nlm.nih.gov/39286117"},"language":"en","primary_location":{"id":"doi:10.1016/j.heliyon.2024.e37230","doi":"https://doi.org/10.1016/j.heliyon.2024.e37230","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e37230","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.heliyon.2024.e37230","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100668398","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0001-5032-5290","observed_orcids":["https://orcid.org/0000-0001-5032-5290"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100775055","display_name":"Zhongyu Wang","orcid":"https://orcid.org/0009-0008-8343-7035","observed_orcids":["https://orcid.org/0009-0008-8343-7035"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhong-Yu Wang","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","Pituitary Tumor Center, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]},{"raw_affiliation_string":"Pituitary Tumor Center, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113526938","display_name":"Hui\u2010Tong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Tong Chen","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111307889","display_name":"Yu-You Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-You Luo","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114217141","display_name":"Li Siyuan","orcid":"https://orcid.org/0000-0002-8136-1021","observed_orcids":["https://orcid.org/0000-0002-8136-1021"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-Yuan Li","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102121259","display_name":"Xiongming Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiong-Ming Luo","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, China","School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]},{"raw_affiliation_string":"School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027911001","display_name":"Junhua Yang","orcid":"https://orcid.org/0000-0003-4117-7569","observed_orcids":["https://orcid.org/0000-0003-4117-7569"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun-Hua Yang","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100773813","display_name":"Yuxin Ma","orcid":"https://orcid.org/0000-0002-6849-2131","observed_orcids":["https://orcid.org/0000-0002-6849-2131"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-Xin Ma","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021696018","display_name":"Xiaobao Jin","orcid":"https://orcid.org/0000-0001-5450-1730","observed_orcids":["https://orcid.org/0000-0001-5450-1730"]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Bao Jin","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101901429","display_name":"Zongming Wang","orcid":"https://orcid.org/0000-0001-6133-8038","observed_orcids":["https://orcid.org/0000-0001-6133-8038"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I190242452","display_name":"Guangdong Pharmaceutical University","ror":"https://ror.org/02vg7mz57","country_code":"CN","type":"education","lineage":["https://openalex.org/I190242452"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zong-Ming Wang","raw_affiliation_strings":["Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","Pituitary Tumor Center, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China","institution_ids":["https://openalex.org/I190242452"]},{"raw_affiliation_string":"Pituitary Tumor Center, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.2712,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.61779451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"10","issue":"17","first_page":"e37230","last_page":"e37230"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.07890000194311142,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonfunctioning-pituitary-adenoma","display_name":"non-functioning pituitary adenoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ppp1cb","display_name":"PPP1CB","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mangrove-endophytic-fungi","display_name":"mangrove endophytic fungi","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.5080000162124634},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lc3-ii-lc3-i-ratio","display_name":"LC3-II/LC3-I ratio","score":0.7990000247955322},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8029999732971191},{"id":"https://openalex.org/keywords/anticancer-natural-products","display_name":"anticancer natural products","score":0.7200000286102295},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8580799102783203},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.593755841255188},{"id":"https://openalex.org/C68874143","wikidata":"https://www.wikidata.org/wiki/Q19756","display_name":"Mangrove","level":2,"score":0.48867538571357727},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.46292993426322937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42205607891082764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39486297965049744},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3609861135482788},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.3211436867713928},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32054603099823},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26102179288864136},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1861940622329712},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12197351455688477},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10573753714561462},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.heliyon.2024.e37230","doi":"https://doi.org/10.1016/j.heliyon.2024.e37230","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e37230","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},{"id":"pmid:39286117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39286117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11402753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11402753","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11402753/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:f7e385c650e842f4a81c91c4a1cbd8a0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f7e385c650e842f4a81c91c4a1cbd8a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Heliyon, Vol 10, Iss 17, Pp e37230- (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.heliyon.2024.e37230","doi":"https://doi.org/10.1016/j.heliyon.2024.e37230","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.heliyon.2024.e37230","pdf_url":null,"source":{"id":"https://openalex.org/S2898612692","display_name":"Heliyon","issn_l":"2405-8440","issn":["2405-8440"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","ki-jl-1","norway-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heliyon","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.46000000834465027,"display_name":"Zero hunger"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2396789468","display_name":null,"funder_award_id":"202102021116","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G2804293475","display_name":null,"funder_award_id":"202201010307","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G6056297225","display_name":null,"funder_award_id":"2018A030310107","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"},{"id":"https://openalex.org/G789452835","display_name":null,"funder_award_id":"81802678","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W193469943","https://openalex.org/W1484891738","https://openalex.org/W1512761670","https://openalex.org/W1521411817","https://openalex.org/W1984994493","https://openalex.org/W1996286498","https://openalex.org/W2000447075","https://openalex.org/W2008393452","https://openalex.org/W2012070379","https://openalex.org/W2019222394","https://openalex.org/W2061452996","https://openalex.org/W2062038945","https://openalex.org/W2073652625","https://openalex.org/W2080424286","https://openalex.org/W2088330927","https://openalex.org/W2106926141","https://openalex.org/W2132850522","https://openalex.org/W2150549896","https://openalex.org/W2150767029","https://openalex.org/W2166616170","https://openalex.org/W2605800382","https://openalex.org/W2793210792","https://openalex.org/W2910147789","https://openalex.org/W2972755270","https://openalex.org/W3004409334","https://openalex.org/W3016477903","https://openalex.org/W3042397662","https://openalex.org/W3106636144","https://openalex.org/W3107931854","https://openalex.org/W3120684613","https://openalex.org/W3142613310","https://openalex.org/W3175718466","https://openalex.org/W3195574553","https://openalex.org/W3197920132","https://openalex.org/W3208947510","https://openalex.org/W3215238140","https://openalex.org/W4200077201","https://openalex.org/W4210663722","https://openalex.org/W4210788249","https://openalex.org/W4211064852","https://openalex.org/W4214676316","https://openalex.org/W4223457423","https://openalex.org/W4237188050","https://openalex.org/W4283156085","https://openalex.org/W4283692078","https://openalex.org/W4295908393","https://openalex.org/W4309944413","https://openalex.org/W4312041724","https://openalex.org/W4313491557","https://openalex.org/W4315436171","https://openalex.org/W4320710112","https://openalex.org/W6804259102","https://openalex.org/W6808758108","https://openalex.org/W6818415046"],"related_works":["https://openalex.org/W2379904645","https://openalex.org/W2382019598","https://openalex.org/W2368164637","https://openalex.org/W4285797717","https://openalex.org/W2621002353","https://openalex.org/W1975953955","https://openalex.org/W2355313044","https://openalex.org/W3032366046","https://openalex.org/W3028609428","https://openalex.org/W2911848948"],"abstract_inverted_index":{"Background:":[0],"sp.":[1],"(No.":[2],"1403)":[3],"collected":[4],"from":[5,72],"the":[6,49,73,86,101,109,124,154,158,207,213,244,272,290,299,305],"South":[7],"China":[8],"Sea,":[9],"has":[10,40],"shown":[11],"strong":[12],"anticancer":[13],"activities.":[14],"Non-functioning":[15],"pituitary":[16,60],"adenomas":[17],"(NFPAs)":[18],"are":[19],"a":[20,33,57,148,264],"type":[21],"of":[22,56,88,108,126,131,138,151,157,179,210,215,242,246,255,271,285,292,301,316],"tumor":[23],"that":[24,42,230],"can":[25],"be":[26],"challenging":[27],"to":[28,83,99,122,217,308,314],"manage":[29],"clinically":[30],"and":[31,53,70,85,112,163,182,196,219,221,226,252,269,278,303],"have":[32],"significant":[34],"unmet":[35],"medical":[36],"need.":[37],"Our":[38],"research":[39],"found":[41],"SZ-685C":[43,67,89,132,169,205,256,262,288],"showed":[44,145,229],"an":[45],"inhibitory":[46],"effect":[47,87,254],"on":[48,90,133,257],"viability,":[50,247],"migration":[51,180,248],"ability,":[52,249,251],"proliferation":[54,183,250],"ability":[55,181],"human":[58],"non-functioning":[59],"tumor-derived":[61],"folliculostellate":[62],"(PDFS)":[63],"cell":[64,171,311,318],"line.":[65],"Methods:":[66],"was":[68,93,97,120,161,281],"prepared":[69],"purified":[71],"mangrove":[74],"endophytic":[75],"fungus":[76],"No.":[77],"1403.":[78],"PDFS":[79,91,106,134,174,235,258,276,295,317],"cells":[80,92,107,135,236,259],"were":[81,140,260],"exposed":[82],"SZ-685C,":[84],"evaluated.":[94,141],"RNA":[95],"sequencing":[96,225],"used":[98],"analyze":[100],"miRNA":[102],"expression":[103,125,268,291,300],"profile":[104],"in":[105,173,234,266,275,294],"control":[110],"group":[111],"SZ-685C-treated":[113],"group.":[114],"Quantitative":[115],"polymerase":[116],"chain":[117],"reaction":[118],"(qPCR)":[119],"performed":[121],"verify":[123],"selected":[127,159],"miR-340-3p.":[128,152,286],"The":[129,185],"effects":[130],"after":[136,283],"overexpression":[137,241,284],"miR-340-3p":[139,160,231,293],"Dual-luciferase":[142],"reporter":[143],"assays":[144],"PPP1CB":[146,267,302],"is":[147,191,200],"direct":[149],"target":[150],"Finally,":[153],"action":[155],"pathway":[156,274,307],"predicted":[162],"evaluated":[164],"through":[165],"bioinformatics":[166],"analysis.":[167],"Results:":[168],"reduced":[170],"viability":[172],"cells,":[175,277,296],"accompanied":[176],"by":[177],"inhibition":[178,245,315],"ability.":[184],"IC50":[186],"value":[187],"for":[188,197],"24":[189],"h":[190,199],"9.144":[192],"\u00b1":[193,202],"0.991":[194],"\u03bcM,":[195],"48":[198],"4.635":[201],"0.551":[203],"\u03bcM.":[204],"increased":[206],"protein":[208],"levels":[209],"Beclin":[211],"1,":[212],"ratio":[214],"LC3-II":[216],"LC3-I,":[218],"LAMP-1,":[220],"down-regulated":[222],"p62.":[223],"MiRNA":[224],"further":[227],"validation":[228],"significantly":[232],"decreased":[233],"treated":[237],"with":[238],"SZ-685C.":[239],"After":[240],"miR-340-3p,":[243],"autophagy-promoting":[253],"weakened.":[261],"caused":[263],"decrease":[265],"activation":[270],"ERK":[273,306],"this":[279],"trend":[280],"reversed":[282],"Conclusions:":[287],"downregulates":[289],"thereby":[297],"reducing":[298],"activating":[304],"promote":[309],"autophagic":[310],"death,":[312],"leading":[313],"growth.":[319]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}