{"id":"https://openalex.org/W4402024921","doi":"https://doi.org/10.1177/1934578x241271698","title":"Anti-Oxidant and Anti-Inflammatory Properties of Talinum triangulare Methanol Leaf Extract on Cadmium-Induced Cognitive Dysfunction in Male Wistar Rats","display_name":"Anti-Oxidant and Anti-Inflammatory Properties of Talinum triangulare Methanol Leaf Extract on Cadmium-Induced Cognitive Dysfunction in Male Wistar Rats","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4402024921","doi":"https://doi.org/10.1177/1934578x241271698"},"language":"en","primary_location":{"id":"doi:10.1177/1934578x241271698","doi":"https://doi.org/10.1177/1934578x241271698","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x241271698","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/1934578x241271698","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070005760","display_name":"Uduak Anthony Inwang","orcid":"https://orcid.org/0000-0002-6370-3817","observed_orcids":["https://orcid.org/0000-0002-6370-3817"]},"institutions":[{"id":"https://openalex.org/I4387155461","display_name":"Alex Ekwueme Federal University, Ndufu-Alike","ror":"https://ror.org/04thacr56","country_code":null,"type":"education","lineage":["https://openalex.org/I4387155461"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Uduak Anthony Inwang","raw_affiliation_strings":["Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Nigeria"],"raw_orcid":"https://orcid.org/0000-0002-6370-3817","affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Nigeria","institution_ids":["https://openalex.org/I4387155461"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107970902","display_name":"Ezekiel Etim Ben","orcid":"https://orcid.org/0000-0001-8022-3199","observed_orcids":["https://orcid.org/0000-0001-8022-3199"]},"institutions":[{"id":"https://openalex.org/I4405255170","display_name":"David Umahi Federal University of Health Sciences Uburu","ror":"https://ror.org/02ph9d254","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405255170"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ezekiel Etim Ben","raw_affiliation_strings":["Department of Industrial Chemistry, David Umahi Federal University of Health Sciences, Uburu, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial Chemistry, David Umahi Federal University of Health Sciences, Uburu, Nigeria","institution_ids":["https://openalex.org/I4405255170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078407438","display_name":"Obinna Onwe Uchewa","orcid":"https://orcid.org/0000-0003-0609-8179","observed_orcids":["https://orcid.org/0000-0003-0609-8179"]},"institutions":[{"id":"https://openalex.org/I37797678","display_name":"University of Uyo","ror":"https://ror.org/0127mpp72","country_code":"NG","type":"education","lineage":["https://openalex.org/I37797678"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Obinna Onwe Uchewa","raw_affiliation_strings":["Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria","institution_ids":["https://openalex.org/I37797678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074543063","display_name":"Emmanuel Onyi Nwuzor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405263049","display_name":"Arthur Jarvis University","ror":"https://ror.org/01st4fj80","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405263049"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Emmanuel Onyi Nwuzor","raw_affiliation_strings":["Department of Physiology, Faculty of Basic Medical Sciences, Arthur Javis University, Akpabuyo, Cross Rivers State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Basic Medical Sciences, Arthur Javis University, Akpabuyo, Cross Rivers State, Nigeria","institution_ids":["https://openalex.org/I4405263049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081288889","display_name":"Azubuike Raphael Nwaji","orcid":"https://orcid.org/0000-0002-4313-5357","observed_orcids":["https://orcid.org/0000-0002-4313-5357"]},"institutions":[{"id":"https://openalex.org/I4387155461","display_name":"Alex Ekwueme Federal University, Ndufu-Alike","ror":"https://ror.org/04thacr56","country_code":null,"type":"education","lineage":["https://openalex.org/I4387155461"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Azubuike Raphael Nwaji","raw_affiliation_strings":["Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Nigeria","institution_ids":["https://openalex.org/I4387155461"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034582034","display_name":"Ekementeabasi Aniebo Umoh","orcid":"https://orcid.org/0000-0001-8643-8764","observed_orcids":["https://orcid.org/0000-0001-8643-8764"]},"institutions":[{"id":"https://openalex.org/I4387155461","display_name":"Alex Ekwueme Federal University, Ndufu-Alike","ror":"https://ror.org/04thacr56","country_code":null,"type":"education","lineage":["https://openalex.org/I4387155461"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ekementeabasi Aniebo Umoh","raw_affiliation_strings":["Department of Anatomy, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Nigeria"],"raw_orcid":"https://orcid.org/0000-0001-8643-8764","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu Alike, Ikwo, Nigeria","institution_ids":["https://openalex.org/I4387155461"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070005760"],"corresponding_institution_ids":["https://openalex.org/I4387155461"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":0.8367,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75462298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"19","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/talinum-triangulare","display_name":"Talinum triangulare","score":1.0},{"id":"https://openalex.org/keywords/cadmium-neurotoxicity","display_name":"cadmium neurotoxicity","score":0.890999972820282},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8930000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.824999988079071},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.996999979019165},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibition","display_name":"acetylcholinesterase inhibition","score":0.8199999928474426},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.7419999837875366},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7730000019073486},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.875},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9490000009536743},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":0.8090000152587891},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5770000219345093},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C544657597","wikidata":"https://www.wikidata.org/wiki/Q1091","display_name":"Cadmium","level":2,"score":0.6699985265731812},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.5431411266326904},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5166783332824707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5135447978973389},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4379366338253021},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3128589689731598},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.092964768409729}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/1934578x241271698","doi":"https://doi.org/10.1177/1934578x241271698","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x241271698","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a8ff3a2628dc4aa0973de405950ebd14","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a8ff3a2628dc4aa0973de405950ebd14","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Natural Product Communications, Vol 19 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1934578x241271698","doi":"https://doi.org/10.1177/1934578x241271698","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x241271698","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.833299994468689,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1546592314","https://openalex.org/W1967039443","https://openalex.org/W1971048984","https://openalex.org/W1989780177","https://openalex.org/W1990146820","https://openalex.org/W2044460323","https://openalex.org/W2050842146","https://openalex.org/W2055298956","https://openalex.org/W2071618166","https://openalex.org/W2082965467","https://openalex.org/W2088169551","https://openalex.org/W2144487298","https://openalex.org/W2147993424","https://openalex.org/W2153394357","https://openalex.org/W2171555296","https://openalex.org/W2334522672","https://openalex.org/W2415344130","https://openalex.org/W2781239192","https://openalex.org/W4220752650","https://openalex.org/W4224042448","https://openalex.org/W4295539403","https://openalex.org/W4313824570","https://openalex.org/W4328051367","https://openalex.org/W4378515859","https://openalex.org/W4390168791"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Objective":[0],"Oxidative":[1],"stress":[2],"results":[3],"in":[4,12,49,154,158,166],"neuronal":[5],"degeneration":[6],"leading":[7],"to":[8,29],"cognitive":[9,231],"decline.":[10],"Microglia":[11],"brain":[13],"tissue":[14,200],"produces":[15],"reactive":[16],"oxygen":[17],"species":[18],"(ROS),":[19],"which":[20,31],"modulate":[21],"synaptic":[22],"communication":[23],"between":[24,61],"neurons.":[25],"ROS":[26],"can":[27,32],"lead":[28],"neuroinflammation,":[30],"cause":[33],"neurodegeneration":[34],"and":[35,46,54,90,97,114,118,131,150,162,176,183,191,207,217,233,236],"memory":[36,132],"loss.":[37],"Talinum":[38],"triangulare":[39,94,171,188,227],"was":[40,133,141],"investigated":[41],"for":[42,111],"its":[43],"cognitive,":[44],"anti-oxidative":[45,235],"anti-inflammatory":[47,237],"potentials":[48],"male":[50],"wistar":[51],"rats.":[52],"Materials":[53],"methods":[55],"25":[56],"adult":[57],"female":[58],"rats":[59],"weighing":[60],"150":[62],"g\u2013200":[63],"g":[64],"were":[65,83,124],"grouped":[66],"(n":[67],"=":[68],"5)":[69],"into":[70],"Group":[71],"1":[72,76],"(control":[73],"group)":[74],"received":[75],"mL/kg":[77],"of":[78,121,128],"distilled":[79],"water,":[80],"group":[81],"2\u20135":[82],"administered":[84],"with":[85,180],"100":[86,101],"mg/kg,":[87],"200":[88,175],"mg/kg":[89,92,99,102],"400":[91,177],"T.":[93,170,187,226],"methanol":[95,172,189,228],"extract":[96,173,190,229],"2.5":[98],"donepezil,":[100],"cadmium":[103,184],"respectively":[104],"via":[105],"oral":[106],"gavage.":[107],"The":[108,126],"administration":[109],"lasted":[110],"21":[112],"days":[113],"neurobehavioural":[115],"parameters,":[116],"biochemical":[117],"histological":[119],"analysis":[120],"the":[122,155,167,181],"hippocampus":[123],"evaluated.":[125],"assessment":[127],"spatial":[129],"learning":[130],"evaluated":[134],"using":[135],"Classic":[136],"labyrinth":[137,168],"task.":[138],"Results":[139],"There":[140],"significantly":[142,193,208],"(p":[143,194,209],"<":[144,195,210],"0.05)":[145,196,211],"reduced":[146,163,197],"escape":[147],"time":[148,152,164],"latency":[149,153,165],"increased":[151,212],"probe":[156],"trial":[157],"Morris":[159],"water":[160],"maze;":[161],"by":[169],"(100,":[174],"mg/kg)":[178],"compared":[179],"control":[182],"treated":[185],"groups.":[186],"donepezil":[192],"acetylcholinesterase":[198],"(AChE),":[199],"necrosis":[201],"factor-\u03b1":[202],"(TNF-\u03b1),":[203],"interleukin-6":[204],"(IL-6)":[205],"activities":[206],"gluthathione":[213],"peroxidase":[214],"activity":[215],"(GPx)":[216],"catalase":[218],"(CAT)":[219],"respectively.":[220],"Conclusion":[221],"These":[222],"findings":[223],"revealed":[224],"that":[225],"enhanced":[230],"function":[232],"exhibited":[234],"potentials.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}