{"id":"https://openalex.org/W4402000728","doi":"https://doi.org/10.17116/repro20243004151","title":"An integrated approach to endometrial examination in case of repeated failures in ART cycles: a pilot study","display_name":"An integrated approach to endometrial examination in case of repeated failures in ART cycles: a pilot study","publication_year":2024,"publication_date":"2024-04-23","ids":{"openalex":"https://openalex.org/W4402000728","doi":"https://doi.org/10.17116/repro20243004151"},"language":"en","primary_location":{"id":"doi:10.17116/repro20243004151","doi":"https://doi.org/10.17116/repro20243004151","is_oa":false,"landing_page_url":"https://doi.org/10.17116/repro20243004151","pdf_url":null,"source":{"id":"https://openalex.org/S4210201184","display_name":"Russian Journal of Human Reproduction","issn_l":"1025-7217","issn":["1025-7217","2309-4885"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Human Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013221263","display_name":"Yu.E. Dobrokhotova","orcid":"https://orcid.org/0000-0002-7830-2290","observed_orcids":["https://orcid.org/0000-0002-7830-2290","https://orcid.org/0000-0003-2786-6181"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Yu.E. Dobrokhotova","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0002-7830-2290","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003978766","display_name":"Irina A. Lapina","orcid":"https://orcid.org/0000-0001-9680-4887","observed_orcids":["https://orcid.org/0000-0001-9680-4887"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"I.A. Lapina","raw_affiliation_strings":["Medsi Clinical Diagnostic Center on Solyanka","Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0001-9680-4887","affiliations":[{"raw_affiliation_string":"Medsi Clinical Diagnostic Center on Solyanka","institution_ids":[]},{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106900720","display_name":"G. I. Elchieva","orcid":"https://orcid.org/0009-0002-1330-0451","observed_orcids":["https://orcid.org/0009-0002-1330-0451"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G.I. Elchieva","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0009-0002-1330-0451","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024417918","display_name":"Valeriia M. Gomzikova","orcid":"https://orcid.org/0000-0001-6297-8811","observed_orcids":["https://orcid.org/0000-0001-6297-8811"]},"institutions":[{"id":"https://openalex.org/I337778094","display_name":"Pirogov Russian National Research Medical University","ror":"https://ror.org/018159086","country_code":"RU","type":"education","lineage":["https://openalex.org/I337778094","https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.M. Gomzikova","raw_affiliation_strings":["Pirogov Russian National Research Medical University"],"raw_orcid":"https://orcid.org/0000-0001-6297-8811","affiliations":[{"raw_affiliation_string":"Pirogov Russian National Research Medical University","institution_ids":["https://openalex.org/I337778094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075115432","display_name":"Yury \u0410. Sorokin","orcid":"https://orcid.org/0000-0001-9305-323X","observed_orcids":["https://orcid.org/0000-0001-9305-323X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu.A. Sorokin","raw_affiliation_strings":["Medsi Clinical Diagnostic Center on Solyanka"],"raw_orcid":"https://orcid.org/0000-0001-9305-323X","affiliations":[{"raw_affiliation_string":"Medsi Clinical Diagnostic Center on Solyanka","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066981878","display_name":"Maria \u0410. Tverdikova","orcid":"https://orcid.org/0000-0003-0462-2838","observed_orcids":["https://orcid.org/0000-0003-0462-2838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M.A. Tverdikova","raw_affiliation_strings":["Medsi Clinical Diagnostic Center on Solyanka"],"raw_orcid":"https://orcid.org/0000-0003-0462-2838","affiliations":[{"raw_affiliation_string":"Medsi Clinical Diagnostic Center on Solyanka","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"4","first_page":"51","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.4878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.4878000020980835,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.21879999339580536,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.14890000224113464,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-microbiota","display_name":"endometrial microbiota","score":0.9950000047683716},{"id":"https://openalex.org/keywords/recurrent-ivf-failure","display_name":"recurrent IVF failure","score":0.7480000257492065},{"id":"https://openalex.org/keywords/female-infertility","display_name":"female infertility","score":0.9490000009536743},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8019999861717224},{"id":"https://openalex.org/keywords/metagenomic-analysis","display_name":"metagenomic analysis","score":0.6320000290870667},{"id":"https://openalex.org/keywords/endometrial-biopsy","display_name":"endometrial biopsy","score":0.7419999837875366},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.6309999823570251},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.6650000214576721},{"id":"https://openalex.org/keywords/gardnerella","display_name":"Gardnerella","score":0.5559999942779541},{"id":"https://openalex.org/keywords/pregnancy-rate","display_name":"pregnancy rate","score":0.3919999897480011},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/uterine-microbiota","display_name":"uterine microbiota","score":0.6650000214576721},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.5590000152587891},{"id":"https://openalex.org/keywords/endometrial-receptivity-array","display_name":"endometrial receptivity array","score":0.40400001406669617},{"id":"https://openalex.org/keywords/endometrial-scratching","display_name":"endometrial scratching","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35568767786026},{"id":"https://openalex.org/C200601418","wikidata":"https://www.wikidata.org/wiki/Q2193887","display_name":"Reliability engineering","level":1,"score":0.3497493863105774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3349211812019348},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2872249484062195}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17116/repro20243004151","doi":"https://doi.org/10.17116/repro20243004151","is_oa":false,"landing_page_url":"https://doi.org/10.17116/repro20243004151","pdf_url":null,"source":{"id":"https://openalex.org/S4210201184","display_name":"Russian Journal of Human Reproduction","issn_l":"1025-7217","issn":["1025-7217","2309-4885"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Human Reproduction","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2010571114","https://openalex.org/W2131186249","https://openalex.org/W2411639498","https://openalex.org/W2528495505","https://openalex.org/W2635422715","https://openalex.org/W2890526629","https://openalex.org/W2978681731","https://openalex.org/W3011039914","https://openalex.org/W3015251032","https://openalex.org/W3040245690","https://openalex.org/W3043207992","https://openalex.org/W3173675742","https://openalex.org/W3207050574","https://openalex.org/W4307920437","https://openalex.org/W4312848841","https://openalex.org/W4313066178"],"related_works":["https://openalex.org/W4414102676","https://openalex.org/W7127606155","https://openalex.org/W4405375810","https://openalex.org/W7164133729","https://openalex.org/W7221234988","https://openalex.org/W3198227714","https://openalex.org/W6893443202","https://openalex.org/W7135215998","https://openalex.org/W4283723237","https://openalex.org/W4295350529"],"abstract_inverted_index":{"Background.":[0],"Female":[1],"infertility":[2,149,180,411],"is":[3,34,51],"still":[4],"an":[5,125,233],"actual":[6],"issue":[7],"in":[8,14,45,70,114,121,141,146,186,195,236,308,377,392,433,464],"gynecology,":[9],"despite":[10],"the":[11,19,30,46,54,57,63,86,101,104,107,118,131,134,138,204,207,221,224,228,240,257,262,277,305,314,317,321,372,405,425,434,455],"numerous":[12],"advances":[13],"reproductive":[15,59,156,173,211],"medicine.":[16],"According":[17,312],"to":[18,40,116,176,216,223,238,303,313],"World":[20],"Health":[21],"Organization,":[22],"17.5%":[23],"of":[24,48,56,69,81,89,103,106,133,140,154,172,201,209,227,249,259,266,271,273,281,286,298,307,316,320,324,355,383,399,430,458],"couples":[25],"suffer":[26],"from":[27,220],"infertility.":[28],"At":[29],"same":[31],"time,":[32],"there":[33],"no":[35],"tendency":[36],"for":[37,65,206],"this":[38,49,99,465],"indicator":[39],"decrease.":[41],"A":[42,79,161],"special":[43],"place":[44],"solution":[47],"problem":[50],"occupied":[52],"by":[53,243,332,340,364],"methods":[55],"assisted":[58,155,210],"technologies":[60],"(ART).":[61],"However,":[62,453],"reasons":[64],"repeated":[66,182,413],"unsuccessful":[67],"attempts":[68,153,185,416],"vitro":[71,142,309],"fertilization":[72,143],"have":[73,83,419],"not":[74],"yet":[75],"been":[76],"sufficiently":[77],"studied.":[78],"number":[80,457],"studies":[82,461],"shown":[84],"that":[85],"uterine":[87,422],"microbiome":[88,136,242,323],"infertile":[90],"and":[91,150,159,181,214,276,351,412,446],"fertile":[92],"women":[93,337,385,401],"differs":[94],"significantly":[95],"[1,":[96],"2].":[97],"In":[98,424],"connection,":[100],"study":[102,168,301],"influence":[105,132],"endometrial":[108,135,234,241,322,435],"biotope":[109],"on":[110,137,256],"embryo":[111,390],"implantation":[112],"ability":[113],"order":[115,237],"increase":[117,450],"pregnancy":[119,451],"rate":[120],"ART":[122],"cycles":[123],"remains":[124],"urgent":[126],"issue.":[127],"Aim.":[128],"To":[129],"assess":[130,239],"outcome":[139],"(IVF)":[144],"programs":[145],"patients":[147,171,191,250,267,282],"with":[148,179,197,268,283,292,360,410,427],"previous":[151],"failed":[152,183,414],"technologies.":[157],"Patients":[158],"methods.":[160],"pilot":[162,164,300],"prospective":[163,165],"single-center":[166],"non-randomized":[167],"including":[169],"22":[170,325],"age":[174],"(18":[175],"45":[177],"years)":[178],"IVF":[184,415,439],"history":[187],"was":[188,231,253,302,366],"conducted.":[189],"All":[190],"were":[192,290,330,338,375],"fully":[193],"examined":[194],"accordance":[196],"Order":[198],"No.":[199],"803n":[200],"31.07.20":[202],"\u00abOn":[203],"procedure":[205],"use":[208],"technologies,":[212],"contraindications":[213],"limitations":[215],"their":[217],"use\u00bb.":[218],"Additionally,":[219],"15th":[222],"25th":[225],"day":[226],"menstrual":[229],"cycle":[230],"performed":[232],"biopsy":[235],"metagenomic":[244,318],"analysis":[245,319],"(MEMA).":[246],"The":[247,295],"distribution":[248],"into":[251],"groups":[252],"carried":[254,367],"out":[255,382,398],"basis":[258],"test":[260],"results:":[261],"first":[263],"group":[264,279,354,378,393,426],"consisted":[265,280],"a":[269,284,370,420,428],"predominance":[270,285,429],"Lactobacillus>90%":[272],"total":[274],"microorganisms,":[275],"second":[278],"pathogenic":[287],"flora":[288],"who":[289],"treated":[291],"etiotropic":[293],"therapy.":[294],"final":[296],"point":[297],"our":[299],"evaluate":[304],"results":[306,315],"fertilization.":[310],"Results.":[311],"women,":[326],"only":[327,395],"7":[328,384],"(31.8%)":[329],"dominated":[331,339],"Lactobacilli":[333],"strains,":[334],"15":[335,400],"(68.1%)":[336],"opportunistic":[341],"microorganisms":[342],"such":[343],"as":[344],"Gardnerella,":[345],"Streptococcus,":[346],"Apotobium,":[347],"Prevotella,":[348],"Enterococcus,":[349],"Corynebacterium":[350],"others.":[352],"This":[353],"patients,":[356,459],"underwent":[357],"etiological":[358],"therapy":[359,445],"antibacterial":[361],"drugs":[362],"followed":[363],"probiotics":[365],"out.":[368],"As":[369],"result,":[371],"following":[373],"data":[374],"obtained:":[376],"1,":[379],"6":[380],"(85.7%)":[381],"became":[386,402],"pregnant":[387,403],"after":[388,404],"frozen-thawed":[389],"transfer,":[391],"2,":[394],"5":[396],"(33.3%)":[397],"recommended":[406],"treatment.":[407],"Conclusions.":[408],"Women":[409],"more":[417,437],"often":[418],"\u00abnon-lactobacillus\u00bb":[421],"microbiome.":[423],"Lactobacillus":[431],"bacteria":[432],"microflora,":[436],"favourable":[438],"outcomes":[440],"are":[441,462],"observed.":[442],"Etiotropic":[443],"antibiotic":[444],"probiotic":[447],"supplementation":[448],"also":[449],"rates.":[452],"given":[454],"small":[456],"large-scale":[460],"needed":[463],"area.":[466]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2024-08-30T00:00:00"}