{"id":"https://openalex.org/W4402001997","doi":"https://doi.org/10.53555/jptcp.v31i6.7568","title":"ASSOCIATION OF HOMOCYSTEINE AND ISCHEMIC STROKE IN PAKISTANI POPULATION","display_name":"ASSOCIATION OF HOMOCYSTEINE AND ISCHEMIC STROKE IN PAKISTANI POPULATION","publication_year":2024,"publication_date":"2024-08-01","ids":{"openalex":"https://openalex.org/W4402001997","doi":"https://doi.org/10.53555/jptcp.v31i6.7568"},"language":"en","primary_location":{"id":"doi:10.53555/jptcp.v31i6.7568","doi":"https://doi.org/10.53555/jptcp.v31i6.7568","is_oa":true,"landing_page_url":"http://dx.doi.org/10.53555/jptcp.v31i6.7568","pdf_url":"https://www.jptcp.com/index.php/jptcp/article/download/7568/7170","source":null,"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Population Therapeutics & Clinical Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4402001997"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jptcp.com/index.php/jptcp/article/download/7568/7170","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000353885","display_name":"Lal Shehbaz","orcid":"https://orcid.org/0000-0003-0607-5241","observed_orcids":["https://orcid.org/0000-0003-0607-5241"]},"institutions":[{"id":"https://openalex.org/I4210140751","display_name":"Ziauddin Hospital","ror":"https://ror.org/041g86f21","country_code":"PK","type":"healthcare","lineage":["https://openalex.org/I4210140751"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":true,"raw_author_name":"Dr Lal Shehbaz","raw_affiliation_strings":["Assistant Professor Emergency Medicine , Ziauddin University and Hospital , Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor Emergency Medicine , Ziauddin University and Hospital , Karachi","institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000353885"],"corresponding_institution_ids":["https://openalex.org/I4210140751","https://openalex.org/I923305593"],"apc_list":null,"apc_paid":null,"fwci":0.228,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44087269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":"3309","last_page":"3314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homocysteine","display_name":"homocysteine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hyperhomocysteinemia","display_name":"hyperhomocysteinemia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/stroke-risk-factors","display_name":"stroke risk factors","score":0.8820000290870667},{"id":"https://openalex.org/keywords/folate-deficiency","display_name":"folate deficiency","score":0.9520000219345093},{"id":"https://openalex.org/keywords/vitamin-b12-deficiency","display_name":"vitamin B12 deficiency","score":1.0},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9679999947547913},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stroke-severity","display_name":"stroke severity","score":0.847000002861023},{"id":"https://openalex.org/keywords/pakistani-population","display_name":"Pakistani population","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C2777090595","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Homocysteine","level":2,"score":0.6974775195121765},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.6486839056015015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6068880558013916},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5603809356689453},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5419484376907349},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5100758671760559},{"id":"https://openalex.org/C3017560507","wikidata":"https://www.wikidata.org/wiki/Q192466","display_name":"Plasma homocysteine","level":3,"score":0.49826717376708984},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44783759117126465},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4226444959640503},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17945006489753723},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.14471864700317383},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08659544587135315},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.05515444278717041},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.53555/jptcp.v31i6.7568","doi":"https://doi.org/10.53555/jptcp.v31i6.7568","is_oa":true,"landing_page_url":"http://dx.doi.org/10.53555/jptcp.v31i6.7568","pdf_url":"https://www.jptcp.com/index.php/jptcp/article/download/7568/7170","source":null,"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Population Therapeutics & Clinical Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.53555/jptcp.v31i6.7568","doi":"https://doi.org/10.53555/jptcp.v31i6.7568","is_oa":true,"landing_page_url":"http://dx.doi.org/10.53555/jptcp.v31i6.7568","pdf_url":"https://www.jptcp.com/index.php/jptcp/article/download/7568/7170","source":null,"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Population Therapeutics & Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4402001997.pdf","grobid_xml":"https://content.openalex.org/works/W4402001997.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2317390658","https://openalex.org/W2978090407","https://openalex.org/W4390907142"],"related_works":["https://openalex.org/W4375944509","https://openalex.org/W7217620487","https://openalex.org/W3217663978","https://openalex.org/W3195674334","https://openalex.org/W6950107001","https://openalex.org/W4390539944","https://openalex.org/W7220888602","https://openalex.org/W4412467771","https://openalex.org/W4290053042","https://openalex.org/W4299843641"],"abstract_inverted_index":{"Introduction:":[0],"Ischemic":[1],"stroke,":[2],"characterized":[3],"by":[4,88],"a":[5,16,19,23,83,89,124,182,244],"sudden":[6],"interruption":[7],"of":[8,32,40,49,69,95,106,111,127,174,184,199,232,234,248,268,280],"blood":[9,20],"flow":[10],"to":[11,15,36,64,91,135],"the":[12,33,38,50,79,93,139,203,272,278],"brain":[13],"due":[14],"blockage":[17],"in":[18,45,78,172,177,271,287],"vessel,":[21],"poses":[22],"significant":[24],"health":[25],"challenge":[26],"worldwide.":[27],"Objectives:":[28],"The":[29,103,118,148,186,197,275],"main":[30],"objective":[31],"study":[34,54,119,276],"is":[35,255],"find":[37],"association":[39],"homocysteine":[41,151,200,238,246,259,284],"and":[42,98,114,144,163,179,212,220,223,282,294],"ischemic":[43,74,96,269],"stroke":[44,75,97,191,270,291],"Pakistani":[46,273],"population.":[47,274],"Methodology":[48],"study:":[51],"This":[52],"cross-sectional":[53],"was":[55,153,170,193],"conducted":[56,87],"at":[57],"Allied":[58],"Hospital,":[59],"Faisalabad":[60],"during":[61],"April":[62],"2022":[63],"October":[65],"2022.":[66],"A":[67,230],"total":[68,231],"185":[70,121],"patients":[71,122,204,235],"diagnosed":[72],"with":[73,123,158,243,264,289],"were":[76,142,146],"included":[77,120],"study.":[80],"Patients":[81],"underwent":[82],"comprehensive":[84],"clinical":[85],"evaluation":[86],"neurologist":[90],"confirm":[92],"diagnosis":[94],"collected":[99],"detailed":[100],"medical":[101],"history.":[102],"data":[104],"captured":[105],"this":[107],"risk":[108,267,292],"factors":[109,293],"comprised":[110],"hypertension,":[112],"diabetes,":[113],"smoking":[115],"status.":[116],"Results:":[117],"mean":[125,187,245],"age":[126],"52.34":[128],"\u00b1":[129,155,195,250],"10.01":[130],"years,":[131],"ranging":[132],"from":[133],"40":[134],"85":[136],"years.":[137],"Among":[138],"participants,":[140],"70%":[141],"male":[143],"30%":[145,207],"female.":[147],"average":[149],"serum":[150],"level":[152,247],"15.8":[154,249],"4.2":[156,251],"\u00b5mol/L,":[157,214,222],"45%":[159],"showing":[160],"folate":[161],"deficiency":[162],"35%":[164],"exhibiting":[165],"vitamin":[166],"B12":[167],"deficiency.":[168],"Hypertension":[169],"present":[171],"75%":[173],"patients,":[175],"diabetes":[176],"60%,":[178],"40%":[180],"had":[181,208,216,225],"history":[183],"smoking.":[185],"NIHSS":[188],"score,":[189],"indicating":[190],"severity,":[192],"10.3":[194],"3.9.":[196],"distribution":[198],"levels":[201,209,217,226,239,260],"among":[202],"revealed":[205],"that":[206,257],"between":[210,218],"13.0":[211,241],"15.0":[213],"25%":[215],"15.1":[219],"17.0":[221,228],"13%":[224],"above":[227],"\u00b5mol/L.":[229,252],"68%":[233],"exhibited":[236],"elevated":[237,258],"(above":[240],"\u00b5mol/L),":[242],"Conclusion:":[253],"It":[254],"concluded":[256],"are":[261],"significantly":[262],"associated":[263],"an":[265],"increased":[266],"highlights":[277],"importance":[279],"monitoring":[281],"managing":[283],"levels,":[285],"particularly":[286],"individuals":[288],"additional":[290],"nutritional":[295],"deficiencies.":[296]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2024-08-30T00:00:00"}